4,6-Dihydroxy-2-quinolinecarboxylic acid (BioDeep_00000004251)

 

Secondary id: BioDeep_00000606525, BioDeep_00000869511

human metabolite


代谢物信息卡片


1,4-dihydro-6-Hydroxy-4-oxo-2-quinolinecarboxylic acid, 9ci

化学式: C10H7NO4 (205.0375062)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.99%

分子结构信息

SMILES: c1(ccc2c(c1)c(=O)cc([nH]2)C(=O)O)O
InChI: InChI=1S/C10H7NO4/c12-5-1-2-7-6(3-5)9(13)4-8(11-7)10(14)15/h1-4,12H,(H,11,13)(H,14,15)

描述信息

4,6-Dihydroxy-2-quinolinecarboxylic acid is found in fats and oils. 4,6-Dihydroxy-2-quinolinecarboxylic acid is an alkaloid from Ginkgo biloba (ginkgo).
Alkaloid from Ginkgo biloba (ginkgo). 4,6-Dihydroxy-2-quinolinecarboxylic acid is found in fats and oils.

同义名列表

7 个代谢物同义名

1,4-dihydro-6-Hydroxy-4-oxo-2-quinolinecarboxylic acid, 9ci; 6-hydroxy-4-oxo-1,4-dihydroquinoline-2-carboxylic acid; 4,6-Dihydroxy-2-quinolinecarboxylic acid; 4,6-Dihydroxy-2-quinolinecarboxylate; 4,6-Dihydroxyquinaldic acid; 6-Hydroxykynurenic acid; 6-Hydroxykynurenate



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

55 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhuowei Shen, Haihong Hu, Jie Pan, Mingcheng Xu, Fengting Ou, Kaifeng He, Kui Zeng, Jianbiao Yao, Ruwei Wang, Yan Lou, Su Zeng. Pharmacokinetics and brain distribution studies of 6-hydroxykynurenic acid and its structural modified compounds. The Journal of pharmacy and pharmacology. 2022 Jan; 74(1):22-31. doi: 10.1093/jpp/rgab132. [PMID: 34586411]
  • Jadera Talap, Zhuowei Shen, Jing Nie, Jie Pan, Mingcheng Xu, Kui Zeng, Kaifeng He, Fengting Ou, Houhong He, Jianbiao Yao, Ruwei Wang, Lushan Yu, Su Zeng. The characterisation of the in vitro metabolism and transport of 6-hydroxykynurenic acid, an important constituent of Ginkgo biloba extracts. Xenobiotica; the fate of foreign compounds in biological systems. 2021 May; 51(5):513-521. doi: 10.1080/00498254.2021.1881654. [PMID: 33512253]
  • Zhuowei Shen, Kaifeng He, Mingcheng Xu, Kui Zeng, Jie Pan, Fengting Ou, Jianbiao Yao, Ruwei Wang, Su Zeng. Development and validation of a sensitive LC-MS/MS method for the determination of 6-hydroxykynurenic acid in rat plasma and its application to pharmacokinetics study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 May; 1116(?):44-50. doi: 10.1016/j.jchromb.2019.03.033. [PMID: 30981181]
  • Sook Kyung Hyun, Hyun Ah Jung, Hae Young Chung, Jae Sue Choi. In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from Gingko biloba yellow leaves. Archives of pharmacal research. 2006 Dec; 29(12):1074-9. doi: 10.1007/bf02969294. [PMID: 17225453]