Hyoscyamine (BioDeep_00000000748)

Main id: BioDeep_00000398480

Secondary id: BioDeep_00000000486, BioDeep_00000399157, BioDeep_00000406224

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, ENDO-(+/-)-

化学式: C17H23NO3 (289.1678)
中文名称: 阿托平, 阿脱品, 阿妥品, 阿托品, 菱胺, L-天仙子胺, 苯乳酸
谱图信息: 最多检出来源 Homo sapiens(blood) 32.21%

分子结构信息

SMILES: CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
InChI: InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3

描述信息

Atropine is a racemate composed of equimolar concentrations of (S)- and (R)-atropine. It is obtained from deadly nightshade (Atropa belladonna) and other plants of the family Solanaceae. It has a role as a muscarinic antagonist, an anaesthesia adjuvant, an anti-arrhythmia drug, a mydriatic agent, a parasympatholytic, a bronchodilator agent, a plant metabolite, an antidote to sarin poisoning and a oneirogen. It contains a (S)-atropine and a (R)-atropine.
Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active. Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods. Oral atropine is only available in combination products. Atropine is a competitive, reversible antagonist of muscarinic receptors that blocks the effects of acetylcholine and other choline esters. It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes. Atropine is a relatively inexpensive drug and is included in the World Health Organization List of Essential Medicines.
Atropine is an Anticholinergic and Cholinergic Muscarinic Antagonist. The mechanism of action of atropine is as a Cholinergic Antagonist and Cholinergic Muscarinic Antagonist.
Hyoscyamine as a natural plant alkaloid derivative and anticholinergic that is used to treat mild to moderate nausea, motion sickness, hyperactive bladder and allergic rhinitis. Hyoscyamine has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.
Atropine is a natural product found in Cyphanthera tasmanica, Anthocercis ilicifolia, and other organisms with data available.
Atropine Sulfate is the sulfate salt of atropine, a naturally-occurring alkaloid isolated from the plant Atropa belladonna. Atropine functions as a sympathetic, competitive antagonist of muscarinic cholinergic receptors, thereby abolishing the effects of parasympathetic stimulation. This agent may induce tachycardia, inhibit secretions, and relax smooth muscles. (NCI04)
Atropine is a synthetically-derived form of the endogenous alkaloid isolated from the plant Atropa belladonna. Atropine functions as a sympathetic, competitive antagonist of muscarinic cholinergic receptors, thereby abolishing the effects of parasympathetic stimulation. This agent may induce tachycardia, inhibit secretions, and relax smooth muscles. (NCI04)
Hyoscyamine is a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility.
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03B - Belladonna and derivatives, plain > A03BA - Belladonna alkaloids, tertiary amines
S - Sensory organs > S01 - Ophthalmologicals > S01F - Mydriatics and cycloplegics > S01FA - Anticholinergics
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D009184 - Mydriatics
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2292
INTERNAL_ID 2292; CONFIDENCE Reference Standard (Level 1)
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3334
D002491 - Central Nervous System Agents
KEIO_ID A080; [MS2] KO008864
KEIO_ID A080
Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia[1][2][3][4].
Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia[1][2][3][4].
Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia[1][2][3][4].
L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205)[1][2].
L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205)[1][2].
L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205)[1][2].

同义名列表

114 个代谢物同义名

BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, ENDO-(+/-)-; Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+/-)-; Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+-)-; Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+-)-; Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3,2,1)oct-3-yl ester, endo-(+-)-; Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-(3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER; Benzeneacetic acid, alpha-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; (3-exo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl alpha-(hydroxymethyl)benzeneacetate; Atropine for peak identification, European Pharmacopoeia (EP) Reference Standard; [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenyl-propanoate; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenyl-propanoate; rac-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) (8CI); 1.ALPHA.H,5.ALPHA.H-TROPAN-3.ALPHA.-OL (+/-)-TROPATE (ESTER); 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester); Atropine, European Pharmacopoeia (EP) Reference Standard; beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester [German]; beta-Phenyl-gamma-oxypropionsaure-tropyl-ester [German]; 1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester); (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; (3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL TROPATE; HOMATROPINE HYDROBROMIDE IMPURITY D [EP IMPURITY]; rac-tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate; 2-Phenylhydracrylic acid 3-alpha-tropanyl ester; beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester; beta-Phenyl-gamma-oxypropionsaure-tropyl-ester; tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; Atropine, meets USP testing specifications; DL-Tropanyl 2-hydroxy-1-phenylpropionate; Tropic acid, 3-alpha-tropanyl ester; Tropic acid, ester with tropine; Tropine tropate;DL-Hyoscyamine; Atropine, >=99\\% (TLC), powder; ATROPINE COMPONENT OF DUODOTE; Atropine, analytical standard; Sulfate Anhydrous, Atropine; RKUNBYITZUJHSG-SPUOUPEWSA-N; ATROPINE COMPONENT OF ATNAA; Atropine ((+/-)-Hyoscyamin); Anhydrous, Atropine Sulfate; DUODOTE COMPONENT ATROPINE; Atropine Sulfate Anhydrous; ATROPINE [USP MONOGRAPH]; Tropine, tropate (ester); ATNAA COMPONENT ATROPINE; ATROPINE [EP MONOGRAPH]; Atropine, >=95.0\\% (NT); ATROPINE [ORANGE BOOK]; ATROPINE [EP IMPURITY]; Tropine (+/-)-tropate; ATROPINE [GREEN BOOK]; Protamine & Atropine; (+,-)-Tropyl tropate; 3-tropoyloxytropane; Atropine [USP:BAN]; Atropina [Italian]; DL-Tropyl tropate; Sulfate, Atropine; ATROPINE ((+/-)-); Atropin-flexiolen; ATROPINE [USP-RS]; (+/-)-Hyoscyamine; ATROPINE [WHO-DD]; (+-)-hyoscyamine; ATROPINE [MART.]; ATROPINE [VANDF]; Atropine sulfate; Atropin [German]; ATROPINUM [HPUS]; ATROPINE, (+/-)-; dl-Tropyltropate; Augenöl, Atropin; Atropin Augenöl; Isopto-atropine; Tropine tropate; UNII-7C0697DR9I; dl-Hyoscyamine; Atropine (USP); (+/-)-Atropine; ropine tropate; ATROPINE [MI]; L-Hyoscyamine; MEGxp0_001878; Troyl tropate; (+-)-atropine; ACon1_000046; Tox21_111590; Tox21_110816; Atropen (TN); Tox21_200487; CAS-51-55-8; Hyoscyamine; 7C0697DR9I; Atropinol; Atropinum; AI3-60219; Eyesules; Atropine; Atropina; Atropin; Atropen; Phenyllactic acid; Atropine; L-Hyoscyamine; (-)-Atropine



数据库引用编号

71 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

270 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ACE, ALB, AXIN2, CA1, CA3, CHAT, PPY
Nucleus 4 ALB, AXIN2, CHAT, RERE
cytosol 6 ALB, AXIN2, CA1, CA3, CHAT, SST
nuclear body 1 RERE
centrosome 2 ALB, AXIN2
nucleoplasm 1 RERE
Cell membrane 2 ACE, ADRB3
Multi-pass membrane protein 2 ADRB3, CACNA1I
Synapse 2 CHAT, TAC1
Golgi apparatus 1 ALB
Golgi membrane 1 INS
neuronal cell body 2 SST, TAC1
Cytoplasmic vesicle, secretory vesicle 1 NTS
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 7 ACE, ADRB3, AXIN2, BCHE, CACNA1I, GCG, KNG1
Membrane 2 ACE, CACNA1I
axon 2 CCK, TAC1
extracellular exosome 4 ACE, ALB, CA1, KNG1
endoplasmic reticulum 1 ALB
extracellular space 10 ACE, ALB, BCHE, CCK, GCG, INS, KNG1, PPY, SST, TAC1
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 1 NTS
Single-pass type I membrane protein 1 ACE
Secreted 10 ACE, ALB, BCHE, CCK, GCG, INS, NTS, PPY, SST, VIP
extracellular region 13 ACE, ALB, BCHE, CCK, GCG, INS, KNG1, MLN, NTS, PPY, SST, TAC1, VIP
Single-pass membrane protein 1 MLN
anchoring junction 1 ALB
external side of plasma membrane 1 ACE
beta-catenin destruction complex 1 AXIN2
GABA-ergic synapse 1 SST
collagen-containing extracellular matrix 1 KNG1
receptor complex 1 ADRB3
neuron projection 2 CHAT, VIP
ciliary basal body 1 ALB
centriole 1 ALB
Secreted, extracellular space 1 KNG1
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 3 ALB, BCHE, KNG1
sperm midpiece 1 ACE
endosome lumen 1 INS
basal plasma membrane 1 ACE
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 ALB, BCHE, GCG, INS, KNG1
platelet alpha granule lumen 2 ALB, KNG1
axon terminus 1 NTS
voltage-gated calcium channel complex 1 CACNA1I
histone deacetylase complex 1 RERE
transport vesicle 2 INS, NTS
Sarcoplasmic reticulum membrane 1 MLN
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 SST
nuclear envelope lumen 1 BCHE
[Glucagon-like peptide 1]: Secreted 1 GCG
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
ciliary transition fiber 1 ALB


文献列表

  • Yuqin Gou, Yanming Jing, Jiaxin Song, Mohammad Mahmoud Nagdy, Chao Peng, Lingjiang Zeng, Min Chen, Xiaozhong Lan, Zun Lai Lai Htun, Zhihua Liao, Yan Li. A novel bHLH gene responsive to low nitrogen positively regulates the biosynthesis of medicinal tropane alkaloids in Atropa belladonna. International journal of biological macromolecules. 2024 May; 266(Pt 1):131012. doi: 10.1016/j.ijbiomac.2024.131012. [PMID: 38522709]
  • Riccardo Lorrai, Dario Cavaterra, Sara Giammaria, Diego Sbardella, Grazia Raffaella Tundo, Alessandra Boccaccini. Eye Diseases: When the Solution Comes from Plant Alkaloids. Planta medica. 2024 May; 90(6):426-439. doi: 10.1055/a-2283-2350. [PMID: 38452806]
  • F Rafique, M N Mushtaq, H Ahmed, W Younis. Evaluation and estimation of diuretic activity of the linalyl acetate in the rats. Brazilian journal of biology = Revista brasleira de biologia. 2024; 83(?):e277354. doi: 10.1590/1519-6984.277354. [PMID: 38452187]
  • Xiehe Kong, Guang Yang, Zhi Chen, Rong Han, Yue Zhao, Li Zeng, Xiaocong Guo, Zheng Shi, Dan Zhang, Yanting Yang, Jie Liu, Xingtao Zhou, Xiaopeng Ma. Addition of Auricular Acupoint Stimulation to 0.01\% Atropine for Myopia: 12-Month Results from a Randomized Trial. Journal of integrative and complementary medicine. 2023 Sep; 29(9):574-583. doi: 10.1089/jicm.2022.0769. [PMID: 36971804]
  • Jun-Yuan Guo, Bin-Bin Han, Nai-Guang Jia. Atropine combined with dopamine in a patient with sinus bradycardia scheduled for laparoscopic surgery. Asian journal of surgery. 2023 Aug; ?(?):. doi: 10.1016/j.asjsur.2023.08.012. [PMID: 37597976]
  • Zahra Tardast, Alireza Iranbakhsh, Mostafa Ebadi, Zahra Oraghi Ardebili. Carboxylic acid-functionalized multiwalled carbon nanotubes (COOH-MWCNTs) improved production of atropine in callus of Datura inoxia by influencing metabolism, gene regulation, and DNA cytosine methylation; an in vitro biological assessment. Plant physiology and biochemistry : PPB. 2023 Aug; 202(?):107975. doi: 10.1016/j.plaphy.2023.107975. [PMID: 37634333]
  • Shaida Mahmoudi, Mohamad Javad Chaichi, Mojtaba Shamsipur, Ome Leila Nazari, Abdolrauf SamadiMaybodi. Fe3 O4 and bimetal-organic framework Zn/Mg composites peroxides- like catalyze luminol chemiluminescence for specific measurement of atropine in Datura plant. Luminescence : the journal of biological and chemical luminescence. 2023 Jul; ?(?):. doi: 10.1002/bio.4557. [PMID: 37455562]
  • Shaida Mahmoudi, Mohamad Javad Chaichi, Mojtaba Shamsipur, Ome Leila Nazari, Abdol Rauf Samadi Mayodi. Determination of Atropine by HPLC in Plant of Datura by Liquid-Liquid Extraction and Magnet Solid-Phase Extraction. Journal of chromatographic science. 2023 Jun; ?(?):. doi: 10.1093/chromsci/bmad041. [PMID: 37316168]
  • Juan M Minoia, María E Villanueva, Guillermo J Copello, Julián Rodríguez Talou, Alejandra B Cardillo. Recycling of hyoscyamine 6β-hydroxylase for the in vitro production of anisodamine and scopolamine. Applied microbiology and biotechnology. 2023 Apr; ?(?):. doi: 10.1007/s00253-023-12537-w. [PMID: 37099059]
  • Yong-Jiang Wang, Tian Tain, Jia-Yi Yu, Jie Li, Bingyan Xu, Jianghua Chen, John C D'Auria, Jian-Ping Huang, Sheng-Xiong Huang. Genomic and structural basis for evolution of tropane alkaloid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 2023 Apr; 120(17):e2302448120. doi: 10.1073/pnas.2302448120. [PMID: 37068250]
  • Ana Rita Soares Mateus, Carmen Crisafulli, Matilde Vilhena, Sílvia Cruz Barros, Angelina Pena, Ana Sanches Silva. The Bright and Dark Sides of Herbal Infusions: Assessment of Antioxidant Capacity and Determination of Tropane Alkaloids. Toxins. 2023 03; 15(4):. doi: 10.3390/toxins15040245. [PMID: 37104183]
  • Fangyuan Zhang, Fei Qiu, Junlan Zeng, Zhichao Xu, Yueli Tang, Tengfei Zhao, Yuqin Gou, Fei Su, Shiyi Wang, Xiuli Sun, Zheyong Xue, Weixing Wang, Chunxian Yang, Lingjiang Zeng, Xiaozhong Lan, Min Chen, Junhui Zhou, Zhihua Liao. Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family. Nature communications. 2023 Mar; 14(1):1446. doi: 10.1038/s41467-023-37133-4. [PMID: 36922496]
  • Monique de Nijs, Colin Crews, Folke Dorgelo, Susan MacDonald, Patrick P J Mulder. Emerging Issues on Tropane Alkaloid Contamination of Food in Europe. Toxins. 2023 Jan; 15(2):. doi: 10.3390/toxins15020098. [PMID: 36828413]
  • Farheen Tariq, Rabia Mobeen, Xinhai Wang, Xiao Lin, Qingdong Bao, Jinhui Liu, Hua Gao. Advances in myopia prevention strategies for school-aged children: a comprehensive review. Frontiers in public health. 2023; 11(?):1226438. doi: 10.3389/fpubh.2023.1226438. [PMID: 37655278]
  • Zengying Wang, Pengfei Wang, Bohua Jiang, Yifei Meng, Sufang Qie, Zhipeng Yan. The efficacy and safety of 0.01\% atropine alone or combined with orthokeratology for children with myopia: A meta-analysis. PloS one. 2023; 18(7):e0282286. doi: 10.1371/journal.pone.0282286. [PMID: 37494360]
  • Lorena González-Gómez, Sonia Morante-Zarcero, Jorge A M Pereira, José S Câmara, Isabel Sierra. Improved Analytical Approach for Determination of Tropane Alkaloids in Leafy Vegetables Based on µ-QuEChERS Combined with HPLC-MS/MS. Toxins. 2022 Sep; 14(10):. doi: 10.3390/toxins14100650. [PMID: 36287919]
  • Emad A Ahmed, Mayyadah A Alkuwayti, Hairul-Islam M Ibrahim. Atropine Is a Suppressor of Epithelial-Mesenchymal Transition (EMT) That Reduces Stemness in Drug-Resistant Breast Cancer Cells. International journal of molecular sciences. 2022 Aug; 23(17):. doi: 10.3390/ijms23179849. [PMID: 36077256]
  • Tian Tian, Yong-Jiang Wang, Jian-Ping Huang, Jie Li, Bingyan Xu, Yin Chen, Li Wang, Jing Yang, Yijun Yan, Sheng-Xiong Huang. Catalytic innovation underlies independent recruitment of polyketide synthases in cocaine and hyoscyamine biosynthesis. Nature communications. 2022 08; 13(1):4994. doi: 10.1038/s41467-022-32776-1. [PMID: 36008484]
  • Nir Erdinest, Naomi London, Nadav Levinger, Itay Lavy, Eran Pras, Yair Morad. Decreased effectiveness of 0.01\% atropine treatment for myopia control during prolonged COVID-19 lockdowns. Contact lens & anterior eye : the journal of the British Contact Lens Association. 2022 Aug; 45(4):101475. doi: 10.1016/j.clae.2021.101475. [PMID: 34238687]
  • Qiaozhuo Zhang, Mengjiao Liang, Junlan Zeng, Chunxian Yang, Jianbo Qin, Wei Qiang, Xiaozhong Lan, Min Chen, Min Lin, Zhihua Liao. Engineering tropane alkaloid production and glyphosate resistance by overexpressing AbCaM1 and G2-EPSPS in Atropa belladonna. Metabolic engineering. 2022 07; 72(?):237-246. doi: 10.1016/j.ymben.2022.03.014. [PMID: 35390492]
  • Sigal Klainbart, Meital Grabarnik, Efrat Kelmer, Orit Chai, Olga Cuneah, Gilad Segev, Itamar Aroch. Clinical manifestations, laboratory findings, treatment and outcome of acute organophosphate or carbamate intoxication in 39 cats. The Veterinary record. 2022 07; 191(1):e1633. doi: 10.1002/vetr.1633. [PMID: 35437770]
  • Ashok Kumar Pannu, Sahil Garg, Ashish Bhalla, Deba Prasad Dhibar, Navneet Sharma. Lipid emulsion for the treatment of acute organophosphate poisoning: an Open-Label randomized trial. Clinical toxicology (Philadelphia, Pa.). 2022 May; 60(5):602-608. doi: 10.1080/15563650.2021.2013496. [PMID: 34928182]
  • Ewelina Kowalczyk, Krzysztof Kwiatek. Scopolamine and atropine in feeds - determination with liquid chromatography mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2022 May; 39(5):977-989. doi: 10.1080/19440049.2022.2037724. [PMID: 35302907]
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