2-Keto-L-gluconate (BioDeep_00000003201)
Secondary id: BioDeep_00000015327
human metabolite Endogenous
代谢物信息卡片
化学式: C6H10O7 (194.0427)
中文名称: 2-酮基-L-古龙酸
谱图信息:
最多检出来源 Homo sapiens(feces) 10.47%
分子结构信息
SMILES: C(C(C(C(C(=O)C(=O)O)O)O)O)O
InChI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-4,7-10H,1H2,(H,12,13)
描述信息
2-Keto-L-gluconate is a derivative of gluconic acid, which occurs naturally in fruit, honey and wine and is used as a food additive, an acidity regulator. It is also used in cleaning products where it helps cleaning up mineral deposits. It is a strong chelating agent, especially in alkaline solution. It chelates the anions of calcium, iron, aluminium, copper, and other heavy metals. [HMDB]
2-Keto-L-gluconate is a derivative of gluconic acid, which occurs naturally in fruit, honey and wine and is used as a food additive, an acidity regulator. It is also used in cleaning products where it helps cleaning up mineral deposits. It is a strong chelating agent, especially in alkaline solution. It chelates the anions of calcium, iron, aluminium, copper, and other heavy metals.
同义名列表
20 个代谢物同义名
(3S,4S,5R)-3,4,5,6-tetrahydroxy-2-oxohexanoic acid; 3,4,5,6-tetrahydroxy-2-oxohexanoic acid; Provitamin C, (L-xylo)-isomer; Provitamin C, monosodium salt; 2-Keto-L-gluconic acid; 2-keto-D-gluconic acid; 2-keto-l-gulonic acid; 2-Dehydro-D-gluconate; 2-Dehydro-L-gluconate; 2-Dehydro-L-idonate; 2-keto-L-gluconate; 2-oxogluconic acid; 2-Keto-D-gluconate; 2-Keto-L-gulonate; L-Sorbosonic acid; L-Ketoidonic acid; L-Sorbosonate; L-Ketoidonate; 2-Ketoidonate; Provitamin C
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:88378
- KEGG: C03342
- PubChem: 6337064
- PubChem: 50
- HMDB: HMDB0011732
- MetaCyc: CPD-13059
- foodb: FDB028412
- chemspider: 49
- CAS: 342385-52-8
- CAS: 91548-32-2
- CAS: 16722-49-9
- CAS: 73803-83-5
- PMhub: MS000008476
- ChEBI: CHEBI:28023
- PubChem: 6185
- NIKKAJI: J383.015B
- LOTUS: LTS0218508
- wikidata: Q27160223
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(2)
- Ketogluconate Metabolism:
5-Keto-D-gluconate + Hydrogen Ion + NADPH ⟶ Gluconic acid + NADP - Ketogluconate Metabolism:
2-Keto-L-gluconate + Hydrogen Ion + NADPH ⟶ Gluconic acid + NADP
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuanfeng Wang, Zhiwei Yang, Xinlin Wei. Antioxidant activities potential of tea polysaccharide fractions obtained by ultra filtration.
International journal of biological macromolecules.
2012 Apr; 50(3):558-64. doi:
10.1016/j.ijbiomac.2011.12.028. [PMID: 22230610] - Elisabetta Zinellu, Antonio Junior Lepedda, Antonio Cigliano, Salvatore Pisanu, Angelo Zinellu, Ciriaco Carru, Pietro Paolo Bacciu, Franco Piredda, Anna Guarino, Rita Spirito, Marilena Formato. Association between Human Plasma Chondroitin Sulfate Isomers and Carotid Atherosclerotic Plaques.
Biochemistry research international.
2012; 2012(?):281284. doi:
10.1155/2012/281284. [PMID: 22216412] - Rafael S Aquino, Clicia Grativol, Paulo A S Mourão. Rising from the sea: correlations between sulfated polysaccharides and salinity in plants.
PloS one.
2011 Apr; 6(4):e18862. doi:
10.1371/journal.pone.0018862. [PMID: 21552557] - Neha Potnis, Ksenia Krasileva, Virginia Chow, Nalvo F Almeida, Prabhu B Patil, Robert P Ryan, Molly Sharlach, Franklin Behlau, J Max Dow, Mt Momol, Frank F White, James F Preston, Boris A Vinatzer, Ralf Koebnik, João C Setubal, David J Norman, Brian J Staskawicz, Jeffrey B Jones. Comparative genomics reveals diversity among xanthomonads infecting tomato and pepper.
BMC genomics.
2011 Mar; 12(?):146. doi:
10.1186/1471-2164-12-146. [PMID: 21396108] - Jianshe Lang, Ning Yang, Jiejie Deng, Kangtai Liu, Peng Yang, Guigen Zhang, Chengyu Jiang. Inhibition of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate proteoglycans.
PloS one.
2011; 6(8):e23710. doi:
10.1371/journal.pone.0023710. [PMID: 21887302] - Jianing Bai, Sean P McAteer, Edith Paxton, Arvind Mahajan, David L Gally, Jai J Tree. Screening of an E. coli O157:H7 Bacterial Artificial Chromosome Library by Comparative Genomic Hybridization to Identify Genomic Regions Contributing to Growth in Bovine Gastrointestinal Mucus and Epithelial Cell Colonization.
Frontiers in microbiology.
2011; 2(?):168. doi:
10.3389/fmicb.2011.00168. [PMID: 21887152] - Rupesh Thakur, Nitika Jain, Raghvendra Pathak, Sardul Singh Sandhu. Practices in wound healing studies of plants.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):438056. doi:
10.1155/2011/438056. [PMID: 21716711] - Giampiero Capobianco, Pierina de Muro, Gian Mario Cherchi, Marilena Formato, Antonio Junior Lepedda, Antonio Cigliano, Elisabetta Zinellu, Francesco Dessole, Laila Gordini, Salvatore Dessole. Plasma levels of C-reactive protein, leptin and glycosaminoglycans during spontaneous menstrual cycle: differences between ovulatory and anovulatory cycles.
Archives of gynecology and obstetrics.
2010 Aug; 282(2):207-13. doi:
10.1007/s00404-010-1432-2. [PMID: 20306065] - Ken F Jarrell, Gareth M Jones, Lina Kandiba, Divya B Nair, Jerry Eichler. S-layer glycoproteins and flagellins: reporters of archaeal posttranslational modifications.
Archaea (Vancouver, B.C.).
2010 Jul; 2010(?):. doi:
10.1155/2010/612948. [PMID: 20721273] - P K Agarwal, A Singh, K Gaurav, Shalini Goel, H D Khanna, R K Goel. Evaluation of wound healing activity of extracts of plantain banana (Musa sapientum var. paradisiaca) in rats.
Indian journal of experimental biology.
2009 Jan; 47(1):32-40. doi:
. [PMID: 19317349] - P Anandakumar, S Jagan, S Kamaraj, G Ramakrishnan, A A Titto, T Devaki. Beneficial influence of capsaicin on lipid peroxidation, membrane-bound enzymes and glycoprotein profile during experimental lung carcinogenesis.
The Journal of pharmacy and pharmacology.
2008 Jun; 60(6):803-8. doi:
10.1211/jpp.60.6.0017. [PMID: 18498718] - Somashekar Shetty, Saraswati Udupa, Laxminarayana Udupa. Evaluation of Antioxidant and Wound Healing Effects of Alcoholic and Aqueous Extract of Ocimum sanctum Linn in Rats.
Evidence-based complementary and alternative medicine : eCAM.
2008 Mar; 5(1):95-101. doi:
10.1093/ecam/nem004. [PMID: 18317555] - Katarzyna B Komosińska-Vassev, Katarzyna Winsz-Szczotka, Kornelia Kuznik-Trocha, Paweł Olczyk, Krystyna Olczyk. Age-related changes of plasma glycosaminoglycans.
Clinical chemistry and laboratory medicine.
2008; 46(2):219-24. doi:
10.1515/cclm.2008.048. [PMID: 18076349] - Bence György, László Tóthfalusi, György Nagy, Mária Pásztói, Pál Géher, Zsolt Lörinc, Anna Polgár, Bernadett Rojkovich, Ilona Ujfalussy, Gyula Poór, Péter Pócza, Zoltán Wiener, Petra Misják, Agnes Koncz, András Falus, Edit I Buzás. Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis.
Arthritis research & therapy.
2008; 10(5):R110. doi:
10.1186/ar2507. [PMID: 18789149] - Pierina De Muro, Rossana Faedda, Andrea E Satta, Antonio Masala, Alessandro Cigni, Daniela Falconi, Giovanni Maria Sanna, Gian Mario Cherchi. Quali-quantitative analysis of urinary glycosaminoglycans for monitoring glomerular inflammatory activity.
Scandinavian journal of urology and nephrology.
2007; 41(3):230-6. doi:
10.1080/00365590601017105. [PMID: 17469033] - Vanu Ramkumar Ramprasath, Palanivelu Shanthi, Panchanatham Sachdanandam. Therapeutic effects of Semecarpus anacardium Linn. nut milk extract on the changes associated with collagen and glycosaminoglycan metabolism in adjuvant arthritic Wistar rats.
Chemico-biological interactions.
2006 Jul; 162(1):43-52. doi:
10.1016/j.cbi.2006.05.003. [PMID: 16797506] - P R Deepa, P Varalakshmi. Favourable modulation of the inflammatory changes in hypercholesterolemic atherogenesis by a low-molecular-weight heparin derivative.
International journal of cardiology.
2006 Jan; 106(3):338-47. doi:
10.1016/j.ijcard.2005.02.012. [PMID: 16337042] - Laura Botto, Egidio Beretta, Rossella Daffara, Giuseppe Miserocchi, Paola Palestini. Biochemical and morphological changes in endothelial cells in response to hypoxic interstitial edema.
Respiratory research.
2006 Jan; 7(?):7. doi:
10.1186/1465-9921-7-7. [PMID: 16412226] - Katarzyna Komosińska-Vassev, Katarzyna Winsz-Szczotka, Krystyna Olczyk, Ewa M Koźma. Alterations in serum glycosaminoglycan profiles in Graves' patients.
Clinical chemistry and laboratory medicine.
2006; 44(5):582-8. doi:
10.1515/cclm.2006.105. [PMID: 16681428] - P R Deepa, P Varalakshmi. Biochemical evaluation of the inflammatory changes in cardiac, hepatic and renal tissues of adriamycin-administered rats and the modulatory role of exogenous heparin-derivative treatment.
Chemico-biological interactions.
2005 Oct; 156(2-3):93-100. doi:
10.1016/j.cbi.2005.07.008. [PMID: 16154121] - Marcus V O Maroclo, Sávio D Pereira, Francisco J B Sampaio, Luiz E M Cardoso. Urinary glycosaminoglycan excretion during the menstrual cycle in normal young women.
The Journal of urology.
2005 May; 173(5):1789-92. doi:
10.1097/01.ju.0000154621.18695.b7. [PMID: 15821588] - Iris J Edwards, Janice D Wagner, Catherine A Vogl-Willis, Kenneth N Litwak, William T Cefalu. Arterial heparan sulfate is negatively associated with hyperglycemia and atherosclerosis in diabetic monkeys.
Cardiovascular diabetology.
2004 Apr; 3(?):6. doi:
10.1186/1475-2840-3-6. [PMID: 15117408] - Elsie L Campbell, Francis C Y Wong, John C Meeks. DNA binding properties of the HrmR protein of Nostoc punctiforme responsible for transcriptional regulation of genes involved in the differentiation of hormogonia.
Molecular microbiology.
2003 Jan; 47(2):573-82. doi:
10.1046/j.1365-2958.2003.03320.x. [PMID: 12519206] - Giuseppe M Campo, Angela Avenoso, Salvatore Campo, Alida M Ferlazzo, Domenica Altavilla, Alberto Calatroni. Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats.
Arthritis research & therapy.
2003; 5(3):R122-31. doi:
10.1186/ar748. [PMID: 12723984] - Camilla Westling, Ulf Lindahl. Location of N-unsubstituted glucosamine residues in heparan sulfate.
The Journal of biological chemistry.
2002 Dec; 277(51):49247-55. doi:
10.1074/jbc.m209139200. [PMID: 12374790] - Robert D Hancock, Roberto Viola. Biotechnological approaches for L-ascorbic acid production.
Trends in biotechnology.
2002 Jul; 20(7):299-305. doi:
10.1016/s0167-7799(02)01991-1. [PMID: 12062975] - Hsi-Hsien Liu, Wen-Ching Ko, Miao-Lin Hu. Hypolipidemic effect of glycosaminoglycans from the sea cucumber Metriatyla scabra in rats fed a cholesterol-supplemented diet.
Journal of agricultural and food chemistry.
2002 Jun; 50(12):3602-6. doi:
10.1021/jf020070k. [PMID: 12033836] - Valerie A Wilson, John T Gallagher, Catherine L R Merry. Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development.
Glycoconjugate journal.
2002 May; 19(4-5):347-54. doi:
10.1023/a:1025325222530. [PMID: 12975615] - . .
.
. doi:
. [PMID: 12213822] - . .
.
. doi:
. [PMID: 20554947] - . .
.
. doi:
. [PMID: 11773048]
