Halothane (BioDeep_00000006518)

 

Secondary id: BioDeep_00001867807

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


1,1,1-Trifluoro-2-bromo-2-chloroethane

化学式: C2HBrClF3 (195.89022319999998)
中文名称: 氟烷
谱图信息: 最多检出来源 Homo sapiens(blood) 3.39%

分子结构信息

SMILES: C(C(F)(F)F)(Cl)Br
InChI: InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H

描述信息

A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AB - Halogenated hydrocarbons
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent

同义名列表

22 个代谢物同义名

1,1,1-Trifluoro-2-bromo-2-chloroethane; 2-Bromo-2-chloro-1,1,1-trifluoroethane; 1,1,1-Trifluoro-2-chloro-2-bromoethane; 1-Bromo-1-chloro-2,2,2-trifluoroethane; 2,2,2-Trifluoro-1-chloro-1-bromoethane; Bromochlorotrifluoroethane; Bromchlortrifluoraethanum; Narcotann ne-spofa; Phthorothanum; Rhodialothan; Fluorothane; Freon 123b1; Fluorotane; Ftuorotan; CF3CHCLBR; Narcotane; Fluothane; halothane; Narcotan; Ftorotan; Halothan; Alotano



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(6)

BioCyc(0)

PlantCyc(0)

代谢反应

78 个相关的代谢反应过程信息。

Reactome(78)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Vesna Benković, Nada Oršolić, Anica Horvat Knežević, Nikola Borojević, Gordana Brozović, Mirta Milić. Kidney cell DNA damage caused by combined exposure to volatile anaesthetics and 1 Gy or 2 Gy radiotherapy dose in vivo. Arhiv za higijenu rada i toksikologiju. 2022 Apr; 73(1):62-70. doi: 10.2478/aiht-2022-73-3600. [PMID: 35390237]
  • C Philip Larson. Scientific Accuracy Matters. Anesthesiology. 2021 10; 135(4):724-727. doi: 10.1097/aln.0000000000003952. [PMID: 34499097]
  • Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma, Noriaki Manaka, Hiroyuki Kagechika, Arkady Uryash, Jose Adams, Jose R Lopez, Xiaochen Liu, Christine Diggle, Paul D Allen, Sho Kakizawa, Keigo Ikeda, Bangzhong Lin, Yui Ikemi, Kazuto Nunomura, Shinsaku Nakagawa, Takashi Sakurai, Takashi Murayama. A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke. Nature communications. 2021 07; 12(1):4293. doi: 10.1038/s41467-021-24644-1. [PMID: 34257294]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Koki Chiba, Takeshi Wada, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama. Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones. Naunyn-Schmiedeberg's archives of pharmacology. 2021 04; 394(4):581-589. doi: 10.1007/s00210-020-01997-w. [PMID: 33064166]
  • Ai Goto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Shinichi Kawai, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama. Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs. Heart and vessels. 2021 Mar; 36(3):424-429. doi: 10.1007/s00380-020-01716-8. [PMID: 33136260]
  • Vesna Benković, Nikola Borojević, Dunja Šikić, Anica Horvat Knežević, Mirta Milić. DNA damage assessment in peripheral blood of Swiss albino mice after combined exposure to volatile anesthetics and 1 or 2 Gy radiotherapy in vivo. International journal of radiation biology. 2021; 97(10):1425-1435. doi: 10.1080/09553002.2021.1962565. [PMID: 34328801]
  • Monica Aleman, Rui Zhang, Wei Feng, Lihong Qi, Jose R Lopez, Chelsea Crowe, Yao Dong, Genady Cherednichenko, Isaac N Pessah. Dietary Caffeine Synergizes Adverse Peripheral and Central Responses to Anesthesia in Malignant Hyperthermia Susceptible Mice. Molecular pharmacology. 2020 10; 98(4):351-363. doi: 10.1124/mol.120.119412. [PMID: 32764093]
  • Ru Jia, Shingo Oda, Tsuyoshi Yokoi. Pharmacological evidence for the involvement of ryanodine receptors in halothane-induced liver injury in mice. Toxicology. 2020 10; 443(?):152560. doi: 10.1016/j.tox.2020.152560. [PMID: 32795494]
  • Yoshiki Kondo, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Atsushi Sugiyama. Electropharmacological Characterization of Aciclovir in the Halothane-Anesthetized Dogs: A Proposal of Evaluation Method for Cardiovascular Safety Pharmacology of Anti-virus Drugs. Cardiovascular toxicology. 2020 08; 20(4):419-426. doi: 10.1007/s12012-020-09568-4. [PMID: 32193875]
  • Sandeep Raj Karna, Preet Singh, Paul Chambers, Kavitha Kongara. Pharmacokinetics of morphine in combination with dexmedetomidine and maropitant following intramuscular injection in dogs anaesthetized with halothane. Journal of veterinary pharmacology and therapeutics. 2020 Mar; 43(2):153-161. doi: 10.1111/jvp.12831. [PMID: 31856324]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Atsushi Sugiyama, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Kentaro Ando, Atsuhiko T Naito, Hiroko Izumi-Nakaseko. Electropharmacological effects of intracellular Ca2+ handling modulator caldaret on the heart assessed in the halothane-anesthetized dogs. Journal of pharmacological sciences. 2019 Mar; 139(3):180-185. doi: 10.1016/j.jphs.2019.01.004. [PMID: 30738725]
  • Jorge Alfonso Arvayo-Zatarain, Fernando Favela-Rosales, Claudio Contreras-Aburto, Efrain Urrutia-Bañuelos, Amir Maldonado. Molecular dynamics simulation study of the effect of halothane on mixed DPPC/DPPE phospholipid membranes. Journal of molecular modeling. 2018 Dec; 25(1):4. doi: 10.1007/s00894-018-3890-6. [PMID: 30554281]
  • Ai Goto, Yuji Nakamura, Nur Jaharat Lubna, Koki Chiba, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsuhiko T Naito, Atsushi Sugiyama. Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs. Cardiovascular toxicology. 2018 12; 18(6):530-536. doi: 10.1007/s12012-018-9464-0. [PMID: 29845450]
  • Kentaro Ando, Yuji Nakamura, Mihoko Hagiwara-Nagasawa, Hiroyuki Harada, Hiroyoshi Miyamoto, Naoki Inamura, Kan Takagi, Ai Goto, Koki Chiba, Nur Jaharat Lubna, Hiroko Izumi-Nakaseko, Atsuhiko T Naito, Atsushi Sugiyama. Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsadogenic risk of fexofenadine. The Journal of toxicological sciences. 2018; 43(3):183-192. doi: 10.2131/jts.43.183. [PMID: 29540652]
  • Xin Cao, Takeshi Wada, Yuji Nakamura, Suchitra Matsukura, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsuhiko T Naito, Atsushi Sugiyama. Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome. Basic & clinical pharmacology & toxicology. 2017 Dec; 121(6):465-470. doi: 10.1111/bcpt.12838. [PMID: 28654209]
  • Hitoshi Matsuki, Kentaro Kato, Hirotsugu Okamoto, Shuntaro Yoshida, Masaki Goto, Nobutake Tamai, Shoji Kaneshina. Ligand partitioning into lipid bilayer membranes under high pressure: Implication of variation in phase-transition temperatures. Chemistry and physics of lipids. 2017 12; 209(?):9-18. doi: 10.1016/j.chemphyslip.2017.10.002. [PMID: 29042237]
  • Mohammad Hossien Bakhshaei, Abdorrahman Bahrami, Amin Mirzakhani, Hossien Mahjub, Mohammad Javad Assari. Exposure Assessment, Biological Monitoring, and Liver Function Tests of Operating Room Personnel Exposed to Halothane in Hamedan Hospitals, West of Iran. Journal of research in health sciences. 2017 Nov; 17(4):e00397. doi: . [PMID: 29233951]
  • Koki Chiba, Takeshi Wada, Yuji Nakamura, Xin Cao, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kentaro Ando, Koichiro Tanaka, Atsuhiko T Naito, Atsushi Sugiyama. Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs. Journal of pharmacological sciences. 2017 Aug; 134(4):239-246. doi: 10.1016/j.jphs.2017.08.002. [PMID: 28844424]
  • Balázs Fábián, Marcello Sega, Vladimir P Voloshin, Nikolai N Medvedev, Pál Jedlovszky. Lateral Pressure Profile and Free Volume Properties in Phospholipid Membranes Containing Anesthetics. The journal of physical chemistry. B. 2017 04; 121(13):2814-2824. doi: 10.1021/acs.jpcb.7b00990. [PMID: 28282987]
  • Derek R Laver, John Attia, Christopher Oldmeadow, Anthony W Quail. Cardiac Calcium Release Channel (Ryanodine Receptor 2) Regulation by Halogenated Anesthetics. Anesthesiology. 2017 Mar; 126(3):495-506. doi: 10.1097/aln.0000000000001519. [PMID: 28079567]
  • A Kollmann-Camaiora, E Alsina, A Domínguez, B Del Blanco, M J Yepes, J L Guerrero, A García. Clinical protocol for the management of malignant hyperthermia. Revista espanola de anestesiologia y reanimacion. 2017 Jan; 64(1):32-40. doi: 10.1016/j.redar.2016.06.004. [PMID: 27633384]
  • Jun Katagi, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Atsushi Honda, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama. Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K(+) Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model. Cardiovascular toxicology. 2016 Apr; 16(2):138-46. doi: 10.1007/s12012-015-9322-2. [PMID: 25822712]
  • Valentina Vellecco, Antonio Mancini, Angela Ianaro, Vincenzo Calderone, Chiara Attanasio, Anna Cantalupo, Barbara Andria, Gennaro Savoia, Elisabetta Panza, Antonietta Di Martino, Giuseppe Cirino, Mariarosaria Bucci. Cystathionine β-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia. Clinical science (London, England : 1979). 2016 Jan; 130(1):35-44. doi: 10.1042/cs20150521. [PMID: 26460077]
  • Jiansheng Wang, Xiaojun Yang, Huan Xiao, Jianqiang Kong, Miao Bing. Determination of the mechanism of action of repetitive halothane exposure on rat brain tissues using a combined method of microarray gene expression profiling and bioinformatics analysis. Molecular medicine reports. 2015 Dec; 12(6):8071-6. doi: 10.3892/mmr.2015.4462. [PMID: 26497548]
  • David L Worcester, Michael Weinrich. Hydrostatic Pressure Promotes Domain Formation in Model Lipid Raft Membranes. The journal of physical chemistry letters. 2015 Nov; 6(21):4417-21. doi: 10.1021/acs.jpclett.5b02134. [PMID: 26538052]
  • Brian A MacDonald, Krishnan V Chakravarthy, Bruce A Davidson, Barbara A Mullan, Ravi Alluri, Anders P Hakansson, Paul R Knight. Halothane modulates the type i interferon response to influenza and minimizes the risk of secondary bacterial pneumonia through maintenance of neutrophil recruitment in an animal model. Anesthesiology. 2015 Sep; 123(3):590-602. doi: 10.1097/aln.0000000000000766. [PMID: 26120770]
  • Mala Chakraborty, Aaron M Fullerton, Kenrick Semple, Lynette S Chea, William R Proctor, Mohammed Bourdi, David E Kleiner, Xiangbin Zeng, Pauline M Ryan, Pradeep K Dagur, Julia D Berkson, Timothy P Reilly, Lance R Pohl. Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment. Hepatology (Baltimore, Md.). 2015 Aug; 62(2):546-57. doi: 10.1002/hep.27764. [PMID: 25712247]
  • William R Proctor, Mala Chakraborty, Aaron M Fullerton, Midhun C Korrapati, Pauline M Ryan, Kenrick Semple, Jeffrey C Morrison, Julia D Berkson, Lynette S Chea, Qian Yang, Albert P Li, Rosanne Spolski, Erin E West, Yrina Rochman, Warren J Leonard, Mohammed Bourdi, Lance R Pohl. Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice. Hepatology (Baltimore, Md.). 2014 Nov; 60(5):1741-52. doi: 10.1002/hep.27169. [PMID: 24723460]
  • Sandy Blin, Franck C Chatelain, Sylvain Feliciangeli, Dawon Kang, Florian Lesage, Delphine Bichet. Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels. The Journal of biological chemistry. 2014 Oct; 289(41):28202-12. doi: 10.1074/jbc.m114.600437. [PMID: 25148687]
  • Hiroko Izumi-Nakaseko, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Yukiko Yamazaki, Naoya Ueda, Kentaro Ando, Atsushi Sugiyama. Effects of selective IKr channel blockade by E-4031 on ventricular electro-mechanical relationship in the halothane-anesthetized dogs. European journal of pharmacology. 2014 Oct; 740(?):263-70. doi: 10.1016/j.ejphar.2014.06.064. [PMID: 25038475]
  • Mohammed Fanchaouy, Luis Cubano, Hector Maldonado, Rostislav Bychkov. PKC independent inhibition of voltage gated calcium channels by volatile anesthetics in freshly isolated vascular myocytes from the aorta. Cell calcium. 2013 Oct; 54(4):257-65. doi: 10.1016/j.ceca.2013.07.001. [PMID: 23948226]
  • B Frossard, C Combret, D Benhamou. [Analgesia for labour and delivery in a parturient with paramytonia congenita]. Annales francaises d'anesthesie et de reanimation. 2013 May; 32(5):372-4. doi: 10.1016/j.annfar.2013.03.007. [PMID: 23648013]
  • Hilmi Orhan, Altan Sahin, Gonul Sahin, Ulku Aypar, Nico P E Vermeulen. Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2013 Feb; 18(1):73-81. doi: 10.3109/1354750x.2012.737026. [PMID: 23136842]
  • Leigh D Plant, Leandro Zuniga, Dan Araki, Jeremy D Marks, Steve A N Goldstein. SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons. Science signaling. 2012 Nov; 5(251):ra84. doi: 10.1126/scisignal.2003431. [PMID: 23169818]
  • Mária Darvas, Paul N M Hoang, Sylvain Picaud, Marcello Sega, Pál Jedlovszky. Anesthetic molecules embedded in a lipid membrane: a computer simulation study. Physical chemistry chemical physics : PCCP. 2012 Oct; 14(37):12956-69. doi: 10.1039/c2cp41581j. [PMID: 22903224]
  • R O Bates, M E Doumit, N E Raney, E E Helman, C W Ernst. Association of halothane sensitivity with growth and meat quality in pigs. Animal : an international journal of animal bioscience. 2012 Sep; 6(9):1537-42. doi: 10.1017/s1751731112000134. [PMID: 23031527]
  • Jozef Krajcovic, Frantisek Novomesky, Frantisek Stuller, Lubomir Straka, Juraj Mokry. An unusual case of anesthetic abuse by a full-face gas mask. The American journal of forensic medicine and pathology. 2012 Sep; 33(3):256-8. doi: 10.1097/paf.0b013e31820f1529. [PMID: 21415699]
  • Michael Weinrich, Hirsh Nanda, David L Worcester, Charles F Majkrzak, Brian B Maranville, Sergey M Bezrukov. Halothane changes the domain structure of a binary lipid membrane. Langmuir : the ACS journal of surfaces and colloids. 2012 Mar; 28(10):4723-8. doi: 10.1021/la204317k. [PMID: 22352350]
  • Kei Hichiri, Osamu Shirai, Kenji Kano. Influence of inhalation anesthetics on ion transport across a planar bilayer lipid membrane. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2012; 28(1):45-9. doi: 10.2116/analsci.28.45. [PMID: 22232223]
  • Serhan Turkyilmaz, Paulo F Almeida, Steven L Regen. Effects of isoflurane, halothane, and chloroform on the interactions and lateral organization of lipids in the liquid-ordered phase. Langmuir : the ACS journal of surfaces and colloids. 2011 Dec; 27(23):14380-5. doi: 10.1021/la2035278. [PMID: 21995557]
  • Gordana Brozovic, Nada Orsolic, Fabijan Knezevic, Anica Horvat Knezevic, Vesna Benkovic, Katarina Sakic, Nikola Borojevic, Domagoj Dikic. The in vivo genotoxicity of cisplatin, isoflurane and halothane evaluated by alkaline comet assay in Swiss albino mice. Journal of applied genetics. 2011 Aug; 52(3):355-61. doi: 10.1007/s13353-011-0046-0. [PMID: 21509577]
  • Jan K Schütte, Sandra Becker, Sascha Burmester, Alexander Starosse, Daniel Lenz, Lars Kröner, Frank Wappler, Mark U Gerbershagen. Comparison of the therapeutic effectiveness of a dantrolene sodium solution and a novel nanocrystalline suspension of dantrolene sodium in malignant hyperthermia normal and susceptible pigs. European journal of anaesthesiology. 2011 Apr; 28(4):256-64. doi: . [PMID: 21513076]
  • Christine M Dugan, Aaron M Fullerton, Robert A Roth, Patricia E Ganey. Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis. Toxicological sciences : an official journal of the Society of Toxicology. 2011 Apr; 120(2):507-18. doi: 10.1093/toxsci/kfr005. [PMID: 21245496]
  • Darío Colucci, Guillermina Harvey, María Cristina Gayol, Gustavo Elena, Nora Puig. Halothane anesthesia in mice: effect on the phagocytic activity and respiratory burst of peritoneal macrophages. Neuroimmunomodulation. 2011; 18(1):11-8. doi: 10.1159/000313367. [PMID: 20606489]
  • Elizaveta Kon, Giuseppe Filardo, Marco Delcogliano, Milena Fini, Francesca Salamanna, Gianluca Giavaresi, Ivan Martin, Maurilio Marcacci. Platelet autologous growth factors decrease the osteochondral regeneration capability of a collagen-hydroxyapatite scaffold in a sheep model. BMC musculoskeletal disorders. 2010 Sep; 11(?):220. doi: 10.1186/1471-2474-11-220. [PMID: 20875101]
  • Dan Willenbring, Yan Xu, Pei Tang. The role of structured water in mediating general anesthetic action on alpha4beta2 nAChR. Physical chemistry chemical physics : PCCP. 2010 Sep; 12(35):10263-9. doi: 10.1039/c003573d. [PMID: 20661501]
  • Peter G Mantle, Katharine M McHugh, John E Fincham. Contrasting nephropathic responses to oral administration of extract of cultured Penicillium polonicum in rat and primate. Toxins. 2010 08; 2(8):2083-97. doi: 10.3390/toxins2082083. [PMID: 22069673]
  • Kamila Zurkova, Petr Hainz, Jitka Krystofova, Luda Kutinova, Miloslav Sanda, Sarka Nemeckova. Attenuation of vaccinia virus by the expression of human Flt3 ligand. Virology journal. 2010 May; 7(?):109. doi: 10.1186/1743-422x-7-109. [PMID: 20504356]
  • Julia O Subbotina, Jonathan Johannes, Bogdan Lev, Sergei Yu Noskov. Halothane solvation in water and organic solvents from molecular simulations with new polarizable potential function. The journal of physical chemistry. B. 2010 May; 114(19):6401-8. doi: 10.1021/jp908339j. [PMID: 20411978]
  • Qiang You, Linling Cheng, Cynthia Ju. Generation of T cell responses targeting the reactive metabolite of halothane in mice. Toxicology letters. 2010 May; 194(3):79-85. doi: 10.1016/j.toxlet.2010.02.009. [PMID: 20156533]
  • Christine M Dugan, Allen E MacDonald, Robert A Roth, Patricia E Ganey. A mouse model of severe halothane hepatitis based on human risk factors. The Journal of pharmacology and experimental therapeutics. 2010 May; 333(2):364-72. doi: 10.1124/jpet.109.164541. [PMID: 20124411]
  • Hiroaki Kise, Yuji Nakamura, Minako Hoshiai, Hisashi Sugiyama, Kanji Sugita, Atsushi Sugiyama. Cardiac and haemodynamic effects of tacrolimus in the halothane-anaesthetized dog. Basic & clinical pharmacology & toxicology. 2010 Apr; 106(4):288-95. doi: 10.1111/j.1742-7843.2009.00477.x. [PMID: 19912168]
  • Tanxing Cui, Christian G Canlas, Yan Xu, Pei Tang. Anesthetic effects on the structure and dynamics of the second transmembrane domains of nAChR alpha4beta2. Biochimica et biophysica acta. 2010 Feb; 1798(2):161-6. doi: 10.1016/j.bbamem.2009.08.009. [PMID: 19715664]
  • Tomomichi Ishizaka, Akira Takahara, Hiroshi Iwasaki, Yoshitaka Mitsumori, Hiroaki Kise, Yuji Nakamura, Atsushi Sugiyama. Cardiovascular effects of azelnidipine in comparison with those of amlodipine assessed in the halothane-anaesthetized dog. Basic & clinical pharmacology & toxicology. 2010 Feb; 106(2):135-43. doi: 10.1111/j.1742-7843.2009.00478.x. [PMID: 19906049]
  • Satyavani Vemparala, Carmen Domene, Michael L Klein. Computational studies on the interactions of inhalational anesthetics with proteins. Accounts of chemical research. 2010 Jan; 43(1):103-10. doi: 10.1021/ar900149j. [PMID: 19788306]
  • Joanna C Murrell, Sheryl L Mitchinson, Lucy Lesperance, Subathira Sivakumaran, Craig B Johnson. Electroencephalography during ovariohysterectomy in rats anaesthetized with halothane. Veterinary anaesthesia and analgesia. 2010 Jan; 37(1):14-24. doi: 10.1111/j.1467-2995.2009.00504.x. [PMID: 20017815]
  • Alfredo González Gil, Gema Silván, Alberto Villa, Pilar Millán, Leticia Martínez-Fernández, Juan C Illera. Serum biochemical response to inhalant anesthetics in New Zealand white rabbits. Journal of the American Association for Laboratory Animal Science : JAALAS. 2010 Jan; 49(1):52-6. doi: . [PMID: 20122317]
  • Emmanuel Mas, Marie Danjoux, Virginie Garcia, Stéphane Carpentier, Bruno Ségui, Thierry Levade. IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. PloS one. 2009 Nov; 4(11):e7929. doi: 10.1371/journal.pone.0007929. [PMID: 19936233]
  • Eisuke Kobayashi, Masanori Kobayashi, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. Halothane-induced liver injury is mediated by interleukin-17 in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2009 Oct; 111(2):302-10. doi: 10.1093/toxsci/kfp165. [PMID: 19633216]
  • D Carpenter, R L Robinson, R J Quinnell, C Ringrose, M Hogg, F Casson, P Booms, D E Iles, P J Halsall, D S Steele, M-A Shaw, P M Hopkins. Genetic variation in RYR1 and malignant hyperthermia phenotypes. British journal of anaesthesia. 2009 Oct; 103(4):538-48. doi: 10.1093/bja/aep204. [PMID: 19648156]
  • Michael Weinrich, Tatiana K Rostovtseva, Sergey M Bezrukov. Lipid-dependent effects of halothane on gramicidin channel kinetics: a new role for lipid packing stress. Biochemistry. 2009 Jun; 48(24):5501-3. doi: 10.1021/bi900494y. [PMID: 19405539]
  • Dieter Fuchs, Rolf Christofferson, Mats Stridsberg, Elin Lindhagen, Faranak Azarbayjani. Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments. Journal of translational medicine. 2009 Mar; 7(?):16. doi: 10.1186/1479-5876-7-16. [PMID: 19284605]
  • Tomomichi Ishizaka, Yu Yoshimatsu, Minori Ozawa, Tomofumi Kimotsuki, Wataru Takasaki, Sunao Manabe, Mitsuya Yasuda. Evaluation of drug-induced QT prolongation in a halothane-anesthetized monkey model: effects of sotalol. Journal of pharmacological and toxicological methods. 2009 Mar; 59(2):86-93. doi: 10.1016/j.vascn.2009.01.002. [PMID: 19367688]
  • Galina P Simeonova, Emil Slavov, Roustislav Usunov, Krasimira Halacheva, Dinco N Dinev. Increased apoptosis of peripheral blood mononuclear cells (PBMC) during general and epidural anaesthesia in dogs. Veterinary research communications. 2008 Dec; 32(8):619-26. doi: 10.1007/s11259-008-9063-9. [PMID: 18491210]
  • P W L Tas, C Stössel, N Roewer. Inhibition of the histamine-induced Ca2+ influx in primary human endothelial cells (HUVEC) by volatile anaesthetics. European journal of anaesthesiology. 2008 Dec; 25(12):976-85. doi: 10.1017/s0265021508004778. [PMID: 18631421]
  • Y Rao, Y L Wang, H Li, W Zhang, J Liu. Effects of pregnancy on the solubility of halogenated volatile anaesthetics in rat blood and tissues. Anaesthesia and intensive care. 2008 Nov; 36(6):830-4. doi: 10.1177/0310057x0803600612. [PMID: 19115652]
  • E D Kharasch. Adverse drug reactions with halogenated anesthetics. Clinical pharmacology and therapeutics. 2008 Jul; 84(1):158-62. doi: 10.1038/clpt.2008.97. [PMID: 18509326]
  • Liu-An Li, Dong Xia, Shi Wei, Xiao Li, Nahid Parvizi, Ru-Qian Zhao. Diminished expression of ACTH signaling proteins and steroidogenic limiting factors in adrenocortical cells isolated from halothane nn pigs. Domestic animal endocrinology. 2008 Jul; 35(1):1-7. doi: 10.1016/j.domaniend.2007.12.005. [PMID: 18304776]
  • Satyavani Vemparala, Carmen Domene, Michael L Klein. Interaction of anesthetics with open and closed conformations of a potassium channel studied via molecular dynamics and normal mode analysis. Biophysical journal. 2008 Jun; 94(11):4260-9. doi: 10.1529/biophysj.107.119958. [PMID: 18310250]
  • A Yurdakoc, I Gunday, D Memiş. Effects of halothane, isoflurane, and sevoflurane on lipid peroxidation following experimental closed head trauma in rats. Acta anaesthesiologica Scandinavica. 2008 May; 52(5):658-63. doi: 10.1111/j.1399-6576.2008.01635.x. [PMID: 18419720]
  • Mohammad Reza Seddighi, Mehrdad Mohri. Anesthesia in Caspian ponies. Veterinary anaesthesia and analgesia. 2008 May; 35(3):237-41. doi: 10.1111/j.1467-2995.2007.00366.x. [PMID: 17927676]
  • Annalucia Serafino, Paola Sinibaldi Vallebona, Federica Andreola, Manuela Zonfrillo, Luana Mercuri, Memmo Federici, Guido Rasi, Enrico Garaci, Pasquale Pierimarchi. Stimulatory effect of Eucalyptus essential oil on innate cell-mediated immune response. BMC immunology. 2008 Apr; 9(?):17. doi: 10.1186/1471-2172-9-17. [PMID: 18423004]
  • Paula L Diaz-Sylvester, Maura Porta, Julio A Copello. Halothane modulation of skeletal muscle ryanodine receptors: dependence on Ca2+, Mg2+, and ATP. American journal of physiology. Cell physiology. 2008 Apr; 294(4):C1103-12. doi: 10.1152/ajpcell.90642.2007. [PMID: 18305228]
  • Y M Bahnasi, H M Wright, C J Milligan, A M Dedman, F Zeng, P M Hopkins, A N Bateson, D J Beech. Modulation of TRPC5 cation channels by halothane, chloroform and propofol. British journal of pharmacology. 2008 Apr; 153(7):1505-12. doi: 10.1038/sj.bjp.0707689. [PMID: 18204473]
  • Ying-Lin Wang, Xiang-Yang Guo, Zhong-Huang Xu, Yu-Guang Huang, Ai-Lun Luo. [Application of caffeine-halothane contracture test in the diagnosis of malignant hyperthermia]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 2008 Apr; 30(2):182-6. doi: . [PMID: 18505122]
  • Shelley N Jackson, Sachin K Singhal, Amina S Woods, Marisela Morales, Toni Shippenberg, Li Zhang, Murat Oz. Volatile anesthetics and endogenous cannabinoid anandamide have additive and independent inhibitory effects on alpha(7)-nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes. European journal of pharmacology. 2008 Mar; 582(1-3):42-51. doi: 10.1016/j.ejphar.2007.12.023. [PMID: 18242598]
  • Tilemahos L Anagnostou, Ioannis Savvas, George M Kazakos, Dimitris Raptopoulos, Haralabos Ververidis, Nikolaos Roubies. Thiopental and halothane dose-sparing effects of magnesium sulphate in dogs. Veterinary anaesthesia and analgesia. 2008 Mar; 35(2):93-9. doi: 10.1111/j.1467-2995.2007.00359.x. [PMID: 17850224]
  • Daniel P Bray, Malcolm Bennett, Paula Stockley, Jane L Hurst, Anja Kipar. Composition and function of haemolymphatic tissues in the European common shrew. PloS one. 2008; 3(10):e3413. doi: 10.1371/journal.pone.0003413. [PMID: 18923707]
  • J G Bovill. Inhalation anaesthesia: from diethyl ether to xenon. Handbook of experimental pharmacology. 2008; ?(182):121-42. doi: 10.1007/978-3-540-74806-9_6. [PMID: 18175089]
  • Evelin Vicente, Francine Tramontina, Marina C Leite, Patricia Nardin, Mariane Silva, Ana R Karkow, Rafael Adolf, Aldo B Lucion, Carlos A Netto, Carmem Gottfried, Carlos A Gonçalves. S100B levels in the cerebrospinal fluid of rats are sex and anaesthetic dependent. Clinical and experimental pharmacology & physiology. 2007 Nov; 34(11):1126-30. doi: 10.1111/j.1440-1681.2007.04687.x. [PMID: 17880365]
  • Piet W L Tas, Stepan Gambaryan, Norbert Roewer. Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation. Journal of cellular biochemistry. 2007 Oct; 102(2):368-76. doi: 10.1002/jcb.21294. [PMID: 17492663]
  • Alfredo González Gil, Gema Silván, Juan C Illera. Pituitary-adrenocortical axis, serum serotonin and biochemical response after halothane or isoflurane anaesthesia in rabbits. Laboratory animals. 2007 Oct; 41(4):411-9. doi: 10.1258/002367707782314274. [PMID: 17988436]
  • Paulo H C Diniz, Janice H Silva, Marcus V Gomez, Cristina Guatimosim, Renato S Gomez. Halothane increases non-vesicular [(3)H]dopamine release from brain cortical slices. Cellular and molecular neurobiology. 2007 Sep; 27(6):757-70. doi: 10.1007/s10571-007-9162-0. [PMID: 17680357]
  • S Zhang, T J Knight, K J Stalder, R N Goodwin, S M Lonergan, D C Beitz. Effects of breed, sex, and halothane genotype on fatty acid composition of pork longissimus muscle. Journal of animal science. 2007 Mar; 85(3):583-91. doi: 10.2527/jas.2006-239. [PMID: 17060410]
  • Jaishri Bogra, R Gangoo, V C Pandey, Pratima Srivastava. Effect on free radical generation with different anaesthesia. Journal of the Indian Medical Association. 2007 Mar; 105(3):128-9, 132. doi: . [PMID: 17824463]
  • R Turan, H Yagmurdur, M Kavutcu, B Dikmen. Propofol and tourniquet induced ischaemia reperfusion injury in lower extremity operations. European journal of anaesthesiology. 2007 Feb; 24(2):185-9. doi: 10.1017/s0265021506001347. [PMID: 16938161]
  • Ralitca Valtcheva-Sarker, Elena Stephanova, Kamelia Hristova, George Altankov, Albena Momchilova, Roumen Pankov. Halothane affects focal adhesion proteins in the A 549 cells. Molecular and cellular biochemistry. 2007 Jan; 295(1-2):59-64. doi: 10.1007/s11010-006-9272-x. [PMID: 16855789]
  • Luis Josino Brasil, José Luiz Gomes do Amaral, Claudio Galeano Zettler, Claudio Augusto Marroni, Rafael Vercelino, Norma Marroni. [Experimental model of liver oxidative damage induction in rats by halothane]. Arquivos de gastroenterologia. 2007 Jan; 44(1):73-7. doi: 10.1590/s0004-28032007000100016. [PMID: 17639188]
  • Y S Prakash, Adeyemi Iyanoye, Binnaz Ay, Gary C Sieck, Christina M Pabelick. Store-operated Ca2+ influx in airway smooth muscle: Interactions between volatile anesthetic and cyclic nucleotide effects. Anesthesiology. 2006 Nov; 105(5):976-83. doi: 10.1097/00000542-200611000-00019. [PMID: 17065892]
  • John H Streiff, Thomas W Allen, Elena Atanasova, Nenad Juranic, Slobodan Macura, Alan R Penheiter, Keith A Jones. Prediction of volatile anesthetic binding sites in proteins. Biophysical journal. 2006 Nov; 91(9):3405-14. doi: 10.1529/biophysj.106.082586. [PMID: 16877516]
  • Satyavani Vemparala, Leonor Saiz, Roderic G Eckenhoff, Michael L Klein. Partitioning of anesthetics into a lipid bilayer and their interaction with membrane-bound peptide bundles. Biophysical journal. 2006 Oct; 91(8):2815-25. doi: 10.1529/biophysj.106.085324. [PMID: 16877515]
  • Shugaku Himukashi, Hiroshi Takeshima, Sahoko Koyanagi, Tsutomu Shichino, Kazuhiko Fukuda. The involvement of the nociceptin receptor in the antinociceptive action of nitrous oxide. Anesthesia and analgesia. 2006 Sep; 103(3):738-41. doi: 10.1213/01.ane.0000230601.64098.cc. [PMID: 16931689]
  • Tetsuzo Nakayama, Alan R Penheiter, Sumedha G Penheiter, Eduardo N Chini, Michael Thompson, David O Warner, Keith A Jones. Differential effects of volatile anesthetics on M3 muscarinic receptor coupling to the Galphaq heterotrimeric G protein. Anesthesiology. 2006 Aug; 105(2):313-24. doi: 10.1097/00000542-200608000-00014. [PMID: 16871065]
  • A González-Gil, G Silván, P García-Partida, J C Illera. Serum glucocorticoid concentrations after halothane and isoflurane anaesthesia in New Zealand white rabbits. The Veterinary record. 2006 Jul; 159(2):51-2. doi: 10.1136/vr.159.2.51. [PMID: 16829601]
  • Fatma Saricaoğlu, Seda Banu Akinci, Bahar Oç, Meral Kanbak, Birkan Akbulut, Bilge Celebioglu. The effect of halothane, isoflurane, sevoflurane and propofol infusion on renal function after coronary artery bypass surgery. Middle East journal of anaesthesiology. 2006 Jun; 18(5):955-64. doi: . [PMID: 17094535]
  • Z Leonenko, E Finot, D Cramb. AFM study of interaction forces in supported planar DPPC bilayers in the presence of general anesthetic halothane. Biochimica et biophysica acta. 2006 Apr; 1758(4):487-92. doi: 10.1016/j.bbamem.2006.02.033. [PMID: 16626631]
  • Saiid Bina, George Cowan, John Karaian, Sheila Muldoon, Paul Mongan, Rolf Bünger. Effects of caffeine, halothane, and 4-chloro-m-cresol on skeletal muscle lactate and pyruvate in malignant hyperthermia-susceptible and normal swine as assessed by microdialysis. Anesthesiology. 2006 Jan; 104(1):90-100. doi: 10.1097/00000542-200601000-00015. [PMID: 16394695]