Paramethasone Acetate (BioDeep_00000002740)

   


代谢物信息卡片


6alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione acetate

化学式: C24H31FO6 (434.2105)
中文名称: 帕拉米松乙酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OCC(=O)C1(O)C(C)CC2C3CC(F)C4=CC(=O)C=CC4(C)C3C(O)CC21C
InChI: InChI=1S/C24H31FO6/c1-12-7-16-15-9-18(25)17-8-14(27)5-6-22(17,3)21(15)19(28)10-23(16,4)24(12,30)20(29)11-31-13(2)26/h5-6,8,12,15-16,18-19,21,28,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19+,21-,22+,23+,24+/m1/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
Same as: D01229

同义名列表

4 个代谢物同义名

6alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione acetate; Paramethasone Acetate; 16-alpha-Methyl-6-alpha-fluoro-prednisolone-21-acetate; Paramethasone acetate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CALCA, CD34, GUCY1A1, KITLG
cytosol 3 GUCY1A1, IL1B, PRKCQ
Cell membrane 3 GLDN, KITLG, TNF
lamellipodium 1 KITLG
Cell projection, axon 1 GLDN
Multi-pass membrane protein 2 CACNA1I, PROM1
cell surface 3 GLDN, PROM1, TNF
glutamatergic synapse 1 GUCY1A1
neuronal cell body 2 CALCA, TNF
Cytoplasm, cytosol 1 IL1B
Lysosome 2 CD34, IL1B
plasma membrane 8 CACNA1I, CD34, GLDN, IGHE, KITLG, PRKCQ, PROM1, TNF
terminal bouton 1 CALCA
Membrane 3 CACNA1I, CD34, KITLG
apical plasma membrane 2 CD34, PROM1
axon 1 GLDN
extracellular exosome 1 PROM1
endoplasmic reticulum 1 PROM1
extracellular space 9 CALCA, GLDN, IGHE, IL1B, IL6, KITLG, PROM1, THPO, TNF
perinuclear region of cytoplasm 1 CD34
filopodium 1 KITLG
Single-pass type I membrane protein 3 CD34, IGHE, KITLG
Secreted 6 CALCA, GLDN, IL1B, IL6, KITLG, THPO
extracellular region 8 CALCA, CD34, IGHE, IL1B, IL6, KITLG, THPO, TNF
hippocampal mossy fiber to CA3 synapse 1 CALCA
centriolar satellite 1 PRKCQ
photoreceptor outer segment 1 PROM1
external side of plasma membrane 2 CD34, TNF
Secreted, extracellular space, extracellular matrix 1 GLDN
recycling endosome 1 TNF
Single-pass type II membrane protein 2 GLDN, TNF
vesicle 1 PROM1
Apical cell membrane 1 PROM1
Cell projection, lamellipodium 1 KITLG
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 KITLG
GABA-ergic synapse 1 GUCY1A1
collagen trimer 1 GLDN
secretory granule 1 IL1B
Cell projection, filopodium 1 KITLG
cilium 1 PROM1
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
cytoskeleton 1 KITLG
Cell projection, cilium, photoreceptor outer segment 1 PROM1
Cell projection, microvillus membrane 1 PROM1
microvillus membrane 1 PROM1
[Isoform 2]: Cell membrane 1 IGHE
intercellular bridge 1 CD34
microvillus 1 PROM1
basal plasma membrane 1 CD34
endoplasmic reticulum lumen 1 IL6
voltage-gated calcium channel complex 1 CACNA1I
Secreted, extracellular exosome 1 IL1B
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 CALCA
aggresome 1 PRKCQ
[Isoform 2]: Cytoplasm 1 KITLG
endoplasmic reticulum-Golgi intermediate compartment 1 PROM1
photoreceptor outer segment membrane 1 PROM1
prominosome 1 PROM1
guanylate cyclase complex, soluble 1 GUCY1A1
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
interleukin-6 receptor complex 1 IL6
glomerular endothelium fenestra 1 CD34
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Gliomedin shedded ectodomain]: Secreted 1 GLDN


文献列表

  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • V Cortés-Gallegos, R Alonso, G Castañeda, I Sojo, A Carranco, C Cervantes, A Parra. Paramethasone acetate (PA): corticosteroid potency vs hypothalamic pituitary-gonadal axis. Journal of steroid biochemistry. 1984 Jan; 20(1):353-6. doi: 10.1016/0022-4731(84)90232-2. [PMID: 6423900]