Phenylpropanolamine (BioDeep_00000002012)

 

Secondary id: BioDeep_00000397895

human metabolite Endogenous blood metabolite natural product


代谢物信息卡片


(1S,2R)-2-amino-1-phenylpropan-1-ol

化学式: C9H13NO (151.0997)
中文名称: 左旋去甲麻黄碱, 去甲基麻黄素, 去甲麻黄碱, 苯丙醇胺
谱图信息: 最多检出来源 Homo sapiens(plant) 5.46%

分子结构信息

SMILES: CC(C(C1=CC=CC=C1)O)N
InChI: InChI=1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3

描述信息

Phenylpropanolamine is a sympathomimetic that acts mainly by causing release of norepinephrine but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant. -- Pubchem [HMDB]
Phenylpropanolamine is a sympathomimetic that acts mainly by causing release of norepinephrine but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant. -- Pubchem.
R - Respiratory system > R01 - Nasal preparations > R01B - Nasal decongestants for systemic use > R01BA - Sympathomimetics
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D019141 - Respiratory System Agents > D014663 - Nasal Decongestants
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
D019440 - Anti-Obesity Agents > D001067 - Appetite Depressants
CONFIDENCE standard compound; INTERNAL_ID 1547

同义名列表

27 个代谢物同义名

(1S,2R)-2-amino-1-phenylpropan-1-ol; Hydrochloride, phenylpropanolamine; Phenylpropanolamine hydrochloride; 2-Amino-1-phenyl-1-propanol; (1S,2R)-(+)-Norephedrine; DL-Phenylpropanolamine; L-Phenyl propanolamine; phenylpropanolamine; DL-Norephedrine; D-Norephedrine; L-NOREPHEDRINE; Prestwick_388; Norephedrine; Triaminic DM; Hydriatine; Propadrine; Prolamine; Propagest; Dexatrim; Mucorama; Obestat; Nobese; (+)-Norephedrine; Phenylpropanolamine; Norephedrine; Norephedrine; Phenylpropanolamine



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

58 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ADRA1A, CACNA1A, CAT, POMC
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 2 CYP1B1, MBOAT4
Nucleus 2 ADRA1A, CACNA1A
cytosol 3 ADRA1A, CAT, CBL
dendrite 1 GRM2
nucleoplasm 1 ADRA1A
Cell membrane 6 ADRA1A, ADRB3, CACNA1A, GRM2, GRM3, SLC1A2
Multi-pass membrane protein 9 ADRA1A, ADRB3, CACNA1A, GHSR, GRM2, GRM3, MBOAT4, SLC1A2, UCP1
Synapse 3 CACNA1A, CARTPT, GRM2
cell surface 2 GHSR, SLC1A2
glutamatergic synapse 5 GHRL, GHSR, GRM2, GRM3, SLC1A2
Golgi apparatus 2 CBL, NPY
Golgi membrane 1 INS
growth cone 1 CBL
mitochondrial inner membrane 1 UCP1
neuronal cell body 1 CACNA1A
postsynapse 2 GHRL, GHSR
presynaptic membrane 3 GRM2, GRM3, SLC1A2
plasma membrane 9 ADRA1A, ADRB3, CACNA1A, CBL, GHSR, GRM2, GRM3, REN, SLC1A2
Membrane 9 CACNA1A, CAT, CYP1B1, GHSR, GRM2, GRM3, MBOAT4, REN, SLC1A2
axon 4 CCK, GHRL, GRM2, GRM3
caveola 1 ADRA1A
extracellular exosome 1 CAT
endoplasmic reticulum 1 MBOAT4
extracellular space 8 CARTPT, CCK, GHRL, GNRH1, INS, NPY, POMC, REN
perinuclear region of cytoplasm 1 CBL
Schaffer collateral - CA1 synapse 2 GHRL, GHSR
mitochondrion 3 CAT, CYP1B1, UCP1
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 3 ADRA1A, CAT, CYP1B1
Microsome membrane 1 CYP1B1
postsynaptic density 1 GRM3
Secreted 7 CARTPT, CCK, GHRL, INS, NPY, POMC, REN
extracellular region 8 CAT, CCK, GHRL, GNRH1, INS, NPY, POMC, REN
mitochondrial matrix 1 CAT
Cell projection, cilium 1 CBL
Nucleus membrane 1 ADRA1A
nuclear membrane 1 ADRA1A
dendritic spine 1 GRM3
neuronal dense core vesicle lumen 1 GHRL
apical part of cell 1 REN
vesicle 1 SLC1A2
postsynaptic membrane 2 GRM2, GRM3
Mitochondrion inner membrane 1 UCP1
Membrane raft 3 CBL, GHSR, SLC1A2
focal adhesion 2 CAT, CBL
axolemma 1 SLC1A2
GABA-ergic synapse 1 NPY
flotillin complex 1 CBL
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 2 CARTPT, POMC
receptor complex 1 ADRB3
neuron projection 1 GHSR
cilium 1 CBL
cell projection 1 CACNA1A
endosome lumen 1 INS
Membrane, caveola 1 ADRA1A
monoatomic ion channel complex 1 CACNA1A
Cell projection, dendrite 1 GRM2
cell body 1 SLC1A2
synaptic membrane 1 GHSR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 4 CAT, GHRL, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 GHRL, INS
voltage-gated calcium channel complex 1 CACNA1A
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 NPY
astrocyte projection 3 GRM2, GRM3, SLC1A2
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
catalase complex 1 CAT
neuron projection terminus 1 SLC1A2
membrane protein complex 1 SLC1A2


文献列表

  • Jian Guo, Zhiping He, Chao Ma, Wanting Li, Jiaoyu Wang, Fucheng Lin, Xingquan Liu, Ling Li. Evaluation of cold plasma for decontamination of molds and mycotoxins in rice grain. Food chemistry. 2023 Feb; 402(?):134159. doi: 10.1016/j.foodchem.2022.134159. [PMID: 36137380]
  • Sharoen Y M Lim, Jason Siau Ee Loo, Mustafa Alshagga, Mohammed A Alshawsh, Chin E Ong, Yan Pan. Protein-Ligand Identification and In Vitro Inhibitory Effects of Cathine on 11 Major Human Drug Metabolizing Cytochrome P450s. International journal of toxicology. 2022 Sep; 41(5):355-366. doi: 10.1177/10915818221103790. [PMID: 35658727]
  • Hsin-Yi Hung, Shih-Min Lin, Chia-Ying Li, Sio-Hong Lam, Yu-Yi Chan, Meei-Jen Liou, Po-Chuen Shieh, Fu-An Chen, Ping-Chung Kuo, Tian-Shung Wu. A Rapid and Feasible 1H-NMR Quantification Method of Ephedrine Alkaloids in Ephedra Herbal Preparations. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061599. [PMID: 33805790]
  • Elisabeth Pendl, Udo Pauritsch, Manfred Kollroser, Martin G Schmid. Determination of cathinone and cathine in Khat plant material by LC-MS/MS: Fresh vs. dried leaves. Forensic science international. 2021 Feb; 319(?):110658. doi: 10.1016/j.forsciint.2020.110658. [PMID: 33370655]
  • Stamatios Angelopoulos, Orestis Ioannidis, Nikolaos Ouzounidis, Chrysovalantis Mariorakis, Christos Chatzakis, Savvas Symeonidis, Ioannis Mantzoros, Efstathios Kotidis, Manousos George Pramateftakis, Konstantinos Tsalis. Variations of plasma levels of insulin, glucagon, amylase and glucose and histopathological lesions of pancreatic tissue after complete elimination of exocrine pancreatic function with surgical ligation versus prolamine occlusion. Annali italiani di chirurgia. 2021; 92(?):441-451. doi: . [PMID: 34524119]
  • Rutao Lin, Zixu Wang, Jing Cao, Ting Gao, Yulan Dong, Yaoxing Chen. Role of melatonin in intestinal mucosal injury induced by restraint stress in mice. Pharmaceutical biology. 2020 Dec; 58(1):342-351. doi: 10.1080/13880209.2020.1750659. [PMID: 32298156]
  • Matthew D Lynes, Sean D Kodani, Yu-Hua Tseng. Lipokines and Thermogenesis. Endocrinology. 2019 10; 160(10):2314-2325. doi: 10.1210/en.2019-00337. [PMID: 31504387]
  • Hong-Li Chou, Li Tian, Masako Fukuda, Toshihiro Kumamaru, Thomas W Okita. The Role of RNA-Binding Protein OsTudor-SN in Post-Transcriptional Regulation of Seed Storage Proteins and Endosperm Development. Plant & cell physiology. 2019 Oct; 60(10):2193-2205. doi: 10.1093/pcp/pcz113. [PMID: 31198964]
  • Li Tian, Hong-Li Chou, Laining Zhang, Thomas W Okita. Targeted Endoplasmic Reticulum Localization of Storage Protein mRNAs Requires the RNA-Binding Protein RBP-L. Plant physiology. 2019 03; 179(3):1111-1131. doi: 10.1104/pp.18.01434. [PMID: 30659066]
  • Yu A Kupriyanov, G R Kasyan, D Yu Pushkar. [A role of fesoterodine in treatment of overactive bladder]. Urologiia (Moscow, Russia : 1999). 2018 Dec; ?(6):155-162. doi: 10.18565/urology.2018.6.155-162. [PMID: 30742396]
  • Worku Bedada, Fernando de Andrés, Ephrem Engidawork, Jemal Hussein, Adrián LLerena, Eleni Aklillu. Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations. Scientific reports. 2018 08; 8(1):12726. doi: 10.1038/s41598-018-31191-1. [PMID: 30143732]
  • Eeva J Vainio, Jaana Jurvansuu, Rafiqul Hyder, Muhammad Kashif, Tuula Piri, Tero Tuomivirta, Anna Poimala, Ping Xu, Salla Mäkelä, Dina Nitisa, Jarkko Hantula. Heterobasidion Partitivirus 13 Mediates Severe Growth Debilitation and Major Alterations in the Gene Expression of a Fungal Forest Pathogen. Journal of virology. 2018 03; 92(5):. doi: 10.1128/jvi.01744-17. [PMID: 29237832]
  • María José Ojeda-Montes, Andrea Ardid-Ruiz, Sarah Tomás-Hernández, Aleix Gimeno, Adrià Cereto-Massagué, Raúl Beltrán-Debón, Miquel Mulero, Santiago Garcia-Vallvé, Gerard Pujadas, Cristina Valls. Ephedrine as a lead compound for the development of new DPP-IV inhibitors. Future medicinal chemistry. 2017 12; 9(18):2129-2146. doi: 10.4155/fmc-2017-0080. [PMID: 29172693]
  • Luke R Tembrock, Corey D Broeckling, Adam L Heuberger, Mark P Simmons, Frank R Stermitz, Jessica M Uvarov. Employing Two-stage Derivatisation and GC-MS to Assay for Cathine and Related Stimulant Alkaloids across the Celastraceae. Phytochemical analysis : PCA. 2017 Jul; 28(4):257-266. doi: 10.1002/pca.2671. [PMID: 28124803]
  • Zhi-Cheng Yao, Si-Cong Chen, Zeeshan Ahmad, Jie Huang, Ming-Wei Chang, Jing-Song Li. Essential Oil Bioactive Fibrous Membranes Prepared via Coaxial Electrospinning. Journal of food science. 2017 Jun; 82(6):1412-1422. doi: 10.1111/1750-3841.13723. [PMID: 28471056]
  • Takeshi Funakoshi, Toshihiko Aki, Masateru Tajiri, Kana Unuma, Koichi Uemura. Necroptosis-like Neuronal Cell Death Caused by Cellular Cholesterol Accumulation. The Journal of biological chemistry. 2016 Nov; 291(48):25050-25065. doi: 10.1074/jbc.m116.727404. [PMID: 27756839]
  • Masako Fukuda, Yasushi Kawagoe, Takahiro Murakami, Haruhiko Washida, Aya Sugino, Ai Nagamine, Thomas W Okita, Masahiro Ogawa, Toshihiro Kumamaru. The Dual Roles of the Golgi Transport 1 (GOT1B): RNA Localization to the Cortical Endoplasmic Reticulum and the Export of Proglutelin and α-Globulin from the Cortical ER to the Golgi. Plant & cell physiology. 2016 Nov; 57(11):2380-2391. doi: 10.1093/pcp/pcw154. [PMID: 27565205]
  • Chuixiu Huang, Knut Fredrik Seip, Astrid Gjelstad, Stig Pedersen-Bjergaard. Electromembrane extraction of polar basic drugs from plasma with pure bis(2-ethylhexyl) phosphite as supported liquid membrane. Analytica chimica acta. 2016 Aug; 934(?):80-7. doi: 10.1016/j.aca.2016.06.002. [PMID: 27506347]
  • Eun Sook Jeong, Ki Hun Kim, Eunju Cha, Oh-Seung Kwon, Sangwon Cha, Jaeick Lee. Direct and rapid quantitation of ephedrines in human urine by paper spray ionization/high resolution mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Aug; 1028(?):237-241. doi: 10.1016/j.jchromb.2016.06.040. [PMID: 27393909]
  • Minaleshewa Atlabachew, Nelson Torto, Bhagwan Singh Chandravanshi, Mesfin Redi-Abshiro, Samuel Chigome, Kediemetse Mothibedi, Sandra Combrinck. A (-)-norephedrine-based molecularly imprinted polymer for the solid-phase extraction of psychoactive phenylpropylamino alkaloids from Khat (Catha edulis Vahl. Endl.) chewing leaves. Biomedical chromatography : BMC. 2016 Jul; 30(7):1007-1015. doi: 10.1002/bmc.3643. [PMID: 26531856]
  • Borbála Molnár, Blanka Fodor, Imre Boldizsár, Ibolya Molnár-Perl. Trimethylsilyl speciations of cathine, cathinone and norephedrine followed by gas chromatography mass spectrometry: Direct sample preparation and analysis of khatamines. Journal of chromatography. A. 2016 Apr; 1440(?):172-178. doi: 10.1016/j.chroma.2016.02.044. [PMID: 26928873]
  • J G Pallarés, Á López-Samanes, V E Fernández-Elías, R Aguado-Jiménez, J F Ortega, C Gómez, R Ventura, J Segura, R Mora-Rodríguez. Pseudoephedrine and circadian rhythm interaction on neuromuscular performance. Scandinavian journal of medicine & science in sports. 2015 Dec; 25(6):e603-12. doi: 10.1111/sms.12385. [PMID: 25515692]
  • Luísa C Carvalho, João L Coito, Silvana Colaço, Maurício Sangiogo, Sara Amâncio. Heat stress in grapevine: the pros and cons of acclimation. Plant, cell & environment. 2015 Apr; 38(4):777-89. doi: 10.1111/pce.12445. [PMID: 25211707]
  • Shuai Song, Qingfa Tang, Huiling Huo, Hancheng Li, Xuefeng Xing, Jiabo Luo. Simultaneous quantification and pharmacokinetics of alkaloids in Herba Ephedrae-Radix Aconiti Lateralis extracts. Journal of analytical toxicology. 2015 Jan; 39(1):58-68. doi: 10.1093/jat/bku113. [PMID: 25324527]
  • Nilesh B Patel. "Natural Amphetamine" Khat: A Cultural Tradition or a Drug of Abuse?. International review of neurobiology. 2015; 120(?):235-55. doi: 10.1016/bs.irn.2015.02.006. [PMID: 26070760]
  • Ravinder Earla, Santosh Kumar, Lei Wang, Steven Bosinger, Junhao Li, Ankit Shah, Mohitkumar Gangwani, Anantha Nookala, Xun Liu, Lu Cao, Austin Jackson, Peter S Silverstein, Howard S Fox, Weihua Li, Anil Kumar. Enhanced methamphetamine metabolism in rhesus macaque as compared with human: an analysis using a novel method of liquid chromatography with tandem mass spectrometry, kinetic study, and substrate docking. Drug metabolism and disposition: the biological fate of chemicals. 2014 Dec; 42(12):2097-108. doi: 10.1124/dmd.114.059378. [PMID: 25301936]
  • Hua Tang, Jian Chen, Yongfu Wang, Ting Yu, Changping Guo, Xiaoqi Liao. Combination of sacral neuromodulation and tolterodine for treatment of idiopathic overactive bladder in women: a clinical trial. Urology journal. 2014 Sep; 11(4):1800-5. doi: . [PMID: 25194079]
  • Xuri Wu, Mengdan Fei, Yong Chen, Zongqiang Wang, Yijun Chen. Enzymatic synthesis of L-norephedrine by coupling recombinant pyruvate decarboxylase and ω-transaminase. Applied microbiology and biotechnology. 2014 Sep; 98(17):7399-408. doi: 10.1007/s00253-014-5797-1. [PMID: 24818692]
  • Ximing Liu, Lu Fu, Wenwen Dai, Wei Liu, Jinlong Zhao, Yi Wu, Lengsheng Teng, Fengying Sun, Youxin Li. Design of transparent film-forming hydrogels of tolterodine and their effects on stratum corneum. International journal of pharmaceutics. 2014 Aug; 471(1-2):322-31. doi: 10.1016/j.ijpharm.2014.05.051. [PMID: 24882035]
  • Osamu Yamaguchi, Eiji Marui, Hidehiro Kakizaki, Yukio Homma, Yasuhiko Igawa, Masayuki Takeda, Osamu Nishizawa, Momokazu Gotoh, Masaki Yoshida, Osamu Yokoyama, Narihito Seki, Yasushi Ikeda, Sumito Ohkawa. Phase III, randomised, double-blind, placebo-controlled study of the β3-adrenoceptor agonist mirabegron, 50 mg once daily, in Japanese patients with overactive bladder. BJU international. 2014 Jun; 113(6):951-60. doi: 10.1111/bju.12649. [PMID: 24471907]
  • Chunlan Jin, Xinyao Zhou, Ran Pang. Effect of electroacupuncture combined with tolterodine on treating female mixed urinary incontinence. Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society. 2014 May; 41(3):268-72. doi: 10.1097/won.0000000000000025. [PMID: 24805179]
  • Yongil Yang, Andrew J Crofts, Naoko Crofts, Thomas W Okita. Multiple RNA binding protein complexes interact with the rice prolamine RNA cis-localization zipcode sequences. Plant physiology. 2014 Mar; 164(3):1271-82. doi: 10.1104/pp.113.234187. [PMID: 24488967]
  • Tahereh Eftekhar, Nastaran Teimoory, Elahe Miri, Abolghasem Nikfallah, Mahsa Naeimi, Mahsa Ghajarzadeh. Posterior tibial nerve stimulation for treating neurologic bladder in women: a randomized clinical trial. Acta medica Iranica. 2014; 52(11):816-21. doi: NULL. [PMID: 25415813]
  • Rong Yi, Sarah Zhao, Geoffrey Lam, Jasmeet Sandhu, Devan Loganathan, Barbara Morrissey. Detection and elimination profile of cathinone in equine after norephedrine (Propalin®) administration using a validated liquid chromatography-tandem mass spectrometry method. Analytical and bioanalytical chemistry. 2013 Dec; 405(30):9711-22. doi: 10.1007/s00216-013-7073-0. [PMID: 23954941]
  • Yang-Yun Wang, Guo-Wei Shi, Jia-Yang He, Yan-Bin Zhang. [Cardura monotherapy versus combination therapy of cardura and tolterodine L-tartrate tablets for II° ? benign prostatic hyperplasia with overactive bladder]. Zhonghua nan ke xue = National journal of andrology. 2013 Dec; 19(12):1099-102. doi: NULL. [PMID: 24432622]
  • Fengying Sun, Cheng Sui, Yulin Zhou, Ximing Liu, Yanan Shi, Yi Wu, Youxin Li. Preparation, characterization and pharmacological evaluation of tolterodine hydrogels for the treatment of overactive bladder. International journal of pharmaceutics. 2013 Sep; 454(1):532-8. doi: 10.1016/j.ijpharm.2013.07.041. [PMID: 23891744]
  • Chiu-Lin Wang, Chin-Hu Wu, Cheng-Min Liu, Ching-Ju Shen, Kun-Ling Lin, Cheng-Yu Long. Clinical and urodynamic effects of tolterodine in women with an overactive bladder. Taiwanese journal of obstetrics & gynecology. 2013 Sep; 52(3):381-4. doi: 10.1016/j.tjog.2012.06.001. [PMID: 24075377]
  • Fatma Gurdal, Mahmut Asirdizer, Rezzan Gulhan Aker, Senol Korkut, Yasemin Gocer, E Esra Kucukibrahimoglu, C Haluk Ince. Review of detection frequency and type of synthetic cannabinoids in herbal compounds analyzed by Istanbul Narcotic Department of the Council of Forensic Medicine, Turkey. Journal of forensic and legal medicine. 2013 Aug; 20(6):667-72. doi: 10.1016/j.jflm.2013.03.041. [PMID: 23910858]
  • Therese Bredholt, Elisabeth Ersvær, Bjarte Skoe Erikstein, André Sulen, Håkon Reikvam, Hans Jørgen Aarstad, Anne Christine Johannessen, Olav Karsten Vintermyr, Øystein Bruserud, Bjørn Tore Gjertsen. Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine. BMC pharmacology & toxicology. 2013 Jul; 14(?):35. doi: 10.1186/2050-6511-14-35. [PMID: 23845085]
  • Abdurrahman Karaman, Emine Samdancı, Sadegül Sayın, Ismail Karabulut, Ersin Fadıllıoglu. Effects of tolterodine and trospium chloride on renal damage induced by partial upper urinary tract obstruction. Urology. 2013 Jul; 82(1):194-200. doi: 10.1016/j.urology.2013.01.030. [PMID: 23453648]
  • Gabriella Roda, Vincenzo Liberti, Sebastiano Arnoldi, Antonella Argo, Chiara Rusconi, Sonia Suardi, Veniero Gambaro. Capillary electrophoretic and extraction conditions for the analysis of Catha edulis FORKS active principles. Forensic science international. 2013 May; 228(1-3):154-9. doi: 10.1016/j.forsciint.2013.02.034. [PMID: 23597752]
  • Chun-Hou Liao, Yu-Chen Kuo, Hann-Chorng Kuo. Predictors of successful first-line antimuscarinic monotherapy in men with enlarged prostate and predominant storage symptoms. Urology. 2013 May; 81(5):1030-3. doi: 10.1016/j.urology.2013.01.018. [PMID: 23506731]
  • Lorenza Bellani, Stefania Giglioni, Simonetta Muccifora. Protein characterization of protein bodies from cotyledons of Mucuna pruriens (L.) DC. Plant foods for human nutrition (Dordrecht, Netherlands). 2013 Mar; 68(1):47-51. doi: 10.1007/s11130-012-0331-z. [PMID: 23329422]
  • Toshiki Hatanaka, Masashi Ukai, Mai Watanabe, Akiyoshi Someya, Akiyoshi Ohtake, Masanori Suzuki, Koji Ueshima, Shuichi Sato, Seiji Kaku. Effect of mirabegron, a novel β3-adrenoceptor agonist, on bladder function during storage phase in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2013 Jan; 386(1):71-8. doi: 10.1007/s00210-012-0814-3. [PMID: 23224420]
  • Hsin-Tzu Liu, Yuan-Hong Jiang, Hann-Chorng Kuo. Increased serum adipokines implicate chronic inflammation in the pathogenesis of overactive bladder syndrome refractory to antimuscarinic therapy. PloS one. 2013; 8(10):e76706. doi: 10.1371/journal.pone.0076706. [PMID: 24098552]
  • Raz Krizevski, Einat Bar, O R Shalit, Asaf Levy, Jillian M Hagel, Korey Kilpatrick, Frédéric Marsolais, Peter J Facchini, Shimon Ben-Shabat, Yaron Sitrit, Efraim Lewinsohn. Benzaldehyde is a precursor of phenylpropylamino alkaloids as revealed by targeted metabolic profiling and comparative biochemical analyses in Ephedra spp. Phytochemistry. 2012 Sep; 81(?):71-9. doi: 10.1016/j.phytochem.2012.05.018. [PMID: 22727117]
  • Nasir Idkaidek, Tawfiq Arafat. Saliva versus plasma pharmacokinetics: theory and application of a salivary excretion classification system. Molecular pharmaceutics. 2012 Aug; 9(8):2358-63. doi: 10.1021/mp300250r. [PMID: 22784220]
  • Jie Liu, Zhongyan Wang, Chao Liu, Honglei Xi, Chunmei Li, Yang Chen, Lin Sun, Liwei Mu, Liang Fang. Silicone adhesive, a better matrix for tolterodine patches-a research based on in vitro/in vivo studies. Drug development and industrial pharmacy. 2012 Aug; 38(8):1008-14. doi: 10.3109/03639045.2011.637049. [PMID: 22126709]
  • Usama Alshana, Nilgün G Göğer, Nusret Ertaş. Ultrasound-assisted emulsification microextraction for the determination of ephedrines in human urine by capillary electrophoresis with direct injection. Comparison with dispersive liquid-liquid microextraction. Journal of separation science. 2012 Aug; 35(16):2114-21. doi: 10.1002/jssc.201200308. [PMID: 22730227]
  • Marwa M Sakr, Rasha M El Nashar. Potentiometric determination of tolterodine in batch and flow injection conditions. Talanta. 2012 Jul; 96(?):153-60. doi: 10.1016/j.talanta.2012.02.018. [PMID: 22817943]
  • Osquel Barroso, Danielle Goudreault, Marcel-lí Carbó Banús, Christiane Ayotte, Irene Mazzoni, Thierry Boghosian, Olivier Rabin. Determination of urinary concentrations of pseudoephedrine and cathine after therapeutic administration of pseudoephedrine-containing medications to healthy subjects: implications for doping control analysis of these stimulants banned in sport. Drug testing and analysis. 2012 May; 4(5):320-9. doi: 10.1002/dta.291. [PMID: 21548139]
  • Veniero Gambaro, Sebastiano Arnoldi, Maria Laura Colombo, Lucia Dell'Acqua, Katia Guerrini, Gabriella Roda. Determination of the active principles of Catha Edulis: quali-quantitative analysis of cathinone, cathine, and phenylpropanolamine. Forensic science international. 2012 Apr; 217(1-3):87-92. doi: 10.1016/j.forsciint.2011.09.028. [PMID: 22024653]
  • Sunju Park, Jeong-Su Park, ChunHoo Cheon, Yong Joon Yang, Changsuk An, Bo-Hyoung Jang, Yun-Kyung Song, Hoyeon Go, Ju Ah Lee, Yongcheol Shin, Seong-Gyu Ko. A pilot study to evaluate the effect of Taeumjowi-tang on obesity in Korean adults: study protocol for a randomised, double-blind, placebo-controlled, multicentre trial. Trials. 2012 Apr; 13(?):33. doi: 10.1186/1745-6215-13-33. [PMID: 22483238]
  • Saba Kassim, Aamenah Hawash, Atholl Johnston, Ray Croucher. Validation of self-reported khat chewing amongst khat chewers: an exploratory study. Journal of ethnopharmacology. 2012 Mar; 140(1):193-6. doi: 10.1016/j.jep.2011.12.040. [PMID: 22244798]
  • Yi-Liang' Chen, Wei-Ju Feng, Xiao-Li Zhang. [Parkinson's disease combined with overactive bladder syndrome treated with acupuncture and medication]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2012 Mar; 32(3):215-8. doi: NULL. [PMID: 22471132]
  • Isabel Comino, Ana Real, Santiago Vivas, Miguel Ángel Síglez, Alberto Caminero, Esther Nistal, Javier Casqueiro, Alfonso Rodríguez-Herrera, Angel Cebolla, Carolina Sousa. Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces. The American journal of clinical nutrition. 2012 Mar; 95(3):670-7. doi: 10.3945/ajcn.111.026708. [PMID: 22258271]
  • Toshiaki Nagai, Akira Kurosu, Kazumi Matsushima, Junko Maeda, Atsushi Tohei, Shinobu Yamauchi, Masahito Hitosugi, Shogo Tokudome. Simultaneous identification of the enantiomers and diastereomers of N,O-di-trifluoroacetylated ephedrine and norephedrine in blood plasma using chiral capillary gas chromatography-mass spectrometry with selected ion monitoring. Journal of analytical toxicology. 2012 Mar; 36(2):96-105. doi: 10.1093/jat/bkr010. [PMID: 22337778]
  • Thitirat Mantim, Duangjai Nacapricha, Prapin Wilairat, Peter C Hauser. Enantiomeric separation of some common controlled stimulants by capillary electrophoresis with contactless conductivity detection. Electrophoresis. 2012 Jan; 33(2):388-94. doi: 10.1002/elps.201100370. [PMID: 22170109]
  • Itaru Maruyama, Saori Yonekubo, Satoshi Tatemichi, Kazuyasu Maruyama, Yuji Hoyano, Yoshinobu Yamazaki, Hiroshi Kusama. Effects of ritobegron (KUC-7483), a novel β3-adrenoceptor agonist, on both rat bladder function following partial bladder outlet obstruction and on rat salivary secretion: a comparison with the effects of tolterodine. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 2012; 48(5-6):115-24. doi: 10.1540/jsmr.48.115. [PMID: 23538508]
  • Mohamed I Walash, Nahed M El-Enany, Samar Saad. Spectrophotometric determination of certain CNS stimulants in dosage forms and spiked human urine via derivatization with 2,4-Dinitrofluorobenzene. Chemistry Central journal. 2011 Oct; 5(?):65. doi: 10.1186/1752-153x-5-65. [PMID: 22032335]
  • Sun-Ouck Kim, Eu Chang Hwang, Kyung Jin Oh, Dongdeuk Kwon, Kwangsung Park, Soo Bang Ryu. Efficacy and safety of combined therapy with tamsulosin and tolterodine in female patients with a maximal flow rate less than 12 ml/s. International urogynecology journal. 2011 Oct; 22(10):1287-91. doi: 10.1007/s00192-011-1453-9. [PMID: 21617983]
  • Ernesto Callegari, Bimal Malhotra, Peter J Bungay, Rob Webster, Katherine S Fenner, Sarah Kempshall, Jennifer L LaPerle, Martin C Michel, Gary G Kay. A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder. British journal of clinical pharmacology. 2011 Aug; 72(2):235-46. doi: 10.1111/j.1365-2125.2011.03961.x. [PMID: 21392072]
  • Hiroshi Nagabukuro, Katherine L Villa, L Alexandra Wickham, Alison A Kulick, Loise Gichuru, Marcie J Donnelly, Gregory O Voronin, Tony Pereira, Xinchun Tong, Andrew Nichols, Stephen E Alves, Gary P O'Neill, Christopher V Johnson, Emily J Hickey. Comparative analysis of the effects of antimuscarinic agents on bladder functions in both nonhuman primates and rodents. The Journal of pharmacology and experimental therapeutics. 2011 Jul; 338(1):220-7. doi: 10.1124/jpet.111.179747. [PMID: 21459965]
  • Wen-Yih Wu, Sheng-Mou Hsiao, Ting-Chen Chang, Ho-Hsiung Lin. Changes in urodynamic parameters after tolterodine treatment for female overactive bladder syndrome with or without voiding dysfunction. The journal of obstetrics and gynaecology research. 2011 May; 37(5):436-41. doi: 10.1111/j.1447-0756.2010.01370.x. [PMID: 21272154]
  • Wei Gan, Shao-Feng Zhang, Hong-Tao Jia, Sheng Xie, Mao-Hua Luo, Yun-Fei Li. [Tolterodine tartrate combined with alpha-receptor blocker for benign prostatic hyperplasia with detrusor overactivity]. Zhonghua nan ke xue = National journal of andrology. 2011 Apr; 17(4):348-50. doi: . [PMID: 21548214]
  • Mario Suwalsky, Pablo Zambrano, Sigrid Mennickent, Fernando Villena, Carlos P Sotomayor, Luis F Aguilar, Silvia Bolognin. Effects of phenylpropanolamine (PPA) on in vitro human erythrocyte membranes and molecular models. Biochemical and biophysical research communications. 2011 Mar; 406(3):320-5. doi: 10.1016/j.bbrc.2011.01.117. [PMID: 21320467]
  • Stine Mjåvatn Jakobsen, Hege Kersten, Espen Molden. Evaluation of brain anticholinergic activities of urinary spasmolytic drugs using a high-throughput radio receptor bioassay. Journal of the American Geriatrics Society. 2011 Mar; 59(3):501-5. doi: 10.1111/j.1532-5415.2010.03307.x. [PMID: 21391941]
  • Denny Proksch, Jan Jasper Klein, Christoph Arenz. Potent inhibition of Acid ceramidase by novel B-13 analogues. Journal of lipids. 2011; 2011(?):971618. doi: 10.1155/2011/971618. [PMID: 21490813]
  • Marta D Van Loan, Nancy L Keim, Sean H Adams, Elaine Souza, Leslie R Woodhouse, Anthony Thomas, Megan Witbracht, Erik R Gertz, Brian Piccolo, Andrew A Bremer, Michael Spurlock. Dairy Foods in a Moderate Energy Restricted Diet Do Not Enhance Central Fat, Weight, and Intra-Abdominal Adipose Tissue Losses nor Reduce Adipocyte Size or Inflammatory Markers in Overweight and Obese Adults: A Controlled Feeding Study. Journal of obesity. 2011; 2011(?):989657. doi: 10.1155/2011/989657. [PMID: 21941636]
  • Richard Hoffman, Mustafa Al'Absi. Khat use and neurobehavioral functions: suggestions for future studies. Journal of ethnopharmacology. 2010 Dec; 132(3):554-63. doi: 10.1016/j.jep.2010.05.033. [PMID: 20553832]
  • Muchtaridi, Anas Subarnas, Anton Apriyantono, Resmi Mustarichie. Identification of compounds in the essential oil of nutmeg seeds (Myristica fragrans Houtt.) that inhibit locomotor activity in mice. International journal of molecular sciences. 2010 Nov; 11(11):4771-81. doi: 10.3390/ijms11114771. [PMID: 21151471]
  • Christopher R Chapple, Sender Herschorn, Paul Abrams, Joseph T Wang, Marina Brodsky, Zhonghong Guan. Efficacy and safety of tolterodine extended-release in men with overactive bladder symptoms treated with an α-blocker: effect of baseline prostate-specific antigen concentration. BJU international. 2010 Nov; 106(9):1332-8. doi: 10.1111/j.1464-410x.2010.09359.x. [PMID: 20497416]
  • Fengying Sun, Cheng Sui, Lesheng Teng, Ximing Liu, Lirong Teng, Qingfan Meng, Youxin Li. Studies on the preparation, characterization and pharmacological evaluation of tolterodine PLGA microspheres. International journal of pharmaceutics. 2010 Sep; 397(1-2):44-9. doi: 10.1016/j.ijpharm.2010.06.042. [PMID: 20600717]
  • Workineh Getahun, Teferi Gedif, Fikru Tesfaye. Regular Khat (Catha edulis) chewing is associated with elevated diastolic blood pressure among adults in Butajira, Ethiopia: a comparative study. BMC public health. 2010 Jul; 10(?):390. doi: 10.1186/1471-2458-10-390. [PMID: 20594361]
  • Guoyi Ma, Supriya A Bavadekar, Brian T Schaneberg, Ikhlas A Khan, Dennis R Feller. Effects of synephrine and beta-phenethylamine on human alpha-adrenoceptor subtypes. Planta medica. 2010 Jul; 76(10):981-6. doi: 10.1055/s-0029-1240884. [PMID: 20217639]
  • F Badoud, E Grata, L Perrenoud, M Saugy, S Rudaz, J-L Veuthey. Fast analysis of doping agents in urine by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry. II: Confirmatory analysis. Journal of chromatography. A. 2010 Jun; 1217(25):4109-19. doi: 10.1016/j.chroma.2009.11.001. [PMID: 19939397]
  • Lawrence Maayan, Julia Vakhrusheva, Christoph U Correll. Effectiveness of medications used to attenuate antipsychotic-related weight gain and metabolic abnormalities: a systematic review and meta-analysis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2010 Jun; 35(7):1520-30. doi: 10.1038/npp.2010.21. [PMID: 20336059]
  • Philippe Zimmern, Heather J Litman, Elizabeth Mueller, Peggy Norton, Patricia Goode. Effect of fluid management on fluid intake and urge incontinence in a trial for overactive bladder in women. BJU international. 2010 Jun; 105(12):1680-5. doi: 10.1111/j.1464-410x.2009.09055.x. [PMID: 19912207]
  • Daniel A Shoskes, J Curtis Nickel, Michael W Kattan. Phenotypically directed multimodal therapy for chronic prostatitis/chronic pelvic pain syndrome: a prospective study using UPOINT. Urology. 2010 Jun; 75(6):1249-53. doi: 10.1016/j.urology.2010.01.021. [PMID: 20363491]
  • Raz Krizevski, Einat Bar, Or Shalit, Yaron Sitrit, Shimon Ben-Shabat, Efraim Lewinsohn. Composition and stereochemistry of ephedrine alkaloids accumulation in Ephedra sinica Stapf. Phytochemistry. 2010 Jun; 71(8-9):895-903. doi: 10.1016/j.phytochem.2010.03.019. [PMID: 20417943]
  • Sabina Strano-Rossi, Daniele Leone, Xavier de la Torre, Francesco Botrè. Analysis of stimulants in oral fluid and urine by gas chromatography-mass spectrometry II: pseudophedrine. Journal of analytical toxicology. 2010 May; 34(4):210-5. doi: 10.1093/jat/34.4.210. [PMID: 20465867]
  • Stéphanie Noël, Carole Cambier, Kris Baert, Pascal Gustin, Raphael Denooz, Laurent Massart, Annick Hamaide. Combined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female Beagle dogs. Veterinary journal (London, England : 1997). 2010 May; 184(2):201-7. doi: 10.1016/j.tvjl.2009.01.026. [PMID: 19282207]
  • Rex Watson, Ryan Woodman, Warren Lockette. Ephedra alkaloids inhibit platelet aggregation. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2010 Apr; 21(3):266-71. doi: 10.1097/mbc.0b013e328337b39f. [PMID: 20179577]
  • Ulrich Mehnert, André Reitz, Sumaya Abo Youssef, Brigitte Schurch. Proof of principle: The effect of antimuscarinics on bladder filling sensations in healthy subjects--a placebo controlled double blind investigation using 4 and 8 mg tolterodine extended release. Neurourology and urodynamics. 2010 Mar; 29(3):464-9. doi: 10.1002/nau.20743. [PMID: 19637377]
  • Tim Laussmann, Sigrid Meier-Giebing. Forensic analysis of hallucinogenic mushrooms and khat (Catha edulis Forsk) using cation-exchange liquid chromatography. Forensic science international. 2010 Feb; 195(1-3):160-4. doi: 10.1016/j.forsciint.2009.12.013. [PMID: 20047807]
  • John S Chappell, Marsha M Lee. Cathinone preservation in khat evidence via drying. Forensic science international. 2010 Feb; 195(1-3):108-20. doi: 10.1016/j.forsciint.2009.12.002. [PMID: 20036789]
  • Jean-Jacques Wyndaele. Pediatrics: combining antimuscarinics shows promise for overactive bladder. Nature reviews. Urology. 2010 Feb; 7(2):66-8. doi: 10.1038/nrurol.2010.1. [PMID: 20145662]
  • Katsuhiro Hayashi, Kyoko Shimura, Toshiaki Makino, Hajime Mizukami. Comparison of the contents of kampo decoctions containing ephedra herb when prepared simply or by re-boiling according to the traditional theory. Journal of natural medicines. 2010 Jan; 64(1):70-4. doi: 10.1007/s11418-009-0375-z. [PMID: 20091242]
  • David E Scheim. Cytotoxicity of unsaturated fatty acids in fresh human tumor explants: concentration thresholds and implications for clinical efficacy. Lipids in health and disease. 2009 Dec; 8(?):54. doi: 10.1186/1476-511x-8-54. [PMID: 20003514]
  • Therese Bredholt, Elizabeth Ao Dimba, Hanne R Hagland, Line Wergeland, Jørn Skavland, Kjell O Fossan, Karl J Tronstad, Anne C Johannessen, Olav K Vintermyr, Bjørn T Gjertsen. Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Molecular cancer. 2009 Nov; 8(?):101. doi: 10.1186/1476-4598-8-101. [PMID: 19912650]
  • Akira Tsujimura, Tetsuya Takao, Kinya Uchida, Keisuke Yamamoto, Shinichiro Fukuhara, Jiro Nakayama, Tomohiro Ueda, Toshiaki Hirai, Hiroshi Kiuchi, Yasushi Miyagawa, Toru Takahashi, Yasuyuki Kojimaan, Akihiko Okuyama. [Clinical efficacy of tolterodine for patients with overactive bladder after insufficient efficacy by monotherapy with alpha1-adrenoceptor antagonist]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology. 2009 Nov; 100(7):686-92. doi: 10.5980/jpnjurol.100.686. [PMID: 19999133]
  • Stéphane Bolduc, Katherine Moore, Sylvie Lebel, Pascale Lamontagne, Micheline Hamel. Double anticholinergic therapy for refractory overactive bladder. The Journal of urology. 2009 Oct; 182(4 Suppl):2033-8. doi: 10.1016/j.juro.2009.05.099. [PMID: 19695628]
  • Debra S Harris, Thomas Everhart, Peyton Jacob, Emil Lin, John E Mendelson, Reese T Jones. A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. BMC clinical pharmacology. 2009 Aug; 9(?):13. doi: 10.1186/1472-6904-9-13. [PMID: 19646280]
  • A Pokrywka, W Tszyrsznic, D J Kwiatkowska. Problems of the use of pseudoephedrine by athletes. International journal of sports medicine. 2009 Aug; 30(8):569-72. doi: 10.1055/s-0029-1202826. [PMID: 19382058]
  • Sabina Strano-Rossi, Daniele Leone, Xavier de la Torre, Francesco Botrè. The relevance of the urinary concentration of ephedrines in anti-doping analysis: determination of pseudoephedrine, cathine, and ephedrine after administration of over-the-counter medicaments. Therapeutic drug monitoring. 2009 Aug; 31(4):520-6. doi: 10.1097/ftd.0b013e3181ac6006. [PMID: 19571776]
  • Ligang Zhao, Yan Li, Liang Fang, Zhonggui He, Xuntao Liu, Lin Wang, Yongnan Xu, Changshu Ren. Transdermal delivery of tolterodine by O-acylmenthol: In vitro/in vivo correlation. International journal of pharmaceutics. 2009 Jun; 374(1-2):73-81. doi: 10.1016/j.ijpharm.2009.03.005. [PMID: 19446762]
  • Hsin-Tzu Liu, Michael B Chancellor, Hann-Chorng Kuo. Decrease of urinary nerve growth factor levels after antimuscarinic therapy in patients with overactive bladder. BJU international. 2009 Jun; 103(12):1668-72. doi: 10.1111/j.1464-410x.2009.08380.x. [PMID: 19220267]
  • K Deventer, P Van Eenoo, G Baele, O J Pozo, W Van Thuyne, F T Delbeke. Interpretation of urinary concentrations of pseudoephedrine and its metabolite cathine in relation to doping control. Drug testing and analysis. 2009 May; 1(5):209-13. doi: 10.1002/dta.31. [PMID: 20355197]
  • Jan Macek, Pavel Ptácek, Josef Klíma. Determination of tolterodine and its 5-hydroxymethyl metabolite in human plasma by hydrophilic interaction liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Apr; 877(10):968-74. doi: 10.1016/j.jchromb.2009.02.036. [PMID: 19269904]