beta-Elemene (BioDeep_00000000612)

 

Secondary id: BioDeep_00000171470, BioDeep_00000620042, BioDeep_00000860064, BioDeep_00001893340

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


Cyclohexane, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-, (1S-(1-alpha,2-beta,4-beta))-

化学式: C15H24 (204.18779039999998)
中文名称: (-)-β-榄香烯, β-Elemene, 左旋-β-榄香烯, β-榄香烯, 榄香烯, Beta-榄香烯
谱图信息: 最多检出来源 Homo sapiens(natural_products) 7.55%

分子结构信息

SMILES: C=CC1(C)CCC(C(=C)C)CC1C(=C)C
InChI: InChI=1S/C15H24/c1-7-15(6)9-8-13(11(2)3)10-14(15)12(4)5/h7,13-14H,1-2,4,8-10H2,3,5-6H3

描述信息

(-)-beta-elemene is the (-)-enantiomer of beta-elemene that has (1S,2S,4R)-configuration. It has a role as an antineoplastic agent.
beta-Elemene is a natural product found in Xylopia sericea, Eupatorium cannabinum, and other organisms with data available.
Beta-elemene is one of the isomers of elemene, a lipid soluble sesquiterpene and the active component isolated from the Chinese medicinal herb Rhizoma zedoariae with potential antineoplastic and chemopreventive activities. Although the exact mechanism of action through which beta-elemene exerts its effect has yet to be fully elucidated, this agent appears to induce apoptosis through different mechanisms of action and induces cell cycle arrest at different stages based on the tumor cell type involved. Beta-elemene may sensitize cancer cells to other chemotherapeutic agents.
See also: Cannabis sativa subsp. indica top (part of).
Beta-elemene, also known as B-elemen or 2,4-diisopropenyl-1-methyl-1-vinylcyclohexane, is a member of the class of compounds known as elemane sesquiterpenoids. Elemane sesquiterpenoids are sesquiterpenoids with a structure based on the elemane skeleton. Elemane is a monocyclic compound consisting of a cyclohexane ring substituted with a methyl group, an ethyl group, and two 1-methylethyl groups at the 1-, 1-, 2-, and 4-position, respectively. Beta-elemene is a fresh, herbal, and waxy tasting compound and can be found in a number of food items such as lovage, anise, spearmint, and orange mint, which makes beta-elemene a potential biomarker for the consumption of these food products. Beta-elemene can be found primarily in saliva.
beta-Elemene belongs to the class of organic compounds known as elemane sesquiterpenoids. These are sesquiterpenoids with a structure based on the elemane skeleton. Elemane is a monocyclic compound consisting of a cyclohexane ring substituted with a methyl group, an ethyl group, and two 1-methylethyl groups at the 1-, 1-, 2-, and 4-position, respectively. beta-Elemene can be found in herbs, spices, and root vegetables, which makes beta-elemene a potential biomarker for the consumption of these food products. It is a constituent of sweet flag, juniper oils, and Mentha species.
β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma aromatica with an antitumor activity. β-Elemene can induce cell apoptosis.
β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma aromatica with an antitumor activity. β-Elemene can induce cell apoptosis.

同义名列表

46 个代谢物同义名

Cyclohexane, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-, (1S-(1-alpha,2-beta,4-beta))-; Cyclohexane, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-, (1alpha,2beta,4beta)-; (1alpha,2beta,4beta)-1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane; Cyclohexane, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-, (1S,2S,4R)-; rel-(1S,2S,4R)-1-ethenyl-1-methyl-2,4-di(prop-1-en-2-yl)cyclohexane; rel-(1S,2S,4R)-1-methyl-2,4-di(prop-1-en-2-yl)-1-vinylcyclohexane; (1S,2S,4R)-1-Ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane; (1S,2S,4R)-1-ethenyl-1-methyl-2,4-bis(prop-1-en-2-yl)cyclohexane; (1S,2S,4R)-1-ethenyl-1-methyl-2,4-di(prop-1-en-2-yl)cyclohexane; Cyclohexane, 2,4-diisopropenyl-1-methyl-1-vinyl-, (1S,2S,4R)-; (1S,2S,4R)-1-methyl-2,4-di(prop-1-en-2-yl)-1-vinylcyclohexane; (1S,2S,4R)-(-)-1-methyl-1-vinyl-2,4-diisopropenylcyclohexane; (1S,2S,4R)-2,4-diisopropenyl-1-methyl-1-vinylcyclohexane; 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-cyclohexane; 2,4-Diisopropenyl-1-methyl-1-vinylcyclohexane; (-)-beta-Elemene, analytical standard; OPFTUNCRGUEPRZ-QLFBSQMISA-N; Levo-b-elemene(-)-b-Elemene; (1S,2S,4R)-beta-elemene; Beta elemene [WHO-DD]; ELEMENE, (-)-.BETA.-; ELEMENE, (-)-BETA-; (-)-.beta.-Elemene; beta-Elemene, (-)-; E- .beta.-Elemene; Levo-beta-elemene; (-)-bete-elemene; (-)-beta-Elemene; (±)-beta-Elemene; UNII-2QG8CX6LXD; Levo-β-elemene; Levo-b-elemene; .beta.-Elemene; (±)-β-Elemene; (-)-β-Elemene; (-)-b-Elemene; Beta-Elemene; CYCLOHEXANE; beta-Elemen; 2QG8CX6LXD; b-elemene; β-Elemene; Β-elemen; b-Elemen; Elemene; Cyclohexane, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-, (1R,2R,4S)-rel-



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

71 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(69)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

646 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yewen Feng, Qingwen An, Zhengqi Zhao, Mengting Wu, Chuqi Yang, WeiYu Liang, Xuefei Xu, Tao Jiang, Guangji Zhang. Beta-elemene: A phytochemical with promise as a drug candidate for tumor therapy and adjuvant tumor therapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Mar; 172(?):116266. doi: 10.1016/j.biopha.2024.116266. [PMID: 38350368]
  • Bruna de Souza Feitosa, Oberdan Oliveira Ferreira, Celeste de Jesus Pereira Franco, Himani Karakoti, Ravendra Kumar, Marcia Moraes Cascaes, Rahul D Jawarkar, Suraj N Mali, Jorddy Neves Cruz, Ilmarina Campos de Menezes, Mozaniel Santana de Oliveira, Eloisa Helena de Aguiar Andrade. Chemical Composition of Piper nigrum L. Cultivar Guajarina Essential Oils and Their Biological Activity. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29050947. [PMID: 38474459]
  • N R Kiran, Ananth Krishna Narayanan, Soumyajit Mohapatra, Priyanka Gupta, Dinesh A Nagegowda. Analysis of root volatiles and functional characterization of a root-specific germacrene A synthase in Artemisia pallens. Planta. 2024 Feb; 259(3):58. doi: 10.1007/s00425-024-04334-0. [PMID: 38308700]
  • Jixin Chen, Shuqi Chen, Huiyan Luo, Xinliang Wan, Wanyin Wu, Sumei Wang. The complementary and alternative roles of elemene injection in cancer: An umbrella review. Pharmacological research. 2023 Dec; 198(?):107007. doi: 10.1016/j.phrs.2023.107007. [PMID: 37992915]
  • Yuan Gao, Jilong Duan, Xiawen Dang, Yinghui Yuan, Yu Wang, Xingrui He, Renren Bai, Xiang-Yang Ye, Tian Xie. Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β-elemene scaffold. Journal of enzyme inhibition and medicinal chemistry. 2023 Dec; 38(1):2195991. doi: 10.1080/14756366.2023.2195991. [PMID: 37013860]
  • Kai Tan, Changhui Zhang, Zuomei He, Puhua Zeng. Construction of an anoikis-associated lncRNA-miRNA-mRNA network reveals the prognostic role of β-elemene in non-small cell lung cancer. Scientific reports. 2023 11; 13(1):20185. doi: 10.1038/s41598-023-46480-7. [PMID: 37980372]
  • Xiao-Ying Jiang, Li-Ping Shi, Jun-Long Zhu, Ren-Ren Bai, Tian Xie. Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook. Chinese journal of integrative medicine. 2023 Oct; ?(?):. doi: 10.1007/s11655-023-3714-0. [PMID: 37882911]
  • Wenjuan Li, Jie Mai, Lu Lin, Zhi-Gang Zhang, Rodrigo Ledesma-Amaro, Weiliang Dong, Xiao-Jun Ji. Combination of microbial and chemical synthesis for the sustainable production of β-elemene, a promising plant-extracted anticancer compound. Biotechnology and bioengineering. 2023 Sep; ?(?):. doi: 10.1002/bit.28544. [PMID: 37661795]
  • Ting Zhang, Tianhua Zhang, Chuanzhou Gao, Sajid Jalal, Ruqiang Yuan, Hongming Teng, Cong Li, Lin Huang. Antitumor Effects of β-Elemene Through Inducing Autophagy-Mediated Apoptosis in Ewing Sarcoma Family Tumor Cells. DNA and cell biology. 2023 Aug; ?(?):. doi: 10.1089/dna.2023.0084. [PMID: 37610845]
  • Huan Tian, Feng Zhao, Qing-Rui Qi, Bao-Sen Yue, Bing-Tao Zhai. Targeted drug delivery systems for elemene in cancer therapy: The story thus far. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 166(?):115331. doi: 10.1016/j.biopha.2023.115331. [PMID: 37598477]
  • Ty Viet Pham, Nguyen Xuan Ha, Nguyen Dinh Luyen, Thao Hoang Xuan, Thang Le Quoc, Nguyen Huy Hung, Ninh The Son. Chemical Composition, Mosquito Larvicidal and Antimicrobial Activities, and Molecular Docking Study of Essential Oils of Cinnamomum melastomaceum , Neolitsea buisanensis  and Uvaria microcarpa from Vietnam. Chemistry & biodiversity. 2023 Aug; ?(?):e202300652. doi: 10.1002/cbdv.202300652. [PMID: 37531297]
  • Wei Chen, Yongjiang Li, Chuang Liu, Yong Kang, Duotian Qin, Shuying Chen, Jun Zhou, Hai-Jun Liu, Bijan Emiliano Ferdows, Dylan Neal Patel, Xiangang Huang, Seyoung Koo, Na Kong, Xiaoyuan Ji, Yihai Cao, Wei Tao, Tian Xie. In situ Engineering of Tumor-Associated Macrophages via a Nanodrug-Delivering-Drug (β-Elemene@Stanene) Strategy for Enhanced Cancer Chemo-Immunotherapy. Angewandte Chemie (International ed. in English). 2023 Jun; ?(?):e202308413. doi: 10.1002/anie.202308413. [PMID: 37380606]
  • Tuan Quoc Doan, Dien Dinh, Thang Nam Tran, Phu Quynh Dinh Nguyen, Chau Bao Hoai Nguyen, Nhan Trong Le, Hung Quoc Vo, Duc Viet Ho, Anh Le Tuan, Hoai Thi Nguyen, Isiaka A Ogunwande. Chemical composition and acetylcholinesterase inhibitory activity of essential oil from the leaves of Mitrephora poilanei Weeras. & R.M.K. Saunders. Natural product research. 2023 Jun; ?(?):1-5. doi: 10.1080/14786419.2023.2227989. [PMID: 37357615]
  • Diep Trinh Thi, Dung Luong Van, Trung Phung Van, Hoai Nguyen Thi, Thao Do Thi, Uyen Nguyen Thi To, Linh Tran Thi Hoai, Khai Dang Vinh, Thanh Truc Huynh, Tran Le Thi Thanh. Chemical composition, anti-inflammatory and cytotoxic activity of essential oils from two Luvunga species (L. scandens and L. hongiaoensis) from Vietnam. Natural product research. 2023 Jun; ?(?):1-10. doi: 10.1080/14786419.2023.2225125. [PMID: 37337451]
  • Eric Fordjour, Chun-Li Liu, Yunpeng Hao, Isaac Sackey, Yankun Yang, Xiuxia Liu, Ye Li, Tianwei Tan, Zhonghu Bai. Engineering Escherichia coli BL21 (DE3) for high-yield production of germacrene A, a precursor of β-elemene via combinatorial metabolic engineering strategies. Biotechnology and bioengineering. 2023 Jun; ?(?):. doi: 10.1002/bit.28467. [PMID: 37309999]
  • Gao-Qian Song, Pu Wu, Xue-Man Dong, Long-Hui Cheng, Hua-Qiu Lu, Yuan-Yuan Lin, Wei-Yang Tang, Tian Xie, Jian-Liang Zhou. Elemene induces cell apoptosis via inhibiting glutathione synthesis in lung adenocarcinoma. Journal of ethnopharmacology. 2023 Mar; 311(?):116409. doi: 10.1016/j.jep.2023.116409. [PMID: 37003401]
  • Ebru Yüce Babacan, Azize Demirpolat, Uğur Çakılcıoğlu, Eyüp Bagcı. Yield and Composition of the Essential Oil of the Opopanax Genus in Turkey. Molecules (Basel, Switzerland). 2023 Mar; 28(7):. doi: 10.3390/molecules28073055. [PMID: 37049817]
  • Yufei Liang, Shengmian Li. β-elemene suppresses Migration of Esophageal Squamous Cell Carcinoma by Modulating Expression of MMP9 through the PI3K/Akt/NF-κB Pathway. Combinatorial chemistry & high throughput screening. 2023 Mar; ?(?):. doi: 10.2174/1386207326666230303120514. [PMID: 36872359]
  • Min Ye, Jiaoqi Gao, Yongjin J Zhou. Global metabolic rewiring of the nonconventional yeast Ogataea polymorpha for biosynthesis of the sesquiterpenoid β-elemene. Metabolic engineering. 2023 03; 76(?):225-231. doi: 10.1016/j.ymben.2023.02.008. [PMID: 36828231]
  • Shurong Hou, Zhenzhen Li, Xiaoling Chen, Wenxin Wang, Ting Duan, Louis Scampavia, Yaxia Yuan, Timothy P Spicer, Xiabin Chen, Tian Xie. Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism. Signal transduction and targeted therapy. 2023 02; 8(1):87. doi: 10.1038/s41392-023-01373-z. [PMID: 36849489]
  • Jamile Silva da Costa, Jofre Jacob da Silva Freitas, William N Setzer, Joyce Kelly R da Silva, José Guilherme S Maia, Pablo Luis B Figueiredo. Variability in the Chemical Composition of Myrcia sylvatica (G. Mey) DC. Essential Oils Growing in the Brazilian Amazon. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248975. [PMID: 36558108]
  • Heng Deng, Guo Chen, Jun Zhang. β-elemene regulates epithelial-mesenchymal transformation and inhibits invasion and metastasis of colorectal cancer cells. Journal of complementary & integrative medicine. 2022 Dec; ?(?):. doi: 10.1515/jcim-2022-0295. [PMID: 36480470]
  • Yuan Gao, Nian-Dong Mao, Hao Che, Li Xu, Renren Bai, Li-Wei Wang, Xiang-Yang Ye, Tian Xie. Novel hydroxyl carboximates derived from β-elemene: design, synthesis and anti-tumour activities evaluation. Journal of enzyme inhibition and medicinal chemistry. 2022 Dec; 37(1):2403-2416. doi: 10.1080/14756366.2022.2117314. [PMID: 36065895]
  • Renren Bai, Junlong Zhu, Ziqiang Bai, Qing Mao, Yingqian Zhang, Zi Hui, Xinyu Luo, Xiang-Yang Ye, Tian Xie. Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma. Journal of enzyme inhibition and medicinal chemistry. 2022 Dec; 37(1):379-385. doi: 10.1080/14756366.2021.2016734. [PMID: 35012394]
  • Meijie Li, Qifeng Wen, Shuzhe Lv, Rumeng Yang, Tao Cheng, Zhaobao Wang, Jianming Yang. Co-biosynthesis of germacrene A, a precursor of β-elemene, and lycopene in engineered Escherichia coli. Applied microbiology and biotechnology. 2022 Dec; 106(24):8053-8066. doi: 10.1007/s00253-022-12257-7. [PMID: 36374331]
  • Xiang Qi, Songwei Jiang, Zi Hui, Yuan Gao, Yang Ye, Frédéric Lirussi, Carmen Garrido, Li Xu, Xingrui He, Renren Bai, Xiang-Yang Ye, Tian Xie. Design, synthesis and antitumor efficacy evaluation of a series of novel β-elemene-based macrocycles. Bioorganic & medicinal chemistry. 2022 11; 74(?):117049. doi: 10.1016/j.bmc.2022.117049. [PMID: 36240626]
  • Qin Guo, Yujia Li, Yuan Chen, Jin Ji, Shizhong Zheng, Xuefen Xu, Biyun Zhang, Jianzhou Ye. β-Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts. IUBMB life. 2022 06; 74(6):508-518. doi: 10.1002/iub.2614. [PMID: 35294085]
  • Yingyu Zhou, Tomohiro Takano, Xuyang Li, Yimei Wang, Rong Wang, Zhangliang Zhu, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura. β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway. Communications biology. 2022 05; 5(1):519. doi: 10.1038/s42003-022-03369-x. [PMID: 35641589]
  • Wenjuan Sun, Dong Hyun Kim, Chang Hyun Byon, Hoon In Choi, Jung Sun Park, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim. β-Elemene Attenuates Renal Fibrosis in the Unilateral Ureteral Obstruction Model by Inhibition of STAT3 and Smad3 Signaling via Suppressing MyD88 Expression. International journal of molecular sciences. 2022 May; 23(10):. doi: 10.3390/ijms23105553. [PMID: 35628363]
  • Li-Tian Ma, Yang Bai, Peng Cao, Kai-Xi Ren, Jing Chen, Ting Zhang, Bo-Yuan Fan, Yu Qiao, Hong-Yu Yan, Jing-Jie Wang, Yun-Qing Li, Jin Zheng. The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation. Molecular pain. 2022 04; 18(?):17448069221121562. doi: 10.1177/17448069221121562. [PMID: 35976914]
  • JingJing Wu, XiaoJuan Tang, Yao Shi, ChangJu Ma, Hongyu Zhang, Junhong Zhang, Yue Lu, Jianan Wei, Li Li, Ling Han. Crosstalk of LncRNA HOTAIR and SP1-mediated repression of PDK1 contributes to β-Elemene-inhibited proliferation of hepatocellular carcinoma cells. Journal of ethnopharmacology. 2022 Jan; 283(?):114456. doi: 10.1016/j.jep.2021.114456. [PMID: 34333105]
  • Cuiwei Zhang, Shuiqin Li, Ziyi Zhao. β-Elemene Promotes Apoptosis Induced by Hyperthermia via Inhibiting HSP70. Disease markers. 2022; 2022(?):7313026. doi: 10.1155/2022/7313026. [PMID: 35903296]
  • Li-Tian Ma, Yang Bai, Jie Li, Yu Qiao, Yang Liu, Jin Zheng. Elemene Emulsion Injection Administration Reduces Neuropathic Pain by Inhibiting Astrocytic NDRG2 Expression within Spinal Dorsal Horn. Chinese journal of integrative medicine. 2021 Dec; 27(12):912-918. doi: 10.1007/s11655-021-3438-3. [PMID: 33420586]
  • Márcia Moraes Cascaes, Odirleny Dos Santos Carneiro, Lidiane Diniz do Nascimento, Ângelo Antônio Barbosa de Moraes, Mozaniel Santana de Oliveira, Jorddy Neves Cruz, Giselle Maria Skelding Pinheiro Guilhon, Eloisa Helena de Aguiar Andrade. Essential Oils from Annonaceae Species from Brazil: A Systematic Review of Their Phytochemistry, and Biological Activities. International journal of molecular sciences. 2021 Nov; 22(22):. doi: 10.3390/ijms222212140. [PMID: 34830022]
  • Mingyan Shao, Mingmin Wang, Lin Ma, Qian Wang, Pengrong Gao, Xue Tian, Changxiang Li, Linghui Lu, Chun Li, Wei Wang, Yong Wang. β-elemene blocks lipid-induced inflammatory pathways via PPARβ activation in heart failure. European journal of pharmacology. 2021 Nov; 910(?):174450. doi: 10.1016/j.ejphar.2021.174450. [PMID: 34454927]
  • Tianming Zhao, Chao Ma, Guofei Zhu. Chemical Composition and Biological Activities of Essential Oils from the Leaves, Stems, and Roots of Kadsura coccinea. Molecules (Basel, Switzerland). 2021 Oct; 26(20):. doi: 10.3390/molecules26206259. [PMID: 34684838]
  • Jie Li, Huamin Zeng, Yu You, Rongrong Wang, Tiantian Tan, Weiming Wang, Liyan Yin, Zhaowu Zeng, Yiying Zeng, Tian Xie. Active targeting of orthotopic glioma using biomimetic liposomes co-loaded elemene and cabazitaxel modified by transferritin. Journal of nanobiotechnology. 2021 Sep; 19(1):289. doi: 10.1186/s12951-021-01048-3. [PMID: 34565383]
  • Tiantian Tan, Jie Li, Ruhua Luo, Rongrong Wang, Liyan Yin, Mengmeng Liu, Yiying Zeng, Zhaowu Zeng, Tian Xie. Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review. Molecules (Basel, Switzerland). 2021 Sep; 26(19):. doi: 10.3390/molecules26195792. [PMID: 34641334]
  • Chuang Liu, Shan Sun, Qiang Feng, Gongwei Wu, Yiting Wu, Na Kong, Zhangsen Yu, Junlie Yao, Xingcai Zhang, Wei Chen, Zhongmin Tang, Yufen Xiao, Xiangang Huang, Aman Lv, Chenyang Yao, Haibo Cheng, Aiguo Wu, Tian Xie, Wei Tao. Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ß-Elemene for Cancer Therapy. Advanced materials (Deerfield Beach, Fla.). 2021 Sep; 33(37):e2102054. doi: 10.1002/adma.202102054. [PMID: 34309925]
  • Kadis Mujiono, Tilisa Tohi, Islam S Sobhy, Yuko Hojo, Tomonori Shinya, Ivan Galis. Herbivore-induced and constitutive volatiles are controlled by different oxylipin-dependent mechanisms in rice. Plant, cell & environment. 2021 08; 44(8):2687-2699. doi: 10.1111/pce.14126. [PMID: 34114241]
  • Elisa Ovidi, Stefania Garzoli, Valentina Laghezza Masci, Giovanni Turchetti, Antonio Tiezzi. GC-MS investigation and antiproliferative activities of extracts from male and female flowers of Schinus molle L. Natural product research. 2021 Jun; 35(11):1923-1927. doi: 10.1080/14786419.2019.1644628. [PMID: 31328565]
  • Pu Wu, Xue-Man Dong, Gao-Qian Song, Meng-Meng Wei, Can Fang, Fu-Bo Zheng, Yue-Ji Zhao, Hua-Qiu Lu, Long-Hui Cheng, Jian-Liang Zhou, Tian Xie. Bioactivity-guided discovery of quality control markers in rhizomes of Curcuma wenyujin based on spectrum-effect relationship against human lung cancer cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jun; 86(?):153559. doi: 10.1016/j.phymed.2021.153559. [PMID: 33857848]
  • Mariana Gomes Vidal Sampaio, Cícero Ramon Bezerra Dos Santos, Lilian Cortez Sombra Vandesmet, Bruno Souza Dos Santos, Izabelly Bianca Da Silva Santos, Maria Tereza Dos Santos Correia, Arthur Lima de Berrêdo Martins, Luis Claudio Nascimento da Silva, Irwin Rose De Alencar Menezes, Maria Celeste Veja Gomez, Márcia Vanusa Da Silva. Chemical composition, antioxidant and antiprotozoal activity of Eugenia gracillima Kiaersk. leaves essential oil. Natural product research. 2021 Jun; 35(11):1914-1918. doi: 10.1080/14786419.2019.1644506. [PMID: 31328548]
  • Celeste de Jesus Pereira Franco, Oberdan Oliveira Ferreira, Ângelo Antônio Barbosa de Moraes, Everton Luiz Pompeu Varela, Lidiane Diniz do Nascimento, Sandro Percário, Mozaniel Santana de Oliveira, Eloisa Helena de Aguiar Andrade. Chemical Composition and Antioxidant Activity of Essential Oils from Eugenia patrisii Vahl, E. punicifolia (Kunth) DC., and Myrcia tomentosa (Aubl.) DC., Leaf of Family Myrtaceae. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113292. [PMID: 34072598]
  • Juan I Burneo, Ángel Benítez, James Calva, Pablo Velastegui, Vladimir Morocho. Soil and Leaf Nutrients Drivers on the Chemical Composition of the Essential Oil of Siparuna muricata (Ruiz & Pav.) A. DC. from Ecuador. Molecules (Basel, Switzerland). 2021 May; 26(10):. doi: 10.3390/molecules26102949. [PMID: 34063513]
  • Ziqiang Bai, Chuansheng Yao, Junlong Zhu, Yuanyuan Xie, Xiang-Yang Ye, Renren Bai, Tian Xie. Anti-Tumor Drug Discovery Based on Natural Product β-Elemene: Anti-Tumor Mechanisms and Structural Modification. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061499. [PMID: 33801899]
  • Bruna R de Lima, Felipe M A da Silva, Elzalina R Soares, Richardson A de Almeida, Jessica B Maciel, Carromberth C Fernandes, André C de Oliveira, Wanderli P Tadei, Hector H F Koolen, Afonso D L de Souza, Maria L B Pinheiro. Chemical composition and larvicidal activity of the essential oil from the leaves of Onychopetalum periquino (Rusby) D.M. Johnson & N.A. Murray. Natural product research. 2021 Mar; 35(6):1038-1041. doi: 10.1080/14786419.2019.1613989. [PMID: 31135221]
  • Luccas M Barata, Eloísa H Andrade, Alessandra R Ramos, Oriel F de Lemos, William N Setzer, Kendall G Byler, José Guilherme S Maia, Joyce Kelly R da Silva. Secondary Metabolic Profile as a Tool for Distinction and Characterization of Cultivars of Black Pepper (Piper nigrum L.) Cultivated in Pará State, Brazil. International journal of molecular sciences. 2021 Jan; 22(2):. doi: 10.3390/ijms22020890. [PMID: 33477389]
  • Shuiping Liu, Qiujie Li, Guohua Li, Qin Zhang, Lvjia Zhuo, Xuemeng Han, Mingming Zhang, Xiaying Chen, Ting Pan, Lili Yan, Ting Jin, Jianjun Wang, Qun Lv, Xinbing Sui, Tian Xie. The mechanism of m6A methyltransferase METTL3-mediated autophagy in reversing gefitinib resistance in NSCLC cells by β-elemene. Cell death & disease. 2020 11; 11(11):969. doi: 10.1038/s41419-020-03148-8. [PMID: 33177491]
  • Xing Hu, Liang Wang, Lili Zhang, Tao Zhang. β-Elemene inhibits 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced skin tumorigenesis through suppression of NF-κB-associated signaling events in the mouse skin model. Journal of biochemical and molecular toxicology. 2020 Oct; 34(10):e22550. doi: 10.1002/jbt.22550. [PMID: 32662567]
  • Bingtao Zhai, Peng Chen, Wengang Wang, Shuiping Liu, Jiao Feng, Ting Duan, Yu Xiang, Ruonan Zhang, Mingming Zhang, Xuemeng Han, Xiaying Chen, Qiujie Li, Guohua Li, Ying Liu, Xingxing Huang, Wenzheng Zhang, Ting Pan, Lili Yan, Ting Jin, Tian Xie, Xinbing Sui. An ATF24 peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment. Cancer biology & medicine. 2020 08; 17(3):676-692. doi: 10.20892/j.issn.2095-3941.2020.0454. [PMID: 32944399]
  • Myriam Lamine, Mahmoud Gargouri, Ahmed Mliki. Identification of the NaCl-responsive metabolites in Citrus roots: A lipidomic and volatomic signature. Plant signaling & behavior. 2020 08; 15(8):1777376. doi: 10.1080/15592324.2020.1777376. [PMID: 32508206]
  • Lin Li, Dongkai Zhao, Guangyu Cheng, Qingjie Li, Yunjie Chu, Hongbo Chu, Yunlu Ding, Chikun Li. β-elemene suppresses Warburg effect in NCI-H1650 non-small-cell lung cancer cells by regulating the miR-301a-3p/AMPKα axis. Bioscience reports. 2020 06; 40(6):. doi: 10.1042/bsr20194389. [PMID: 32463461]
  • Chengcheng Ling, Lujie Zheng, Xiaorui Yu, Huanhuan Wang, Chengxiang Wang, Haiyan Wu, Jie Zhang, Ping Yao, Yuling Tai, Yi Yuan. Cloning and functional analysis of three aphid alarm pheromone genes from German chamomile (Matricaria chamomilla L.). Plant science : an international journal of experimental plant biology. 2020 May; 294(?):110463. doi: 10.1016/j.plantsci.2020.110463. [PMID: 32234219]
  • Bagora Bayala, Ahmed Y Coulibaly, Florencia W Djigma, Bolni Marius Nagalo, Silvère Baron, Gilles Figueredo, Jean-Marc A Lobaccaro, Jacques Simpore. Chemical composition, antioxidant, anti-inflammatory and antiproliferative activities of the essential oil of Cymbopogon nardus, a plant used in traditional medicine. Biomolecular concepts. 2020 Apr; 11(1):86-96. doi: 10.1515/bmc-2020-0007. [PMID: 32304294]
  • Mingming Deng, Bofang Liu, Huicong Song, Ruoxi Yu, Dan Zou, Yang Chen, Yanju Ma, Fei Lv, Ling Xu, Zhe Zhang, Qingjie Lv, Xianghong Yang, Xiaofang Che, Xiujuan Qu, Yunpeng Liu, Ye Zhang, Xuejun Hu. β-Elemene inhibits the metastasis of multidrug-resistant gastric cancer cells through miR-1323/Cbl-b/EGFR pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Apr; 69(?):153184. doi: 10.1016/j.phymed.2020.153184. [PMID: 32199253]
  • Xin-Bing Sui, Tian Xie. Combination of Chinese and Western Medicine to Prevent and Reverse Resistance of Cancer Cells to Anticancer Drugs. Chinese journal of integrative medicine. 2020 Apr; 26(4):251-255. doi: 10.1007/s11655-019-3180-x. [PMID: 31705451]
  • Elaine C D Gonçalves, Gabriela M Baldasso, Maíra A Bicca, Rodrigo S Paes, Raffaele Capasso, Rafael C Dutra. Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant. Molecules (Basel, Switzerland). 2020 Mar; 25(7):. doi: 10.3390/molecules25071567. [PMID: 32235333]
  • Ying Liu, Liuxi Chen, Ruonan Zhang, Bi Chen, Yu Xiang, Mingming Zhang, Xingxing Huang, Wenzheng Zhang, Xiaying Chen, Ting Pan, Lili Yan, Ting Jin, Shuiping Liu, Jiao Feng, Ting Duan, Tian Xie, Shuang Lin, Xinbing Sui. Efficacy and safety of elemene combined with chemotherapy in advanced gastric cancer: A Meta-analysis. Medicine. 2020 Mar; 99(11):e19481. doi: 10.1097/md.0000000000019481. [PMID: 32176081]
  • Bingtao Zhai, Qibiao Wu, Wengang Wang, Mingming Zhang, Xuemeng Han, Qiujie Li, Peng Chen, Xiaying Chen, Xingxing Huang, Guohua Li, Qin Zhang, Ruonan Zhang, Yu Xiang, Shuiping Liu, Ting Duan, Jianshu Lou, Tian Xie, Xinbing Sui. Preparation, characterization, pharmacokinetics and anticancer effects of PEGylated β-elemene liposomes. Cancer biology & medicine. 2020 02; 17(1):60-75. doi: 10.20892/j.issn.2095-3941.2019.0156. [PMID: 32296587]
  • Hongxuan Tong, Yihua Liu, Lijie Jiang, Jingshang Wang. Multi-Targeting by β-Elemene and Its Anticancer Properties: A Good Choice for Oncotherapy and Radiochemotherapy Sensitization. Nutrition and cancer. 2020; 72(4):554-567. doi: 10.1080/01635581.2019.1648694. [PMID: 31387393]
  • Yuan-Hui Wang, Ya-Ru Zhang. Variations in compositions and antioxidant activities of essential oils from leaves of Luodian Blumea balsamifera from different harvest times in China. PloS one. 2020; 15(6):e0234661. doi: 10.1371/journal.pone.0234661. [PMID: 32544201]
  • Qiang Xie, Fengzhou Li, Lei Fang, Wenzhi Liu, Chundong Gu. The Antitumor Efficacy of β-Elemene by Changing Tumor Inflammatory Environment and Tumor Microenvironment. BioMed research international. 2020; 2020(?):6892961. doi: 10.1155/2020/6892961. [PMID: 32149121]
  • Peng Chen, Xuejie Li, Ruonan Zhang, Shuiping Liu, Yu Xiang, Mingming Zhang, Xiaying Chen, Ting Pan, Lili Yan, Jiao Feng, Ting Duan, Da Wang, Bi Chen, Ting Jin, Wengang Wang, Liuxi Chen, Xingxing Huang, Wenzheng Zhang, Yitian Sun, Guohua Li, Lingpan Kong, Xiaohui Chen, Yongqiang Li, Zuyi Yang, Qin Zhang, Lvjia Zhuo, Xinbing Sui, Tian Xie. Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation. Theranostics. 2020; 10(11):5107-5119. doi: 10.7150/thno.44705. [PMID: 32308771]
  • Haipeng Zhang, Huan Wen, Jiajing Chen, Zhaoxin Peng, Meiyan Shi, Mengjun Chen, Ziyu Yuan, Yuan Liu, Hongyan Zhang, Juan Xu. Volatile Compounds in Fruit Peels as Novel Biomarkers for the Identification of Four Citrus Species. Molecules (Basel, Switzerland). 2019 Dec; 24(24):. doi: 10.3390/molecules24244550. [PMID: 31842378]
  • Lvkeng Luo, Shuling Wu, Xiaoxiao Zhu, Weiwei Su. The profiling and identification of the absorbed constituents and metabolites of Naoshuantong capsule in mice biofluids and brain by ultra- fast liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Oct; 1129(?):121791. doi: 10.1016/j.jchromb.2019.121791. [PMID: 31610480]
  • Yanhong Pan, Wei Wang, Shuai Huang, Wenting Ni, Zhonghong Wei, Yuzhu Cao, Suyun Yu, Qi Jia, Yuanyuan Wu, Chuan Chai, Qian Zheng, Lei Zhang, Aiyun Wang, Zhiguang Sun, Shile Huang, Shijun Wang, Wenxing Chen, Yin Lu. Beta-elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation. Journal of cellular and molecular medicine. 2019 10; 23(10):6846-6858. doi: 10.1111/jcmm.14568. [PMID: 31343107]
  • Mingming Deng, Ye Zhang, Bofang Liu, Yang Chen, Huicong Song, Ruoxi Yu, Xiaofang Che, Xiujuan Qu, Yunpeng Liu, Xuejun Hu, Xiuying Xu. β-Elemene inhibits peritoneal metastasis of gastric cancer cells by modulating FAK/Claudin-1 signaling. Phytotherapy research : PTR. 2019 Sep; 33(9):2448-2456. doi: 10.1002/ptr.6436. [PMID: 31342604]
  • Bi Wang, Fei Liu, Qi Li, Shu Xu, Xingzeng Zhao, Peilin Xue, Xu Feng. Antifungal activity of zedoary turmeric oil against Phytophthora capsici through damaging cell membrane. Pesticide biochemistry and physiology. 2019 Sep; 159(?):59-67. doi: 10.1016/j.pestbp.2019.05.014. [PMID: 31400785]
  • Xuewei Wang, Zhengtang Liu, Xinbing Sui, Qibiao Wu, Jue Wang, Cong Xu. Elemene injection as adjunctive treatment to platinum-based chemotherapy in patients with stage III/IV non-small cell lung cancer: A meta-analysis following the PRISMA guidelines. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Jun; 59(?):152787. doi: 10.1016/j.phymed.2018.12.010. [PMID: 31005810]
  • Bingtao Zhai, Nana Zhang, Xuemeng Han, Qiujie Li, Mingming Zhang, Xiaying Chen, Guohua Li, Ruonan Zhang, Peng Chen, Wengang Wang, Chenxi Li, Yu Xiang, Shuiping Liu, Ting Duan, Jianshu Lou, Tian Xie, Xinbing Sui. Molecular targets of β-elemene, a herbal extract used in traditional Chinese medicine, and its potential role in cancer therapy: A review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jun; 114(?):108812. doi: 10.1016/j.biopha.2019.108812. [PMID: 30965237]
  • Qian Zhang, Xin Tian, Xiufeng Cao. Transferrin-functionalised microemulsion co-delivery of β-elemene and celastrol for enhanced anti-lung cancer treatment and reduced systemic toxicity. Drug delivery and translational research. 2019 06; 9(3):667-678. doi: 10.1007/s13346-019-00623-4. [PMID: 30798476]
  • Bastien Durenne, Alodie Blondel, Philippe Druart, Marie-Laure Fauconnier. Epoxiconazole exposure affects terpenoid profiles of oilseed rape plantlets based on a targeted metabolomic approach. Environmental science and pollution research international. 2019 Jun; 26(17):17362-17372. doi: 10.1007/s11356-019-05110-4. [PMID: 31012076]
  • Abdelsamed I Elshamy, Ahmed M Abd-ElGawad, Abd El-Nasser G El Gendy, Abdulaziz M Assaeed. Chemical Characterization of Euphorbia heterophylla L. Essential Oils and Their Antioxidant Activity and Allelopathic Potential on Cenchrus echinatus L. Chemistry & biodiversity. 2019 May; 16(5):e1900051. doi: 10.1002/cbdv.201900051. [PMID: 30875445]
  • Yi-Ying Zeng, Yi-Jun Zeng, Na-Na Zhang, Chen-Xi Li, Tian Xie, Zhao-Wu Zeng. The Preparation, Determination of a Flexible Complex Liposome Co-Loaded with Cabazitaxel and β-Elemene, and Animal Pharmacodynamics on Paclitaxel-Resistant Lung Adenocarcinoma. Molecules (Basel, Switzerland). 2019 Apr; 24(9):. doi: 10.3390/molecules24091697. [PMID: 31052317]
  • Yixuan Huang, Changsong Xue, Wenbing He, Xingchen Zhao. Inhibition effect of Zedoary turmeric oil on Listeria monocytogenes and Staphylococcus aureus growth and exotoxin proteins production. Journal of medical microbiology. 2019 Apr; 68(4):657-666. doi: 10.1099/jmm.0.000949. [PMID: 30882292]
  • Elwira Sieniawska, Piotr Michel, Tomasz Mroczek, Sebastian Granica, Krystyna Skalicka-Woźniak. Nigella damascena L. essential oil and its main constituents, damascenine and β-elemene modulate inflammatory response of human neutrophils ex vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Mar; 125(?):161-169. doi: 10.1016/j.fct.2018.12.057. [PMID: 30610933]
  • Paula Araújo Monteiro, Ícaro Augusto Maccari Zelioli, Ilza Maria de Oliveira Sousa, Ana Lúcia Tasca Gois Ruiz, Débora Barbosa Vendramini-Costa, Mary Ann Foglio, João Ernesto de Carvalho. Chemical composition and antiproliferative activity of Croton campestris A.St.-Hil. essential oil. Natural product research. 2019 Feb; 33(4):580-583. doi: 10.1080/14786419.2017.1399377. [PMID: 29117729]
  • Akhila Nair, Augustine Amalraj, Joby Jacob, Ajaikumar B Kunnumakkara, Sreeraj Gopi. Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations. Biomolecules. 2019 01; 9(1):. doi: 10.3390/biom9010013. [PMID: 30609771]
  • Chengsong Cao, Qun Wang, Yong Liu. Lung cancer combination therapy: doxorubicin and β-elemene co-loaded, pH-sensitive nanostructured lipid carriers. Drug design, development and therapy. 2019; 13(?):1087-1098. doi: 10.2147/dddt.s198003. [PMID: 31118562]
  • Ana E T Alcoba, Daiana C de Melo, Priscila M de Andrade, Herbert J Dias, Mariana C Pagotti, Lizandra G Magalhães, Walnir G F Júnior, Antônio E M Crotti, Mayker L D Miranda. Chemical composition and in vitro antileishmanial and cytotoxic activities of the essential oils of Ocotea dispersa (Nees) Mez and Ocotea odorifera (Vell) Rohwer (Lauraceae). Natural product research. 2018 Dec; 32(23):2865-2868. doi: 10.1080/14786419.2017.1385007. [PMID: 29022353]
  • Fang Zheng, Qing Tang, Xiao-Hua Zheng, JingJing Wu, HaiDing Huang, Haibo Zhang, Swei Sunny Hann. Inactivation of Stat3 and crosstalk of miRNA155-5p and FOXO3a contribute to the induction of IGFBP1 expression by beta-elemene in human lung cancer. Experimental & molecular medicine. 2018 09; 50(9):1-14. doi: 10.1038/s12276-018-0146-6. [PMID: 30209296]
  • Ling Xu, Tianshu Guo, Xiujuan Qu, Xuejun Hu, Ye Zhang, Xiaofang Che, Huicong Song, Jing Gong, Rui Ma, Ce Li, Yibo Fan, Yanju Ma, Kezuo Hou, Peihong Wu, Hang Dong, Yunpeng Liu. β-elemene increases the sensitivity of gastric cancer cells to TRAIL by promoting the formation of DISC in lipid rafts. Cell biology international. 2018 Sep; 42(10):1377-1385. doi: 10.1002/cbin.11023. [PMID: 29957841]
  • Shi Liping, Chen Tingting, Yuan Zheng, Xie Tian, Cheng Haibo. Apoptosis and antitumor effects between β-elemene and astragaloside and drug mechanism analysis. Pakistan journal of pharmaceutical sciences. 2018 Sep; 31(5(Special)):2271-2276. doi: . [PMID: 30463823]
  • Zongbing Guo, Zhenzhen Liu, Haifeng Yue, Jingyuan Wang. Beta-elemene increases chemosensitivity to 5-fluorouracil through down-regulating microRNA-191 expression in colorectal carcinoma cells. Journal of cellular biochemistry. 2018 08; 119(8):7032-7039. doi: 10.1002/jcb.26914. [PMID: 29737579]
  • Ju-Qin Cao, Shan-Shan Guo, Yang Wang, Xue Pang, Zhu-Feng Geng, Shu-Shan Du. Contact Toxicity and Repellency of the Essential Oils of Evodia lenticellata Huang and Evodia rutaecarpa (Juss.) Benth. Leaves against Three Stored Product Insects. Journal of oleo science. 2018 Aug; 67(8):1027-1034. doi: 10.5650/jos.ess17251. [PMID: 30012895]
  • Jingyu Wang, Heyangzi Li, Ying Yao, Yucheng Ren, Jiangtao Lin, Jue Hu, Mingzhi Zheng, Xinghui Song, Tengfei Zhao, Ying-Ying Chen, Yueliang Shen, Yong-Jian Zhu, Lin-Lin Wang. β-Elemene Enhances GAP-43 Expression and Neurite Outgrowth by Inhibiting RhoA Kinase Activation in Rats with Spinal Cord Injury. Neuroscience. 2018 07; 383(?):12-21. doi: 10.1016/j.neuroscience.2018.04.045. [PMID: 29751054]
  • Stefania Garzoli, Mijat Božović, Anna Baldisserotto, Elisa Andreotti, Federico Pepi, Vanja Tadić, Stefano Manfredini, Rino Ragno. Sideritis romana L. subsp. purpurea (Tal. ex Benth.) Heywood, a new chemotype from Montenegro. Natural product research. 2018 May; 32(9):1056-1061. doi: 10.1080/14786419.2017.1378212. [PMID: 28927300]
  • Cheng Xue, Ling-Ling Hong, Jun-Sheng Lin, Xiang-Yang Yao, Ding-Hui Wu, Xiao-Ping Lin, Jia-Min Zhang, Xiao-Bin Zhang, Yi-Ming Zeng. β-Elemene inhibits the proliferation of primary human airway granulation fibroblasts by down-regulating canonical Wnt/β-catenin pathway. Bioscience reports. 2018 04; 38(2):. doi: 10.1042/bsr20171386. [PMID: 29358311]
  • Marimuthu Govindarajan, Mohan Rajeswary, Sengamalai Senthilmurugan, Periasamy Vijayan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Giovanni Benelli. Curzerene, trans-β-elemenone, and γ-elemene as effective larvicides against Anopheles subpictus, Aedes albopictus, and Culex tritaeniorhynchus: toxicity on non-target aquatic predators. Environmental science and pollution research international. 2018 Apr; 25(11):10272-10282. doi: 10.1007/s11356-017-8822-y. [PMID: 28353108]
  • Lufang Wang, Yanyan Zhao, Qiong Wu, Yifu Guan, Xin Wu. Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells. Molecular medicine reports. 2018 03; 17(3):4299-4306. doi: 10.3892/mmr.2018.8455. [PMID: 29363722]
  • Rafal Sawicki, Elwira Sieniawska, Marta Swatko-Ossor, Joanna Golus, Grazyna Ginalska. The frequently occurring components of essential oils beta elemene and R-limonene alter expression of dprE1 and clgR genes of Mycobacterium tuberculosis H37Ra. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Feb; 112(?):145-149. doi: 10.1016/j.fct.2017.12.052. [PMID: 29288759]
  • Elwira Sieniawska, Rafal Sawicki, Joanna Golus, Marta Swatko-Ossor, Grazyna Ginalska, Krystyna Skalicka-Wozniak. Nigella damascena L. Essential Oil-A Valuable Source of β-Elemene for Antimicrobial Testing. Molecules (Basel, Switzerland). 2018 01; 23(2):. doi: 10.3390/molecules23020256. [PMID: 29382097]
  • Yangyi Fang, Yanhua Kang, Han Zou, Xiaxuan Cheng, Tian Xie, Liyun Shi, Hang Zhang. β-elemene attenuates macrophage activation and proinflammatory factor production via crosstalk with Wnt/β-catenin signaling pathway. Fitoterapia. 2018 Jan; 124(?):92-102. doi: 10.1016/j.fitote.2017.10.015. [PMID: 29066299]
  • Lixiang Ding, Genai Zhang, Yu Hou, Jiao Chen, Yukun Yin. Elemene inhibits osteosarcoma growth by suppressing the renin‑angiotensin system signaling pathway. Molecular medicine reports. 2018 Jan; 17(1):1022-1030. doi: 10.3892/mmr.2017.7965. [PMID: 29115494]
  • Wen Chen, Shi-Qi Weng, Meng-Ge Lv, Wen-Qiong Chen, Zhuo-Fei Bi, Hou-Yang Chen, Tao Luo, Hai Hu, Wen-Bo Liao. β-Elemene Inhibits Human Sperm Function by Affecting Sperm Vitality and Intracellular Calcium. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 51(5):2019-2029. doi: 10.1159/000495821. [PMID: 30522107]
  • Bingtao Zhai, Yiying Zeng, Zhaowu Zeng, Nana Zhang, Chenxi Li, Yijun Zeng, Yu You, Shuling Wang, Xiabin Chen, Xinbing Sui, Tian Xie. Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy. International journal of nanomedicine. 2018; 13(?):6279-6296. doi: 10.2147/ijn.s174527. [PMID: 30349250]
  • Mohammad Reza Morshedloo, Luana Quassinti, Massimo Bramucci, Giulio Lupidi, Filippo Maggi. Chemical composition, antioxidant activity and cytotoxicity on tumour cells of the essential oil from flowers of Magnolia grandiflora cultivated in Iran. Natural product research. 2017 Dec; 31(24):2857-2864. doi: 10.1080/14786419.2017.1303699. [PMID: 28299950]
  • Meng Liu, Xiaotong Chen, Ji Ma, Waseem Hassan, Huali Wu, Jiawei Ling, Jing Shang. β-Elemene attenuates atherosclerosis in apolipoprotein E-deficient mice via restoring NO levels and alleviating oxidative stress. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Nov; 95(?):1789-1798. doi: 10.1016/j.biopha.2017.08.092. [PMID: 28962084]