Juglanin (BioDeep_00000228358)
Main id: BioDeep_00000270396
human metabolite PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C20H18O10 (418.0899928)
中文名称: 胡桃苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: c1(cc(c2c(c1)oc(c(c2=O)O[C@@H]1[C@H]([C@@H]([C@H](O1)CO)O)O)c1ccc(cc1)O)O)O
InChI: InChI=1S/C20H18O10/c21-7-13-15(25)17(27)20(29-13)30-19-16(26)14-11(24)5-10(23)6-12(14)28-18(19)8-1-3-9(22)4-2-8/h1-6,13,15,17,20-25,27H,7H2/t13-,15-,17+,20-/m0/s1
描述信息
Isolated from walnuts (Juglans regia). Juglanin is found in many foods, some of which are nuts, common hazelnut, fennel, and sweet bay.
Juglanin, a natural occurring flavonoid, is a JNK acticator, with inflammation and anti-tumor activities. Juglanin can induce apoptosis and autophagy on human breast cancer cells[1].
Juglanin, a natural occurring flavonoid, is a JNK acticator, with inflammation and anti-tumor activities. Juglanin can induce apoptosis and autophagy on human breast cancer cells[1].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:167534
- PubChem: 5318717
- HMDB: HMDB0303587
- ChEMBL: CHEMBL469440
- KNApSAcK: C00005132
- foodb: FDB016302
- chemspider: 10365524
- CAS: 5041-67-8
- medchemexpress: HY-N3442
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tao Wei, Lei Wang, Jian Tang, Tolulope Joshua Ashaolu, Opeyemi Joshua Olatunji. Protective effect of Juglanin against doxorubicin-induced cognitive impairment in rats: Effect on oxidative, inflammatory and apoptotic machineries.
Metabolic brain disease.
2022 04; 37(4):1185-1195. doi:
10.1007/s11011-022-00923-8. [PMID: 35138546] - Qiang Li, Chenxu Ge, Jun Tan, Yan Sun, Qin Kuang, Xianling Dai, Shaoyu Zhong, Chao Yi, Lin-Feng Hu, De-Shuai Lou, Minxuan Xu. Juglanin protects against high fat diet-induced renal injury by suppressing inflammation and dyslipidemia via regulating NF-κB/HDAC3 signaling.
International immunopharmacology.
2021 Jun; 95(?):107340. doi:
10.1016/j.intimp.2020.107340. [PMID: 33667999] - Shi-Chao Sun, Ru Han, Shuang-Shuang Hou, Hua-Qiang Yi, Shou-Jun Chi, Ai-Hua Zhang. Juglanin alleviates bleomycin-induced lung injury by suppressing inflammation and fibrosis via targeting sting signaling.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Jul; 127(?):110119. doi:
10.1016/j.biopha.2020.110119. [PMID: 32276127] - Guang Wang, Bing Wu, Wenzhou Xu, Xuefei Jin, Kun Wang, Heyuan Wang. The Inhibitory Effects of Juglanin on Adipogenesis in 3T3-L1 Adipocytes.
Drug design, development and therapy.
2020; 14(?):5349-5357. doi:
10.2147/dddt.s256504. [PMID: 33293796] - Morio Yoshimura, Saori Yamakami, Yoshiaki Amakura, Takashi Yoshida. Diarylheptanoid sulfates and related compounds from Myrica rubra bark.
Journal of natural products.
2012 Oct; 75(10):1798-802. doi:
10.1021/np300212c. [PMID: 23066712] - Heejung Yang, Sang Hyun Sung, Jinwoong Kim, Young Choong Kim. Neuroprotective diarylheptanoids from the leaves and twigs of juglans sinensis against glutamate-induced toxicity in HT22 cells.
Planta medica.
2011 May; 77(8):841-5. doi:
10.1055/s-0030-1250609. [PMID: 21157684] - Télesphore Benoît Nguelefack, Félicité Hermine Kamga Mbakam, Léon Azéfack Tapondjou, Pierre Watcho, Elvine Pami Nguelefack-Mbuyo, Beaudelaire Kemvoufo Ponou, Albert Kamanyi, Hee-Juhn Park. A dimeric triterpenoid glycoside and flavonoid glycosides with free radical-scavenging activity isolated from Rubus rigidus var. camerunensis.
Archives of pharmacal research.
2011 Apr; 34(4):543-50. doi:
10.1007/s12272-011-0404-9. [PMID: 21544719] - Xin-Yi Huang, Qiu-Yan Duan, Jun-Xi Liu, Duo-Long Di. Determination of a novel diarylheptanoid (Juglanin B) from green walnut husks (Juglans regia L.) in rat plasma by high-performance liquid chromatography.
Biomedical chromatography : BMC.
2010 Mar; 24(3):307-11. doi:
10.1002/bmc.1290. [PMID: 19606417] - Van Kiem Phan, Thi Mai Nguyen, Chau Van Minh, Huu Khoi Nguyen, Hai Dang Nguyen, Phuong Thao Nguyen, Xuan Cuong Nguyen, Hoai Nam Nguyen, Xuan Nhiem Nguyen, Yvan Vander Heyden, Joëlle Quetin-Leclercq, Gyo Nam Kim, Hae Dong Jang, Young Ho Kim. Two new C-glucosyl benzoic acids and flavonoids from Mallotus nanus and their antioxidant activity.
Archives of pharmacal research.
2010 Feb; 33(2):203-8. doi:
10.1007/s12272-010-0203-8. [PMID: 20195819] - Haitao Liu, Lijia Xu, Yong Peng, Rongtao Li, Peigen Xiao. [Chemical study on ethyl acetate soluble portion of Kadsura oblongifolia].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2009 Apr; 34(7):864-6. doi:
". [PMID: 19623983] - Chen Li, Jun-Xi Liu, Liang Zhao, Duo-Long Di, Min Meng, Sheng-Xiang Jiang. Capillary zone electrophoresis for separation and analysis of four diarylheptanoids and an alpha-tetralone derivative in the green walnut husks (Juglans regia L.).
Journal of pharmaceutical and biomedical analysis.
2008 Nov; 48(3):749-53. doi:
10.1016/j.jpba.2008.07.016. [PMID: 18771874] - Jian-Feng Xu, Ning-Hua Tan. [Studies on the chemical constituents from the branches and leaves of Cupressus duolouxiana].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2007 Jun; 30(6):669-71. doi:
". [PMID: 17918437] - M S Marzouk, F M Soliman, I A Shehata, M Rabee, G A Fawzy. Flavonoids and biological activities of Jussiaea repens.
Natural product research.
2007 May; 21(5):436-43. doi:
10.1080/14786410600943288. [PMID: 17487615] - Yi-Fen Wang, Jian-Xin Cao, Thomas Efferth, Gou-Fang Lai, Shi-De Luo. Cytotoxic and new tetralone derivatives from Berchemia floribunda (Wall.) Brongn.
Chemistry & biodiversity.
2006 Jun; 3(6):646-53. doi:
10.1002/cbdv.200690067. [PMID: 17193298]