9,10,13-TriHOME (BioDeep_00000004349)

 

Secondary id: BioDeep_00001883282

human metabolite Endogenous blood metabolite


代谢物信息卡片


(9S,10R,11E,13S)-9,10,13-trihydroxyoctadec-11-enoic acid

化学式: C18H34O5 (330.2406114)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.88%

分子结构信息

SMILES: C(O)(/C=C/C(O)CCCCC)C(O)CCCCCCCC(=O)O
InChI: InChI=1S/C18H34O5/c1-2-3-7-10-15(19)13-14-17(21)16(20)11-8-5-4-6-9-12-18(22)23/h13-17,19-21H,2-12H2,1H3,(H,22,23)/b14-13+

描述信息

9,10,13-TriHOME is a trihydroxyoctadecenoic acid metabolite of linoleic acid, one of the major fatty acids found in lipids. Vascular tissue converts various polyunsaturated fatty acids to monohydroxy and trihydroxy metabolites derived from hydroperoxides which may be involved in regulating prostaglandin synthesis. [HMDB]
9,10,13-TriHOME is a trihydroxyoctadecenoic acid metabolite of linoleic acid, one of the major fatty acids found in lipids. Vascular tissue converts various polyunsaturated fatty acids to monohydroxy and trihydroxy metabolites derived from hydroperoxides which may be involved in regulating prostaglandin synthesis.

同义名列表

13 个代谢物同义名

(9S,10R,11E,13S)-9,10,13-trihydroxyoctadec-11-enoic acid; (9S,10R,11E,13S)-9,10,13-Trihydroxyoctadec-11-enoate; (11E)-9,10,13-Trihydroxyoctadec-11-enoic acid; (e)-9,10,13-Trihydroxy-11-octadecenoic acid; (11E)-9,10,13-Trihydroxyoctadec-11-enoate; 9,10,13-Trihydroxyoctadec-11-enoic acid; (e)-9,10,13-Trihydroxy-11-octadecenoate; 9,10,13-trihydroxy-11-octadecenoic acid; 9,10,13-Trihydroxy-11-octadecenoate; 9,10,13-Trihydroxyoctadec-11-enoate; 9,10,13-TriHOME(11); 9,10,13-TriHOME; FA 18:1;O3



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Matthew L Edin, Haruto Yamanashi, William E Boeglin, Joan P Graves, Laura M DeGraff, Fred B Lih, Darryl C Zeldin, Alan R Brash. Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function. The Journal of biological chemistry. 2021 Jan; 296(?):100198. doi: 10.1074/jbc.ra120.016570. [PMID: 33334892]
  • David Fuchs, Xiao Tang, Anna-Karin Johnsson, Sven-Erik Dahlén, Mats Hamberg, Craig E Wheelock. Eosinophils synthesize trihydroxyoctadecenoic acids (TriHOMEs) via a 15-lipoxygenase dependent process. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 04; 1865(4):158611. doi: 10.1016/j.bbalip.2020.158611. [PMID: 31918007]
  • Yuwei Chang, Chunxia Zhao, Zhen Zhu, Zeming Wu, Jia Zhou, Yanni Zhao, Xin Lu, Guowang Xu. Metabolic profiling based on LC/MS to evaluate unintended effects of transgenic rice with cry1Ac and sck genes. Plant molecular biology. 2012 Mar; 78(4-5):477-87. doi: 10.1007/s11103-012-9876-3. [PMID: 22271304]
  • Huan-yang Qi, Rui Wang, Yong Liu, Yan-ping Shi. [Studies on the chemical constituents of Codonopsis pilosula]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Apr; 34(4):546-8. doi: . [PMID: 21809539]
  • Jian-Hua Zhu, Rong-Min Yu, Li Yang, Wei-Min Li. Two new compounds from transgenic Panax quinquefolium. Fitoterapia. 2010 Jul; 81(5):339-42. doi: 10.1016/j.fitote.2009.10.006. [PMID: 19836436]
  • Hideto Kimura, Kazushige Yokota. Characterization of metabolic pathway of linoleic acid 9-hydroperoxide in cytosolic fraction of potato tubers and identification of reaction products. Applied biochemistry and biotechnology. 2004 Jul; 118(1-3):115-32. doi: 10.1385/abab:118:1-3:115. [PMID: 15304744]
  • D Gansser, G Spiteller. Plant constituents interfering with human sex hormone-binding globulin. Evaluation of a test method and its application to Urtica dioica root extracts. Zeitschrift fur Naturforschung. C, Journal of biosciences. 1995 Jan; 50(1-2):98-104. doi: . [PMID: 7702715]