Norephedrine (BioDeep_00000397895)

Main id: BioDeep_00000002012

 


代谢物信息卡片


2-Amino-1-phenyl-1-propanol

化学式: C9H13NO (151.0997088)
中文名称: 左旋去甲麻黄碱, 去甲基麻黄素
谱图信息: 最多检出来源 Homo sapiens(urine) 75%

分子结构信息

SMILES: CC(C(C1=CC=CC=C1)O)N
InChI: InChI=1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3

描述信息

R - Respiratory system > R01 - Nasal preparations > R01B - Nasal decongestants for systemic use > R01BA - Sympathomimetics
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D019141 - Respiratory System Agents > D014663 - Nasal Decongestants
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
D019440 - Anti-Obesity Agents > D001067 - Appetite Depressants
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3684

同义名列表

4 个代谢物同义名

(1S,2R)-(+)-Norephedrine; phenylpropanolamine; Norephedrine; 2-Amino-1-phenyl-1-propanol



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

26 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jian Guo, Zhiping He, Chao Ma, Wanting Li, Jiaoyu Wang, Fucheng Lin, Xingquan Liu, Ling Li. Evaluation of cold plasma for decontamination of molds and mycotoxins in rice grain. Food chemistry. 2023 Feb; 402(?):134159. doi: 10.1016/j.foodchem.2022.134159. [PMID: 36137380]
  • Sharoen Y M Lim, Jason Siau Ee Loo, Mustafa Alshagga, Mohammed A Alshawsh, Chin E Ong, Yan Pan. Protein-Ligand Identification and In Vitro Inhibitory Effects of Cathine on 11 Major Human Drug Metabolizing Cytochrome P450s. International journal of toxicology. 2022 Sep; 41(5):355-366. doi: 10.1177/10915818221103790. [PMID: 35658727]
  • Hsin-Yi Hung, Shih-Min Lin, Chia-Ying Li, Sio-Hong Lam, Yu-Yi Chan, Meei-Jen Liou, Po-Chuen Shieh, Fu-An Chen, Ping-Chung Kuo, Tian-Shung Wu. A Rapid and Feasible 1H-NMR Quantification Method of Ephedrine Alkaloids in Ephedra Herbal Preparations. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061599. [PMID: 33805790]
  • Elisabeth Pendl, Udo Pauritsch, Manfred Kollroser, Martin G Schmid. Determination of cathinone and cathine in Khat plant material by LC-MS/MS: Fresh vs. dried leaves. Forensic science international. 2021 Feb; 319(?):110658. doi: 10.1016/j.forsciint.2020.110658. [PMID: 33370655]
  • Stamatios Angelopoulos, Orestis Ioannidis, Nikolaos Ouzounidis, Chrysovalantis Mariorakis, Christos Chatzakis, Savvas Symeonidis, Ioannis Mantzoros, Efstathios Kotidis, Manousos George Pramateftakis, Konstantinos Tsalis. Variations of plasma levels of insulin, glucagon, amylase and glucose and histopathological lesions of pancreatic tissue after complete elimination of exocrine pancreatic function with surgical ligation versus prolamine occlusion. Annali italiani di chirurgia. 2021; 92(?):441-451. doi: . [PMID: 34524119]
  • Rutao Lin, Zixu Wang, Jing Cao, Ting Gao, Yulan Dong, Yaoxing Chen. Role of melatonin in intestinal mucosal injury induced by restraint stress in mice. Pharmaceutical biology. 2020 Dec; 58(1):342-351. doi: 10.1080/13880209.2020.1750659. [PMID: 32298156]
  • Matthew D Lynes, Sean D Kodani, Yu-Hua Tseng. Lipokines and Thermogenesis. Endocrinology. 2019 10; 160(10):2314-2325. doi: 10.1210/en.2019-00337. [PMID: 31504387]
  • Hong-Li Chou, Li Tian, Masako Fukuda, Toshihiro Kumamaru, Thomas W Okita. The Role of RNA-Binding Protein OsTudor-SN in Post-Transcriptional Regulation of Seed Storage Proteins and Endosperm Development. Plant & cell physiology. 2019 Oct; 60(10):2193-2205. doi: 10.1093/pcp/pcz113. [PMID: 31198964]
  • Li Tian, Hong-Li Chou, Laining Zhang, Thomas W Okita. Targeted Endoplasmic Reticulum Localization of Storage Protein mRNAs Requires the RNA-Binding Protein RBP-L. Plant physiology. 2019 03; 179(3):1111-1131. doi: 10.1104/pp.18.01434. [PMID: 30659066]
  • Yu A Kupriyanov, G R Kasyan, D Yu Pushkar. [A role of fesoterodine in treatment of overactive bladder]. Urologiia (Moscow, Russia : 1999). 2018 Dec; ?(6):155-162. doi: 10.18565/urology.2018.6.155-162. [PMID: 30742396]
  • Worku Bedada, Fernando de Andrés, Ephrem Engidawork, Jemal Hussein, Adrián LLerena, Eleni Aklillu. Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations. Scientific reports. 2018 08; 8(1):12726. doi: 10.1038/s41598-018-31191-1. [PMID: 30143732]
  • Eeva J Vainio, Jaana Jurvansuu, Rafiqul Hyder, Muhammad Kashif, Tuula Piri, Tero Tuomivirta, Anna Poimala, Ping Xu, Salla Mäkelä, Dina Nitisa, Jarkko Hantula. Heterobasidion Partitivirus 13 Mediates Severe Growth Debilitation and Major Alterations in the Gene Expression of a Fungal Forest Pathogen. Journal of virology. 2018 03; 92(5):. doi: 10.1128/jvi.01744-17. [PMID: 29237832]
  • María José Ojeda-Montes, Andrea Ardid-Ruiz, Sarah Tomás-Hernández, Aleix Gimeno, Adrià Cereto-Massagué, Raúl Beltrán-Debón, Miquel Mulero, Santiago Garcia-Vallvé, Gerard Pujadas, Cristina Valls. Ephedrine as a lead compound for the development of new DPP-IV inhibitors. Future medicinal chemistry. 2017 12; 9(18):2129-2146. doi: 10.4155/fmc-2017-0080. [PMID: 29172693]
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  • Zhi-Cheng Yao, Si-Cong Chen, Zeeshan Ahmad, Jie Huang, Ming-Wei Chang, Jing-Song Li. Essential Oil Bioactive Fibrous Membranes Prepared via Coaxial Electrospinning. Journal of food science. 2017 Jun; 82(6):1412-1422. doi: 10.1111/1750-3841.13723. [PMID: 28471056]
  • Takeshi Funakoshi, Toshihiko Aki, Masateru Tajiri, Kana Unuma, Koichi Uemura. Necroptosis-like Neuronal Cell Death Caused by Cellular Cholesterol Accumulation. The Journal of biological chemistry. 2016 Nov; 291(48):25050-25065. doi: 10.1074/jbc.m116.727404. [PMID: 27756839]
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  • Chuixiu Huang, Knut Fredrik Seip, Astrid Gjelstad, Stig Pedersen-Bjergaard. Electromembrane extraction of polar basic drugs from plasma with pure bis(2-ethylhexyl) phosphite as supported liquid membrane. Analytica chimica acta. 2016 Aug; 934(?):80-7. doi: 10.1016/j.aca.2016.06.002. [PMID: 27506347]
  • Eun Sook Jeong, Ki Hun Kim, Eunju Cha, Oh-Seung Kwon, Sangwon Cha, Jaeick Lee. Direct and rapid quantitation of ephedrines in human urine by paper spray ionization/high resolution mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Aug; 1028(?):237-241. doi: 10.1016/j.jchromb.2016.06.040. [PMID: 27393909]
  • Minaleshewa Atlabachew, Nelson Torto, Bhagwan Singh Chandravanshi, Mesfin Redi-Abshiro, Samuel Chigome, Kediemetse Mothibedi, Sandra Combrinck. A (-)-norephedrine-based molecularly imprinted polymer for the solid-phase extraction of psychoactive phenylpropylamino alkaloids from Khat (Catha edulis Vahl. Endl.) chewing leaves. Biomedical chromatography : BMC. 2016 Jul; 30(7):1007-1015. doi: 10.1002/bmc.3643. [PMID: 26531856]
  • Borbála Molnár, Blanka Fodor, Imre Boldizsár, Ibolya Molnár-Perl. Trimethylsilyl speciations of cathine, cathinone and norephedrine followed by gas chromatography mass spectrometry: Direct sample preparation and analysis of khatamines. Journal of chromatography. A. 2016 Apr; 1440(?):172-178. doi: 10.1016/j.chroma.2016.02.044. [PMID: 26928873]
  • J G Pallarés, Á López-Samanes, V E Fernández-Elías, R Aguado-Jiménez, J F Ortega, C Gómez, R Ventura, J Segura, R Mora-Rodríguez. Pseudoephedrine and circadian rhythm interaction on neuromuscular performance. Scandinavian journal of medicine & science in sports. 2015 Dec; 25(6):e603-12. doi: 10.1111/sms.12385. [PMID: 25515692]
  • Luísa C Carvalho, João L Coito, Silvana Colaço, Maurício Sangiogo, Sara Amâncio. Heat stress in grapevine: the pros and cons of acclimation. Plant, cell & environment. 2015 Apr; 38(4):777-89. doi: 10.1111/pce.12445. [PMID: 25211707]
  • Shuai Song, Qingfa Tang, Huiling Huo, Hancheng Li, Xuefeng Xing, Jiabo Luo. Simultaneous quantification and pharmacokinetics of alkaloids in Herba Ephedrae-Radix Aconiti Lateralis extracts. Journal of analytical toxicology. 2015 Jan; 39(1):58-68. doi: 10.1093/jat/bku113. [PMID: 25324527]
  • Nilesh B Patel. "Natural Amphetamine" Khat: A Cultural Tradition or a Drug of Abuse?. International review of neurobiology. 2015; 120(?):235-55. doi: 10.1016/bs.irn.2015.02.006. [PMID: 26070760]
  • Ravinder Earla, Santosh Kumar, Lei Wang, Steven Bosinger, Junhao Li, Ankit Shah, Mohitkumar Gangwani, Anantha Nookala, Xun Liu, Lu Cao, Austin Jackson, Peter S Silverstein, Howard S Fox, Weihua Li, Anil Kumar. Enhanced methamphetamine metabolism in rhesus macaque as compared with human: an analysis using a novel method of liquid chromatography with tandem mass spectrometry, kinetic study, and substrate docking. Drug metabolism and disposition: the biological fate of chemicals. 2014 Dec; 42(12):2097-108. doi: 10.1124/dmd.114.059378. [PMID: 25301936]
  • Hua Tang, Jian Chen, Yongfu Wang, Ting Yu, Changping Guo, Xiaoqi Liao. Combination of sacral neuromodulation and tolterodine for treatment of idiopathic overactive bladder in women: a clinical trial. Urology journal. 2014 Sep; 11(4):1800-5. doi: . [PMID: 25194079]
  • Xuri Wu, Mengdan Fei, Yong Chen, Zongqiang Wang, Yijun Chen. Enzymatic synthesis of L-norephedrine by coupling recombinant pyruvate decarboxylase and ω-transaminase. Applied microbiology and biotechnology. 2014 Sep; 98(17):7399-408. doi: 10.1007/s00253-014-5797-1. [PMID: 24818692]
  • Ximing Liu, Lu Fu, Wenwen Dai, Wei Liu, Jinlong Zhao, Yi Wu, Lengsheng Teng, Fengying Sun, Youxin Li. Design of transparent film-forming hydrogels of tolterodine and their effects on stratum corneum. International journal of pharmaceutics. 2014 Aug; 471(1-2):322-31. doi: 10.1016/j.ijpharm.2014.05.051. [PMID: 24882035]
  • Osamu Yamaguchi, Eiji Marui, Hidehiro Kakizaki, Yukio Homma, Yasuhiko Igawa, Masayuki Takeda, Osamu Nishizawa, Momokazu Gotoh, Masaki Yoshida, Osamu Yokoyama, Narihito Seki, Yasushi Ikeda, Sumito Ohkawa. Phase III, randomised, double-blind, placebo-controlled study of the β3-adrenoceptor agonist mirabegron, 50 mg once daily, in Japanese patients with overactive bladder. BJU international. 2014 Jun; 113(6):951-60. doi: 10.1111/bju.12649. [PMID: 24471907]
  • Chunlan Jin, Xinyao Zhou, Ran Pang. Effect of electroacupuncture combined with tolterodine on treating female mixed urinary incontinence. Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society. 2014 May; 41(3):268-72. doi: 10.1097/won.0000000000000025. [PMID: 24805179]
  • Yongil Yang, Andrew J Crofts, Naoko Crofts, Thomas W Okita. Multiple RNA binding protein complexes interact with the rice prolamine RNA cis-localization zipcode sequences. Plant physiology. 2014 Mar; 164(3):1271-82. doi: 10.1104/pp.113.234187. [PMID: 24488967]
  • Tahereh Eftekhar, Nastaran Teimoory, Elahe Miri, Abolghasem Nikfallah, Mahsa Naeimi, Mahsa Ghajarzadeh. Posterior tibial nerve stimulation for treating neurologic bladder in women: a randomized clinical trial. Acta medica Iranica. 2014; 52(11):816-21. doi: NULL. [PMID: 25415813]
  • Rong Yi, Sarah Zhao, Geoffrey Lam, Jasmeet Sandhu, Devan Loganathan, Barbara Morrissey. Detection and elimination profile of cathinone in equine after norephedrine (Propalin®) administration using a validated liquid chromatography-tandem mass spectrometry method. Analytical and bioanalytical chemistry. 2013 Dec; 405(30):9711-22. doi: 10.1007/s00216-013-7073-0. [PMID: 23954941]
  • Yang-Yun Wang, Guo-Wei Shi, Jia-Yang He, Yan-Bin Zhang. [Cardura monotherapy versus combination therapy of cardura and tolterodine L-tartrate tablets for II° ? benign prostatic hyperplasia with overactive bladder]. Zhonghua nan ke xue = National journal of andrology. 2013 Dec; 19(12):1099-102. doi: NULL. [PMID: 24432622]
  • Fengying Sun, Cheng Sui, Yulin Zhou, Ximing Liu, Yanan Shi, Yi Wu, Youxin Li. Preparation, characterization and pharmacological evaluation of tolterodine hydrogels for the treatment of overactive bladder. International journal of pharmaceutics. 2013 Sep; 454(1):532-8. doi: 10.1016/j.ijpharm.2013.07.041. [PMID: 23891744]
  • Chiu-Lin Wang, Chin-Hu Wu, Cheng-Min Liu, Ching-Ju Shen, Kun-Ling Lin, Cheng-Yu Long. Clinical and urodynamic effects of tolterodine in women with an overactive bladder. Taiwanese journal of obstetrics & gynecology. 2013 Sep; 52(3):381-4. doi: 10.1016/j.tjog.2012.06.001. [PMID: 24075377]
  • Fatma Gurdal, Mahmut Asirdizer, Rezzan Gulhan Aker, Senol Korkut, Yasemin Gocer, E Esra Kucukibrahimoglu, C Haluk Ince. Review of detection frequency and type of synthetic cannabinoids in herbal compounds analyzed by Istanbul Narcotic Department of the Council of Forensic Medicine, Turkey. Journal of forensic and legal medicine. 2013 Aug; 20(6):667-72. doi: 10.1016/j.jflm.2013.03.041. [PMID: 23910858]
  • Therese Bredholt, Elisabeth Ersvær, Bjarte Skoe Erikstein, André Sulen, Håkon Reikvam, Hans Jørgen Aarstad, Anne Christine Johannessen, Olav Karsten Vintermyr, Øystein Bruserud, Bjørn Tore Gjertsen. Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine. BMC pharmacology & toxicology. 2013 Jul; 14(?):35. doi: 10.1186/2050-6511-14-35. [PMID: 23845085]
  • Abdurrahman Karaman, Emine Samdancı, Sadegül Sayın, Ismail Karabulut, Ersin Fadıllıoglu. Effects of tolterodine and trospium chloride on renal damage induced by partial upper urinary tract obstruction. Urology. 2013 Jul; 82(1):194-200. doi: 10.1016/j.urology.2013.01.030. [PMID: 23453648]
  • Gabriella Roda, Vincenzo Liberti, Sebastiano Arnoldi, Antonella Argo, Chiara Rusconi, Sonia Suardi, Veniero Gambaro. Capillary electrophoretic and extraction conditions for the analysis of Catha edulis FORKS active principles. Forensic science international. 2013 May; 228(1-3):154-9. doi: 10.1016/j.forsciint.2013.02.034. [PMID: 23597752]
  • Chun-Hou Liao, Yu-Chen Kuo, Hann-Chorng Kuo. Predictors of successful first-line antimuscarinic monotherapy in men with enlarged prostate and predominant storage symptoms. Urology. 2013 May; 81(5):1030-3. doi: 10.1016/j.urology.2013.01.018. [PMID: 23506731]
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