Octreotide (BioDeep_00000019544)
Main id: BioDeep_00000006466
human metabolite blood metabolite Chemicals and Drugs Toxin
代谢物信息卡片
(4R,7S,10S,13R,16S,19R)-19-{[(2R)-2-amino-1-hydroxy-3-phenylpropylidene]amino}-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-6,9,12,15,18-pentahydroxy-7-(1-hydroxyethyl)-13-[(1H-indol-3-yl)methyl]-1,2-dithia-5,8,11,14,17-pentaazacycloicosa-5,8,11,14,17-pentaene-4-carboximidate
化学式: C49H66N10O10S2 (1018.4405)
中文名称: 醋酸奥曲肽
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)NC(=O)C(CC5=CC=CC=C5)N)C(=O)NC(CO)C(C)O)O
InChI: InChI=1S/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)
描述信息
Octreotide is only found in individuals that have used or taken this drug. It is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.Octreotide binds to somatostatin receptors. These receptors are coupled via pertussis toxin sensitive G proteins which lead to inhibition of adenylyl cyclase. Octreotide binding to these receptors also stimulates phosphotyrosine phosphatase and activation of the Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
H - Systemic hormonal preparations, excl. sex hormones and insulins > H01 - Pituitary and hypothalamic hormones and analogues > H01C - Hypothalamic hormones > H01CB - Somatostatin and analogues
D005765 - Gastrointestinal Agents
D000970 - Antineoplastic Agents
Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly[1][2].
同义名列表
18 个代谢物同义名
(4R,7S,10S,13R,16S,19R)-19-{[(2R)-2-amino-1-hydroxy-3-phenylpropylidene]amino}-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-6,9,12,15,18-pentahydroxy-7-(1-hydroxyethyl)-13-[(1H-indol-3-yl)methyl]-1,2-dithia-5,8,11,14,17-pentaazacycloicosa-5,8,11,14,17-pentaene-4-carboximidate; (4R,7S,10S,13R,16S,19R)-19-[(2R)-2-amino-3-phenylpropanamido]-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide; Octreotide acetate salt; Octreotida [Spanish]; Octreotide acetate; Compound 201 995; Compound 201-995; Compound 201995; Sandoz 201 995; Sandoz 201-995; Sandoz 201995; Sandostatine; Sandostatin; Octreotide; Octrotide; Mycapssa; SMS 201-995; Octreotide
数据库引用编号
17 个数据库交叉引用编号
- KEGG: C07306
- PubChem: 6400441
- PubChem: 383414
- HMDB: HMDB0014262
- ChEMBL: CHEMBL3182554
- ChEMBL: CHEMBL262746
- Wikipedia: Octreotide
- MeSH: Octreotide
- chemspider: 10482007
- CAS: 1240797-41-4
- CAS: 83150-76-9
- PMhub: MS000019511
- ChEBI: CHEBI:7726
- PubChem: 9514
- NIKKAJI: J23.724H
- medchemexpress: HY-P0036
- KNApSAcK: 7726
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sara Heebøll, Jeyanthini Risikesan, Steffen Ringgaard, Indumathi Kumarathas, Thomas D Sandahl, Henning Grønbæk, Esben Søndergaard, Søren Nielsen. Impaired Glucagon-Mediated Suppression of VLDL-Triglyceride Secretion in Individuals With Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD).
Diabetes.
2022 11; 71(11):2402-2411. doi:
10.2337/db22-0313. [PMID: 36001750] - Leila Deilami-Nezhad, Leila Moghaddam-Banaem, Mahdi Sadeghi. The preparation, biodistribution, and human's absorbed dose evaluation of Radio-Scandium-HYNIC-TOC for somatostatin-receptor-positive neuroendocrine tumors therapy by animal study.
Nuclear medicine communications.
2022 Aug; 43(8):881-891. doi:
10.1097/mnm.0000000000001586. [PMID: 35660705] - Priscilla Guglielmo, Fiammetta Pesella, Alida Sartorello, Badr El Khouzai, Sara Berti, Simona Muccioli, Michele Gregianin. Metastasis From Clear Cell Renal Cell Carcinoma Mimicking Well-Differentiated Pancreatic Neuroendocrine Tumor at 18F-FDG and 68Ga-DOTATOC PET/CT.
Clinical nuclear medicine.
2022 Jul; 47(7):e498-e499. doi:
10.1097/rlu.0000000000004151. [PMID: 35675141] - Asmaa A Khalifa, Nahed H El Sokkary, Samar S Elblehi, Mohamed A Diab, Mennatallah A Ali. Potential cardioprotective effect of octreotide via NOXs mitigation, mitochondrial biogenesis and MAPK/Erk1/2/STAT3/NF-kβ pathway attenuation in isoproterenol-induced myocardial infarction in rats.
European journal of pharmacology.
2022 Jun; 925(?):174978. doi:
10.1016/j.ejphar.2022.174978. [PMID: 35500641] - Heying Duan, Valentina Ferri, George Albert Fisher, Shagufta Shaheen, Guido Alejandro Davidzon, Andrei Iagaru, Carina Mari Aparici. Evaluation of Liver and Renal Toxicity in Peptide Receptor Radionuclide Therapy for Somatostatin Receptor Expressing Tumors: A 2-Year Follow-Up.
The oncologist.
2022 Jun; 27(6):447-452. doi:
10.1093/oncolo/oyab072. [PMID: 35641196] - Kevin C J Yuen, Susan L Samson. Oral Octreotide: A Review of Recent Clinical Trials and Practical Recommendations for Its Use in the Treatment of Patients With Acromegaly.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2022 Jun; 28(6):637-645. doi:
10.1016/j.eprac.2022.04.009. [PMID: 35452815] - Ivana Capuano, Pasquale Buonanno, Eleonora Riccio, Manuela Rizzo, Antonio Pisani. Tolvaptan vs. somatostatin in the treatment of ADPKD: A review of the literature.
Clinical nephrology.
2022 Mar; 97(3):131-140. doi:
10.5414/cn110510. [PMID: 34846296] - Caroline Boursier, Elodie Chevalier, Laura Filippetti, Laetitia Imbert, Veronique Roch, Olivier Huttin, Marine Claudin, Pierre-Yves Marie. 68Ga-DOTATOC digital-PET imaging of inflammatory cell infiltrates in myocarditis following COVID-19 vaccination.
European journal of nuclear medicine and molecular imaging.
2022 03; 49(4):1433-1434. doi:
10.1007/s00259-021-05609-4. [PMID: 34746968] - Libuse Tauchmanova, Astrid Breitschaft, Geoffrey Holder, Kevin Tianxiang Han, Somesh Choudhury, Christelle Darstein, Michaela Paul, Eric Drutinus, Germo Gericke, Herbert A Schmid, Alberto M Pedroncelli. Combination of pasireotide and octreotide: effects on GH and IGF-I secretion and glucose metabolism in healthy volunteers.
Endocrine.
2022 Feb; 75(2):537-548. doi:
10.1007/s12020-021-02908-6. [PMID: 34741720] - Priscilla Guglielmo, Simona Muccioli, Sara Berti, Alida Sartorello, Fiammetta Pesella, Michele Gregianin. Detection of Unilateral Axillary Nodal Uptake Both at 68Ga-DOTATOC and 18F-FDG PET/CT After 1 Week From COVID-19 Vaccine.
Clinical nuclear medicine.
2022 Feb; 47(2):e123-e124. doi:
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Cancer biotherapy & radiopharmaceuticals.
2022 Feb; 37(1):17-22. doi:
10.1089/cbr.2021.0071. [PMID: 34134512] - Wenying Hao, Longfan Piao, Maojie Sun, Fanzhuo Zeng. Clinical effect of combination of octreotide and omeprazole in children with acute upper gastrointestinal bleeding and the levels of serum creatinine and serum urea nitrogen.
Pakistan journal of pharmaceutical sciences.
2022 Jan; 35(1(Special)):343-347. doi:
NULL. [PMID: 35236645] - Marie Lambert, Lawrence Dierickx, Séverine Brillouet, Frédéric Courbon, Etienne Chatelut. Comparison of Two Types of Amino Acid Solutions on 177Lu-Dotatate Pharmacokinetics and Pharmacodynamics in Patients with Metastatic Gastroenteropancreatic Neuroendocrine Tumors.
Current radiopharmaceuticals.
2022; 15(2):164-172. doi:
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BMJ open.
2021 12; 11(12):e055864. doi:
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European journal of nuclear medicine and molecular imaging.
2021 12; 49(1):54-63. doi:
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Drug delivery.
2021 Dec; 28(1):719-732. doi:
10.1080/10717544.2021.1898702. [PMID: 33825592] - Michal Pudis, José Luis Vercher Conejero, Juan José Martín Marcuartu, Montserrat Cortés Romera. 68Ga-DOTATOC-avid lymphadenopathies induced from COVID-19 mRNA vaccination.
Japanese journal of clinical oncology.
2021 12; 51(12):1765. doi:
10.1093/jjco/hyab129. [PMID: 34363083] - Anna Sowa-Staszczak, Marta Opalińska, Anna Kurzyńska, Karolina Morawiec-Sławek, Aleksandra Gilis-Januszewska, Joanna Palen-Tytko, Helena Olearska, Alicja Hubalewska-Dydejczyk. Self-Administration of Long-Acting Somatostatin Analogues in NET Patients-Does It Affect the Clinical Outcome?.
Medicina (Kaunas, Lithuania).
2021 Nov; 57(12):. doi:
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2021 Nov; 53(11):723-729. doi:
10.1055/a-1654-8542. [PMID: 34740273] - Noémie Worbe, Louise Damian, Véronique Le Cam-Duchez, Hervé Levesque, Pierre Michel, Elske Quak. Hemorrhagic disseminated intravascular coagulation after 177Lu-Dotatate in metastatic midgut neuroendocrine tumor: A case report.
Medicine.
2021 Oct; 100(40):e27455. doi:
10.1097/md.0000000000027455. [PMID: 34622868] - Narges K Tafreshi, Darpan N Pandya, Christopher J Tichacek, Mikalai M Budzevich, Zhen Wang, Jordan N Reff, Robert W Engelman, David C Boulware, Alberto A Chiappori, Jonathan R Strosberg, Haitao Ji, Thaddeus J Wadas, Ghassan El-Haddad, David L Morse. Preclinical evaluation of [225Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms.
European journal of nuclear medicine and molecular imaging.
2021 10; 48(11):3408-3421. doi:
10.1007/s00259-021-05315-1. [PMID: 33772332] - Jeongin Yoo, Se Hyung Kim, Sun Kyung Jeon, Jae Seok Bae, Joon Koo Han. Added value of [68Ga]Ga-DOTA-TOC PET/CT for characterizing pancreatic neuroendocrine neoplasms: a comparison with contrast-enhanced CT and/or MRI in a large study cohort.
European radiology.
2021 Oct; 31(10):7734-7745. doi:
10.1007/s00330-021-07859-0. [PMID: 33787974] - Wouter T Zandee, Tessa Brabander, Anela Blažević, Noémie S Minczeles, Richard A Feelders, Wouter W de Herder, Johannes Hofland. Peptide Receptor Radionuclide Therapy With 177Lu-DOTATATE for Symptomatic Control of Refractory Carcinoid Syndrome.
The Journal of clinical endocrinology and metabolism.
2021 08; 106(9):e3665-e3672. doi:
10.1210/clinem/dgab289. [PMID: 33942075] - Jacob Luty, LesleAnn Hayward, Melanie Jackson, P Barton Duell. Severe respiratory failure in a patient with COVID-19 and acromegaly: rapid improvement after adding octreotide.
BMJ case reports.
2021 Aug; 14(8):. doi:
10.1136/bcr-2021-243900. [PMID: 34404661] - Theresa P Devasia, Yuni K Dewaraja, Kirk A Frey, Ka Kit Wong, Matthew J Schipper. A Novel Time-Activity Information-Sharing Approach Using Nonlinear Mixed Models for Patient-Specific Dosimetry with Reduced Imaging Time Points: Application in SPECT/CT After 177Lu-DOTATATE.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2021 08; 62(8):1118-1125. doi:
10.2967/jnumed.120.256255. [PMID: 33443063] - Caitlin Reilly, Alastair J Gemmell, Ian M McLaughlin, Robert Fleming, Nicholas Reed, David McIntosh, Alice Nicol. Characterisation of 99mTc EDDA/HYNIC-TOC (Tektrotyd) physiological and neuroendocrine tumour uptake using SPECT/CT standardised uptake values: initial experience.
Nuclear medicine communications.
2021 Aug; 42(8):935-939. doi:
10.1097/mnm.0000000000001416. [PMID: 33741866] - Heribert Hänscheid, Philipp E Hartrampf, Andreas Schirbel, Andreas K Buck, Constantin Lapa. Intraindividual comparison of [177Lu]Lu-DOTA-EB-TATE and [177Lu]Lu-DOTA-TOC.
European journal of nuclear medicine and molecular imaging.
2021 07; 48(8):2566-2572. doi:
10.1007/s00259-020-05177-z. [PMID: 33452632] - Lowell B Anthony, Thomas M O'Dorisio. Opportunities to Improve Symptom Control with Somatostatin Congeners in GEP-NETs: A Review of Key Issues.
The oncologist.
2021 07; 26(7):e1171-e1178. doi:
10.1002/onco.13847. [PMID: 34097784] - Dimitrios Papantoniou, Malin Grönberg, Kalle Landerholm, Staffan Welin, Barbara Ziolkowska, Dennis Nordvall, Eva Tiensuu Janson. Assessment of hormonal levels as prognostic markers and of their optimal cut-offs in small intestinal neuroendocrine tumours grade 2.
Endocrine.
2021 06; 72(3):893-904. doi:
10.1007/s12020-020-02534-8. [PMID: 33244704] - Joseph Bennett, Mark T Cunningham, Christin Howard, Marc Hoffmann, Fred V Plapp. Acquired factor V inhibitor in the setting of coronavirus disease 2019 infection.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2021 Jun; 32(4):294-297. doi:
10.1097/mbc.0000000000001009. [PMID: 33443928] - Peng Li, Leigh Ford, Shadabul Haque, Mitchell P McInerney, Hywel D Williams, Peter J Scammells, Philip E Thompson, Vincent Jannin, Christopher J H Porter, Hassan Benameur, Colin W Pouton. Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide.
Pharmaceutical research.
2021 Jun; 38(6):1125-1137. doi:
10.1007/s11095-021-03063-3. [PMID: 34100217] - Chuandong Sun, Zhu Li, Zheng Shi, Guichen Li. Current diagnosis and treatment of acute pancreatitis in China: a real-world, multicenter study.
BMC gastroenterology.
2021 May; 21(1):210. doi:
10.1186/s12876-021-01799-1. [PMID: 33964868] - Federico Veracierto, Nicolas Sanchez, Leandro Mosna, Diego Herrera Vegas, Roberto Salgado. Management of Chylous Ascites After Laparoscopic Nephrectomy for Living Kidney Donor: A Case Report and Literature Review.
Transplantation proceedings.
2021 May; 53(4):1251-1256. doi:
10.1016/j.transproceed.2020.10.024. [PMID: 33288311] - Hao-Nan Yu, Ling Liu, Qiu-Song Chen, Qing He, Yan-Sheng Li, Ying Wang, Shuo Gao. Comparison of 18 F-FDG PET/CT and 68 Ga-DOTATATE PET/CT in the Targeted Imaging of Culprit Tumors Causing Osteomalacia.
Orthopaedic surgery.
2021 May; 13(3):791-798. doi:
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European journal of pharmacology.
2021 Apr; 897(?):173920. doi:
10.1016/j.ejphar.2021.173920. [PMID: 33571535] - Esmail Jafari, Abdul Latif Amini, Hojjat Ahmadzadehfar, Dara Bagheri, Majid Assadi. Cardiotoxicity and cardiac monitoring following the use of radiotheranostics agents including 177Lu-PSMA for prostate cancer and 177Lu-DOTATATE for neuroendocrine tumors.
Nuklearmedizin. Nuclear medicine.
2021 Apr; 60(2):99-105. doi:
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Nuclear medicine communications.
2021 Mar; 42(3):325-331. doi:
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2021 03; 62(3):393-398. doi:
10.2967/jnumed.120.250274. [PMID: 32859703] - Sarit T Kipnis, Matthew Hung, Shria Kumar, Jason M Heckert, Hwan Lee, Bonita Bennett, Michael C Soulen, Daniel A Pryma, David A Mankoff, David C Metz, Jennifer R Eads, Bryson W Katona. Laboratory, Clinical, and Survival Outcomes Associated With Peptide Receptor Radionuclide Therapy in Patients With Gastroenteropancreatic Neuroendocrine Tumors.
JAMA network open.
2021 03; 4(3):e212274. doi:
10.1001/jamanetworkopen.2021.2274. [PMID: 33755166] - Geza Vass, Ria Evans Fry, Charles C Roehr. Should Newborns with Refractory Chylothorax Be Tried on Higher Dose of Octreotide?.
Neonatology.
2021; 118(1):122-126. doi:
10.1159/000512461. [PMID: 33494092] - Jules Zhang-Yin, Nadine Guilabert, Thierry Kiffel, Françoise Montravers, Phillip Calais, Jean Lumbroso, Jean-Noël Talbot. Patient external dose rate after 177Lu-DOTATATE therapy: factors affecting its decrease and predictive value.
International journal of medical sciences.
2021; 18(12):2725-2735. doi:
10.7150/ijms.58680. [PMID: 34104105] - Conor F Murphy, Nicholas Stratford, Neil G Docherty, Brendan Moran, Jessie A Elliott, Marie-Louise Healy, Jason P McMorrow, Narayanasamy Ravi, Anthony P Goldstone, John V Reynolds, Carel W le Roux. A Pilot Study of Gut-Brain Signaling After Octreotide Therapy for Unintentional Weight Loss After Esophagectomy.
The Journal of clinical endocrinology and metabolism.
2021 01; 106(1):e204-e216. doi:
10.1210/clinem/dgaa697. [PMID: 33000149] - Luis David Jiménez-Franco, Gerhard Glatting, Vikas Prasad, Wolfgang A Weber, Ambros J Beer, Peter Kletting. Effect of Tumor Perfusion and Receptor Density on Tumor Control Probability in 177Lu-DOTATATE Therapy: An In Silico Analysis for Standard and Optimized Treatment.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2021 01; 62(1):92-98. doi:
10.2967/jnumed.120.245068. [PMID: 32646878] - Yanxia Gao, Linlin Hou, Yibo Wang, Shigong Guo, Ding Yuan, Ya'nan Jiang, Guoyu Duan, Yan Zhang, Zhigao Xu, Lu Che, Changhua Sun, Sujuan Li, Shoutao Zhang, Tongwen Sun, Yi Li. Octreotide alleviates pancreatic damage caused by paraquat in rats by reducing inflammatory responses and oxidative stress.
Environmental toxicology and pharmacology.
2020 Nov; 80(?):103456. doi:
10.1016/j.etap.2020.103456. [PMID: 32673753] - Afshar Zomorrodi, Alireza Farshi. A Massive Chylous Ascites With Severe Morbidity After Laparoscopic Donor Nephrectomy and Successful Treatment With Total Parenteral Nutrition and Octreotide.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2020 11; 18(6):729-731. doi:
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Pharmaceutical research.
2020 Oct; 37(11):217. doi:
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Molecules (Basel, Switzerland).
2020 Sep; 25(18):. doi:
10.3390/molecules25184155. [PMID: 32932783] - Ahmad Pourahadi, Saeed Nojavan, Saied Saeed Hosseiny Davarani. Gel-electromembrane extraction of peptides: Determination of five hypothalamic agents in human plasma samples.
Talanta.
2020 Sep; 217(?):121025. doi:
10.1016/j.talanta.2020.121025. [PMID: 32498910] - Walaa Alshafie, Yingzhou Edward Pan, Hans-Jürgen Kreienkamp, Thomas Stroh. Characterization of agonist-dependent somatostatin receptor subtype 2 trafficking in neuroendocrine cells.
Endocrine.
2020 09; 69(3):655-669. doi:
10.1007/s12020-020-02329-x. [PMID: 32383089] - Giovanni Paganelli, Lisa Bodei, Irvin Modlin. A metastatic tumor is no different to a viral pandemic: lessons learnt from COVID-19 may teach us to change the PRRT paradigm.
European journal of nuclear medicine and molecular imaging.
2020 09; 47(10):2223-2226. doi:
10.1007/s00259-020-04904-w. [PMID: 32564170] - Mark Lubberink, Helena Wilking, Amalia Öst, Ezgi Ilan, Mattias Sandström, Camilla Andersson, Katarzyna Fröss-Baron, Irina Velikyan, Anders Sundin. In Vivo Instability of 177Lu-DOTATATE During Peptide Receptor Radionuclide Therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2020 09; 61(9):1337-1340. doi:
10.2967/jnumed.119.237818. [PMID: 32005767] - Berta Pérez Martín, Elisa Rodríguez Martínez, Iván Baamonde de la Torre, Natalia Suárez Pazos, Manuel Díaz Tie. Gastric Antral Vascular Ectasia Refractory to Endoscopic Treatment.
Cirugia espanola.
2020 Aug; 98(7):416-418. doi:
10.1016/j.ciresp.2019.11.001. [PMID: 31812265] - Sheng Hao, Ying Wu, Yulin Kang, Xiaoling Niu, Guanghua Zhu, Wenyan Huang. A single-center analysis of primary nephrotic syndrome with acute pancreatitis in children.
Medicine.
2020 Jul; 99(27):e21056. doi:
10.1097/md.0000000000021056. [PMID: 32629733] - Elin Pauwels, Sofie Van Binnebeek, Vincent Vandecaveye, Kristof Baete, Hubert Vanbilloen, Michel Koole, Felix M Mottaghy, Karin Haustermans, Paul M Clement, Kristiaan Nackaerts, Eric Van Cutsem, Chris Verslype, Christophe M Deroose. Inflammation-Based Index and 68Ga-DOTATOC PET-Derived Uptake and Volumetric Parameters Predict Outcome in Neuroendocrine Tumor Patients Treated with 90Y-DOTATOC.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2020 07; 61(7):1014-1020. doi:
10.2967/jnumed.119.236935. [PMID: 31806775] - Maria Fleseriu, Olaf M Dekkers, Niki Karavitaki. Endocrinology in the time of COVID-19: Management of pituitary tumours.
European journal of endocrinology.
2020 Jul; 183(1):G17-G23. doi:
10.1530/eje-20-0473. [PMID: 32369770] - Giovanni Tulipano, Andrea Giustina. Effects of octreotide on autophagy markers and cell viability markers related to metabolic activity in rat pituitary tumor cells.
Pituitary.
2020 Jun; 23(3):223-231. doi:
10.1007/s11102-020-01028-0. [PMID: 31997055] - Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E Haefeli. Post-extraction disulfide bond cleavage for MS/MS quantification of collision-induced dissociation-resistant cystine-cyclized peptides and its application to the ultra-sensitive UPLC-MS/MS bioanalysis of octreotide in plasma.
Analytica chimica acta.
2020 Jun; 1114(?):42-49. doi:
10.1016/j.aca.2020.04.016. [PMID: 32359513] - Shuichiro Ogawa, Tomoko Matsuzaki, Makoto Noda. Abundant expression of the membrane-anchored protease-regulator RECK in the anterior pituitary gland and its implication in the growth hormone/insulin-like growth factor 1 axis in mice.
Molecular and cellular endocrinology.
2020 05; 508(?):110790. doi:
10.1016/j.mce.2020.110790. [PMID: 32165171] - Mary J Thomson, Arthur Taylor, Pratima Sharma, Anna S Lok, Elliot B Tapper. Limited Progress in Hepatorenal Syndrome (HRS) Reversal and Survival 2002-2018: A Systematic Review and Meta-Analysis.
Digestive diseases and sciences.
2020 05; 65(5):1539-1548. doi:
10.1007/s10620-019-05858-2. [PMID: 31571102] - Sanjana Ballal, Madhav Prasad Yadav, Chandrasekhar Bal, Ranjit Kumar Sahoo, Madhavi Tripathi. Broadening horizons with 225Ac-DOTATATE targeted alpha therapy for gastroenteropancreatic neuroendocrine tumour patients stable or refractory to 177Lu-DOTATATE PRRT: first clinical experience on the efficacy and safety.
European journal of nuclear medicine and molecular imaging.
2020 04; 47(4):934-946. doi:
10.1007/s00259-019-04567-2. [PMID: 31707430] - Velid Unsal, Ergül Belge Kurutaş. Investigation of the Effects of Octreotide Agent on Oxidative Stress, 8-Hydroxy Deoxyguanosine in Experimental Hepatic Carcinogenesis Rat Model.
Folia medica.
2020 03; 62(1):70-75. doi:
10.3897/folmed.62.e47735. [PMID: 32337899] - Eugenia Ortiz, Marcelo Peldoza, Eduardo Monnier, Roger Gejman, Miguel Henriquez, Maria Ines Barra, Roxana Gayoso, Jorge Sapunar, Miguel Villaseca, Pablo Guzmán. Ectopic pituitary adenoma of the TSH-secreting sphenoidal sinus with excellent response to somatostatin analogs. Theory of the embryogenesis and literature review from a clinical case.
Steroids.
2020 02; 154(?):108535. doi:
10.1016/j.steroids.2019.108535. [PMID: 31704334] - Thomas L Andersen, Christina Baun, Birgitte B Olsen, Johan H Dam, Helge Thisgaard. Improving Contrast and Detectability: Imaging with [55Co]Co-DOTATATE in Comparison with [64Cu]Cu-DOTATATE and [68Ga]Ga-DOTATATE.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2020 02; 61(2):228-233. doi:
10.2967/jnumed.119.233015. [PMID: 31519803] - Shohei Kawaguchi, Yoshifumi Kadono, Takahiro Nohara, Yuki Kato, Tomomi Nakagawa, Satoko Urata, Hiroshi Yaegashi, Kazufumi Nakashima, Masashi Iijima, Kazuyoshi Shigehara, Kouji Izumi, Atsushi Mizokami. A Case Report of Chyloretroperitoneum Post Living-Donor Transplantation.
Urologia internationalis.
2020; 104(1-2):160-162. doi:
10.1159/000497108. [PMID: 30799423] - Anna Zemczak, Maciej Kołodziej, Paweł Gut, Leszek Królicki, Beata Kos-Kudła, Grzegorz Kamiński, Marek Ruchała, Dariusz Pawlak, Jolanta Kunikowska. Effect of peptide receptor radionuclide therapy (PRRT) with tandem isotopes - [90Y]Y/[177Lu]Lu-DOTATATE in patients with disseminated neuroendocrine tumours depending on [18F]FDG PET/CT qualification in Polish multicentre experience - do we need [18F]FDG PET/CT for qualification to PRRT?.
Endokrynologia Polska.
2020; 71(3):240-248. doi:
10.5603/ep.a2020.0014. [PMID: 32293704] - Sriram Gubbi, Mohammad Al-Jundi, Jaydira Del Rivero, Abhishek Jha, Marianne Knue, Joy Zou, Baris Turkbey, Jorge Amilcar Carrasquillo, Emily Lin, Karel Pacak, Joanna Klubo-Gwiezdzinska, Frank I-Kai Lin. Case Report: Primary Hypothyroidism Associated With Lutetium 177-DOTATATE Therapy for Metastatic Paraganglioma.
Frontiers in endocrinology.
2020; 11(?):587065. doi:
10.3389/fendo.2020.587065. [PMID: 33551992] - Ulrika Jahn, Ezgi Ilan, Mattias Sandström, Ulrike Garske-Román, Mark Lubberink, Anders Sundin. 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy: Dose Response in Small Intestinal Neuroendocrine Tumors.
Neuroendocrinology.
2020; 110(7-8):662-670. doi:
10.1159/000504001. [PMID: 31597134] - Hossein Behnammanesh, Safura Jokar, Mostafa Erfani, Parham Geramifar, Omid Sabzevari, Mohsen Amini, Seyed Mohammad Mazidi, Maliheh Hajiramezanali, Davood Beiki. Design, preparation and biological evaluation of a 177Lu-labeled somatostatin receptor antagonist for targeted therapy of neuroendocrine tumors.
Bioorganic chemistry.
2020 01; 94(?):103381. doi:
10.1016/j.bioorg.2019.103381. [PMID: 31662215] - Donatella Treppiedi, Federica Mangili, Elena Giardino, Rosa Catalano, Marco Locatelli, Andrea Gerardo Lania, Anna Spada, Maura Arosio, Davide Calebiro, Giovanna Mantovani, Erika Peverelli. Cytoskeleton Protein Filamin A Is Required for Efficient Somatostatin Receptor Type 2 Internalization and Recycling through Rab5 and Rab4 Sorting Endosomes in Tumor Somatotroph Cells.
Neuroendocrinology.
2020; 110(7-8):642-652. doi:
10.1159/000503791. [PMID: 31574507] - Marco Galliani, Silvana Chicca, Elio Vitaliano, Eleonora Moscaritolo, Luca Calvaruso, Francesco Iorio, Antonio Paone. [ADPKD treatment: Tolvaptan and Octreotide].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2019 Dec; 36(6):. doi:
NULL. [PMID: 31830392] - Paweł Gut, Marek Ruchała. Evaluation of 5-hydroxyindoloacetic acid excretion in urine in patients with small intestine neuroendocrine neoplasm and carcinoid syndrome treated with somatostatin analogues.
Neuro endocrinology letters.
2019 Dec; 40(7-8):315-318. doi:
. [PMID: 32304367] - Diane Reidy-Lagunes, Neeta Pandit-Taskar, Joseph A O'Donoghue, Simone Krebs, Kevin D Staton, Serge K Lyashchenko, Jason S Lewis, Nitya Raj, Mithat Gönen, Christian Lohrmann, Lisa Bodei, Wolfgang A Weber. Phase I Trial of Well-Differentiated Neuroendocrine Tumors (NETs) with Radiolabeled Somatostatin Antagonist 177Lu-Satoreotide Tetraxetan.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2019 12; 25(23):6939-6947. doi:
10.1158/1078-0432.ccr-19-1026. [PMID: 31439583] - Rémi Lenain, Aghilès Hamroun, Georges Lion, Paul Chamley, Linh Bui, Arnaud Lionet, Marc Hazzan, François Provôt. Description of a transient proximal tubulopathy induced by amino acids perfusion in peptide receptor radionuclide therapy: A case report.
Medicine.
2019 Dec; 98(52):e18478. doi:
10.1097/md.0000000000018478. [PMID: 31876733] - Quan An, Chen-Xiao Shi, Hao Guo, Shi-Min Xie, Ying-Ying Yang, Ying-Nan Liu, Zi-Hao Liu, Chang-Zheng Zhou, Feng-Ju Niu. Development and characterization of octreotide-modified curcumin plus docetaxel micelles for potential treatment of non-small-cell lung cancer.
Pharmaceutical development and technology.
2019 Nov; 24(9):1164-1174. doi:
10.1080/10837450.2019.1647236. [PMID: 31340709] - Charlotte K Andersson, Emman Shubbar, Emil Schüler, Bo Åkerström, Magnus Gram, Eva B Forssell-Aronsson. Recombinant α1-Microglobulin Is a Potential Kidney Protector in 177Lu-Octreotate Treatment of Neuroendocrine Tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2019 11; 60(11):1600-1604. doi:
10.2967/jnumed.118.225243. [PMID: 30926650] - Isa Neshandar Asli, Ghazal Norouzi. Incidental Finding of Benign Trichilemmal Cysts on 99mTc-Octreotide Scan.
Clinical nuclear medicine.
2019 Oct; 44(10):834-835. doi:
10.1097/rlu.0000000000002737. [PMID: 31306209] - He Gong, Jing Wang, Jue Zhang, Jianbing Wu, Zhaozhu Zheng, Xusheng Xie, David L Kaplan, Gang Li, Xiaoqin Wang. Control of octreotide release from silk fibroin microspheres.
Materials science & engineering. C, Materials for biological applications.
2019 Sep; 102(?):820-828. doi:
10.1016/j.msec.2019.05.004. [PMID: 31147054] - Britta Leonhäuser, Christian Happel, Daniel Gröner, Benjamin Bockisch, Martin Fiebich, Dirk Hellwig, Frank Grünwald, Wolfgang Tilman Kranert. [Evaluation of intratherapeutic 177Lu-HA-DOTATATE treatment in neuroendocrine tumors: dosimetry with SPECT, whole-body imaging and gamma probe].
Nuklearmedizin. Nuclear medicine.
2019 Sep; 58(5):379-386. doi:
10.1055/a-0987-9689. [PMID: 31461752] - Wei Zhao, Pedro Luis Esquinas, Andrea Frezza, Xinchi Hou, Jean-Mathieu Beauregard, Anna Celler. Accuracy of kidney dosimetry performed using simplified time activity curve modelling methods: a 177Lu-DOTATATE patient study.
Physics in medicine and biology.
2019 08; 64(17):175006. doi:
10.1088/1361-6560/ab3039. [PMID: 31287093] - Xinchi Hou, Wei Zhao, Jean-Mathieu Beauregard, Anna Celler. Personalized kidney dosimetry in 177Lu-octreotate treatment of neuroendocrine tumours: a comparison of kidney dosimetry estimates based on a whole organ and small volume segmentations.
Physics in medicine and biology.
2019 08; 64(17):175004. doi:
10.1088/1361-6560/ab32a1. [PMID: 31456584] - S Rudisile, A Gosewisch, V Wenter, M Unterrainer, G Böning, F J Gildehaus, W P Fendler, C J Auernhammer, C Spitzweg, P Bartenstein, A Todica, H Ilhan. Salvage PRRT with 177Lu-DOTA-octreotate in extensively pretreated patients with metastatic neuroendocrine tumor (NET): dosimetry, toxicity, efficacy, and survival.
BMC cancer.
2019 Aug; 19(1):788. doi:
10.1186/s12885-019-6000-y. [PMID: 31395036] - Chong Zhang, Ran An, Ya-Wei Bao, Xiao-Ming Meng, Tian-Qi Wang, Hao-Nan Sun, Fa-Ming Pan, Chao Zhang. Inhibitory effects of octreotide on the progression of hepatic fibrosis via the regulation of Bcl-2/Bax and PI3K/AKT signaling pathways.
International immunopharmacology.
2019 Aug; 73(?):515-526. doi:
10.1016/j.intimp.2019.05.055. [PMID: 31173973] - Luca Attuati, Ismail Zaed, Carlotta Morselli, Guido Pecchioli, Maurizio Fornari, Piero Picozzi. Multimodal Management of Metastatic Malignant Meningiomas: The Role of Radiosurgery in Long-Term Local Control.
World neurosurgery.
2019 Aug; 128(?):562-572. doi:
10.1016/j.wneu.2019.05.058. [PMID: 31102770] - Tiziana Feola, Alessia Cozzolino, Ilaria Simonelli, Emilia Sbardella, Carlotta Pozza, Elisa Giannetta, Daniele Gianfrilli, Patrizio Pasqualetti, Andrea Lenzi, Andrea M Isidori. Pegvisomant Improves Glucose Metabolism in Acromegaly: A Meta-Analysis of Prospective Interventional Studies.
The Journal of clinical endocrinology and metabolism.
2019 07; 104(7):2892-2902. doi:
10.1210/jc.2018-02281. [PMID: 30869797] - Thomas A Hope, Amanda Abbott, Karen Colucci, David L Bushnell, Linda Gardner, William S Graham, Sheila Lindsay, David C Metz, Daniel A Pryma, Michael G Stabin, Jonathan R Strosberg. NANETS/SNMMI Procedure Standard for Somatostatin Receptor-Based Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2019 07; 60(7):937-943. doi:
10.2967/jnumed.118.230607. [PMID: 31263080] - G Nunes, R Barosa, M Patita, P Pinto-Marques, D Gonçalves, C Fonseca, A Alves de Matos, J Fonseca. Ménétrier's disease : a case of successful treatment using long-acting octreotide.
Acta gastro-enterologica Belgica.
2019 Jul; 82(3):429-432. doi:
. [PMID: 31566332] - Yuji Nakamoto, Takayoshi Ishimori, Yoichi Shimizu, Kohei Sano, Kaori Togashi. Clinical utility of 68Ga-DOTATOC positron emission tomography/computed tomography for recurrent renal cell carcinoma.
European journal of nuclear medicine and molecular imaging.
2019 Jul; 46(7):1524-1530. doi:
10.1007/s00259-019-04298-4. [PMID: 30847538] - Tengteng Wang, Chunyan Zhang, Wei Zhong, Xiucheng Yang, Aiping Wang, Rongcai Liang. Modification of Three-Phase Drug Release Mode of Octreotide PLGA Microspheres by Microsphere-Gel Composite System.
AAPS PharmSciTech.
2019 Jun; 20(6):228. doi:
10.1208/s12249-019-1438-4. [PMID: 31227940] - Aura D Herrera-Martínez, Rosanna van den Dungen, Fadime Dogan-Oruc, Peter M van Koetsveld, Michael D Culler, Wouter W de Herder, Raúl M Luque, Richard A Feelders, Leo J Hofland. Effects of novel somatostatin-dopamine chimeric drugs in 2D and 3D cell culture models of neuroendocrine tumors.
Endocrine-related cancer.
2019 06; 26(6):585-599. doi:
10.1530/erc-19-0086. [PMID: 30939452] - Fuad Novruzov, Leyla Mehmetbeyli, Jamil A Aliyev, Bahadur Abbasov, Elnur Mehdi. Metastatic Insulinoma Controlled by Targeted Radionuclide Therapy With 177Lu-DOTATATE in a Patient With Solitary Kidney and MEN-1 Syndrome.
Clinical nuclear medicine.
2019 Jun; 44(6):e415-e417. doi:
10.1097/rlu.0000000000002500. [PMID: 30789400] - Amanda Kristiansson, Jonas Ahlstedt, Bo Holmqvist, Anders Brinte, Thuy A Tran, Eva Forssell-Aronsson, Sven-Erik Strand, Magnus Gram, Bo Åkerström. Protection of Kidney Function with Human Antioxidation Protein α1-Microglobulin in a Mouse 177Lu-DOTATATE Radiation Therapy Model.
Antioxidants & redox signaling.
2019 05; 30(14):1746-1759. doi:
10.1089/ars.2018.7517. [PMID: 29943622] - Tania A Rozgaja Stallons, Amal Saidi, Izabela Tworowska, Ebrahim S Delpassand, Julien J Torgue. Preclinical Investigation of 212Pb-DOTAMTATE for Peptide Receptor Radionuclide Therapy in a Neuroendocrine Tumor Model.
Molecular cancer therapeutics.
2019 05; 18(5):1012-1021. doi:
10.1158/1535-7163.mct-18-1103. [PMID: 30926632] - Kosuke Mukai, Michio Otsuki, Daisuke Tamada, Tetsuhiro Kitamura, Reiko Hayashi, Aya Saiki, Yuko Goto, Hideyuki Arita, Satoru Oshino, Eiichi Morii, Youichi Saitoh, Iichiro Shimomura. Clinical Characteristics of Acromegalic Patients With Paradoxical GH Response to Oral Glucose Load.
The Journal of clinical endocrinology and metabolism.
2019 05; 104(5):1637-1644. doi:
10.1210/jc.2018-00975. [PMID: 30476255] - Norberto Perico, Piero Ruggenenti, Annalisa Perna, Anna Caroli, Matias Trillini, Sandro Sironi, Antonio Pisani, Eleonora Riccio, Massimo Imbriaco, Mauro Dugo, Giovanni Morana, Antonio Granata, Michele Figuera, Flavio Gaspari, Fabiola Carrara, Nadia Rubis, Alessandro Villa, Sara Gamba, Silvia Prandini, Monica Cortinovis, Andrea Remuzzi, Giuseppe Remuzzi. Octreotide-LAR in later-stage autosomal dominant polycystic kidney disease (ALADIN 2): A randomized, double-blind, placebo-controlled, multicenter trial.
PLoS medicine.
2019 04; 16(4):e1002777. doi:
10.1371/journal.pmed.1002777. [PMID: 30951521] - Hélène Lasolle, Alexandre Vasiljevic, Françoise Borson-Chazot, Gerald Raverot. Pasireotide: A potential therapeutic alternative for resistant prolactinoma.
Annales d'endocrinologie.
2019 Apr; 80(2):84-88. doi:
10.1016/j.ando.2018.07.013. [PMID: 30318256] - Michael Gabriel, Bernhard Nilica, Bernhard Kaiser, Irene J Virgolini. Twelve-Year Follow-up After Peptide Receptor Radionuclide Therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2019 04; 60(4):524-529. doi:
10.2967/jnumed.118.215376. [PMID: 30115690] - Kanhaiyalal Agrawal, P Sai Sradha Patro, C Preetam. Tc-99m HYNIC-TOC scintigraphy in dedifferentiated thyroid cancer.
BMJ case reports.
2019 Apr; 12(4):. doi:
10.1136/bcr-2018-227910. [PMID: 30940668] - D Magalhães, I L Sampaio, G Ferreira, P Bogalho, D Martins-Branco, R Santos, H Duarte. Peptide receptor radionuclide therapy with 177Lu-DOTA-TATE as a promising treatment of malignant insulinoma: a series of case reports and literature review.
Journal of endocrinological investigation.
2019 Mar; 42(3):249-260. doi:
10.1007/s40618-018-0911-3. [PMID: 29949120] - Chiyi Xiong, Dengke Yin, Junjie Li, Qian Huang, Murali K Ravoori, Vikas Kundra, Hua Zhu, Zhi Yang, Yang Lu, Chun Li. Metformin Reduces Renal Uptake of Radiotracers and Protects Kidneys from Radiation-Induced Damage.
Molecular pharmaceutics.
2019 02; 16(2):808-815. doi:
10.1021/acs.molpharmaceut.8b01091. [PMID: 30608713]
