bestatin (BioDeep_00000003100)

 

Secondary id: BioDeep_00000230884, BioDeep_00001870112

PANOMIX_OTCML-2023 Antitumor activity


代谢物信息卡片


(2R)-2-[[(2S,3R)-3-Amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acid

化学式: C16H24N2O4 (308.1736)
中文名称: 乌苯美司
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 5.35%

分子结构信息

SMILES: CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O
InChI: InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)

描述信息

KEIO_ID B018; [MS2] KO009090
KEIO_ID B018
Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects[1][2].

同义名列表

7 个代谢物同义名

bestatin; (2R)-2-[[(2S,3R)-3-Amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acid; N-(3R-amino-2S-hydroxy-1-oxo-4-phenylbutyl)-L-leucine, monohydrochloride; Bestatin (hydrochloride); Bestatin;Ubenimex; Ubenimex; Ubenimex



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Patricia Gangoiti, Caterina Bernacchioni, Chiara Donati, Francesca Cencetti, Alberto Ouro, Antonio Gómez-Muñoz, Paola Bruni. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts. Biochimie. 2012 Mar; 94(3):597-607. doi: 10.1016/j.biochi.2011.09.009. [PMID: 21945811]
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  • Yanna Zhu, Qiang Meng, Changyuan Wang, Qi Liu, Huijun Sun, Taiichi Kaku, Kexin Liu. Organic anion transporters involved in the excretion of bestatin in the kidney. Peptides. 2012 Feb; 33(2):265-71. doi: 10.1016/j.peptides.2012.01.007. [PMID: 22273603]
  • Ching-Feng Huang, Chia-Hsiang Chu, Chia-Chao Wu, Zo-Nan Chang, Fung-Lin Chue, Ho-Jen Peng. Induction of specific Th1 responses and suppression of IgE antibody formation by vaccination with plasmid DNA encoding Cyn d 1. International archives of allergy and immunology. 2012; 158(2):142-50. doi: 10.1159/000331140. [PMID: 22286313]
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  • Kunio Fujiwara, Masashi Shin, Yohei Yoshizaki, Tsubasa Miyazaki, Tetsuya Saita. Immunocytochemistry for bestatin and its application to drug accumulation studies in rat intestine and kidney. Journal of molecular histology. 2011 Dec; 42(6):589-96. doi: 10.1007/s10735-011-9365-z. [PMID: 22006287]
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  • Thaysa Paschoalin, Adriana K Carmona, Elaine G Rodrigues, Vitor Oliveira, Hugo P Monteiro, Maria A Juliano, Luiz Juliano, Luiz R Travassos. Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth. Molecular cancer. 2007 Jul; 6(?):44. doi: 10.1186/1476-4598-6-44. [PMID: 17620116]
  • Chen Wang, Guorong Fan, Mei Lin, Yi Chen, Weiquan Zhao, Yutian Wu. Development of a liquid chromatography/tandem mass spectrometry assay for the determination of bestatin in rat plasma and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 May; 850(1-2):101-8. doi: 10.1016/j.jchromb.2006.11.015. [PMID: 17141585]
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