Hydrocortisone probutate (BioDeep_00000858903)

   


代谢物信息卡片


Hydrocortisone probutate

化学式: C28H40O7 (488.2774)
中文名称: 氢化可的松17-丁酸酯21-丙酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC(=O)OC1(CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C)C(=O)COC(=O)CC
InChI: InChI=1S/C28H40O7/c1-5-7-24(33)35-28(22(31)16-34-23(32)6-2)13-11-20-19-9-8-17-14-18(29)10-12-26(17,3)25(19)21(30)15-27(20,28)4/h14,19-21,25,30H,5-13,15-16H2,1-4H3/t19-,20-,21-,25+,26-,27-,28-/m0/s1

描述信息

D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AB - Corticosteroids, moderately potent (group ii)
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D000893 - Anti-Inflammatory Agents

同义名列表

3 个代谢物同义名

Hydrocortisone probutate; Hydrocortisone buteprate; Hydrocortisone butyrate propionate



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 2 IL13, STAM2
Peripheral membrane protein 1 STAM2
Endosome membrane 1 CD68
Nucleus 1 POLI
cytosol 2 GPT, STAM2
nucleoplasm 2 POLI, STAM2
Cell membrane 1 CD8A
Cytoplasmic side 1 STAM2
Early endosome membrane 1 STAM2
Multi-pass membrane protein 1 RTL1
cell surface 1 ITGAX
glutamatergic synapse 1 GHRL
Golgi membrane 1 INS
lysosomal membrane 1 CD68
postsynapse 1 GHRL
Lysosome 1 CD68
plasma membrane 3 CD68, CD8A, ITGAX
Membrane 3 CD68, ITGAX, RTL1
axon 1 GHRL
extracellular exosome 1 GPT
Lysosome membrane 1 CD68
extracellular space 4 GHRL, IL13, INS, PTH
Schaffer collateral - CA1 synapse 1 GHRL
intracellular membrane-bounded organelle 1 STAM2
Single-pass type I membrane protein 3 CD68, CD8A, ITGAX
Secreted 3 GHRL, IL13, INS
extracellular region 5 CD8A, GHRL, IL13, INS, PTH
[Isoform 2]: Secreted 1 CD8A
external side of plasma membrane 3 CD8A, IL13, ITGAX
neuronal dense core vesicle lumen 1 GHRL
nuclear speck 1 POLI
receptor complex 1 CD8A
Late endosome membrane 1 CD68
cytoplasmic ribonucleoprotein granule 1 POLI
endosome lumen 1 INS
tertiary granule membrane 1 ITGAX
plasma membrane raft 1 CD8A
secretory granule lumen 2 GHRL, INS
secretory granule membrane 1 ITGAX
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 GHRL, INS
endocytic vesicle 1 STAM2
transport vesicle 1 INS
azurophil granule membrane 1 CD68
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ESCRT-0 complex 1 STAM2
ficolin-1-rich granule membrane 1 ITGAX
[Isoform 1]: Cell membrane 1 CD8A
integrin complex 1 ITGAX
T cell receptor complex 1 CD8A
integrin alphaX-beta2 complex 1 ITGAX


文献列表

  • A Komatsu, K Ohashi, H Oba, T Kakehashi, Y Mizushima, E Shirasawa, M Horiuchi. Application of lipid microsphere drug delivery system to steroidal ophthalmic preparation. Japanese journal of ophthalmology. 1988; 32(1):41-3. doi: ". [PMID: 3411812]
  • A Yanagawa, Y Mizushima, A Komatsu, M Horiuchi, E Shirasawa, R Igarashi. Application of a drug delivery system to a steroidal ophthalmic preparation with lipid microspheres. Journal of microencapsulation. 1987 Oct; 4(4):329-31. doi: 10.3109/02652048709021825. [PMID: 3504514]
  • M Kimura, Y Tarumoto, S Nakane, S Otomo. Comparative toxicity study of hydrocortisone 17-butyrate 21-propionate (HBP) ointment and other topical corticosteroids in rats. Drugs under experimental and clinical research. 1986; 12(8):643-52. doi: . [PMID: 3757761]
  • S Otomo, S Higuchi, S Nakaike, K Takeshita, M Tanaka, Y Gotoh, Y Osada, K Tsuchida, K Inoue, K Kyogoku, Y Tarumoto, M Sasajima, M Ohzeki. [Pharmacological study on hydrocortisone 17-butyrate 21-propionate (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1981 Dec; 78(6):647-58. doi: 10.1254/fpj.78.647. [PMID: 7333567]
  • Y Tarumoto, M Kimura, S Abe, A Kasai, K Noda, S Nakane, M Sasajima, M Ohzeki. [Studies on toxicity of hydrocortisone 17-butyrate 21-propionate -2. Subacute toxicity in rats by subcutaneous administration (author's transl)]. The Journal of toxicological sciences. 1981 Jul; 6 Suppl(?):17-46. doi: 10.2131/jts.6.supplement_17. [PMID: 7310932]
  • Y Tarumoto, S Abe, M Kimura, T Tsuchida, K Noda, S Nakane, M Sasajima, M Ohzeki. [Studies on toxicity of hydrocortisone 17-butyrate 21-propionate -3. Subacute toxicity in rats by percutaneous administration (author's transl)]. The Journal of toxicological sciences. 1981 Jul; 6 Suppl(?):47-66. doi: 10.2131/jts.6.supplement_47. [PMID: 7310933]
  • Y Tarumoto, H Tokado, M Kimura, A Kasai, Y Iwamatsu, T Tsuchida, K Noda, S Nakane, M Sasajima, M Ohzeki. [Studies on toxicity of hydrocortisone 17-butyrate 21-propionate -4. Chronic toxicity in rats by subcutaneous administration (author's transl)]. The Journal of toxicological sciences. 1981 Jul; 6 Suppl(?):67-96. doi: 10.2131/jts.6.supplement_67. [PMID: 7310934]
  • R P KNIGHT, D S KORNFELD, G H GLASER, P K BONDY. Effects of intravenous hydrocortisone on electrolytes of serum and urine in man. The Journal of clinical endocrinology and metabolism. 1955 Feb; 15(2):176-81. doi: 10.1210/jcem-15-2-176. [PMID: 13233328]