Oxymesterone (BioDeep_00000010066)

 

Secondary id: BioDeep_00001874301

human metabolite


代谢物信息卡片


(1S,2R,10R,11S,14S,15S)-6,14-dihydroxy-2,14,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one

化学式: C20H30O3 (318.2195)
中文名称: 羟甲睾酮
谱图信息: 最多检出来源 Homo sapiens(general) 1.11%

分子结构信息

SMILES: CC12CCC(=O)C(=C1CCC3C2CCC4(C3CCC4(C)O)C)O
InChI: InChI=1S/C20H30O3/c1-18-9-8-16(21)17(22)15(18)5-4-12-13(18)6-10-19(2)14(12)7-11-20(19,3)23/h12-14,22-23H,4-11H2,1-3H3/t12-,13+,14+,18-,19+,20+/m1/s1

描述信息

Oxymesterone is an anabolic steroid abused by some athletes and is tested for in regular preventive doping control analysis. Androgenic anabolic steroids (AAS) are defined as natural, synthetic or semi-synthetic drugs chemicals derived from testosterone, used with the aim to improve physical performance by increasing both muscle strength and mass. Despite their reported toxicological effects on the cardiovascular, hepatic and neuro-endocrine systems, the AAS have been extensively used in sports activities. Oxymesterone and other steroids can be detected in human urine using liquid chromatography/electrospray ionization orthogonal acceleration time-of-flight mass spectrometry (LCoaTOFMS) and gas chromatography/electron ionization orthogonal acceleration time-of-flight mass spectrometry (GCoaTOFMS), using methods that have been developed in order to acquire accurate full scan MS data to be used to detect designer steroids. (PMID: 17610244, 17667636, 17723876, 17723877, 2079979, 3308301, 8456050, 8674183, 8725393, 9216475) [HMDB]
Oxymesterone is an anabolic steroid abused by some athletes and is tested for in regular preventive doping control analysis. Androgenic anabolic steroids (AAS) are defined as natural, synthetic or semi-synthetic drugs chemicals derived from testosterone, used with the aim to improve physical performance by increasing both muscle strength and mass. Despite their reported toxicological effects on the cardiovascular, hepatic and neuro-endocrine systems, the AAS have been extensively used in sports activities. Oxymesterone and other steroids can be detected in human urine using liquid chromatography/electrospray ionization orthogonal acceleration time-of-flight mass spectrometry (LCoaTOFMS) and gas chromatography/electron ionization orthogonal acceleration time-of-flight mass spectrometry (GCoaTOFMS), using methods that have been developed in order to acquire accurate full scan MS data to be used to detect designer steroids. (PMID: 17610244, 17667636, 17723876, 17723877, 2079979, 3308301, 8456050, 8674183, 8725393, 9216475).
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid

同义名列表

20 个代谢物同义名

(1S,2R,10R,11S,14S,15S)-6,14-dihydroxy-2,14,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one; 4,17-dihydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one; 17Alpah-methyl-4, 17beta-dihydroxy-androst-4-ene-3-one; 4,17beta-Dihydroxy-17alpha-methylandrost-4-en-3-one; (17b)- 4,17b-Dihydroxy-17-methyl-androst-4-en-3-one; 4,17b-Dihydroxy-17a-methylandrost-4-en-3-one; 4,17b-Dihydroxy-17-methyl-androst-4-en-3-one; 4,17Β-dihydroxy-17α-methylandrost-4-en-3-one; 4,17b-Dihydroxy-17-methylandrost-4-en-3-one; 4-Hydroxy-17alpha-methyltestosterone; 4-Hydroxy-17α-methyltestosterone; 4-Hydroxy-17a-methyltestosterone; 4-Hydroxy-17-methyltestosterone; Oxymesterone; Oxymestrone; Theranabol; Anamidol; Oranabol; Aranabol; Oranabol



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Michael Polet, Wim Van Gansbeke, Lore Geldof, Koen Deventer, Peter Van Eenoo. Identification and characterization of novel long-term metabolites of oxymesterone and mesterolone in human urine by application of selected reaction monitoring GC-CI-MS/MS. Drug testing and analysis. 2017 Nov; 9(11-12):1673-1684. doi: 10.1002/dta.2183. [PMID: 28296258]
  • Sheng Yang, Jianghai Lu, Youxuan Xu, Xiaobing Wang. New oxymesterone metabolites in human by gas chromatography-tandem mass spectrometry and their application for doping control. Drug testing and analysis. 2016 Jul; 8(7):633-43. doi: 10.1002/dta.1836. [PMID: 26197789]