Mepenzolate (BioDeep_00000002983)

 

Secondary id: BioDeep_00001868440

human metabolite blood metabolite


代谢物信息卡片


Mepenzolic acid, bromine salt, 1-(methyl-(14)C)-labeled

化学式: C21H26NO3+ (340.1912586000001)
中文名称:
谱图信息: 最多检出来源 Mus musculus(blood) 66.67%

分子结构信息

SMILES: C[N+]1(C)CCCC(C1)OC(=O)C(O)(C1=CC=CC=C1)C1=CC=CC=C1
InChI: InChI=1S/C21H26NO3/c1-22(2)15-9-14-19(16-22)25-20(23)21(24,17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19,24H,9,14-16H2,1-2H3/q+1

描述信息

Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor. It has not been shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AB - Synthetic anticholinergics, quaternary ammonium compounds
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent

同义名列表

13 个代谢物同义名

Mepenzolic acid, bromine salt, 1-(methyl-(14)C)-labeled; N-Methyl-3-piperidyldiphenylglycolate methobromide; N-Methyl-3-piperidyl benzilate methyl bromide; 1-Methyl-3-piperidyl benzilate methyl bromide; Aventis behring brand OF mepenzolate bromide; N-Methyl-3-piperidylbenzilate methyl bromide; Mepenzolate bromide, (+-)-isomer; Mepenzolic acid, bromine salt; Mepenzolate bromide; Mepenzolate iodide; Mepenzolic acid; mepenzolate; Cantil



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ramesh Bondada, Dilsher Singh Kulaar, Imran Siddiqi, Ravi Maruthachalam. Cantil - a new organ or a morphological oddity?. The New phytologist. 2021 12; 232(5):1904-1908. doi: 10.1111/nph.17744. [PMID: 34537960]
  • Timothy E Gookin, Sarah M Assmann. Cantil: a previously unreported organ in wild-type Arabidopsis regulated by FT, ERECTA and heterotrimeric G proteins. Development (Cambridge, England). 2021 06; 148(11):. doi: 10.1242/dev.195545. [PMID: 34129030]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • C S Tsai, F Guede-Guina, M O Smith, M Vangah-Manda, R F Ochillo. Isolation of cholinergic active ingredients in aqueous extracts of Mareya micrantha using the longitudinal muscle of isolated guinea-pig ileum as a pharmacological activity marker. Journal of ethnopharmacology. 1995 Mar; 45(3):215-22. doi: 10.1016/0378-8741(94)01219-p. [PMID: 7623487]
  • M Cohen-Armon, G Schreiber, M Sokolovsky. Interaction of the antiarrhythmic drug amiodarone with the muscarinic receptor in rat heart and brain. Journal of cardiovascular pharmacology. 1984 Nov; 6(6):1148-55. doi: 10.1097/00005344-198411000-00023. [PMID: 6084773]
  • G R Murray, T N Calvey, N E Williams, K Chan. Quantitative capillary column gas chromatographic method for the determination of glycopyrronium in human plasma. Journal of chromatography. 1984 Jun; 308(?):143-51. doi: 10.1016/s0021-9673(01)87541-5. [PMID: 6746811]
  • S Tsuji, K Nakagawa, T Fukushima. Genetically controlled quantitative variation of ornithine transcarbamylase in the chick kidney. Biochemical genetics. 1983 Oct; 21(9-10):857-69. doi: 10.1007/bf00483945. [PMID: 6419722]
  • A Puigvert, D Ruano. [Etiopathogenesis of so-called congenital hydronephrosis]. Journal d'urologie et de nephrologie. 1979 Jan; 85(1-2):1-12. doi: NULL. [PMID: 439196]
  • M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm. Biochimica et biophysica acta. 1976 Apr; 428(2):525-31. doi: 10.1016/0304-4165(76)90061-1. [PMID: 6049]
  • H H Borden, R W Harris, W E Mosher. A waterborne outbreak of gastroenteritis in western New York State. American journal of public health and the nation's health. 1970 Feb; 60(2):283-8. doi: 10.2105/ajph.60.2.283. [PMID: 5460971]