ACHILLIN (BioDeep_00000003761)

 

Secondary id: BioDeep_00001869724

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(3R,3aS,9aS,9bS)-3,6,9-trimethyl-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione

化学式: C15H18O3 (246.1256)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=O)C2=C(C)CCC3C(C)C(=O)OC3C12
InChI: InChI=1S/C15H18O3/c1-7-4-5-10-9(3)15(17)18-14(10)13-8(2)6-11(16)12(7)13/h6,9-10,13-14H,4-5H2,1-3H3

描述信息

A sesquiterpene lactone that is (3R,3aS,9aS,9bS)-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione carrying three additional methyl substituents at positions 3, 6 and 9.
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.984

同义名列表

3 个代谢物同义名

ACHILLIN; (3R,3aS,9aS,9bS)-3,6,9-trimethyl-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione; Achillin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

46 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 FPR2, NR5A2, PTPN9, PTPRF, RP2
Nucleus 2 NR5A2, PPARA
nuclear body 1 RP2
nucleoplasm 4 NR5A2, PPARA, PTPN9, RP2
RNA polymerase II transcription regulator complex 1 NR5A2
Cell membrane 3 DPP4, FPR2, RP2
Lipid-anchor 1 RP2
Cytoplasmic side 1 RP2
lamellipodium 1 DPP4
Multi-pass membrane protein 2 CACNA1I, FPR2
cell junction 1 DPP4
cell surface 1 DPP4
Golgi apparatus 1 RP2
lysosomal membrane 1 DPP4
neuronal cell body 1 PTPRF
plasma membrane 6 CACNA1I, DPP4, FPR2, IFNLR1, PTPRF, RP2
Membrane 5 CACNA1I, DPP4, FPR2, IFNLR1, PTPRF
apical plasma membrane 1 DPP4
extracellular exosome 5 AMY2A, DPP4, PTPRF, RBP4, RP2
extracellular space 3 AMY2A, IL6, RBP4
intercellular canaliculus 1 DPP4
Single-pass type I membrane protein 1 IFNLR1
Secreted 3 DPP4, IL6, RBP4
extracellular region 4 AMY2A, DPP4, IL6, RBP4
Single-pass membrane protein 2 DPP4, PTPRF
anchoring junction 1 DPP4
Cell projection, cilium 1 RP2
cytoplasmic vesicle 1 RP2
Single-pass type II membrane protein 1 DPP4
Apical cell membrane 1 DPP4
Membrane raft 1 DPP4
focal adhesion 1 DPP4
neuron projection 1 PTPRF
ciliary basal body 1 RP2
cilium 1 RP2
chromatin 2 NR5A2, PPARA
centriole 1 RP2
Endomembrane system 1 DPP4
specific granule membrane 1 FPR2
tertiary granule membrane 1 FPR2
endoplasmic reticulum lumen 1 IL6
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle 1 DPP4
ficolin-1-rich granule membrane 1 FPR2
periciliary membrane compartment 1 RP2
lamellipodium membrane 1 DPP4
Cell projection, lamellipodium membrane 1 DPP4
interleukin-6 receptor complex 1 IL6
Cell projection, invadopodium membrane 1 DPP4
neuron projection terminus 1 PTPN9
[Dipeptidyl peptidase 4 soluble form]: Secreted 1 DPP4
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Luis Arias-Durán, Samuel Estrada-Soto, Monserrat Hernández-Morales, César Millán-Pacheco, Gabriel Navarrete-Vázquez, Rafael Villalobos-Molina, Maximiliano Ibarra-Barajas, Julio C Almanza-Pérez. Antihypertensive and vasorelaxant effect of leucodin and achillin isolated from Achillea millefolium through calcium channel blockade and NO production: In vivo, functional ex vivo and in silico studies. Journal of ethnopharmacology. 2021 Jun; 273(?):113948. doi: 10.1016/j.jep.2021.113948. [PMID: 33610712]
  • J Zapata-Martínez, G Sánchez-Toranzo, F Chaín, C A N Catalán, M I Bühler. Effect of guaianolides in the meiosis reinitiation of amphibian oocytes. Zygote (Cambridge, England). 2017 Feb; 25(1):10-16. doi: 10.1017/s0967199416000265. [PMID: 27806737]
  • Christine Tschiggerl, Franz Bucar. Guaianolides and volatile compounds in chamomile tea. Plant foods for human nutrition (Dordrecht, Netherlands). 2012 Jun; 67(2):129-35. doi: 10.1007/s11130-012-0277-1. [PMID: 22410959]
  • Y S Kim, K N Bahn, C K Hah, H I Gang, Y L Ha. Inhibition of 7,12-dimethylbenz[a]anthracene induced mouse skin carcinogenesis by Artemisia capillaris. Journal of food science. 2008 Jan; 73(1):T16-20. doi: 10.1111/j.1750-3841.2007.00585.x. [PMID: 18211378]
  • Sabine Glasl, Pavel Mucaji, Ingrid Werner, Armin Presser, Johann Jurenitsch. Sesquiterpenes and flavonoid aglycones from a Hungarian taxon of the Achillea millefolium group. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2002 Nov; 57(11-12):976-82. doi: 10.1515/znc-2002-11-1203. [PMID: 12562079]