4-Fluoraniline (BioDeep_00000003026)

 

Secondary id: BioDeep_00001871636


代谢物信息卡片


p-Fluoroaniline

化学式: C6H6FN (111.0484)
中文名称: 4-氟苯胺
谱图信息: 最多检出来源 Rattus norvegicus(plant) 3.78%

分子结构信息

SMILES: C1=CC(=CC=C1N)F
InChI: InChI=1S/C6H6FN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2

描述信息

CONFIDENCE standard compound; INTERNAL_ID 8054
KEIO_ID F048

同义名列表

5 个代谢物同义名

p-Fluoroaniline; 4-FLUOROANILINE; 4-Fluoraniline; 4-Fluoroaniline; 4-Fluoroaniline



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 DHFR, PMP2, PPY, PREP, SNCA, TLR4, TUBB4B
Endosome membrane 1 TLR4
Mitochondrion membrane 1 MAOA
Nucleus 4 PMP2, PREP, SNCA, TUBB4B
cytosol 6 DHFR, MAOA, PMP2, PREP, SNCA, TUBB4B
dendrite 1 MAOB
Cell membrane 1 TLR4
Cytoplasmic side 2 MAOA, MAOB
Cell projection, axon 1 SNCA
Synapse 1 SNCA
cell cortex 1 SNCA
cell surface 1 TLR4
growth cone 1 SNCA
neuronal cell body 2 MAOB, SNCA
postsynapse 1 SNCA
Lysosome 1 SNCA
plasma membrane 2 SNCA, TLR4
synaptic vesicle membrane 1 SNCA
Membrane 4 MAOA, PREP, SNCA, TLR4
axon 1 SNCA
extracellular exosome 2 PMP2, TUBB4B
extracellular space 2 PPY, SNCA
perinuclear region of cytoplasm 2 SNCA, TLR4
mitochondrion 5 DHFR, MAOA, MAOB, PREP, SNCA
protein-containing complex 1 SNCA
Single-pass type I membrane protein 1 TLR4
Secreted 3 PPY, PRB1, SNCA
extracellular region 4 PPY, PRB1, SNCA, TUBB4B
Mitochondrion outer membrane 2 MAOA, MAOB
Single-pass membrane protein 1 MAOA
mitochondrial outer membrane 2 MAOA, MAOB
Mitochondrion matrix 1 PREP
mitochondrial matrix 1 PREP
external side of plasma membrane 1 TLR4
Extracellular vesicle 1 TUBB4B
actin cytoskeleton 1 SNCA
microtubule cytoskeleton 1 TUBB4B
Early endosome 1 TLR4
Cytoplasm, cytoskeleton 1 TUBB4B
microtubule 1 TUBB4B
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
phagocytic cup 1 TLR4
mitotic spindle 1 TUBB4B
supramolecular fiber 1 SNCA
cytoskeleton 1 TUBB4B
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
axonemal microtubule 1 TUBB4B
myelin sheath 1 PMP2
lipopolysaccharide receptor complex 1 TLR4
axon terminus 1 SNCA
azurophil granule lumen 1 TUBB4B
mitochondrial envelope 1 MAOB
Single-pass type IV membrane protein 2 MAOA, MAOB
inclusion body 1 SNCA


文献列表

  • Zhi-Qing Zhao, Xiao-Meng Wei, Xiao-Li Shen, Ghulam Abbas, Rui Fan, Yi Jin. Aerobic degradation of 4-fluoroaniline and 2,4-difluoroaniline: performance and microbial community in response to the inocula. Biodegradation. 2021 Feb; 32(1):53-71. doi: 10.1007/s10532-021-09925-2. [PMID: 33428058]
  • G B Scarfe, M Tugnait, I D Wilson, J K Nicholson. Studies on the metabolism of 4-fluoroaniline and 4-fluoroacetanilide in rat: formation of 4-acetamidophenol (paracetamol) and its metabolites via defluorination and N-acetylation. Xenobiotica; the fate of foreign compounds in biological systems. 1999 Feb; 29(2):205-16. doi: 10.1080/004982599238759. [PMID: 10199596]
  • N H Cnubben, J Vervoort, C Veeger, I M Rietjens. Study on the regioselectivity and mechanism of the aromatic hydroxylation of monofluoroanilines. Chemico-biological interactions. 1992 Dec; 85(2-3):151-72. doi: 10.1016/0009-2797(92)90059-t. [PMID: 1493607]
  • I M Rietjens, J Vervoort. Bioactivation of 4-fluorinated anilines to benzoquinoneimines as primary reaction products. Chemico-biological interactions. 1991; 77(3):263-81. doi: 10.1016/0009-2797(91)90036-7. [PMID: 2009574]
  • C V Eadsforth, P C Coveney, D H Hutson, C J Logan, A J Samuel. The metabolism of o-fluoroaniline by rats, rabbits and marmosets. Xenobiotica; the fate of foreign compounds in biological systems. 1986 Jun; 16(6):555-66. doi: 10.3109/00498258609043544. [PMID: 3092475]
  • C V Eadsforth, C J Logan, B J Morrison, P A Warburton. 2,4-Difluoroaniline and 4-fluoroaniline exposure: monitoring by methaemoglobin and urine analyses. International archives of occupational and environmental health. 1984; 54(3):223-32. doi: 10.1007/bf00379051. [PMID: 6490181]