cis-Hinokiresinol (BioDeep_00000004299)

 

Secondary id: BioDeep_00000897363, BioDeep_00001869395

PANOMIX_OTCML-2023 Antitumor activity natural product


代谢物信息卡片


4-[(1Z,3S)-3-(4-hydroxyphenyl)penta-1,4-dienyl]phenol

化学式: C17H16O2 (252.115)
中文名称: 顺式-扁柏脂素
谱图信息: 最多检出来源 Viridiplantae(plant) 17.24%

Reviewed

Last reviewed on 2024-08-07.

Cite this Page

cis-Hinokiresinol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/cis-hinokiresinol (retrieved 2025-01-08) (BioDeep RN: BioDeep_00000004299). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C=CC(C=CC1=CC=C(C=C1)O)C2=CC=C(C=C2)O
InChI: InChI=1S/C17H16O2/c1-2-14(15-7-11-17(19)12-8-15)6-3-13-4-9-16(18)10-5-13/h2-12,14,18-19H,1H2/b6-3-/t14-/m0/s1

描述信息

cis-Hinokiresinol, a type of lignan, is a natural compound found in various plants, particularly conifers like cypress. Lignans, including cis-Hinokiresinol, have garnered significant interest in the field of pharmacology and nutrition due to their diverse biological functions:
1. **Antioxidant Activity**: cis-Hinokiresinol exhibits antioxidant properties, which means it can help neutralize harmful free radicals in the body. This activity is important for protecting cells from oxidative stress, which is associated with aging and various diseases.
2. **Anti-Inflammatory Effects**: The compound has been found to possess anti-inflammatory properties. Chronic inflammation is linked to numerous diseases, including heart disease, cancer, and autoimmune disorders. By reducing inflammation, cis-Hinokiresinol may contribute to the prevention or treatment of these conditions.
3. **Anticancer Potential**: Some studies suggest that lignans, including cis-Hinokiresinol, may have anti-cancer properties. They may influence cancer cell growth, apoptosis (cell death), and angiogenesis (formation of new blood vessels in tumors). However, more research is needed to fully understand these effects.
4. **Estrogenic and Anti-Estrogenic Activities**: cis-Hinokiresinol and other lignans can bind to estrogen receptors in the body, exhibiting both estrogenic and anti-estrogenic effects. This dual activity might be beneficial in conditions where estrogen balance is crucial, such as in hormone-related cancers.
5. **Prebiotic Effects**: In the gut, lignans can be metabolized by gut bacteria into compounds with estrogenic or anti-estrogenic properties. This transformation contributes to the overall hormonal balance in the body and may have implications for health.

同义名列表

5 个代谢物同义名

4-[(1Z,3S)-3-(4-hydroxyphenyl)penta-1,4-dienyl]phenol; 4,4-(1E)-penta-1,4-diene-1,3-diyldiphenol; trans-Hinokiresinol; cis-Hinokiresinol; cis-Hinokiresinol



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ANG, BDNF, PTGS2, VEGFA
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 1 PTGS2
Nucleus 2 ANG, VEGFA
cytosol 1 ANG
dendrite 1 BDNF
cell surface 1 VEGFA
Golgi apparatus 1 VEGFA
growth cone 1 ANG
lysosomal membrane 1 GAA
neuronal cell body 1 ANG
synaptic vesicle 1 BDNF
Lysosome 1 GAA
plasma membrane 1 GAA
Membrane 3 BDNF, GAA, VEGFA
axon 1 BDNF
caveola 1 PTGS2
extracellular exosome 1 GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 2 PTGS2, VEGFA
extracellular space 4 ANG, BDNF, CTRL, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 BDNF
adherens junction 1 VEGFA
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 1 GAA
Microsome membrane 1 PTGS2
Secreted 4 ANG, BDNF, GAA, VEGFA
extracellular region 5 ANG, BDNF, GAA, PLA2G7, VEGFA
Secreted, extracellular space, extracellular matrix 1 VEGFA
high-density lipoprotein particle 1 PLA2G7
low-density lipoprotein particle 1 PLA2G7
actin cytoskeleton 1 ANG
nucleolus 1 ANG
extracellular matrix 1 VEGFA
basement membrane 1 ANG
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
Chromosome 1 ANG
Secreted, extracellular space 1 PLA2G7
Nucleus, nucleolus 1 ANG
tertiary granule membrane 1 GAA
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
endoplasmic reticulum lumen 2 BDNF, PTGS2
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
azurophil granule membrane 1 GAA
ficolin-1-rich granule membrane 1 GAA
angiogenin-PRI complex 1 ANG
autolysosome lumen 1 GAA
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF


文献列表

  • Ankur Kumar Tanwar, Neha Dhiman, Amit Kumar, Vikas Jaitak. Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach. European journal of medicinal chemistry. 2021 Mar; 213(?):113037. doi: 10.1016/j.ejmech.2020.113037. [PMID: 33257172]
  • Xue-Mei Li, Jin-Long Cai, Wen-Xiang Wang, Hong-Lian Ai, Zi-Chao Mao. Two new acetylenic compounds from Asparagus officinalis. Journal of Asian natural products research. 2016; 18(4):344-8. doi: 10.1080/10286020.2015.1082549. [PMID: 26558641]
  • Eun Jin Lee, Hwa-Jin Chung, Yuna Pyee, Ji-Young Hong, Ui Joung Youn, Eun-Kyoung Seo, Sang Kook Lee. Suppression of inducible nitric oxide synthase expression by nyasol and broussonin A, two phenolic compounds from Anemarrhena asphodeloides, through NF-κB transcriptional regulation in vitro and in vivo. Chemistry & biodiversity. 2014 May; 11(5):749-59. doi: 10.1002/cbdv.201400003. [PMID: 24827684]
  • Hwa Jin Lee, Hua Li, Hee Ryun Chang, Hyeyoun Jung, Da Yeon Lee, Jae-Ha Ryu. (-)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells. Journal of enzyme inhibition and medicinal chemistry. 2013 Oct; 28(5):954-9. doi: 10.3109/14756366.2012.697057. [PMID: 22803672]
  • Green Bae, Jae-Rang Yu, Jun Lee, Jun Chang, Eun-Kyoung Seo. Identification of nyasol and structurally related compounds as the active principles from Anemarrhena asphodeloides against respiratory syncytial virus (RSV). Chemistry & biodiversity. 2007 Sep; 4(9):2231-5. doi: 10.1002/cbdv.200790181. [PMID: 17886842]
  • Y Iida, K B Oh, M Saito, H Matsuoka, H Kurata. In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans. Planta medica. 2000 Jun; 66(5):435-8. doi: 10.1055/s-2000-8589. [PMID: 10909263]
  • . . . . doi: . [PMID: 10563936]
  • . . . . doi: . [PMID: 14561517]
  • . . . . doi: . [PMID: 20165801]