4'-Hydroxyflavanone (BioDeep_00000014848)

Main id: BioDeep_00000003614

 

human metabolite PANOMIX_OTCML-2023 blood metabolite Volatile Flavor Compounds


代谢物信息卡片


2,3-Dihydro-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

化学式: C15H12O3 (240.0786402)
中文名称: 4-羟基黄烷酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(OC2=CC=CC=C2C1=O)C3=CC=C(C=C3)O
InChI: InChI=1S/C15H12O3/c16-11-7-5-10(6-8-11)15-9-13(17)12-3-1-2-4-14(12)18-15/h1-8,15-16H,9H2

描述信息

4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research[1].
4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research[1].
4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research[1].

同义名列表

6 个代谢物同义名

2,3-Dihydro-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one; 4-Hydroxyflavanone; UNII:5K6L8O868Y; 4'-Hydroxyflavanone; 4'-Hydroxyflavanone



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lucie Zemanova, Jakub Hofman, Eva Novotna, Kamil Musilek, Tereza Lundova, Jana Havrankova, Anna Hostalkova, Jakub Chlebek, Lucie Cahlikova, Vladimír Wsol. Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment. Journal of natural products. 2015 Nov; 78(11):2666-74. doi: 10.1021/acs.jnatprod.5b00616. [PMID: 26529431]
  • Guang-ming Xu, Zhe-ming Wang, Nian-zhen Liu, Wei-jun He, Shuai Peng, Xiao-jiang Zhou. [Study on Chemical Constituents from Ethyl Acetate Extraction of Sanicula lamelligera]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Aug; 38(8):1661-4. doi: ". [PMID: 26983240]
  • Huixiao Hong, William S Branham, Hui Wen Ng, Carrie L Moland, Stacey L Dial, Hong Fang, Roger Perkins, Daniel Sheehan, Weida Tong. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Feb; 143(2):333-48. doi: 10.1093/toxsci/kfu231. [PMID: 25349334]
  • Huixiao Hong, William S Branham, Stacey L Dial, Carrie L Moland, Hong Fang, Jie Shen, Roger Perkins, Daniel Sheehan, Weida Tong. Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities. Chemical research in toxicology. 2012 Nov; 25(11):2553-66. doi: 10.1021/tx3003406. [PMID: 23013281]
  • Shingo Miyata, Jun Inoue, Makoto Shimizu, Ryuichiro Sato. 4'-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis. FEBS letters. 2012 Jun; 586(13):1778-82. doi: 10.1016/j.febslet.2012.04.060. [PMID: 22634867]
  • Peter L Katavic, Kenneth Lamb, Hernan Navarro, Thomas E Prisinzano. Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships. Journal of natural products. 2007 Aug; 70(8):1278-82. doi: 10.1021/np070194x. [PMID: 17685652]
  • L Krenn, V Pötsch. An efficient HPLC method for the quantification of isoflavones in soy extracts and soy dietary supplements in routine quality control. Die Pharmazie. 2006 Jul; 61(7):582-5. doi: ". [PMID: 16889063]
  • S Moro, A M van Rhee, L H Sanders, K A Jacobson. Flavonoid derivatives as adenosine receptor antagonists: a comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model. Journal of medicinal chemistry. 1998 Jan; 41(1):46-52. doi: 10.1021/jm970446z. [PMID: 9438021]
  • Y Karton, J L Jiang, X D Ji, N Melman, M E Olah, G L Stiles, K A Jacobson. Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. Journal of medicinal chemistry. 1996 Jun; 39(12):2293-301. doi: 10.1021/jm950923i. [PMID: 8691424]