Guaijaverin (BioDeep_00000230220)

 

Secondary id: BioDeep_00000034600, BioDeep_00000179617, BioDeep_00000402746, BioDeep_00000403013, BioDeep_00000407115

natural product PANOMIX_OTCML-2023


代谢物信息卡片


2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S)-3,4,5-trihydroxytetrahydropyran-2-yl]oxy-chromen-4-one

化学式: C20H18O11 (434.0849)
中文名称: 番石榴苷, 扁蓄苷
谱图信息: 最多检出来源 Viridiplantae(plant) 86.7%

分子结构信息

SMILES: C(C(=O)2)(OC(O4)C(O)C(C(O)C4)O)=C(Oc(c3)c2c(cc(O)3)O)c(c1)cc(c(O)c1)O
InChI: InChI=1/C20H18O11/c21-8-4-11(24)14-13(5-8)30-18(7-1-2-9(22)10(23)3-7)19(16(14)27)31-20-17(28)15(26)12(25)6-29-20/h1-5,12,15,17,20-26,28H,6H2/t12-,15-,17+,20-/m0/s1

描述信息

Acquisition and generation of the data is financially supported in part by CREST/JST.
Guaijaverin is a natural product found in Eucalyptus cypellocarpa, Hypericum scabrum, and other organisms with data available.
Guaijaverin is a urease inhibitor with an IC50 of 120 μM. Guaijaverin shows antioxidant and anti-Streptococcus mutans activities[1][2][3].
Guaijaverin is a urease inhibitor with an IC50 of 120 μM. Guaijaverin shows antioxidant and anti-Streptococcus mutans activities[1][2][3].

同义名列表

17 个代谢物同义名

Guaijaverin; Quercetin-3-Arabinoside; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S)-3,4,5-trihydroxytetrahydropyran-2-yl]oxy-chromen-4-one; 4H-1-Benzopyran-4-one, 3-(.alpha.-L-arabinopyranosyloxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-; 4H-1-Benzopyran-4-one, 3-(alpha-L-arabinopyranosyloxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-; 3-(alpha-L-Arabinopyranosyloxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one; Quercetin 3-O-alpha-L-arabinopyranoside, >=95\\% (HPLC); Quercetin 3-O-.alpha.-L-arabinopyranside; quercetin 3-O-alpha-L-arabinoside; quercetin-3-arabinopyranoside; MEGxp0_000272; ACon1_000559; Guajaverin; guajavarin; 3- [ (alpha-L-Arabinopyranosyl) oxy ] -3,4,5,7-tetrahydroxyflavone; Quercetin 3-O-alpha-L-arabinopyranoside; Quercetin-3-O-α-L-arabinoside



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

475 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Regiane C Duarte, Silvia H Taleb-Contini, Paulo S Pereira, Camila F Oliveira, Carlos Eduardo S Miranda, Bianca W Bertoni, Juliana S Coppede, Guilherme B Willrich, Eduardo J Crevelin, Suzelei C França, Ana Maria S Pereira. Effect of Costus spiralis (Jacq.) Roscoe Leaves, Methanolic Extract and Guaijaverin on Blood Glucose and Lipid Levels in a Type II Diabetic Rat Model. Chemistry & biodiversity. 2019 Jan; 16(1):e1800365. doi: 10.1002/cbdv.201800365. [PMID: 30371987]
  • Z Li, F Meng, Y Zhang, L Sun, L Yu, Z Zhang, S Peng, J Guo. Simultaneous quantification of hyperin, reynoutrin and guaijaverin in mice plasma by LC-MS/MS: application to a pharmacokinetic study. Biomedical chromatography : BMC. 2016 Jul; 30(7):1124-1130. doi: 10.1002/bmc.3660. [PMID: 26588877]
  • Yingzhan Tang, Junhong Ling, Peng Zhang, Xiangrong Zhang, Na Zhang, Wenli Wang, Jiayuan Li, Ning Li. Potential therapeutic agents for circulatory diseases from Bauhinia glauca Benth.subsp. pernervosa. (Da Ye Guan Men). Bioorganic & medicinal chemistry letters. 2015 Aug; 25(16):3217-20. doi: 10.1016/j.bmcl.2015.05.089. [PMID: 26096681]
  • Jin-Long Li, Li-Xin Gao, Fan-Wang Meng, Chun-Lan Tang, Ru-Jun Zhang, Jing-Ya Li, Cheng Luo, Jia Li, Wei-Min Zhao. PTP1B inhibitors from stems of Angelica keiskei (Ashitaba). Bioorganic & medicinal chemistry letters. 2015; 25(10):2028-32. doi: 10.1016/j.bmcl.2015.04.003. [PMID: 25891102]
  • Xiao-He Feng, Zi-Hao Wang, Da-Li Meng, Xian Li. Cytotoxic and antioxidant constituents from the leaves of Psidium guajava. Bioorganic & medicinal chemistry letters. 2015; 25(10):2193-8. doi: 10.1016/j.bmcl.2015.03.058. [PMID: 25862199]
  • Icaro P Caruso, Wagner Vilegas, Marcelo A Fossey, Marinônio L Cornélio. Exploring the binding mechanism of Guaijaverin to human serum albumin: fluorescence spectroscopy and computational approach. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2012 Nov; 97(?):449-55. doi: 10.1016/j.saa.2012.06.043. [PMID: 22820048]
  • Jun Lee, Yun Mi Lee, Byong Won Lee, Joo-Hwan Kim, Jin Sook Kim. Chemical constituents from the aerial parts of Aster koraiensis with protein glycation and aldose reductase inhibitory activities. Journal of natural products. 2012 Feb; 75(2):267-70. doi: 10.1021/np200646e. [PMID: 22264115]
  • Tamara R Calvo, Diego Demarco, Fabio V Santos, Helen P Moraes, Taís M Bauab, Eliana A Varanda, Ilce M S Cólus, Wagner Vilegas. Phenolic compounds in leaves of Alchornea triplinervia: anatomical localization, mutagenicity, and antibacterial activity. Natural product communications. 2010 Aug; 5(8):1225-32. doi: . [PMID: 20839624]
  • Xin Zhou, Xiuhai Gang, Xiaojian Gong, Chao Zhao, Huaguo Chen. [Glycosides from Periploca forrestii]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Mar; 35(5):610-2. doi: 10.4268/cjcmm20100515. [PMID: 20506822]
  • Diana Carrasco, Jeannette Méndez, Alessandra Braca, Marinella De Leo, Freddy González-Mujica, Sandra Duque. Effect of flavonoids from Exellodendron coriaceum (Chrysobalanaceae) on glucose-6-phosphatase. Natural product communications. 2009 Dec; 4(12):1657-9. doi: ". [PMID: 20120101]
  • Walclecio de Moraes Lira, Fabio Vieira dos Santos, Miriam Sannomiya, Clenilson Martins Rodrigues, Wagner Vilegas, Eliana Aparecida Varanda. Modulatory effect of Byrsonima basiloba extracts on the mutagenicity of certain direct and indirect-acting mutagens in Salmonella typhimurium assays. Journal of medicinal food. 2008 Mar; 11(1):111-9. doi: 10.1089/jmf.2007.553. [PMID: 18361746]
  • Miriam Sannomiya, Cássia R P Cardoso, Maria E Figueiredo, Clenilson M Rodrigues, Lourdes C dos Santos, Fabio V dos Santos, Juliana M Serpeloni, Ilce M S Cólus, Wagner Vilegas, Eliana A Varanda. Mutagenic evaluation and chemical investigation of Byrsonima intermedia A. Juss. leaf extracts. Journal of ethnopharmacology. 2007 Jun; 112(2):319-26. doi: 10.1016/j.jep.2007.03.014. [PMID: 17459621]
  • Tamara Regina Calvo, Zeila Pinheiro Lima, Janaina Scaramelo Silva, Kátia Vero Nica Rodrigues Ballesteros, Cláudia Helena Pellizzon, Clélia Akiko Hiruma-Lima, Jorge Tamashiro, Alba Regina Monteiro Souza Brito, Regina Kiomi Takahira, Wagner Vilegas. Constituents and antiulcer effect of Alchornea glandulosa: activation of cell proliferation in gastric mucosa during the healing process. Biological & pharmaceutical bulletin. 2007 Mar; 30(3):451-9. doi: 10.1248/bpb.30.451. [PMID: 17329837]
  • G R Prabu, A Gnanamani, S Sadulla. Guaijaverin -- a plant flavonoid as potential antiplaque agent against Streptococcus mutans. Journal of applied microbiology. 2006 Aug; 101(2):487-95. doi: 10.1111/j.1365-2672.2006.02912.x. [PMID: 16882158]
  • Cássia Regina Primila Cardoso, Ilce Mara de Syllos Cólus, Caroline Cristiane Bernardi, Miriam Sannomiya, Wagner Vilegas, Eliana Aparecida Varanda. Mutagenic activity promoted by amentoflavone and methanolic extract of Byrsonima crassa Niedenzu. Toxicology. 2006 Aug; 225(1):55-63. doi: 10.1016/j.tox.2006.05.003. [PMID: 16781041]
  • M Sannomiya, Vitor B Fonseca, M A da Silva, L R M Rocha, L C Dos Santos, C A Hiruma-Lima, A R M Souza Brito, W Vilegas. Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts. Journal of ethnopharmacology. 2005 Feb; 97(1):1-6. doi: 10.1016/j.jep.2004.09.053. [PMID: 15652267]
  • G Hussein, H Miyashiro, N Nakamura, M Hattori, N Kakiuchi, K Shimotohno. Inhibitory effects of sudanese medicinal plant extracts on hepatitis C virus (HCV) protease. Phytotherapy research : PTR. 2000 Nov; 14(7):510-6. doi: 10.1002/1099-1573(200011)14:7<510::aid-ptr646>3.0.co;2-b. [PMID: 11054840]
  • I T Matsuse, Y A Lim, M Hattori, M Correa, M P Gupta. A search for anti-viral properties in Panamanian medicinal plants. The effects on HIV and its essential enzymes. Journal of ethnopharmacology. 1999 Jan; 64(1):15-22. doi: 10.1016/s0378-8741(98)00099-3. [PMID: 10075118]
  • X Lozoya, M Meckes, M Abou-Zaid, J Tortoriello, C Nozzolillo, J T Arnason. Quercetin glycosides in Psidium guajava L. leaves and determination of a spasmolytic principle. Archives of medical research. 1994; 25(1):11-5. doi: ". [PMID: 8019108]