Indospicine (BioDeep_00000006709)

   

natural product


代谢物信息卡片


Heptanoic acid, 2,7-diamino-7-imino-

化学式: C7H15N3O2 (173.1164)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 11.74%

分子结构信息

SMILES: C(CCC(=N)N)CC(C(=O)O)N
InChI: InChI=1S/C7H15N3O2/c8-5(7(11)12)3-1-2-4-6(9)10/h5H,1-4,8H2,(H3,9,10)(H,11,12)/t5-/m0/s1

描述信息

同义名列表

3 个代谢物同义名

Indospicine; Heptanoic acid, 2,7-diamino-7-imino-; Indospicine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • S E Salmon, S L Hall, D E Phillips, L R Dries, J Sarandopoulos, A Coghill, M C Hawes. Hepatopathy in Victorian dogs consuming pet meat contaminated with indospicine. Australian veterinary journal. 2022 Oct; 100(10):465-475. doi: 10.1111/avj.13171. [PMID: 35982633]
  • Shannon Darby, L Chris Sanchez, Martha F Mallicote, Amanda M House, Caryn E Plummer, Veridiana Nadruz, Rachel H Benmoha, Stephen M Roberts, Hartmut Derendorf, Cecilia Silva-Sanchez, Jami Claire, Robert J MacKay. Plasma l-indospicine and 3-nitropropionic acid in ponies fed creeping indigo: Comparison with results from an episode of presumptive creeping indigo toxicosis. Equine veterinary journal. 2022 Jan; 54(1):145-152. doi: 10.1111/evj.13415. [PMID: 33369767]
  • Rosalind A Gilbert, Gabriele Netzel, Kerri Chandra, Diane Ouwerkerk, Mary T Fletcher. Degradation of the Indospicine Toxin from Indigofera spicata by a Mixed Population of Rumen Bacteria. Toxins. 2021 05; 13(6):. doi: 10.3390/toxins13060389. [PMID: 34071579]
  • Galyna Y Shuvayeva, Yaroslav P Bobak, Olena I Vovk, Leoni A Kunz-Schughart, Mary T Fletcher, Oleh V Stasyk. Indospicine combined with arginine deprivation triggers cancer cell death via caspase-dependent apoptosis. Cell biology international. 2021 Mar; 45(3):518-527. doi: 10.1002/cbin.11321. [PMID: 32068315]
  • Gabriele Netzel, Dieter G Palmer, Anne M Masters, Samantha Y Tai, Jeremy G Allen, Mary T Fletcher. Assessing the risk of residues of the toxin indospicine in bovine muscle and liver from north-west Australia. Toxicon : official journal of the International Society on Toxinology. 2019 May; 163(?):48-58. doi: 10.1016/j.toxicon.2019.03.007. [PMID: 30880189]
  • Gabriele Netzel, Eddie T T Tan, Mukan Yin, Cindy Giles, Ken W L Yong, Rafat Al Jassim, Mary T Fletcher. Bioaccumulation and Distribution of Indospicine and Its Foregut Metabolites in Camels Fed Indigofera spicata. Toxins. 2019 03; 11(3):. doi: 10.3390/toxins11030169. [PMID: 30893830]
  • Saira Sultan, Simone A Osborne, Rama Addepalli, Gabi Netzel, Michael E Netzel, Mary T Fletcher. Indospicine cytotoxicity and transport in human cell lines. Food chemistry. 2018 Nov; 267(?):119-123. doi: 10.1016/j.foodchem.2017.08.029. [PMID: 29934145]
  • Eddie T T Tan, Rafat Al Jassim, Bruce R D'Arcy, Mary T Fletcher. In Vitro Biodegradation of Hepatotoxic Indospicine in Indigofera spicata and Its Degradation Derivatives by Camel Foregut and Cattle Rumen Fluids. Journal of agricultural and food chemistry. 2017 Aug; 65(34):7528-7534. doi: 10.1021/acs.jafc.7b02492. [PMID: 28787565]
  • Eddie T T Tan, Rafat Al Jassim, A Judy Cawdell-Smith, Selina M Ossedryver, Bruce R D'Arcy, Mary T Fletcher. Accumulation, Persistence, and Effects of Indospicine Residues in Camels Fed Indigofera Plant. Journal of agricultural and food chemistry. 2016 Aug; 64(34):6622-9. doi: 10.1021/acs.jafc.6b02707. [PMID: 27477889]
  • Eddie T T Tan, Christopher M Materne, Richard G Silcock, Bruce R D'Arcy, Rafat Al Jassim, Mary T Fletcher. Seasonal and Species Variation of the Hepatotoxin Indospicine in Australian Indigofera Legumes As Measured by UPLC-MS/MS. Journal of agricultural and food chemistry. 2016 Aug; 64(34):6613-21. doi: 10.1021/acs.jafc.6b02437. [PMID: 27509381]
  • Cheng-Shan Lang, Siew-Hoon Wong, Sharon Chow, Victoria L Challinor, Ken W L Yong, Mary T Fletcher, Dionne M Arthur, Jack C Ng, James J De Voss. Synthesis of l-indospicine, [5,5,6-(2)H3]-l-indospicine and l-norindospicine. Organic & biomolecular chemistry. 2016 Jul; 14(28):6826-32. doi: 10.1039/c6ob01187j. [PMID: 27338015]
  • Eddie T T Tan, Mary T Fletcher, Ken W L Yong, Bruce R D'Arcy, Rafat Al Jassim. Determination of hepatotoxic indospicine in Australian camel meat by ultra-performance liquid chromatography-tandem mass spectrometry. Journal of agricultural and food chemistry. 2014 Feb; 62(8):1974-9. doi: 10.1021/jf4052495. [PMID: 24433171]
  • Everton F Lima, Franklin Riet-Correa, Dale R Gardner, Severo S Barros, Rosane M T Medeiros, Mauro P Soares, Gabriela Riet-Correa. Poisoning by Indigofera lespedezioides in horses. Toxicon : official journal of the International Society on Toxinology. 2012 Sep; 60(3):324-8. doi: 10.1016/j.toxicon.2012.04.341. [PMID: 22560887]
  • L M FitzGerald, M T Fletcher, A E H Paul, C S Mansfield, A J O'Hara. Hepatotoxicosis in dogs consuming a diet of camel meat contaminated with indospicine. Australian veterinary journal. 2011 Mar; 89(3):95-100. doi: 10.1111/j.1751-0813.2010.00684.x. [PMID: 21323657]
  • Ihsan Ergün, M Cenk Akbostanci, Başol Canbakan, Bilge Koçer, Arzu Ensari, Gökhan Nergizoglu, Kenan Keven. Minimal change nephrotic syndrome with stiff-person syndrome: is there a link?. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2005 Jul; 46(1):e11-4. doi: 10.1053/j.ajkd.2005.03.009. [PMID: 15983949]
  • S Pollitt, M P Hegarty, M A Pass. Analysis of the amino acid indospicine in biological samples by high performance liquid chromatography. Natural toxins. 1999; 7(6):233-40. doi: 10.1002/1522-7189(199911/12)7:6<233::aid-nt59>3.0.co;2-3. [PMID: 11122512]
  • M P Hegarty, W R Kelly, D McEwan, O J Williams, R Cameron. Hepatotoxicity to dogs of horse meat contaminated with indospicine. Australian veterinary journal. 1988 Nov; 65(11):337-40. doi: 10.1111/j.1751-0813.1988.tb14259.x. [PMID: 3214366]
  • P Rubin, Y G Yee, M Anderson, T Blaschke. Prazosin first-pass metabolism and hepatic extraction in the dog. Journal of cardiovascular pharmacology. 1979 Nov; 1(6):641-7. doi: 10.1097/00005344-197911000-00005. [PMID: 94630]
  • J E Robillard, C Sessions, F G Smith. In vivo demonstration of renal carbonic anhydrase activity in the fetal lamb. Biology of the neonate. 1978; 34(5-6):253-8. doi: 10.1159/000241137. [PMID: 32932]
  • T Egashira. Studies on monoamine oxidase. XVIII. Enzymic properties of placental monoamine oxidase. Japanese journal of pharmacology. 1976 Aug; 26(4):493-500. doi: 10.1254/jjp.26.493. [PMID: 12389]