Chloramphenicol Succinate (BioDeep_00000008831)

   


代谢物信息卡片


Chloramphenicol Succinate

化学式: C15H16Cl2N2O8 (422.0284)
中文名称: 氯霉素琥珀酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C(C(COC(=O)CCC(=O)O)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
InChI: InChI=1S/C15H16Cl2N2O8/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21)/t10-,13-/m1/s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
Same as: D07675

同义名列表

3 个代谢物同义名

Chloramphenicol Succinate; SCHEMBL16011474; Chloramphenicol succinate



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • L A Black, A J McLachlan, J E Griffith, D P Higgins, A Gillett, M B Krockenberger, M Govendir. Pharmacokinetics of chloramphenicol following administration of intravenous and subcutaneous chloramphenicol sodium succinate, and subcutaneous chloramphenicol, to koalas (Phascolarctos cinereus). Journal of veterinary pharmacology and therapeutics. 2013 Oct; 36(5):478-85. doi: 10.1111/jvp.12024. [PMID: 23157306]
  • C S Ambekar, J S K Lee, B M Y Cheung, L C Chan, R Liang, C R Kumana. Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: possible reason for its toxicity. Toxicology in vitro : an international journal published in association with BIBRA. 2004 Aug; 18(4):441-7. doi: 10.1016/j.tiv.2003.12.010. [PMID: 15130601]
  • C S Ambekar, B Cheung, J Lee, L C Chan, R Liang, C R Kumana. Metabolism of chloramphenicol succinate in human bone marrow. European journal of clinical pharmacology. 2000 Aug; 56(5):405-9. doi: 10.1007/s002280000143. [PMID: 11009050]
  • J A Turton, D Yallop, C M Andrews, R Fagg, M York, T C Williams. Haemotoxicity of chloramphenicol succinate in the CD-1 mouse and Wistar Hanover rat. Human & experimental toxicology. 1999 Sep; 18(9):566-76. doi: 10.1191/096032799678845098. [PMID: 10523871]
  • D E Holt, C M Andrews, J P Payne, T C Williams, J A Turton. The myelotoxicity of chloramphenicol: in vitro and in vivo studies: II: In vivo myelotoxicity in the B6C3F1 mouse. Human & experimental toxicology. 1998 Jan; 17(1):8-17. doi: 10.1177/096032719801700102. [PMID: 9491332]
  • M C Nahata. Simultaneous measurement of chloramphenicol sodium succinate and chloramphenicol in presence of furosemide in plasma and urine. Journal of clinical pharmacy and therapeutics. 1993 Aug; 18(4):301. doi: 10.1111/j.1365-2710.1993.tb00592.x. [PMID: 8227239]
  • M Ashton, P Bolme, E Alemayehu, M Eriksson, L Paalzow. Decreased chloramphenicol clearance in malnourished Ethiopian children. European journal of clinical pharmacology. 1993; 45(2):181-6. doi: 10.1007/bf00315503. [PMID: 8223842]
  • T I Ti, E H Monteiro, S Lam, H S Lee. Chloramphenicol concentrations in sera of patients with typhoid fever being treated with oral or intravenous preparation. Antimicrobial agents and chemotherapy. 1990 Sep; 34(9):1809-11. doi: 10.1128/aac.34.9.1809. [PMID: 2285296]
  • M C Nahata. Lack of predictability of chloramphenicol toxicity in paediatric patients. Journal of clinical pharmacy and therapeutics. 1989 Aug; 14(4):297-303. doi: 10.1111/j.1365-2710.1989.tb00250.x. [PMID: 2793954]
  • M C Castle. Alteration of hepatic carboxylesterase activity by soman: inhibition in vitro and enhancement in vivo. Xenobiotica; the fate of foreign compounds in biological systems. 1989 Jan; 19(1):115-21. doi: 10.3109/00498258909034683. [PMID: 2756715]
  • J G Schwartz, D T Casto, S Ayo, J J Carnahan, J H Jorgensen. A commercial enzyme immunoassay method (EMIT) compared with liquid chromatography and bioassay methods for measurement of chloramphenicol. Clinical chemistry. 1988 Sep; 34(9):1872-5. doi: . [PMID: 3046781]
  • C J Dickinson, M D Reed, R C Stern, S C Aronoff, T S Yamashita, J L Blumer. The effect of exocrine pancreatic function on chloramphenicol pharmacokinetics in patients with cystic fibrosis. Pediatric research. 1988 Apr; 23(4):388-92. doi: 10.1203/00006450-198804000-00009. [PMID: 3374992]
  • M C Nahata. Serum concentrations and adverse effects of chloramphenicol in pediatric patients. Chemotherapy. 1987; 33(5):322-7. doi: 10.1159/000238516. [PMID: 3665630]
  • J F Nouws, T B Vree, J Holtkamp, M Baakman, F Driessens, P J Guelen. Pharmacokinetic, residue and irritation aspects of chloramphenicol sodium succinate and a chloramphenicol base formulation following intramuscular administration to ruminants. The veterinary quarterly. 1986 Jul; 8(3):224-32. doi: 10.1080/01652176.1986.9694046. [PMID: 3750804]
  • F Shann, V Linnemann, A Mackenzie, J Barker, M Gratten, N Crinis. Absorption of chloramphenicol sodium succinate after intramuscular administration in children. The New England journal of medicine. 1985 Aug; 313(7):410-4. doi: 10.1056/nejm198508153130703. [PMID: 4022068]
  • J Forster, C Hufschmidt, H Niederhoff, W Künzer. [Need for the determination of chloramphenicol levels in the treatment of bacterial-purulent meningitis with chloramphenicol succinate in infants and small children]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde. 1985 Apr; 133(4):209-13. doi: . [PMID: 4000136]
  • S Shankaran, R E Kauffman. Use of chloramphenicol palmitate in neonates. The Journal of pediatrics. 1984 Jul; 105(1):113-6. doi: 10.1016/s0022-3476(84)80374-1. [PMID: 6737126]
  • P J Ambrose. Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate. Clinical pharmacokinetics. 1984 May; 9(3):222-38. doi: 10.2165/00003088-198409030-00004. [PMID: 6375931]
  • W G Kramer, E R Rensimer, C D Ericsson, L K Pickering. Comparative bioavailability of intravenous and oral chloramphenicol in adults. Journal of clinical pharmacology. 1984 Apr; 24(4):181-6. doi: 10.1002/j.1552-4604.1984.tb01828.x. [PMID: 6725619]
  • M P Brown, R H Kelly, R R Gronwall, S M Stover. Chloramphenicol sodium succinate in the horse: serum, synovial, peritoneal, and urine concentrations after single-dose intravenous administration. American journal of veterinary research. 1984 Mar; 45(3):578-80. doi: NULL. [PMID: 6711989]
  • T Yamakawa, S Itoh, S Onishi, K Isobe, A Hosoe, Y Nishimura. Developmental changes in hepatic esterase activity towards chloramphenicol succinate and its Michaelis-Menten constant of liver, kidney and lung in human. Developmental pharmacology and therapeutics. 1984; 7(3):205-12. doi: 10.1159/000457164. [PMID: 6723494]
  • J H Brasfield, K E Record, W O Griffen, S Mattingly. Chloramphenicol and chloramphenicol succinate concentrations in patients with renal impairment. Clinical pharmacy. 1983 Jul; 2(4):355-8. doi: NULL. [PMID: 6883963]
  • S J Soldin, C Golas, P Rajchgot, C G Prober, S M MacLeod. The high performance liquid chromatographic measurement of chloramphenicol and its succinate esters in serum. Clinical biochemistry. 1983 Jun; 16(3):171-7. doi: 10.1016/s0009-9120(83)90219-9. [PMID: 6851080]
  • M C Nahata, D A Powell. Chloramphenicol serum concentration falls during chloramphenicol succinate dosing. Clinical pharmacology and therapeutics. 1983 Mar; 33(3):308-13. doi: 10.1038/clpt.1983.38. [PMID: 6825386]
  • G J Burckart, F F Barrett, R Della Valle, M C Meyer. Chloramphenicol dosage and pharmacokinetics in infants and children. Journal of clinical pharmacology. 1983 Feb; 23(2-3):106-12. doi: 10.1002/j.1552-4604.1983.tb02712.x. [PMID: 6853742]
  • J T Burke, W A Wargin, R J Sherertz, K L Sanders, M R Blum, F A Sarubbi. Pharmacokinetics of intravenous chloramphenicol sodium succinate in adult patients with normal renal and hepatic function. Journal of pharmacokinetics and biopharmaceutics. 1982 Dec; 10(6):601-14. doi: 10.1007/bf01062543. [PMID: 7182457]
  • P Rajchgot, C G Prober, S Soldin, C Golas, F Good, E Harding, S MacLeod. Initiation of chloramphenicol therapy in the newborn infant. The Journal of pediatrics. 1982 Dec; 101(6):1018-21. doi: 10.1016/s0022-3476(82)80036-x. [PMID: 7143156]
  • C E Akesson, P E Linero. Effect of chloramphenicol on serum salicylate concentrations in cats and dogs. American journal of veterinary research. 1982 Aug; 43(8):1471-2. doi: NULL. [PMID: 7103230]
  • K Krasinski, H Kusmiesz, J D Nelson. Pharmacologic interactions among chloramphenicol, phenytoin and phenobarbital. Pediatric infectious disease. 1982 Jul; 1(4):232-5. doi: 10.1097/00006454-198207000-00008. [PMID: 7177912]
  • C H Clark, J E Thomas, J L Milton, W D Goolsby. Plasma concentrations of chloramphenicol in birds. American journal of veterinary research. 1982 Jul; 43(7):1249-53. doi: NULL. [PMID: 7103207]
  • R Velagapudi, R V Smith, T M Ludden, R Sagraves. Simultaneous determination of chloramphenicol and chloramphenicol succinate in plasma using high-performance liquid chromatography. Journal of chromatography. 1982 Mar; 228(?):423-8. doi: 10.1016/s0378-4347(00)80467-3. [PMID: 7076772]
  • C M Sack, J R Koup, K E Opheim, N Neeley, A L Smith. Chloramphenicol succinate kinetics in infants and young children. Pediatric pharmacology (New York, N.Y.). 1982; 2(2):93-103. doi: NULL. [PMID: 12760401]
  • A L Smith. Antibiotic pharmacokinetics in newborns. Mead Johnson Symposium on Perinatal and Developmental Medicine. 1982; ?(21):52-6. doi: NULL. [PMID: 6765460]
  • R E Kauffman, M C Thirumoorthi, J A Buckley, M K Aravind, A S Dajani. Relative bioavailability of intravenous chloramphenicol succinate and oral chloramphenicol palmitate in infants and children. The Journal of pediatrics. 1981 Dec; 99(6):963-7. doi: 10.1016/s0022-3476(81)80034-0. [PMID: 7310593]
  • J R Koup, A Weber, A L Smith. Chloramphenicol succinate pharmacokinetics in Macaca nemestrina: dose dependency study. The Journal of pharmacology and experimental therapeutics. 1981 Nov; 219(2):316-20. doi: NULL. [PMID: 7288623]
  • M C Nahata, D A Powell. Bioavailability and clearance of chloramphenicol after intravenous chloramphenicol succinate. Clinical pharmacology and therapeutics. 1981 Sep; 30(3):368-72. doi: 10.1038/clpt.1981.174. [PMID: 7273601]
  • M C Nahata, D A Powell, J P Glazer, M D Hilty. Effect of intravenous flow rate and injection site on in vitro delivery of chloramphenicol succinate and in vivo kinetics. The Journal of pediatrics. 1981 Sep; 99(3):463-6. doi: 10.1016/s0022-3476(81)80351-4. [PMID: 7264810]
  • R E Kauffman, J N Miceli, L Strebel, J A Buckley, A K Done, A S Dajani. Pharmacokinetics of chloramphenicol and chloramphenicol succinate in infants and children. The Journal of pediatrics. 1981 Feb; 98(2):315-20. doi: 10.1016/s0022-3476(81)80670-1. [PMID: 7463235]
  • M K Aravind, J N Miceli, R E Kauffman, L E Strebel, A K Done. Simultaneous measurement of chloramphenicol and chloramphenicol succinate by high-performance liquid chromatography. Journal of chromatography. 1980 Nov; 221(1):176-81. doi: 10.1016/s0378-4347(00)81022-1. [PMID: 7451621]
  • J T Burke, W A Wargin, M R Blum. High-pressure liquid chromatographic assay for chloramphenicol, chloramphenicol-3-monosuccinate, and chloramphenicol-1-monosuccinate. Journal of pharmaceutical sciences. 1980 Aug; 69(8):909-12. doi: 10.1002/jps.2600690813. [PMID: 7400935]
  • R L Slaughter, J A Pieper, B Cerra, B Brodsky, J R Koup. Chloramphenicol sodium succinate kinetics in critically ill patients. Clinical pharmacology and therapeutics. 1980 Jul; 28(1):69-77. doi: 10.1038/clpt.1980.133. [PMID: 7389257]
  • K B Oseekey, K L Rowse, H B Kostenbauder. High-performance liquid chromatographic determination of chloramphenicol and its monosuccinate ester in plasma. Journal of chromatography. 1980 Jun; 182(3-4):459-64. doi: 10.1016/s0378-4347(00)81501-7. [PMID: 7391190]
  • P NAUMANN, H J RISTOW. [IS THERE A TRUE ANTIBACTERIAL EFFECT WHEN CHLORAMPHENICOL SUCCINATE IS USED LOCALLY? STUDIES ON THE SPLITTING OF CHLORAMPHENICOL SUCCINATE IN HUMAN BODY FLUIDS AND TISSUES]. Deutsche medizinische Wochenschrift (1946). 1965 Jan; 90(?):204-7. doi: 10.1055/s-0028-1111318. [PMID: 14240836]
  • A D'AGATA, G CARDILLO. [Intravenous chloramphenicol succinate; curve of concentration in blood and urinary elimination]. Rivista di patologia e clinica. 1955 Oct; 10(10):483-6. doi: NULL. [PMID: 13351441]