Dimethyl selenide (BioDeep_00000004937)

 

Secondary id: BioDeep_00001868586

human metabolite


代谢物信息卡片


Dimethylselenide, 75Se-labeled

化学式: C2H6Se (109.9635)
中文名称: 二甲基硒, 二甲基硒化物
谱图信息: 最多检出来源 Homo sapiens(plant) 19.83%

分子结构信息

SMILES: C[Se]C
InChI: InChI=1S/C2H6Se/c1-3-2/h1-2H3

描述信息

Constituent of Allium subspecies Dimethyl selenide is found in many foods, some of which are breadnut tree seed, buffalo currant, guava, and muskmelon.
Dimethyl selenide is found in onion-family vegetables. Dimethyl selenide is a constituent of Allium species.

同义名列表

19 个代谢物同义名

Dimethylselenide, 75Se-labeled; Methane, selenobis- (9ci); (Methylselanyl)methane; Selenobismethane, 9ci; Methyl selenide (8ci); Methyl selenide, 8ci; Selenium dimethyl; Selenobis-methane; Dimethyl-selenide; Dimethyl selenide; Selenobismethane; Dimethylselenide; Dimethylselenium; Methyl selenium; Methyl selenide; DMe-selenide; (CH3)2Se; Dimethyl selenide; Dimethyl selenide



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(3)

PlantCyc(3)

代谢反应

33 个相关的代谢反应过程信息。

Reactome(4)

BioCyc(4)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(25)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AR, CASP3, CASP8, CASP9, IL13, INMT, MAPK14, PMP2, TPMT
Nucleus 8 AR, CASP3, CASP8, CASP9, IDH3A, JUN, MAPK14, PMP2
cytosol 10 AR, CASP3, CASP8, CASP9, GSR, INMT, MAPK14, NNMT, PMP2, TPMT
mitochondrial membrane 1 OXA1L
nucleoplasm 5 AR, CASP3, CASP8, JUN, MAPK14
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 1 SLC26A2
lamellipodium 1 CASP8
Multi-pass membrane protein 2 OXA1L, SLC26A2
glutamatergic synapse 2 CASP3, MAPK14
mitochondrial inner membrane 1 OXA1L
neuronal cell body 1 CASP3
plasma membrane 2 AR, SLC26A2
Membrane 3 AR, OXA1L, SLC26A2
apical plasma membrane 1 SLC26A2
extracellular exosome 3 GSR, PMP2, SLC26A2
extracellular space 2 IL13, IL4
mitochondrion 6 CASP8, CASP9, GSR, IDH3A, MAPK14, OXA1L
protein-containing complex 4 AR, CASP8, CASP9, OXA1L
postsynaptic density 1 CASP3
Secreted 2 IL13, IL4
extracellular region 3 IL13, IL4, MAPK14
mitochondrial outer membrane 1 CASP8
mitochondrial matrix 3 GSR, IDH3A, OXA1L
transcription regulator complex 1 JUN
external side of plasma membrane 2 GSR, IL13
Apical cell membrane 1 SLC26A2
Cell projection, lamellipodium 1 CASP8
Mitochondrion inner membrane 1 OXA1L
nuclear speck 2 AR, MAPK14
chromatin 2 AR, JUN
cytoskeleton 1 CASP8
spindle pole 1 MAPK14
nuclear chromosome 1 JUN
microvillus membrane 1 SLC26A2
euchromatin 1 JUN
cell body 1 CASP8
myelin sheath 1 PMP2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
apoptosome 1 CASP9
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
isocitrate dehydrogenase complex (NAD+) 1 IDH3A
transcription factor AP-1 complex 1 JUN
caspase complex 1 CASP9


文献列表

  • C M Sabbir Ahmed, Biplab Chandra Paul, Yumeng Cui, Alexander L Frie, Abigail Burr, Rohan Kamath, Jin Y Chen, Tara M Nordgren, Roya Bahreini, Ying-Hsuan Lin. Integrative Analysis of lncRNA-mRNA Coexpression in Human Lung Epithelial Cells Exposed to Dimethyl Selenide-Derived Secondary Organic Aerosols. Chemical research in toxicology. 2021 03; 34(3):892-900. doi: 10.1021/acs.chemrestox.0c00516. [PMID: 33656867]
  • C M Sabbir Ahmed, Yumeng Cui, Alexander L Frie, Abigail Burr, Rohan Kamath, Jin Y Chen, Arafat Rahman, Tara M Nordgren, Ying-Hsuan Lin, Roya Bahreini. Exposure to Dimethyl Selenide (DMSe)-Derived Secondary Organic Aerosol Alters Transcriptomic Profiles in Human Airway Epithelial Cells. Environmental science & technology. 2019 12; 53(24):14660-14669. doi: 10.1021/acs.est.9b04376. [PMID: 31751125]
  • Brian Torres, James S Tyler, Kenneth A Satyshur, Arnold E Ruoho. Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants. PloS one. 2019; 14(7):e0219664. doi: 10.1371/journal.pone.0219664. [PMID: 31310642]
  • Woravimol Krittaphol, Philip A Wescombe, Christine D Thomson, Arlene McDowell, John R Tagg, J Paul Fawcett. Metabolism of L-selenomethionine and selenite by probiotic bacteria: in vitro and in vivo studies. Biological trace element research. 2011 Dec; 144(1-3):1358-69. doi: 10.1007/s12011-011-9057-2. [PMID: 21494803]
  • Woravimol Krittaphol, Arlene McDowell, Christine D Thomson, Momir Mikov, J Paul Fawcett. Biotransformation of L-selenomethionine and selenite in rat gut contents. Biological trace element research. 2011 Feb; 139(2):188-96. doi: 10.1007/s12011-010-8653-x. [PMID: 20229173]
  • Kristoffer Lunøe, Søren Skov, Charlotte Gabel-Jensen, Stefan Stürup, Bente Gammelgaard. A method for analysis of dimethyl selenide and dimethyl diselenide by LC-ICP-DRC-MS. Analytical and bioanalytical chemistry. 2010 Dec; 398(7-8):3081-6. doi: 10.1007/s00216-010-4242-2. [PMID: 20890781]
  • Natalia Campillo, Rosa Peñalver, Manuel Hernández-Córdoba. Determination of dimethylselenide and dimethyldiselenide in milk and milk by-products by solid-phase microextraction and gas chromatography with atomic emission detection. Talanta. 2010 Mar; 80(5):1856-61. doi: 10.1016/j.talanta.2009.10.034. [PMID: 20152423]
  • Charlotte Gabel-Jensen, Kristoffer Lunøe, Bente Gammelgaard. Formation of methylselenol, dimethylselenide and dimethyldiselenide in in vitro metabolism models determined by headspace GC-MS. Metallomics : integrated biometal science. 2010 Feb; 2(2):167-73. doi: 10.1039/b914255j. [PMID: 21069149]
  • Yuki Ohta, Yayoi Kobayashi, Sakae Konishi, Seishiro Hirano. Speciation analysis of selenium metabolites in urine and breath by HPLC- and GC-inductively coupled plasma-MS after administration of selenomethionine and methylselenocysteine to rats. Chemical research in toxicology. 2009 Nov; 22(11):1795-801. doi: 10.1021/tx900202m. [PMID: 19715347]
  • Maïté Bueno, Florence Pannier. Quantitative analysis of volatile selenium metabolites in normal urine by headspace solid phase microextraction gas chromatography-inductively coupled plasma mass spectrometry. Talanta. 2009 May; 78(3):759-63. doi: 10.1016/j.talanta.2008.12.044. [PMID: 19269425]
  • Ximena Diaz, William P Johnson, Wade A Oliver, David L Naftz. Volatile selenium flux from the Great Salt Lake, Utah. Environmental science & technology. 2009 Jan; 43(1):53-9. doi: 10.1021/es801638w. [PMID: 19209584]
  • Dijana Juresa, Doris Kuehnelt, Kevin A Francesconi. Consequences of vapor enhancement on selenium speciation analysis by HPLC/ICPMS. Analytical chemistry. 2006 Dec; 78(24):8569-74. doi: 10.1021/ac061496r. [PMID: 17165855]
  • Natalia Campillo, Nerea Aguinaga, Pilar Viñas, Ignacio López-García, Manuel Hernández-Córdoba. Gas chromatography with atomic emission detection for dimethylselenide and dimethyldiselenide determination in waters and plant materials using a purge-and-trap preconcentration system. Journal of chromatography. A. 2005 Nov; 1095(1-2):138-44. doi: 10.1016/j.chroma.2005.08.002. [PMID: 16275294]
  • Daniel Kremer, Gunter Ilgen, Jörg Feldmann. GC-ICP-MS determination of dimethylselenide in human breath after ingestion of (77)Se-enriched selenite: monitoring of in-vivo methylation of selenium. Analytical and bioanalytical chemistry. 2005 Oct; 383(3):509-15. doi: 10.1007/s00216-005-0001-1. [PMID: 16158304]
  • Duangrudee Cherdwongcharoensuk, Rui Henrique, Suchart Upatham, António Sousa Pereira, Artur P Aguas. Tubular kidney damage and centrilobular liver injury after intratracheal instillation of dimethyl selenide. Toxicologic pathology. 2005; 33(2):225-9. doi: 10.1080/01926230590896127. [PMID: 15902965]
  • A Lee, Z Q Lin, I J Pickering, N Terry. X-ray absorption spectroscopy study shows that the rapid selenium volatilizer, pickleweed (Salicornia bigelovii Torr.), reduces selenate to organic forms without the aid of microbes. Planta. 2001 Oct; 213(6):977-80. doi: 10.1007/s004250100574. [PMID: 11722134]
  • M A al-Bayati, O G Raabe, S V Teague. Effect of inhaled dimethylselenide in the Fischer 344 male rat. Journal of toxicology and environmental health. 1992 Dec; 37(4):549-57. doi: 10.1080/15287399209531692. [PMID: 1281509]
  • C Nebbia, J F Gremmels, M G Soffietti. Pathogenesis of sodium selenite and dimethylselenide acute toxicosis in swine: tissue and blood biochemical changes. Research communications in chemical pathology and pharmacology. 1990 Jan; 67(1):117-30. doi: . [PMID: 2158134]
  • N Oyamada. [The behavior of metabolites, methylated selenium, in mouse after oral administration of sodium selenite]. Nihon eiseigaku zasshi. Japanese journal of hygiene. 1988 Aug; 43(3):754-62. doi: 10.1265/jjh.43.754. [PMID: 3249415]
  • S Vadhanavikit, R J Kraus, H E Ganther. Metabolism of selenocyanate in the rat. Archives of biochemistry and biophysics. 1987 Oct; 258(1):1-6. doi: 10.1016/0003-9861(87)90315-8. [PMID: 3662536]
  • J L Hoffman, K P McConnell. Periodate-oxidized adenosine inhibits the formation of dimethylselenide and trimethylselenonium ion in mice treated with selenite. Archives of biochemistry and biophysics. 1987 May; 254(2):534-40. doi: 10.1016/0003-9861(87)90134-2. [PMID: 3579317]
  • S K Tandon, L Magos, M Webb. The stimulation and inhibition of the exhalation of volatile selenium. Biochemical pharmacology. 1986 Aug; 35(16):2763-6. doi: 10.1016/0006-2952(86)90187-5. [PMID: 3741468]
  • J Yonemoto, M Webb, L Magos. Methylmercury stimulates the exhalation of volatile selenium and potentiates the toxicity of selenite. Toxicology letters. 1985 Jan; 24(1):7-14. doi: 10.1016/0378-4274(85)90132-8. [PMID: 3975931]
  • K A Poirier, J A Milner. Factors influencing the antitumorigenic properties of selenium in mice. The Journal of nutrition. 1983 Nov; 113(11):2147-54. doi: 10.1093/jn/113.11.2147. [PMID: 6631533]
  • . . . . doi: . [PMID: 17988700]