Flavoxate (BioDeep_00000004133)

 

Secondary id: BioDeep_00001868369

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


2-(1-Piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid

化学式: C24H25NO4 (391.178349)
中文名称: 黄曲霉, 黄酮哌酯
谱图信息: 最多检出来源 Homo sapiens(blood) 80%

分子结构信息

SMILES: CC1=C(OC2=C(C1=O)C=CC=C2C(=O)OCCN3CCCCC3)C4=CC=CC=C4
InChI: InChI=1S/C24H25NO4/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25/h2,4-5,8-12H,3,6-7,13-16H2,1H3

描述信息

A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem]
G - Genito urinary system and sex hormones > G04 - Urologicals > G04B - Urologicals > G04BD - Drugs for urinary frequency and incontinence
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D000089162 - Genitourinary Agents > D064804 - Urological Agents

同义名列表

35 个代谢物同义名

2-(1-Piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid; 2-Piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid; 2-(piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate; 2-(1-Piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate; 2-Piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate; beta-Piperidinoethyl 3-methylflavone-8-carboxylic acid; Cahill may roberts brand OF flavoxate hydrochloride; Β-piperidinoethyl 3-methylflavone-8-carboxylic acid; 2-Piperidinoethyl 3-methylflavone-8-carboxylic acid; b-Piperidinoethyl 3-methylflavone-8-carboxylic acid; beta-Piperidinoethyl 3-methylflavone-8-carboxylate; b-Piperidinoethyl 3-methylflavone-8-carboxylate; Β-piperidinoethyl 3-methylflavone-8-carboxylate; 2-Piperidinoethyl 3-methylflavone-8-carboxylate; Pierre fabre brand OF flavoxate hydrochloride; Recordati brand OF flavoxate hydrochloride; Hoechst brand OF flavoxate hydrochloride; Negma brand OF flavoxate hydrochloride; Ortho brand OF flavoxate hydrochloride; Shire brand OF flavoxate hydrochloride; Byk brand OF flavoxate hydrochloride; Hydrochloride, flavoxate; Flavoxate hydrochloride; Flavoxic acid; Flavoxate hci; Flavoxatum; Flavoxato; flavoxate; Spasuret; Bladuril; Urispas; BML-278; Uronid; Flavoxate; Flavoxate



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ahmad Junaid Rashid, Sajid Bashir, Nadeem Irfan Bukhari, Nasir Abbas, Atif Raza, Ans Munir, Qazi Aamir Ijaz, Shehla Akbar, Numera Arshad, Saiqa Ishtiaq. Development and validation of single analytical HPLC method for determination of flavoxate HCl in bulk, tablets and biological fluids. Pakistan journal of pharmaceutical sciences. 2021 Jul; 34(4(Supplementary)):1629-1637. doi: NULL. [PMID: 34799341]
  • Gabriel Onn Kit Loh, Emily Yii Ling Wong, Yvonne Tze Fung Tan, Hong Chin Wee, Ru Shing Ng, Chong Yew Lee, Kok Khiang Peh. Simple and rapid LC-MS/MS method for simultaneous determination of flavoxate and 3-methyl-flavone-8-carboxylic acid in human plasma: Application to a bioequivalence study. Journal of pharmaceutical and biomedical analysis. 2021 Feb; 194(?):113758. doi: 10.1016/j.jpba.2020.113758. [PMID: 33248861]
  • Hong C Tang, Wai P Lam, Xin Zhang, Ping C Leung, David T Yew, Willmann Liang. Short-Term Flavoxate Treatment Alters Detrusor Contractility Characteristics: Renewed Interest in Clinical Use?. Lower urinary tract symptoms. 2015 Sep; 7(3):149-54. doi: 10.1111/luts.12063. [PMID: 26663730]
  • Hala E Zaazaa, Afaf O Mohamed, Maha A Hawwam, Mohamed Abdelkawy. Spectrofluorimetric determination of 3-methylflavone-8-carboxylic acid, the main active metabolite of flavoxate hydrochloride in human urine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2015 Jan; 134(?):109-13. doi: 10.1016/j.saa.2014.06.058. [PMID: 25004902]
  • Hossein Zhaleh, Mehri Azadbakht, Ali Bidmeshki Pour. Possible involvement of calcium channels and plasma membrane receptors on Staurosporine-induced neurite outgrowth. Bosnian journal of basic medical sciences. 2012 Feb; 12(1):20-5. doi: 10.17305/bjbms.2012.2526. [PMID: 22364299]
  • Ramisetti N Rao, Pawan K Maurya, Ramakrishna Kuntamukkala, Wani D Vitthal, Murali V N K Talluri. Molecularly imprinted polymer for selective extraction of 3-methylflavone-8-carboxylic acid from human urine followed by its determination using zwitterionic hydrophilic interaction liquid chromatography. Journal of separation science. 2011 Nov; 34(22):3265-71. doi: 10.1002/jssc.201100560. [PMID: 21998024]
  • Manoj K Poonia, Ginpreet Kaur, Meena Chintamaneni, Ilesh Changela. New insights into molecular targets for urinary incontinence. Indian journal of pharmacology. 2010 Oct; 42(5):261-6. doi: 10.4103/0253-7613.69980. [PMID: 21206614]
  • I M Reichler. [Urinary incontinence and puppy coat due to spaying in the bitch. An overview of pathophysiology, diagnosis and therapy]. Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere. 2010 Jun; 38(3):157-62. doi: . [PMID: 22290549]
  • Mohamed Heba, Nesrin Ramadan, Moustafa El-Laithy. Polymeric matrix membrane sensors for stability-indicating potentiometric determination of oxybutynin hydrochloride and flavoxate hydrochloride urogenital system drugs. Journal of AOAC International. 2008 Nov; 91(6):1318-30. doi: NULL. [PMID: 19202792]
  • Shinobu Kato, Mamoru Kusaka, Ryoichi Shiroki, Masanobu Izumitani, Haruyoshi Asano, Takahiro Ooki, Masanori Yanaoka, Kiyotaka Hoshinaga. [Clinical evaluation of supplemental administration of flavoxate hydrochloride in benign prostatic hyperplasia patients with nocturia resistant to an alpha1-adrenoceptor blocker]. Hinyokika kiyo. Acta urologica Japonica. 2008 Mar; 54(3):173-7. doi: NULL. [PMID: 18411771]
  • Kristen Hesch. Agents for treatment of overactive bladder: a therapeutic class review. Proceedings (Baylor University. Medical Center). 2007 Jul; 20(3):307-14. doi: 10.1080/08998280.2007.11928310. [PMID: 17637888]
  • Alaa El-Gindy, Shehab Sallam, Randa A Abdel-Salam. High performance liquid chromatographic determination of 3-methylflavone-8-carboxylic acid, the main active metabolite of flavoxate hydrochloride in human urine. Journal of pharmaceutical and biomedical analysis. 2007 May; 44(1):274-8. doi: 10.1016/j.jpba.2007.01.053. [PMID: 17349765]
  • David Rp Guay. Trospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence. Therapeutics and clinical risk management. 2005 Jun; 1(2):157-67. doi: 10.2147/tcrm.1.2.157.62912. [PMID: 18360555]
  • David R P Guay. Clinical pharmacokinetics of drugs used to treat urge incontinence. Clinical pharmacokinetics. 2003; 42(14):1243-85. doi: 10.2165/00003088-200342140-00004. [PMID: 14606931]
  • M T Sheu, G C Yeh, W T Ke, H O Ho. Development of a high-performance liquid chromatographic method for bioequivalence study of flavoxate tablets. Journal of chromatography. B, Biomedical sciences and applications. 2001 Feb; 751(1):79-86. doi: 10.1016/s0378-4347(00)00451-5. [PMID: 11232858]
  • P Fehrmann-Zumpe, K Karbe, G Blessman. Using flavoxate as primary medication for patients suffering from urge symptomatology. International urogynecology journal and pelvic floor dysfunction. 1999; 10(2):91-5. doi: 10.1007/pl00004018. [PMID: 10384969]
  • Y Kimura, Y Sasaki, K Hamada, H Fukui, Y Ukai, Y Yoshikuni, K Kimura, K Sugaya, O Nishizawa. Mechanisms of the suppression of the bladder activity by flavoxate. International journal of urology : official journal of the Japanese Urological Association. 1996 May; 3(3):218-27. doi: 10.1111/j.1442-2042.1996.tb00520.x. [PMID: 8776621]
  • C X Zhang, Z P Sun, D K Ling, J S Zheng, J Guo, X Y Li. Determination of 3-methylflavone-8-carboxylic acid, the main metabolite of flavoxate, in human urine by capillary electrophoresis with direct injection. Journal of chromatography. 1993 Feb; 612(2):287-94. doi: 10.1016/0378-4347(93)80175-4. [PMID: 8468387]
  • A Ogawa, J Shimazaki, H Mitsuya, S Miyazaki, T Kurita. [Clinical effects of terodiline hydrochloride on urinary frequency and sense of residual urine--a double blind clinical trial using flavoxate hydrochloride as a control]. Hinyokika kiyo. Acta urologica Japonica. 1988 Apr; 34(4):739-53. doi: NULL. [PMID: 3041785]
  • L Daccò, M Barbagallo, A Carbognati, G Girasole. Rociverine for nocturia in the elderly: medium-term controlled clinical trial. Clinical therapeutics. 1986; 8(4):450-8. doi: . [PMID: 3524844]
  • L Daccó, L Intrieri. Rociverine for nocturia in the elderly. Clinical therapeutics. 1986; 8(2):170-4. doi: . [PMID: 3698063]
  • J M Robinson, J C Brocklehurst. Emepronium bromide and flavoxate hydrochloride in the treatment of urinary incontinence associated with detrusor instability in elderly women. British journal of urology. 1983 Aug; 55(4):371-6. doi: 10.1111/j.1464-410x.1983.tb03325.x. [PMID: 6349743]
  • R C Briel, K Gassner. [First experience with flavoxat in bladder - conditioned types of incontinence in gynaecology (author's transl)]. Geburtshilfe und Frauenheilkunde. 1980 Mar; 40(3):242-5. doi: 10.1055/s-2008-1037005. [PMID: 6988285]
  • G Chiodini, N Elicio, S Bertolini, S Valice, E Reggiani, L Innocenti-Ducci. [Effects of chronic inhibition of adipocyte phosphodiesterase on lipolysis induced with noradrenaline in normal and obese subjects]. Archivio "E. Maragliano" di patologia e clinica. 1978; 34(2):91-108. doi: ". [PMID: 233626]
  • A Scanni, M Tomirotti, M Biraghi, A Cova. [Urinary excretion of flavoxate administered in combination with metamizole]. Bollettino chimico farmaceutico. 1977 Oct; 116(10):584-8. doi: NULL. [PMID: 343796]
  • C Benvenuti, A Cova, I Simonazzi. [Urinary kinetics and tolerance of oral flavoxate in man]. Il Farmaco; edizione pratica. 1977 Feb; 32(2):99-107. doi: NULL. [PMID: 849779]
  • E Pedersen. Studies on the effect and mode of action of flavoxate in human urinary bladder and sphincter. Urologia internationalis. 1977; 32(2-3):202-8. doi: 10.1159/000280131. [PMID: 906183]
  • S Hebjorn. Treatment of detrusor hyperreflexia in multiple sclerosis: a double-blind, crossover clinical trial comparing methantheline bromide (Banthine), flavoxate chloride (Urispas) and meladrazine tartrate (Lisidonil). Urologia internationalis. 1977; 32(2-3):209-17. doi: 10.1159/000280132. [PMID: 20683]