Atropine (BioDeep_00000398480)

 

Secondary id: BioDeep_00000000486, BioDeep_00000000748, BioDeep_00000171512, BioDeep_00000406224

natural product PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, ENDO-(+/-)-

化学式: C17H23NO3 (289.1678)
中文名称: 阿托平, 阿脱品, 阿妥品, 阿托品, 菱胺, L-天仙子胺
谱图信息: 最多检出来源 Homo sapiens(blood) 10.72%

分子结构信息

SMILES: CN1C2CCC1CC(C2)OC(=O)C(CO)C1=CC=CC=C1
InChI: InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3

描述信息

Atropine is a racemate composed of equimolar concentrations of (S)- and (R)-atropine. It is obtained from deadly nightshade (Atropa belladonna) and other plants of the family Solanaceae. It has a role as a muscarinic antagonist, an anaesthesia adjuvant, an anti-arrhythmia drug, a mydriatic agent, a parasympatholytic, a bronchodilator agent, a plant metabolite, an antidote to sarin poisoning and a oneirogen. It contains a (S)-atropine and a (R)-atropine.
Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active. Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods. Oral atropine is only available in combination products. Atropine is a competitive, reversible antagonist of muscarinic receptors that blocks the effects of acetylcholine and other choline esters. It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes. Atropine is a relatively inexpensive drug and is included in the World Health Organization List of Essential Medicines.
Atropine is an Anticholinergic and Cholinergic Muscarinic Antagonist. The mechanism of action of atropine is as a Cholinergic Antagonist and Cholinergic Muscarinic Antagonist.
Hyoscyamine as a natural plant alkaloid derivative and anticholinergic that is used to treat mild to moderate nausea, motion sickness, hyperactive bladder and allergic rhinitis. Hyoscyamine has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.
Atropine is a natural product found in Cyphanthera tasmanica, Anthocercis ilicifolia, and other organisms with data available.
Atropine Sulfate is the sulfate salt of atropine, a naturally-occurring alkaloid isolated from the plant Atropa belladonna. Atropine functions as a sympathetic, competitive antagonist of muscarinic cholinergic receptors, thereby abolishing the effects of parasympathetic stimulation. This agent may induce tachycardia, inhibit secretions, and relax smooth muscles. (NCI04)
Atropine is a synthetically-derived form of the endogenous alkaloid isolated from the plant Atropa belladonna. Atropine functions as a sympathetic, competitive antagonist of muscarinic cholinergic receptors, thereby abolishing the effects of parasympathetic stimulation. This agent may induce tachycardia, inhibit secretions, and relax smooth muscles. (NCI04)
Hyoscyamine is a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility.
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03B - Belladonna and derivatives, plain > A03BA - Belladonna alkaloids, tertiary amines
A racemate composed of equimolar concentrations of (S)- and (R)-atropine . It is obtained from deadly nightshade (Atropa belladonna) and other plants of the family Solanaceae.
S - Sensory organs > S01 - Ophthalmologicals > S01F - Mydriatics and cycloplegics > S01FA - Anticholinergics
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D009184 - Mydriatics
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002491 - Central Nervous System Agents
Annotation level-1
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.421
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.416
Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia[1][2][3][4].
Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia[1][2][3][4].
Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia[1][2][3][4].
L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205)[1][2].
L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205)[1][2].
L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205)[1][2].

同义名列表

113 个代谢物同义名

BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, ENDO-(+/-)-; Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+/-)-; Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+-)-; Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+-)-; Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3,2,1)oct-3-yl ester, endo-(+-)-; Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-(3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER; Benzeneacetic acid, alpha-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; (3-exo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl alpha-(hydroxymethyl)benzeneacetate; Atropine for peak identification, European Pharmacopoeia (EP) Reference Standard; [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenyl-propanoate; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenyl-propanoate; rac-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) (8CI); 1.ALPHA.H,5.ALPHA.H-TROPAN-3.ALPHA.-OL (+/-)-TROPATE (ESTER); 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester); Atropine, European Pharmacopoeia (EP) Reference Standard; beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester [German]; beta-Phenyl-gamma-oxypropionsaure-tropyl-ester [German]; 1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester); (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; (3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL TROPATE; HOMATROPINE HYDROBROMIDE IMPURITY D [EP IMPURITY]; rac-tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate; 2-Phenylhydracrylic acid 3-alpha-tropanyl ester; beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester; beta-Phenyl-gamma-oxypropionsaure-tropyl-ester; tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; Atropine, meets USP testing specifications; DL-Tropanyl 2-hydroxy-1-phenylpropionate; Tropic acid, 3-alpha-tropanyl ester; Tropic acid, ester with tropine; Tropine tropate;DL-Hyoscyamine; Atropine, >=99\\% (TLC), powder; ATROPINE COMPONENT OF DUODOTE; Atropine, analytical standard; Sulfate Anhydrous, Atropine; RKUNBYITZUJHSG-SPUOUPEWSA-N; ATROPINE COMPONENT OF ATNAA; Atropine ((+/-)-Hyoscyamin); Anhydrous, Atropine Sulfate; DUODOTE COMPONENT ATROPINE; Atropine Sulfate Anhydrous; ATROPINE [USP MONOGRAPH]; Tropine, tropate (ester); ATNAA COMPONENT ATROPINE; ATROPINE [EP MONOGRAPH]; Atropine, >=95.0\\% (NT); ATROPINE [ORANGE BOOK]; ATROPINE [EP IMPURITY]; Tropine (+/-)-tropate; ATROPINE [GREEN BOOK]; Protamine & Atropine; (+,-)-Tropyl tropate; 3-tropoyloxytropane; Atropine [USP:BAN]; Atropina [Italian]; DL-Tropyl tropate; Sulfate, Atropine; ATROPINE ((+/-)-); Atropin-flexiolen; ATROPINE [USP-RS]; (+/-)-Hyoscyamine; ATROPINE [WHO-DD]; (+-)-hyoscyamine; ATROPINE [MART.]; ATROPINE [VANDF]; Atropine sulfate; Atropin [German]; ATROPINUM [HPUS]; ATROPINE, (+/-)-; dl-Tropyltropate; Augenöl, Atropin; Atropin Augenöl; Isopto-atropine; Tropine tropate; UNII-7C0697DR9I; dl-Hyoscyamine; Atropine (USP); (+/-)-Atropine; ropine tropate; ATROPINE [MI]; L-Hyoscyamine; MEGxp0_001878; Troyl tropate; (+-)-atropine; ACon1_000046; Tox21_111590; Tox21_110816; Atropen (TN); Tox21_200487; CAS-51-55-8; Hyoscyamine; 7C0697DR9I; Atropinol; Atropinum; AI3-60219; Eyesules; Atropine; Atropina; Atropin; Atropen; Atropine; L-Hyoscyamine; (-)-Atropine



数据库引用编号

84 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

114 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, CA1, CA3, CHAT, POMC, PPY, PRL
Nucleus 5 ALB, CHAT, FOS, PRL, RERE
cytosol 6 ALB, CA1, CA3, CHAT, FOS, SST
dendrite 1 DRD2
nuclear body 1 RERE
centrosome 1 ALB
nucleoplasm 3 FOS, PRL, RERE
RNA polymerase II transcription regulator complex 2 FOS, PRL
Cell membrane 1 DRD2
Multi-pass membrane protein 1 DRD2
Golgi apparatus membrane 1 DRD2
Synapse 3 CHAT, DRD2, TAC1
glutamatergic synapse 1 DRD2
Golgi apparatus 1 ALB
Golgi membrane 2 DRD2, INS
neuronal cell body 2 SST, TAC1
presynaptic membrane 1 DRD2
Cytoplasmic vesicle, secretory vesicle 1 NTS
acrosomal vesicle 1 DRD2
plasma membrane 3 CD160, DRD2, REN
synaptic vesicle membrane 1 DRD2
Membrane 1 REN
axon 3 CCK, DRD2, TAC1
extracellular exosome 2 ALB, CA1
endoplasmic reticulum 2 ALB, FOS
extracellular space 10 ALB, CCK, GAST, INS, POMC, PPY, PRL, REN, SST, TAC1
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 1 NTS
Secreted 11 ALB, CCK, GAST, INS, NTS, POMC, PPY, PRL, REN, SST, TRH
extracellular region 14 ALB, CCK, CD160, GAST, INS, MLN, NTS, POMC, PPY, PRL, REN, SST, TAC1, TRH
Single-pass membrane protein 1 MLN
anchoring junction 1 ALB
ciliary membrane 1 DRD2
dendritic spine 1 DRD2
perikaryon 1 DRD2
apical part of cell 1 REN
postsynaptic membrane 1 DRD2
GABA-ergic synapse 2 DRD2, SST
secretory granule 2 POMC, TRH
lateral plasma membrane 1 DRD2
neuron projection 1 CHAT
ciliary basal body 1 ALB
cilium 1 DRD2
chromatin 2 FOS, PRL
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
non-motile cilium 1 DRD2
Lipid-anchor, GPI-anchor 1 CD160
sperm flagellum 1 DRD2
endosome lumen 2 INS, PRL
side of membrane 1 CD160
secretory granule lumen 2 INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
nuclear matrix 1 FOS
platelet alpha granule lumen 1 ALB
axon terminus 2 DRD2, NTS
histone deacetylase complex 1 RERE
endocytic vesicle 1 DRD2
transport vesicle 2 INS, NTS
Sarcoplasmic reticulum membrane 1 MLN
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 SST
protein-DNA complex 1 FOS
dopaminergic synapse 1 DRD2
[CD160 antigen]: Cell membrane 1 CD160
transcription factor AP-1 complex 1 FOS
G protein-coupled receptor complex 1 DRD2
ciliary transition fiber 1 ALB


文献列表

  • Riccardo Lorrai, Dario Cavaterra, Sara Giammaria, Diego Sbardella, Grazia Raffaella Tundo, Alessandra Boccaccini. Eye Diseases: When the Solution Comes from Plant Alkaloids. Planta medica. 2024 May; 90(6):426-439. doi: 10.1055/a-2283-2350. [PMID: 38452806]
  • Yuqin Gou, Yanming Jing, Jiaxin Song, Mohammad Mahmoud Nagdy, Chao Peng, Lingjiang Zeng, Min Chen, Xiaozhong Lan, Zun Lai Lai Htun, Zhihua Liao, Yan Li. A novel bHLH gene responsive to low nitrogen positively regulates the biosynthesis of medicinal tropane alkaloids in Atropa belladonna. International journal of biological macromolecules. 2024 May; 266(Pt 1):131012. doi: 10.1016/j.ijbiomac.2024.131012. [PMID: 38522709]
  • F Rafique, M N Mushtaq, H Ahmed, W Younis. Evaluation and estimation of diuretic activity of the linalyl acetate in the rats. Brazilian journal of biology = Revista brasleira de biologia. 2024; 83(?):e277354. doi: 10.1590/1519-6984.277354. [PMID: 38452187]
  • Xiehe Kong, Guang Yang, Zhi Chen, Rong Han, Yue Zhao, Li Zeng, Xiaocong Guo, Zheng Shi, Dan Zhang, Yanting Yang, Jie Liu, Xingtao Zhou, Xiaopeng Ma. Addition of Auricular Acupoint Stimulation to 0.01\% Atropine for Myopia: 12-Month Results from a Randomized Trial. Journal of integrative and complementary medicine. 2023 Sep; 29(9):574-583. doi: 10.1089/jicm.2022.0769. [PMID: 36971804]
  • Jun-Yuan Guo, Bin-Bin Han, Nai-Guang Jia. Atropine combined with dopamine in a patient with sinus bradycardia scheduled for laparoscopic surgery. Asian journal of surgery. 2023 Aug; ?(?):. doi: 10.1016/j.asjsur.2023.08.012. [PMID: 37597976]
  • Zahra Tardast, Alireza Iranbakhsh, Mostafa Ebadi, Zahra Oraghi Ardebili. Carboxylic acid-functionalized multiwalled carbon nanotubes (COOH-MWCNTs) improved production of atropine in callus of Datura inoxia by influencing metabolism, gene regulation, and DNA cytosine methylation; an in vitro biological assessment. Plant physiology and biochemistry : PPB. 2023 Aug; 202(?):107975. doi: 10.1016/j.plaphy.2023.107975. [PMID: 37634333]
  • Shaida Mahmoudi, Mohamad Javad Chaichi, Mojtaba Shamsipur, Ome Leila Nazari, Abdolrauf SamadiMaybodi. Fe3 O4 and bimetal-organic framework Zn/Mg composites peroxides- like catalyze luminol chemiluminescence for specific measurement of atropine in Datura plant. Luminescence : the journal of biological and chemical luminescence. 2023 Jul; ?(?):. doi: 10.1002/bio.4557. [PMID: 37455562]
  • Shaida Mahmoudi, Mohamad Javad Chaichi, Mojtaba Shamsipur, Ome Leila Nazari, Abdol Rauf Samadi Mayodi. Determination of Atropine by HPLC in Plant of Datura by Liquid-Liquid Extraction and Magnet Solid-Phase Extraction. Journal of chromatographic science. 2023 Jun; ?(?):. doi: 10.1093/chromsci/bmad041. [PMID: 37316168]
  • Juan M Minoia, María E Villanueva, Guillermo J Copello, Julián Rodríguez Talou, Alejandra B Cardillo. Recycling of hyoscyamine 6β-hydroxylase for the in vitro production of anisodamine and scopolamine. Applied microbiology and biotechnology. 2023 Apr; ?(?):. doi: 10.1007/s00253-023-12537-w. [PMID: 37099059]
  • Yong-Jiang Wang, Tian Tain, Jia-Yi Yu, Jie Li, Bingyan Xu, Jianghua Chen, John C D'Auria, Jian-Ping Huang, Sheng-Xiong Huang. Genomic and structural basis for evolution of tropane alkaloid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 2023 Apr; 120(17):e2302448120. doi: 10.1073/pnas.2302448120. [PMID: 37068250]
  • Ana Rita Soares Mateus, Carmen Crisafulli, Matilde Vilhena, Sílvia Cruz Barros, Angelina Pena, Ana Sanches Silva. The Bright and Dark Sides of Herbal Infusions: Assessment of Antioxidant Capacity and Determination of Tropane Alkaloids. Toxins. 2023 03; 15(4):. doi: 10.3390/toxins15040245. [PMID: 37104183]
  • Fangyuan Zhang, Fei Qiu, Junlan Zeng, Zhichao Xu, Yueli Tang, Tengfei Zhao, Yuqin Gou, Fei Su, Shiyi Wang, Xiuli Sun, Zheyong Xue, Weixing Wang, Chunxian Yang, Lingjiang Zeng, Xiaozhong Lan, Min Chen, Junhui Zhou, Zhihua Liao. Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family. Nature communications. 2023 Mar; 14(1):1446. doi: 10.1038/s41467-023-37133-4. [PMID: 36922496]
  • Monique de Nijs, Colin Crews, Folke Dorgelo, Susan MacDonald, Patrick P J Mulder. Emerging Issues on Tropane Alkaloid Contamination of Food in Europe. Toxins. 2023 Jan; 15(2):. doi: 10.3390/toxins15020098. [PMID: 36828413]
  • Farheen Tariq, Rabia Mobeen, Xinhai Wang, Xiao Lin, Qingdong Bao, Jinhui Liu, Hua Gao. Advances in myopia prevention strategies for school-aged children: a comprehensive review. Frontiers in public health. 2023; 11(?):1226438. doi: 10.3389/fpubh.2023.1226438. [PMID: 37655278]
  • Zengying Wang, Pengfei Wang, Bohua Jiang, Yifei Meng, Sufang Qie, Zhipeng Yan. The efficacy and safety of 0.01\% atropine alone or combined with orthokeratology for children with myopia: A meta-analysis. PloS one. 2023; 18(7):e0282286. doi: 10.1371/journal.pone.0282286. [PMID: 37494360]
  • Lorena González-Gómez, Sonia Morante-Zarcero, Jorge A M Pereira, José S Câmara, Isabel Sierra. Improved Analytical Approach for Determination of Tropane Alkaloids in Leafy Vegetables Based on µ-QuEChERS Combined with HPLC-MS/MS. Toxins. 2022 Sep; 14(10):. doi: 10.3390/toxins14100650. [PMID: 36287919]
  • Emad A Ahmed, Mayyadah A Alkuwayti, Hairul-Islam M Ibrahim. Atropine Is a Suppressor of Epithelial-Mesenchymal Transition (EMT) That Reduces Stemness in Drug-Resistant Breast Cancer Cells. International journal of molecular sciences. 2022 Aug; 23(17):. doi: 10.3390/ijms23179849. [PMID: 36077256]
  • Tian Tian, Yong-Jiang Wang, Jian-Ping Huang, Jie Li, Bingyan Xu, Yin Chen, Li Wang, Jing Yang, Yijun Yan, Sheng-Xiong Huang. Catalytic innovation underlies independent recruitment of polyketide synthases in cocaine and hyoscyamine biosynthesis. Nature communications. 2022 08; 13(1):4994. doi: 10.1038/s41467-022-32776-1. [PMID: 36008484]
  • Nir Erdinest, Naomi London, Nadav Levinger, Itay Lavy, Eran Pras, Yair Morad. Decreased effectiveness of 0.01\% atropine treatment for myopia control during prolonged COVID-19 lockdowns. Contact lens & anterior eye : the journal of the British Contact Lens Association. 2022 Aug; 45(4):101475. doi: 10.1016/j.clae.2021.101475. [PMID: 34238687]
  • Sigal Klainbart, Meital Grabarnik, Efrat Kelmer, Orit Chai, Olga Cuneah, Gilad Segev, Itamar Aroch. Clinical manifestations, laboratory findings, treatment and outcome of acute organophosphate or carbamate intoxication in 39 cats. The Veterinary record. 2022 07; 191(1):e1633. doi: 10.1002/vetr.1633. [PMID: 35437770]
  • Qiaozhuo Zhang, Mengjiao Liang, Junlan Zeng, Chunxian Yang, Jianbo Qin, Wei Qiang, Xiaozhong Lan, Min Chen, Min Lin, Zhihua Liao. Engineering tropane alkaloid production and glyphosate resistance by overexpressing AbCaM1 and G2-EPSPS in Atropa belladonna. Metabolic engineering. 2022 07; 72(?):237-246. doi: 10.1016/j.ymben.2022.03.014. [PMID: 35390492]
  • Ewelina Kowalczyk, Krzysztof Kwiatek. Scopolamine and atropine in feeds - determination with liquid chromatography mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2022 May; 39(5):977-989. doi: 10.1080/19440049.2022.2037724. [PMID: 35302907]
  • Ashok Kumar Pannu, Sahil Garg, Ashish Bhalla, Deba Prasad Dhibar, Navneet Sharma. Lipid emulsion for the treatment of acute organophosphate poisoning: an Open-Label randomized trial. Clinical toxicology (Philadelphia, Pa.). 2022 May; 60(5):602-608. doi: 10.1080/15563650.2021.2013496. [PMID: 34928182]
  • Marquis Von Angelo Syquio G Joson, Fides Roxanne M Castor, Charmaine Victoria Micu-Oblefias. Role of intravenous lipid emulsion therapy and packed red blood cell transfusion as adjuvant treatment in the management of a child with severe organophosphate poisoning (chlorpyrifos). BMJ case reports. 2022 Apr; 15(4):. doi: 10.1136/bcr-2021-246381. [PMID: 35396244]
  • Nikhitha Lakshmi, Ameer Basha Shaik, Pragya Paramita Pal, Sajeli Begum Ahil, Ramya Vittal, Saida Naik, Uma Devi Gali, Vidya Sagar Bokka. Piperine, Reserpine and β-Sitosterol Attenuate Stem Rot (Sclerotium rolfsii Sacc.) of Groundnut by Inducing the Secretion of defense Enzymes and Phenolic Acids. Chemistry & biodiversity. 2022 Apr; 19(4):e202100880. doi: 10.1002/cbdv.202100880. [PMID: 35182415]
  • Sabrina Schmoll, Katrin Romanek, Gabriel Zorn, Hans Eiglmeier, Florian Eyer. Anticholinergic syndrome after atropine overdose in a supposedly homeopathic solution: a case report. Clinical toxicology (Philadelphia, Pa.). 2022 Feb; 60(2):252-254. doi: 10.1080/15563650.2021.1918704. [PMID: 33988064]
  • Xinxin Xu, Wenliang Ge, Steven Suryoprabowo, Xin Guo, Jianping Zhu, Liqiang Liu, Chuanlai Xu, Hua Kuang. Fluorescence-based immunochromatographic test strip for the detection of hyoscyamine. The Analyst. 2022 Jan; 147(2):293-302. doi: 10.1039/d1an01973b. [PMID: 34907412]
  • Ari Shinojima, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara. Multiple Factors Causing Myopia and the Possible Treatments: A Mini Review. Frontiers in public health. 2022; 10(?):897600. doi: 10.3389/fpubh.2022.897600. [PMID: 35619815]
  • Hsin-Yu Huang, Kai-Yueh Liao, Wei-Yau Shia, Chao-Chin Chang, Hsien-Chi Wang. Effect of administering dexmedetomidine with or without atropine on cardiac troponin I level in isoflurane-anesthetized dogs. The Journal of veterinary medical science. 2021 Dec; 83(12):1869-1876. doi: 10.1292/jvms.20-0657. [PMID: 34629333]
  • Samah M El Sohafy, Eman Shawky, Shaimaa M Sallam. Effect of ontogeny on the content of the hallucinogenic alkaloids atropine and scopolamine in the different organs of some Solanaceae plants. Natural product research. 2021 Dec; 35(24):5894-5898. doi: 10.1080/14786419.2020.1800698. [PMID: 32748646]
  • Małgorzata Gołąb, Martyna Przybyłowska, Petr Kubáň, Petra Itterheimová, Michał Woźniakiewicz. Development of CE-C4D Method for Determination Tropane Alkaloids. Molecules (Basel, Switzerland). 2021 Sep; 26(19):. doi: 10.3390/molecules26195749. [PMID: 34641293]
  • Rosa Linares, Xóchitl N Acuña, Gabriela Rosas, Elizabeth Vieyra, Deyra A Ramírez, Andrea Chaparro, Julieta A Espinoza, Roberto Domínguez, Leticia Morales-Ledesma. Participation of the Cholinergic System in the Development of Polycystic Ovary Syndrome. Molecules (Basel, Switzerland). 2021 Sep; 26(18):. doi: 10.3390/molecules26185506. [PMID: 34576975]
  • Zi-Yang Chan, Premanand Krishnan, Sayed Mohammadhossein Modaresi, Ling-Wei Hii, Chun-Wai Mai, Wei-Meng Lim, Chee-Onn Leong, Yun-Yee Low, Soon-Kit Wong, Kien-Thai Yong, Alyssa Zi-Xin Leong, Mei-Kee Lee, Kang-Nee Ting, Kuan-Hon Lim. Monomeric, Dimeric, and Trimeric Tropane Alkaloids from Pellacalyx saccardianus. Journal of natural products. 2021 08; 84(8):2272-2281. doi: 10.1021/acs.jnatprod.1c00374. [PMID: 34342431]
  • Q Chen, Z Jiang, J Zhang, L Cao, Z Chen. Arecoline hydrobromide enhances jejunum smooth muscle contractility via voltage-dependent potassium channels in W/Wv mice. Physiological research. 2021 07; 70(3):437-446. doi: 10.33549/physiolres.934557. [PMID: 33982580]
  • Alex Christoff, Xinxing Guo, Michael X Repka. Remote Pediatric Ophthalmology and Adult Strabismus during the COVID-19 Pandemic. Journal of binocular vision and ocular motility. 2021 Jul; 71(3):110-117. doi: NULL. [PMID: 34348581]
  • Sakib Aman, Shrebash Paul, Fazle Rabbi Chowdhury. Management of Organophosphorus Poisoning: Standard Treatment and Beyond. Critical care clinics. 2021 Jul; 37(3):673-686. doi: 10.1016/j.ccc.2021.03.011. [PMID: 34053713]
  • Jia-Ruei Yu, Yi-Chou Hou, Jen-Fen Fu, I-Kuan Wang, Ming-Jen Chan, Chao-Yu Chen, Cheng-Hao Weng, Wen-Hung Huang, Huang-Yu Yang, Ching-Wei Hsu, Tzung-Hai Yen. Outcomes of elderly patients with organophosphate intoxication. Scientific reports. 2021 06; 11(1):11615. doi: 10.1038/s41598-021-91230-2. [PMID: 34079035]
  • Mariana Koetz, Luiz C Klein-Junior, Marí C Santos, Thamires A da Silva, Natally S B Toson, Amélia T Henriques. An ultrasound assisted extraction-solid-phase extraction-ultra-performance liquid chromatography combined strategy for atropine determination in Atropa belladonna leaves. Biomedical chromatography : BMC. 2021 May; 35(5):e5053. doi: 10.1002/bmc.5053. [PMID: 33314218]
  • M H Zhang, S Z Zhao, X X Tian, G Q Fu, B L Wang. [Factors affecting the recovery of cholinesterase activity in patients with acute chlorpyrifos poisoning]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2021 Apr; 39(4):286-288. doi: 10.3760/cma.j.cn121094-20200619-00348. [PMID: 33910290]
  • Vincent Courdavault, Julien Cassereau, Nicolas Papon. Engineered Microbes for Producing Anticholinergics. Chembiochem : a European journal of chemical biology. 2021 04; 22(8):1368-1370. doi: 10.1002/cbic.202000757. [PMID: 33215811]
  • L Ström, F Dalin, M Domberg, C Stenlund, U Bondesson, M Hedeland, P-L Toutain, C Ekstrand. Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility. BMC veterinary research. 2021 Apr; 17(1):149. doi: 10.1186/s12917-021-02847-4. [PMID: 33827566]
  • Bandar Ali Alyami, Suneela Akhtar, - Alamgeer, Taseer Ahmad, Ali Omar Alqarni, Yahya Saeed Alqahtani, Mater Hussen Mahnashi, Sumera Qasim, Hafiz Muhammad Irfan, Muhammad Akram, Humayun Riaz, Rukhsana Anwar. Evaluation of phytochemical, anti-oxidant and cardiac depressant effect of Rumex dentatus by using Langendorff's isolated heart apparatus. Pakistan journal of pharmaceutical sciences. 2021 Mar; 34(2(Supplementary)):671-677. doi: ". [PMID: 34275801]
  • Lingjiang Zeng, Qiaozhuo Zhang, Chunxue Jiang, Yueyue Zheng, Youwei Zuo, Jianbo Qin, Zhihua Liao, Hongping Deng. Development of Atropa belladonna L. Plants with High-Yield Hyoscyamine and without Its Derivatives Using the CRISPR/Cas9 System. International journal of molecular sciences. 2021 Feb; 22(4):. doi: 10.3390/ijms22041731. [PMID: 33572199]
  • Zile Wang, Pimiao Zheng, Jianyi Wang, Shuang He, Zhenhui Ren, Yanfang Zhang, Jincheng Xiong, Haiyang Jiang. Indirect competitive enzyme-linked immunosorbent assay based on a broad-spectrum monoclonal antibody for tropane alkaloids detection in pig urine, pork and cereal flours. Food chemistry. 2021 Feb; 337(?):127617. doi: 10.1016/j.foodchem.2020.127617. [PMID: 32799156]
  • Jiska Kentrop, Vladimir Savransky, Steven D Klaassen, Tomas van Groningen, Sara Bohnert, Alex S Cornelissen, Laura Cochrane, John Barry, Marloes J A Joosen. Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride co-formulation against VX in a guinea pig model. Regulatory toxicology and pharmacology : RTP. 2021 Feb; 119(?):104823. doi: 10.1016/j.yrtph.2020.104823. [PMID: 33212192]
  • Suzhen Wang, Jie Wang, Ningli Wang. Combined Orthokeratology with Atropine for Children with Myopia: A Meta-Analysis. Ophthalmic research. 2021; 64(5):723-731. doi: 10.1159/000510779. [PMID: 32781450]
  • Yang Lv, Hongyu Liang, Jun Li, Xiuxiu Li, Xiaohui Tang, Songyu Gao, Hao Zou, Jing Zhang, Mei Wang, Liang Xiao. Central inhibition prevents the in vivo acute toxicity of harmine in mice. The Journal of toxicological sciences. 2021; 46(6):289-301. doi: 10.2131/jts.46.289. [PMID: 34078836]
  • Oluwaseyi K Wakeel, Abraham I Abe, Oluropo B Awosan, Mokaila K Olapade, Temitope J Olatoyan-Layonu, Olugbenga A Olowe, Oluwaseyi A Adeyeba. Anti-Nociceptive and Anti-Inflammatory Effects of Stem Bark Extract of Ficus Capensis Thunb (Moraceae) by Bioactivity Fractionation. Anti-inflammatory & anti-allergy agents in medicinal chemistry. 2021; 20(2):206-218. doi: 10.2174/1871523019666200825194616. [PMID: 32842947]
  • Wilfred A Abia, Holly Montgomery, Anne P Nugent, Christopher T Elliott. Tropane alkaloid contamination of agricultural commodities and food products in relation to consumer health: Learnings from the 2019 Uganda food aid outbreak. Comprehensive reviews in food science and food safety. 2021 01; 20(1):501-525. doi: 10.1111/1541-4337.12664. [PMID: 33443796]
  • Ingo Hartter, Daniela Remane, Christian Rabe, Dirk K Wissenbach, Frank T Peters, Florian Eyer. Surviving chlormequat poisoning - pharmacokinetics and the role of atropine. Clinical toxicology (Philadelphia, Pa.). 2021 01; 59(1):74-76. doi: 10.1080/15563650.2020.1758326. [PMID: 32336166]
  • Hae Ri Yum, Shin Hae Park, Sun Young Shin. Influence of coronavirus disease 2019 on myopic progression in children treated with low-concentration atropine. PloS one. 2021; 16(9):e0257480. doi: 10.1371/journal.pone.0257480. [PMID: 34520481]
  • S U Xu, Jinhai Zhai, K E Xu, Xingguo Zuo, Chenghua Wu, Tao Lin, L I Zeng. M1 macrophages-derived exosomes miR-34c-5p regulates interstitial cells of Cajal through targeting SCF. Journal of biosciences. 2021; 46(?):. doi: . [PMID: 34544909]
  • Joe-Anthony Rotella, Shaun L Greene, Zeff Koutsogiannis, Andis Graudins, Yit Hung Leang, Kelvin Kuan, Helen Baxter, Elyssia Bourke, Anselm Wong. Treatment for beta-blocker poisoning: a systematic review. Clinical toxicology (Philadelphia, Pa.). 2020 10; 58(10):943-983. doi: 10.1080/15563650.2020.1752918. [PMID: 32310006]
  • Heena Garg. Can glycopyrrolate come to the airway rescue in Covid-19 patients?. Journal of clinical anesthesia. 2020 09; 64(?):109843. doi: 10.1016/j.jclinane.2020.109843. [PMID: 32361688]
  • Prashanth Srinivasan, Christina D Smolke. Biosynthesis of medicinal tropane alkaloids in yeast. Nature. 2020 09; 585(7826):614-619. doi: 10.1038/s41586-020-2650-9. [PMID: 32879484]
  • Hiroya Mizutani, Fukumitsu Sakakibara, Eiji Sasaki. TAS-303 Ameliorates Carbachol-Induced Detrusor Overactivity in Rats, Revealing Its Therapeutic Potential for Overactive Bladder. The Journal of pharmacology and experimental therapeutics. 2020 07; 374(1):84-92. doi: 10.1124/jpet.119.264572. [PMID: 32332112]
  • Hira Asif, - Alamgeer, Muhammad Ishfaq Ahmad, Nasser Hadal Alotaibi, Khalid Saad Alharbi, Syed Nasir Abbas Bukhari, Hammad Saleem, Marcello Locatelli. Phytochemical analysis and reappraisal of diuretic activity of Delphinium brunonianum Royle and its mode of action in experimental rats. Pakistan journal of pharmaceutical sciences. 2020 Jul; 33(4(Supplementary)):1833-1838. doi: NULL. [PMID: 33612467]
  • Durdana Shah, Azra N Kamili, Aijaz A Wani, Umer Majeed, Zubair Ahmad Wani, Nasreena Sajjad, Parvaiz Ahmad. Promoting the accumulation of scopolamine and hyoscyamine in Hyoscyamus niger L. through EMS based mutagenesis. PloS one. 2020; 15(5):e0231355. doi: 10.1371/journal.pone.0231355. [PMID: 32437389]
  • A B Olorukooba, S Odoma. Elucidation of the possible mechanism of analgesic action of methanol stem bark extract of Uapaca togoensis pax in mice. Journal of ethnopharmacology. 2019 Dec; 245(?):112156. doi: 10.1016/j.jep.2019.112156. [PMID: 31415847]
  • Zhen Wang, Mingyi Li, Lu Liu, Bin Geng. Muscarinic M1 and M2 receptor subtypes play opposite roles in LPS-induced septic shock. Pharmacological reports : PR. 2019 Dec; 71(6):1108-1114. doi: 10.1016/j.pharep.2019.06.005. [PMID: 31634798]
  • Tycho J Olgers, Jan C Ter Maaten, Daan J Touw. Remember Atropine for 'Killer B's'. The Journal of emergency medicine. 2019 11; 57(5):731. doi: 10.1016/j.jemermed.2018.09.061. [PMID: 31761009]
  • Eva Gatineau, Ming C Gong, Frédérique Yiannikouris. Soluble Prorenin Receptor Increases Blood Pressure in High Fat-Fed Male Mice. Hypertension (Dallas, Tex. : 1979). 2019 10; 74(4):1014-1020. doi: 10.1161/hypertensionaha.119.12906. [PMID: 31378099]
  • Luísa Nathália Bolda Mariano, Thaise Boeing, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Valdir Cechinel-Filho, Rivaldo Niero, Luisa Mota da Silva, Priscila de Souza, Sergio Faloni de Andrade. 1,3,5,6-Tetrahydroxyxanthone, a natural xanthone, induces diuresis and saluresis in normotensive and hypertensive rats. Chemico-biological interactions. 2019 Sep; 311(?):108778. doi: 10.1016/j.cbi.2019.108778. [PMID: 31377058]
  • Fan Wu, Haixia Duan, Yaying Xie. Preventive Effects of Dexmedetomidine on Renal Dysfunction and Hemodynamic Stability in Malignant Obstructive Jaundice Patients During Peri-Operative Period. Medical science monitor : international medical journal of experimental and clinical research. 2019 Sep; 25(?):6782-6787. doi: 10.12659/msm.916329. [PMID: 31498783]
  • Pradeep Paudel, Su Hui Seong, Hyun Ah Jung, Jae Sue Choi. Characterizing fucoxanthin as a selective dopamine D3/D4 receptor agonist: Relevance to Parkinson's disease. Chemico-biological interactions. 2019 Sep; 310(?):108757. doi: 10.1016/j.cbi.2019.108757. [PMID: 31323226]
  • Jawad Zaheer, Qazi Najam-Us-Saqib, Asif Mehmmod Hashmi, Muhammad Mukhtiar, Sadia Zafar, Muhammad Riaz, Ghulam Rasool, Muhammad Akram, Syed Muhammad-Ali Shah, Saher Rahat, Faid Said Khan. Ex-vivo abortifacient activity of Androsace foliosa n-hexane leaves extract on isolated rabbit uterus. Pakistan journal of pharmaceutical sciences. 2019 Sep; 32(5(Supplementary)):2333-2339. doi: . [PMID: 31894063]
  • Kilambi Pundarikakshudu, Anil Kumar Sharma, Chaitanya J Bhatt, Niranjan S Kanaki. Development and Validation of a High-Performance Thin-Layer Chromatographic (HPTLC) Method for Simultaneous Quantification of Reserpine, Atropine, and Piperine in Sarpagandha Ghanvati, a Classical Ayurvedic Preparation. Journal of AOAC International. 2019 Jul; 102(4):1021-1026. doi: 10.5740/jaoacint.18-0382. [PMID: 30558695]
  • Itsuka Hirano, Hitomi Iida, Yasuaki Ito, Ho-Dong Park, Koichi Takahashi. Effects of light conditions on growth and defense compound contents of Datura inoxia and D. stramonium. Journal of plant research. 2019 Jul; 132(4):473-480. doi: 10.1007/s10265-019-01111-z. [PMID: 31020486]
  • Zeina Harhous, Sally Badawi, Noelle Gallo Bona, Bruno Pillot, Lionel Augeul, Melanie Paillard, George W Booz, Emmanuelle Canet-Soulas, Michel Ovize, Mazen Kurdi, Gabriel Bidaux. Critical appraisal of STAT3 pattern in adult cardiomyocytes. Journal of molecular and cellular cardiology. 2019 06; 131(?):91-100. doi: 10.1016/j.yjmcc.2019.04.021. [PMID: 31022374]
  • Lorena R Braid, Catherine A Wood, Barry N Ford. Human umbilical cord perivascular cells: A novel source of the organophosphate antidote butyrylcholinesterase. Chemico-biological interactions. 2019 May; 305(?):66-78. doi: 10.1016/j.cbi.2019.03.022. [PMID: 30926319]
  • Anupam Ranjan, Nayer Jamshed, Praveen Aggarwal, Vibhor Upadhyay. Fasciculating toxicity. The American journal of emergency medicine. 2019 04; 37(4):798.e1-798.e2. doi: 10.1016/j.ajem.2019.01.033. [PMID: 30686539]
  • Seang-Mei Saw, Saiko Matsumura, Quan V Hoang. Prevention and Management of Myopia and Myopic Pathology. Investigative ophthalmology & visual science. 2019 02; 60(2):488-499. doi: 10.1167/iovs.18-25221. [PMID: 30707221]
  • Alciene Almeida Siqueira, Alexandre Frinhani Cunha, Graziany Leite Moreira Marques, Igor Simões Assunção Felippe, Vitor Sampaio Minassa, Thallis Coelho da Silva Gramelich, Maria Aparecida Cicilini, Tamara Andrea Alarcon, Rita Gomes Wanderley Pires, Karla Nivea Sampaio, Vanessa Beijamini. Atropine counteracts the depressive-like behaviour elicited by acute exposure to commercial chlorpyrifos in rats. Neurotoxicology and teratology. 2019 Jan; 71(?):6-15. doi: 10.1016/j.ntt.2018.11.002. [PMID: 30458229]
  • Marloes J A Joosen, Steven D Klaassen, Elwin Verheij, Tomas van Groningen, Alex S Cornelissen, Mario H Skiadopoulos, Laura Cochrane, Jeff D Shearer. Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs. Chemico-biological interactions. 2018 Dec; 296(?):34-42. doi: 10.1016/j.cbi.2018.09.004. [PMID: 30217478]
  • Szymon Chowański, Joanna Pacholska-Bogalska, Grzegorz Rosiński. Cholinergic Agonists and Antagonists Have an Effect on the Metabolism of the Beetle Tenebrio Molitor. Molecules (Basel, Switzerland). 2018 Dec; 24(1):. doi: 10.3390/molecules24010017. [PMID: 30577556]
  • Boualem Harfi, Lakhdar Khelifi, Majda Khelifi-Slaoui, Corinne Assaf-Ducrocq, Eric Gontier. Tropane alkaloids GC/MS analysis and low dose elicitors' effects on hyoscyamine biosynthetic pathway in hairy roots of Algerian Datura species. Scientific reports. 2018 12; 8(1):17951. doi: 10.1038/s41598-018-36625-4. [PMID: 30560886]
  • Yunfei Ma, Lianfang Du, Fan Li, Zhengqiu Zhu. Use of atropine in four-dimensional hysterosalpingo-contrast sonography: Does it suppress pain during infertility examination?. Clinical and experimental pharmacology & physiology. 2018 12; 45(12):1334-1340. doi: 10.1111/1440-1681.12919. [PMID: 29381225]
  • Harald John, Michael Rychlik, Horst Thiermann, Christian Schmidt. Simultaneous quantification of atropine and scopolamine in infusions of herbal tea and Solanaceae plant material by matrix-assisted laser desorption/ionization time-of-flight (tandem) mass spectrometry. Rapid communications in mass spectrometry : RCM. 2018 Nov; 32(22):1911-1921. doi: 10.1002/rcm.8264. [PMID: 30117208]
  • Luísa Nathália Bolda Mariano, Thaise Boeing, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Valdir Cechinel-Filho, Rivaldo Niero, Luisa Mota da Silva, Priscila de Souza, Sérgio Faloni de Andrade. Preclinical evaluation of the diuretic and saluretic effects of (-)-epicatechin and the result of its combination with standard diuretics. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Nov; 107(?):520-525. doi: 10.1016/j.biopha.2018.08.045. [PMID: 30114635]
  • Wataru Suto, Yusuke Ando, Takahiro Hirabayashi, Fumiko Takenoya, Seiji Shioda, Junzo Kamei, Hiroyasu Sakai, Yoshihiko Chiba. Prostaglandin D₂ Induces Ca2+ Sensitization of Contraction without Affecting Cytosolic Ca2+ Level in Bronchial Smooth Muscle. International journal of molecular sciences. 2018 Oct; 19(10):. doi: 10.3390/ijms19103036. [PMID: 30301147]
  • Jesús Marín-Sáez, Roberto Romero-González, Antonia Garrido Frenich, Francisco Javier Egea-González. Screening of drugs and homeopathic products from Atropa belladonna seed extracts: Tropane alkaloids determination and untargeted analysis. Drug testing and analysis. 2018 Oct; 10(10):1579-1589. doi: 10.1002/dta.2416. [PMID: 29808589]
  • Yi Yang, Cui-Ping Zhang, Xing Liu, Yue Wei, Neng-Biao Wu. [Effects of methyl jasmonate on metabolism of topical alkaloids and expression of relate genes in Atropa belladonna]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Oct; 43(20):4044-4049. doi: 10.19540/j.cnki.cjcmm.20180726.018. [PMID: 30486528]
  • M E Price, C L Whitmore, J E H Tattersall, A C Green, H Rice. Efficacy of the antinicotinic compound MB327 against soman poisoning - Importance of experimental end point. Toxicology letters. 2018 Sep; 293(?):167-171. doi: 10.1016/j.toxlet.2017.11.006. [PMID: 29127032]
  • C Whitmore, A R Cook, T Mann, M E Price, E Emery, N Roughley, D Flint, S Stubbs, S J Armstrong, H Rice, J E H Tattersall. The efficacy of HI-6 DMS in a sustained infusion against percutaneous VX poisoning in the guinea-pig. Toxicology letters. 2018 Sep; 293(?):207-215. doi: 10.1016/j.toxlet.2017.11.007. [PMID: 29129798]
  • Ritesh G Menezes, Muhammad Shariq Usman, Syed Ather Hussain, Mohammed Madadin, Tariq Jamal Siddiqi, Huda Fatima, Pradhum Ram, Syed Bilal Pasha, S Senthilkumaran, Tooba Qadir Fatima, Sushil Allen Luis. Cerbera odollam toxicity: A review. Journal of forensic and legal medicine. 2018 Aug; 58(?):113-116. doi: 10.1016/j.jflm.2018.05.007. [PMID: 29778924]
  • Sara Bocanegra-Rodríguez, Neus Jornet-Martínez, Carmen Molins-Legua, Pilar Campíns-Falcó. Delivering Inorganic and Organic Reagents and Enzymes from Zein and Developing Optical Sensors. Analytical chemistry. 2018 07; 90(14):8501-8508. doi: 10.1021/acs.analchem.8b01338. [PMID: 29932323]
  • Gunnar F Kwakye, Jennifer Jiménez, Jessica A Jiménez, Michael Aschner. Atropa belladonna neurotoxicity: Implications to neurological disorders. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Jun; 116(Pt B):346-353. doi: 10.1016/j.fct.2018.04.022. [PMID: 29653183]
  • Elena S Catap, Markyn Jared L Kho, Maria Rexie R Jimenez. In vivo nonspecific immunomodulatory and antispasmodic effects of common purslane (Portulaca oleracea Linn.) leaf extracts in ICR mice. Journal of ethnopharmacology. 2018 Apr; 215(?):191-198. doi: 10.1016/j.jep.2018.01.009. [PMID: 29325915]
  • Shuang Guo, Yi Yang, Xing Liu, Neng-Biao Wu. [Mechanism exploration on nitrogen metabolism and secondary metabolism in Atropa belladonna hairy roots treated with yeast extract]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Apr; 43(8):1610-1617. doi: 10.19540/j.cnki.cjcmm.20180201.008. [PMID: 29751707]
  • Eeva J Vainio, Jaana Jurvansuu, Rafiqul Hyder, Muhammad Kashif, Tuula Piri, Tero Tuomivirta, Anna Poimala, Ping Xu, Salla Mäkelä, Dina Nitisa, Jarkko Hantula. Heterobasidion Partitivirus 13 Mediates Severe Growth Debilitation and Major Alterations in the Gene Expression of a Fungal Forest Pathogen. Journal of virology. 2018 03; 92(5):. doi: 10.1128/jvi.01744-17. [PMID: 29237832]
  • Maria G Zizzo, Monica Frinchi, Domenico Nuzzo, Hyder A Jinnah, Giuseppa Mudò, Daniele F Condorelli, Francesco Caciagli, Renata Ciccarelli, Patrizia Di Iorio, Flavia Mulè, Natale Belluardo, Rosa Serio. Altered gastrointestinal motility in an animal model of Lesch-Nyhan disease. Autonomic neuroscience : basic & clinical. 2018 03; 210(?):55-64. doi: 10.1016/j.autneu.2017.12.007. [PMID: 29305058]
  • Songyan Wang, Lauren Z Oestricker, Michael J Wallendorf, Karin Sterl, Judit Dunai, C Rachel Kilpatrick, Bruce W Patterson, Dominic N Reeds, Burton M Wice. Cholinergic signaling mediates the effects of xenin-25 on secretion of pancreatic polypeptide but not insulin or glucagon in humans with impaired glucose tolerance. PloS one. 2018; 13(2):e0192441. doi: 10.1371/journal.pone.0192441. [PMID: 29466430]
  • Kathrin Laura Kohnen, Selahaddin Sezgin, Michael Spiteller, Hansjörg Hagels, Oliver Kayser. Localization and Organization of Scopolamine Biosynthesis in Duboisia myoporoides R. Br. Plant & cell physiology. 2018 Jan; 59(1):107-118. doi: 10.1093/pcp/pcx165. [PMID: 29095998]
  • Ashton D Lesiak, Kristen L Fowble, Rabi A Musah. A Rapid, High-Throughput Validated Method for the Quantification of Atropine in Datura stramonium Seeds Using Direct Analysis in Real Time-High Resolution Mass Spectrometry (DART-HRMS). Methods in molecular biology (Clifton, N.J.). 2018; 1810(?):207-215. doi: 10.1007/978-1-4939-8579-1_18. [PMID: 29974430]
  • Yue Wei, Cui-Ping Zhang, Shuang Guo, Ke-Huan Lu, Xing Liu, Yi Yang, Zhi-Hua Liao, Neng-Biao Wu. [Effects of nitrogen form on accumulation of alkaloids and expression of relative genes in Atropa belladonna]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Jan; 43(1):72-78. doi: 10.19540/j.cnki.cjcmm.2018.0003. [PMID: 29552814]
  • Ming Zhang, Misha Vrolijk, Guido R M M Haenen. The Screening of Anticholinergic Accumulation by Traditional Chinese Medicine. International journal of molecular sciences. 2017 Dec; 19(1):. doi: 10.3390/ijms19010018. [PMID: 29267212]
  • Rita F Wehrman, Anne J Gemensky-Metzler, Ashley E Zibura, Amelia B Nyhart, Heather L Chandler. Objective evaluation of the systemic effects of topical application of 1\% atropine sulfate ophthalmic solution in healthy horses. Journal of the American Veterinary Medical Association. 2017 Dec; 251(11):1324-1330. doi: 10.2460/javma.251.11.1324. [PMID: 29154707]
  • P Kumar, D Swami, D P Nagar, K P Singh, J Acharya, H N Karade, R Yadav. In vivo protection studies of bis-quaternary 2-(hydroxyimino)- N-(pyridin-3-yl) acetamide derivatives (HNK oximes) against tabun and soman poisoning in Swiss albino mice. Human & experimental toxicology. 2017 Dec; 36(12):1270-1285. doi: 10.1177/0960327116685888. [PMID: 28078916]
  • Thaise Boeing, Luísa Mota da Silva, Marihá Mariott, Sérgio Faloni de Andrade, Priscila de Souza. Diuretic and natriuretic effect of luteolin in normotensive and hypertensive rats: Role of muscarinic acetylcholine receptors. Pharmacological reports : PR. 2017 Dec; 69(6):1121-1124. doi: 10.1016/j.pharep.2017.05.010. [PMID: 29128789]