(R)-mandelic Acid (BioDeep_00000000324)

 

Secondary id: BioDeep_00000265246, BioDeep_00000400462, BioDeep_00000400470, BioDeep_00000415763, BioDeep_00000860467

natural product human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


Sertraline impurity E, European Pharmacopoeia (EP) Reference Standard

化学式: C8H8O3 (152.0473418)
中文名称: (R)-(-)-扁桃酸, D-(-)-扁桃酸, D-苯羟乙酸, 扁桃酸, 扁桃酸
谱图信息: 最多检出来源 Viridiplantae(plant) 6.04%

分子结构信息

SMILES: C1=CC=C(C=C1)C(C(=O)O)O
InChI: InChI=1S/C8H8O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7,9H,(H,10,11)/t7-/m1/s1

描述信息

(R)-mandelic acid is the (R)-enantiomer of mandelic acid. It has a role as a human xenobiotic metabolite. It is a conjugate acid of a (R)-mandelate. It is an enantiomer of a (S)-mandelic acid.
(r)-Mandelic acid is a natural product found in Pisolithus tinctorius, Pisolithus arhizus, and other organisms with data available.
(R)-mandelic Acid, also known as (R)-2-Hydroxy-2-phenylacetic acid or (-)-(R)-Mandelate, is classified as a benzene or a Benzene derivative. Benzenes are aromatic compounds containing one monocyclic ring system consisting of benzene. (R)-mandelic Acid is considered to be soluble (in water) and acidic
The (R)-enantiomer of mandelic acid.
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID M068
D-(-)-Mandelic acid is a natural compound isolated from bitter almonds.
D-(-)-Mandelic acid is a natural compound isolated from bitter almonds.

同义名列表

99 个代谢物同义名

Sertraline impurity E, European Pharmacopoeia (EP) Reference Standard; (R)-(-)-Mandelic acid, ChiPros(R), produced by BASF, 99\\%; (R)-(-)-Mandelic acid, Vetec(TM) reagent grade, 98\\%; (2R)-Hydroxyphenylacetic Acid ((R)-Mandelic Acid); Benzeneacetic acid, .alpha.-hydroxy-, (.alpha.R)-; SERTRALINE HYDROCHLORIDE IMPURITY E [EP IMPURITY]; (R)-(-)-Mandelic acid, ReagentPlus(R), >=99\\%; Benzeneacetic acid, alpha-hydroxy-, (alphaR)-; D-(-)-Mandelic acid, puriss., >=99.0\\% (T); D-(-)-Mandelic acid, purum, >=98.0\\% (T); Benzeneacetic acid, alpha-hydroxy-, (R)-; Benzeneacetic acid, alpha-hydroxy-, (-)-; (-)-(R) alpha-hydroxybenzeneacetic acid; (-)-(R)alpha-hydroxybenzeneacetic acid; (2R)-2-oxidanyl-2-phenyl-ethanoic acid; (R)-.ALPHA.-HYDROXYBENZENEACETIC ACID; 08C65DF7-6DDF-44B3-9490-02A43D9D33C1; D-mandelic acid(R-(-)-mandelic acid); (R)-alpha-Hydroxybenzeneacetic acid; (2R)-2-hydroxy-2-phenyl-acetic acid; (R)-alpha-Hydroxyphenylacetic acid; (-)-alpha-Hydroxyphenylacetic acid; (2R)-2-hydroxy-2-phenylacetic acid; (2R)-hydroxy(phenyl)ethanoic acid; (R)-2-Hydroxy-2-phenylacetic acid; D,L-mandelic acid redetermination; Hydroxy-Phenyl-Acetic Acid Anion; (R)-a-Hydroxybenzeneacetic acid; L-2-Hydroxy-2-phenylacetic acid; (R)-alpha-Hydroxybenzeneacetate; (2R)-hydroxy(phenyl)acetic acid; (R)-Α-hydroxybenzeneacetic acid; (-)-alpha-Hydroxyphenylacetate; (-)-Α-hydroxyphenylacetic acid; (2R)-2-hydroxy-2-phenylacetate; (R)-alpha-Hydroxyphenylacetate; (R)-A-Hydroxyphenylacetic acid; (R)-Α-hydroxyphenylacetic acid; (R)-Hydroxy(phenyl)acetic acid; (-)-a-Hydroxyphenylacetic acid; (2R)-HYDROXYPHENYLACETIC ACID; (R)-2-Hydroxy-2-phenylacetate; Hydroxy-phenyl-acetate anion; (R)-Hydroxyphenylaceticacid; (R)-Α-hydroxybenzeneacetate; (R)-a-Hydroxybenzeneacetate; IWYDHOAUDWTVEP-SSDOTTSWSA-N; (R)-(-)-Mandelic acid, 98\\%; (-)-Α-hydroxyphenylacetate; (-)-a-Hydroxyphenylacetate; (R)-Α-hydroxyphenylacetate; (R)-a-Hydroxyphenylacetate; (r)-(-)-d-mandelic acid; D-2-Phenylglycolic acid; (R)-(-)-Amygdalic Acid; (R)-(-)- mandelic acid; (R)-(+)-mandelic acid; (-)-(R)-Mandelic acid; (R)-(-)-Mandelic acid; (L)-(+)-Mandelic acid; Sertraline impurity E; (r)-(-) mandelic acid; (r)(-)-mandelic acid; mandelic acid, (+-)-; Mandelic acid, (R)-; D-(-)-MANDELIC ACID; D-2-Phenylglycolate; R-(?)-Mandelic Acid; (-)-D-MANDELIC ACID; R-(-) Mandelic acid; R-(-)-Mandelic acid; D-(?)-Mandelic acid; D(-)-Mandelic acid; R(-)-Mandelic Acid; d - mandelic acid; (-)-Mandelic acid; Mandelic acid, D-; (-)-(R)-Mandelate; (r)-Mandelic acid; Maybridge1_004148; (R)-Mandelsaeure; D-Mandelic acid; UNII-PPL7YW1M9W; Tox21_112292_1; D(-)-mandelate; Oprea1_502663; (-)-mandelate; mandelic-acid; mandelic_acid; (R)-Mandelate; (R)-Mandelic; Tox21_112292; D-Mandelate; PPL7YW1M9W; 1mcz; 1mdl; RMN; αR-hydroxy-benzeneacetic acid; MANDELIC ACID



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Zhoutong Sun, Yuanyuan Ning, Lixia Liu, Yingmiao Liu, Bingbing Sun, Weihong Jiang, Chen Yang, Sheng Yang. Metabolic engineering of the L-phenylalanine pathway in Escherichia coli for the production of S- or R-mandelic acid. Microbial cell factories. 2011 Sep; 10(?):71. doi: 10.1186/1475-2859-10-71. [PMID: 21910908]
  • H J Hilderson, M J De Wolf, A R Lagrou, W S Dierick. Subcellular structure of bovine thyroid gland. A study on bovine thyroid membranes by buoyant-density-gradient centrifugation in a B-XIV zonal rotor. The Biochemical journal. 1975 Dec; 152(3):601-7. doi: 10.1042/bj1520601. [PMID: 5997]