10-Formyldihydrofolate (BioDeep_00000005129)

 

Secondary id: BioDeep_00001869248

human metabolite Endogenous


代谢物信息卡片


(2S)-2-[(4-{N-[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]formamido}phenyl)formamido]pentanedioic acid

化学式: C20H21N7O7 (471.1502396)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 11.11%

分子结构信息

SMILES: C1C(=NC2=C(N1)N=C(NC2=O)N)CN(C=O)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C20H21N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,13H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t13-/m0/s1

描述信息

10-Formyldihydrofolate is a folate compound that has not been found as a component of intracellular folates in normal tissues but has been identified in the cytosol of methotrexate (MTX)-treated MCF-7 breast cancer cells and normal human myeloid precursor cells. The origin of 10-formyldihydrofolate remains an enigma. Its appearance only in the extracts from MTX-treated cells is not consistent with a simple oxidation of lO-formyl-H4folate during the extraction procedure. This, however, does not exclude the occurrence of spontaneous oxidation of 10-formyl-H4folate within the intact cells prior to the folate extraction. (PMID: 3366769) [HMDB]
10-formyldihydrofolate is a folate compound that has not been found as a component of intracellular folates in normal tissues but has been identified in the cytosol of methotrexate (MTX)-treated MCF-7 breast cancer cells and normal human myeloid precursor cells. The origin of 10-formyldihydrofolate remains an enigma. Its appearance only in the extracts from MTX-treated cells is not consistent with a simple oxidation of lO-formyl-H4folate during the extraction procedure. This, however, does not exclude the occurrence of spontaneous oxidation of 10-formyl-H4folate within the intact cells prior to the folate extraction. (PMID: 3366769).

同义名列表

9 个代谢物同义名

(2S)-2-[(4-{N-[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]formamido}phenyl)formamido]pentanedioic acid; N-(10-Formyl-7,8-dihydropteroyl)-L-glutamic acid; N-(10-Formyl-7,8-dihydropteroyl)-L-glutamate; 10-Formyldihydropteroylglutamate; 10-Formyl-7,8-dihydrofolic acid; 10-Formyl-7,8-dihydrofolate; 10-Formyldihydrofolic acid; Folinic Acid Impurity F; 10-Formyldihydrofolate



数据库引用编号

13 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Yasue Uchida, Saiko Sugiura, Fujiko Ando, Tsutomu Nakashima, Hiroshi Shimokata. Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study. BMC medical genetics. 2011 Mar; 12(?):35. doi: 10.1186/1471-2350-12-35. [PMID: 21385350]
  • J E Baggott, C B Robinson, K E Johnston. Bioactivity of [6R]-5-formyltetrahydrofolate, an unusual isomer, in humans and Enterococcus hirae, and cytochrome c oxidation of 10-formytetrahydrofolate to 10-formyldihydrofolate. The Biochemical journal. 2001 Feb; 354(Pt 1):115-22. doi: 10.1042/0264-6021:3540115. [PMID: 11171086]
  • J E Baggott, G L Johanning, K E Branham, C W Prince, S L Morgan, I Eto, W H Vaughn. Cofactor role for 10-formyldihydrofolic acid. The Biochemical journal. 1995 Jun; 308 ( Pt 3)(?):1031-6. doi: 10.1042/bj3081031. [PMID: 8948466]