Tranexamic Acid (BioDeep_00000001965)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(1r,4r)-4-(aminomethyl)cyclohexane-1-carboxylic acid
化学式: C8H15NO2 (157.110273)
中文名称: 4-(氨甲基)环己甲酸 (顺反混合物), 顺式氨甲环酸, 氨甲环酸
谱图信息:
最多检出来源 Homo sapiens(blood) 0.6%
分子结构信息
SMILES: C1CC(CCC1CN)C(=O)O
InChI: InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
描述信息
Tranexamic Acid is only found in individuals that have used or taken this drug. It is an antifibrinolytic hemostatic used in severe hemorrhage. [PubChem]Tranexamic acid competitively inhibits activation of plasminogen (via binding to the kringle domain), thereby reducing conversion of plasminogen to plasmin (fibrinolysin), an enzyme that degrades fibrin clots, fibrinogen, and other plasma proteins, including the procoagulant factors V and VIII. Tranexamic acid also directly inhibits plasmin activity, but higher doses are required than are needed to reduce plasmin formation.
B - Blood and blood forming organs > B02 - Antihemorrhagics > B02A - Antifibrinolytics > B02AA - Amino acids
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
C78275 - Agent Affecting Blood or Body Fluid > C78311 - Hemostatic Agent
D050299 - Fibrin Modulating Agents > D000933 - Antifibrinolytic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis [1][2][3][4][5].
同义名列表
22 个代谢物同义名
(1r,4r)-4-(aminomethyl)cyclohexane-1-carboxylic acid; trans-4-AMINOMETHYLCYCLOHEXANE-1-carboxylIC ACID; trans-4-(Aminomethyl)cyclohexanecarboxylic acid; cis-4-aminomethyl-1-cyclohexanecarboxylic acid; trans-4-AMINOMETHYLCYCLOHEXANE-1-carboxylate; trans-4-(Aminomethyl)cyclohexanecarboxylate; trans-Tranexamic acid; Acidum tranexamicum; Acide tranexamique; trans-Tranexamate; Acido tranexamico; Tranhexamic acid; tranexamic acid; Tranexmic acid; Tranexamsaeure; Tranhexamate; Cyklokapron; trans-Amcha; Tranexamate; trans AMCHA; Tranexmate; cyclocapron
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:48669
- ChEBI: CHEBI:94518
- KEGG: C12535
- PubChem: 5526
- HMDB: HMDB0014447
- Metlin: METLIN2893
- DrugBank: DB00302
- ChEMBL: CHEMBL292500
- ChEMBL: CHEMBL877
- Wikipedia: Tranexamic_Acid
- MeSH: Tranexamic Acid
- chemspider: 10482000
- CAS: 1197-18-8
- CAS: 1197-17-7
- CAS: 701-54-2
- PMhub: MS000001559
- PubChem: 582925
- PDB-CCD: AMH
- RefMet: Tranexamic acid
- medchemexpress: HY-B0149
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuan Zhu, Jinhui Xu, Xiuzu Song, Wenzhong Xiang. Comparative study of melasma in patients before and after treatment based on lipomics.
Lipids in health and disease.
2024 May; 23(1):138. doi:
10.1186/s12944-024-02130-z. [PMID: 38734619] - Gang Tan, Jia Li, Jing Xu, Yongzhan Zhu, Hui Zhang. The efficacy and safety of different does of intravenous tranexamic acid on blood loss in fresh foot and ankle fractures: a prospective, randomized controlled study.
BMC musculoskeletal disorders.
2024 Apr; 25(1):274. doi:
10.1186/s12891-024-07410-4. [PMID: 38589854] - Wenhao Zheng, Sutao Liu, Liming Tian, Dan Ke. Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma.
Journal of visualized experiments : JoVE.
2024 Jan; ?(203):. doi:
10.3791/66015. [PMID: 38314835] - Si-Cheng Xiang, Shao-Ning Shen, Rui Wang, Zheng-Ming Wang, Zhao-Kai Jin, Hai Su, Pei-Jian Tong, Shuai-Jie Lv. Intra-articular injection of tranexamic acid in patients with haemophilia arthritis: retrospective controlled study in total knee arthroplasty.
International orthopaedics.
2023 Sep; ?(?):. doi:
10.1007/s00264-023-05983-8. [PMID: 37740768] - Yong-Ze Yang, Qing-Hao Cheng, An-Ren Zhang, Xin Yang, Zhuang-Zhuang Zhang, Hong-Zhang Guo. Efficacy and safety of single- and double-dose intravenous tranexamic acid in hip and knee arthroplasty: a systematic review and meta-analysis.
Journal of orthopaedic surgery and research.
2023 Aug; 18(1):593. doi:
10.1186/s13018-023-03929-9. [PMID: 37563702] - Luhan Bao, Zhiqiang Zhang, Xiaoxiao Li, Lei Zhang, Hua Tian, Minwei Zhao, Tingjun Ye, Wenguo Cui. Bacteriosynthetic Degradable Tranexamic Acid-Functionalized Short Fibers for Inhibiting Invisible Hemorrhage.
Small (Weinheim an der Bergstrasse, Germany).
2023 Jul; ?(?):e2303615. doi:
10.1002/smll.202303615. [PMID: 37501326] - Jinlong Zhao, Guihong Liang, Hetao Huang, Kunhao Hong, Jianke Pan, Weiyi Yang, Jun Liu, Lingfeng Zeng. Intravenous Tranexamic Acid Significantly Improved Visualisation and Shortened the Operation Time in Arthroscopic Rotator Cuff Repair: A Systematic Review & Meta-Analysis of Level I and II Studies.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.
2023 Jul; ?(?):. doi:
10.1016/j.arthro.2023.06.055. [PMID: 37423470] - Piyush Verma, Khushwant S Yadav. Novel formulations for topical delivery of tranexamic acid: assessing the need of epidermal targeting for hyperpigmentation disorders.
Expert opinion on drug delivery.
2023 Apr; ?(?):1-11. doi:
10.1080/17425247.2023.2206645. [PMID: 37086183] - Fasika A Woreta, Kristina B Lindsley, Almutez Gharaibeh, Sueko M Ng, Roberta W Scherer, Morton F Goldberg. Medical interventions for traumatic hyphema.
The Cochrane database of systematic reviews.
2023 03; 3(?):CD005431. doi:
10.1002/14651858.cd005431.pub5. [PMID: 36912744] - Lin Li, Hao Pan, Guoqiang Liu, Feng Wang, Shouchao Zheng, Jiangjing Wang. Value of Tranexamic Acid and Progressive Nursing in Accelerating Postoperative Rehabilitation After Total Knee Arthroplasty.
Alternative therapies in health and medicine.
2023 Jan; 29(1):111-117. doi:
". [PMID: 35951070] - Jiahao Li, Yijin Li, Yiwei Huang, Haitao Zhang, Pengcheng Ye, Peng Deng, Jinlun Chen, Jie Li, Xinyu Qi, Jianchun Zeng, Wenjun Feng, Yirong Zeng. Predictors and complications of blood transfusion in rheumatoid arthritis patients undergoing total joint arthroplasty.
Clinical rheumatology.
2023 Jan; 42(1):67-73. doi:
10.1007/s10067-022-06376-9. [PMID: 36121576] - Berat Metin Adak, Nihat Laçin, Fatma Şimşek, Ersin Uysal, Fahri Emrah Soylu, İrem Özkan. Evaluation of the effects of different hemostatic agent applications on mental nerve.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.
2022 Nov; 279(11):5355-5362. doi:
10.1007/s00405-022-07434-3. [PMID: 35767059] - Erik R Strauss, Shuhui Li, Reney Henderson, Ross Carpenter, Dong Guo, Kiruphagaran Thangaraju, Upendra Katneni, Paul W Buehler, Jogarao V S Gobburu, Kenichi A Tanaka. A Pharmacokinetic and Plasmin-Generation Pharmacodynamic Assessment of a Tranexamic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass.
Journal of cardiothoracic and vascular anesthesia.
2022 Aug; 36(8 Pt A):2473-2482. doi:
10.1053/j.jvca.2021.12.029. [PMID: 35094925] - Taylor E Wallen, Kathleen E Singer, Matthew R Baucom, Lisa G England, Rebecca M Schuster, Timothy A Pritts, Michael D Goodman. Effects of antifibrinolytics on systemic and cerebral inflammation after traumatic brain injury.
The journal of trauma and acute care surgery.
2022 07; 93(1):30-37. doi:
10.1097/ta.0000000000003607. [PMID: 35319541] - Nitin Krishna Patil, Aditya Kumar Bubna. A comparative evaluation of the efficacy of intralesional tranexamic acid versus platelet rich plasma in the treatment of melasma.
Dermatologic therapy.
2022 Jul; 35(7):e15534. doi:
10.1111/dth.15534. [PMID: 35460158] - Jordan W Harmer, Elizabeth N Dewey, Eric N Meier, Susan E Rowell, Martin A Schreiber. Tranexamic acid is not inferior to placebo with respect to adverse events in suspected traumatic brain injury patients not in shock with a normal head computed tomography scan: A retrospective study of a randomized trial.
The journal of trauma and acute care surgery.
2022 Jul; 93(1):98-105. doi:
10.1097/ta.0000000000003635. [PMID: 35358154] - Willy Baccaglini, Antonio Flávio Rodrigues, Felipe P A Glina, Vinicius DallAqua, Sidney Glina, Antonio C Lopes Neto. Tranexamic Acid Use for Hemorrhagic Events Prevention in Percutaneous Nephrolithotomy: Systematic Review and Meta-Analysis.
Journal of endourology.
2022 Jul; 36(7):906-915. doi:
10.1089/end.2021.0792. [PMID: 35072547] - Yağmur Polat, Gülbahar Saraç. Comparison of clinical results of oral tranexamic acid and platelet rich plasma therapies in melasma treatment.
Dermatologic therapy.
2022 Jul; 35(7):e15499. doi:
10.1111/dth.15499. [PMID: 35395121] - Federico Aletti, Frank A DeLano, Elisa Maffioli, Hao Mu, Geert W Schmid-Schönbein, Gabriella Tedeschi, Erik B Kistler. Continuous enteral protease inhibition as a novel treatment for experimental trauma/hemorrhagic shock.
European journal of trauma and emergency surgery : official publication of the European Trauma Society.
2022 Jun; 48(3):1579-1588. doi:
10.1007/s00068-020-01591-y. [PMID: 33483765] - Stephanie G Lee, John Fralick, Christopher J D Wallis, Monica Boctor, Michelle Sholzberg, Michael Fralick. Systematic review of hematuria and acute renal failure with tranexamic acid.
European journal of haematology.
2022 Jun; 108(6):510-517. doi:
10.1111/ejh.13762. [PMID: 35266205] - N E Sigrist, L Langenegger, R S Jud Schefer, K Kluge, A P N Kutter. Effect of early administration of tranexamic acid on ongoing haemorrhage in dogs with non-surgically treated haemoabdomen.
Schweizer Archiv fur Tierheilkunde.
2022 Jun; 164(6):437-446. doi:
10.17236/sat00357. [PMID: 35652254] - Haleema Shakur-Still, Stanislas Grassin-Delyle, Kopalasuntharam Muhunthan, Homa K Ahmadzia, David Faraoni, Monica Arribas, Ian Roberts. Alternative routes to intravenous tranexamic acid for postpartum hemorrhage: A systematic search and narrative review.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.
2022 Jun; 158 Suppl 1(?):40-45. doi:
10.1002/ijgo.14201. [PMID: 35762806] - C Tapking, G Hundeshagen, M Kirchner, S Fischer, U Kneser, B Bliesener. Tranexamic acid reduced blood transfusions in acute burn surgery: A retrospective case-controlled trial.
Burns : journal of the International Society for Burn Injuries.
2022 May; 48(3):522-528. doi:
10.1016/j.burns.2022.03.002. [PMID: 35339324] - Jeffrey M Wilde, Steven N Copp, Kace A Ezzet, Adam S Rosen, Richard H Walker, Julie C McCauley, Audree S Evans, William D Bugbee. No Difference in Blood Loss and Risk of Transfusion Between Patients Treated with One or Two Doses of Intravenous Tranexamic Acid After Simultaneous Bilateral TKA.
Clinical orthopaedics and related research.
2022 04; 480(4):702-711. doi:
10.1097/corr.0000000000002037. [PMID: 35302971] - Adrian Joseph Michel Bailey, Heidi Oi-Yee Li, Marcus G Tan, Wei Cheng, Jeffrey S Dover. Microneedling as an adjuvant to topical therapies for melasma: A systematic review and meta-analysis.
Journal of the American Academy of Dermatology.
2022 04; 86(4):797-810. doi:
10.1016/j.jaad.2021.03.116. [PMID: 33857549] - Changwei Chen, Jing Liu, Lei Du. Tranexamic acid after cardiopulmonary bypass does not increase risk of postoperative seizures: a retrospective study.
General thoracic and cardiovascular surgery.
2022 Apr; 70(4):337-346. doi:
10.1007/s11748-021-01709-y. [PMID: 34561761] - Gabriel Eustache, Nicolas Nardi, Chloé Rousseau, Sandra Aouaissia, Sylvie Aillet, Severine Delahaye Larralde, Eric Wodey, Laurent Riffaud. Importance of tranexamic acid in pediatric monosutural craniosynostosis surgery.
Journal of neurosurgery. Pediatrics.
2022 04; 29(4):412-418. doi:
10.3171/2021.10.peds21438. [PMID: 34952528] - Philip C Spinella, Julie C Leonard, Barbara A Gaines, James F Luther, Stephen R Wisniewski, Cassandra D Josephson, Christine M Leeper. Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage: A Prospective Observational Multicenter Study.
Critical care medicine.
2022 04; 50(4):e382-e392. doi:
10.1097/ccm.0000000000005383. [PMID: 34661553] - Vladimir Černý, Marc Maegele, Vanessa Agostini, Dietmar Fries, Santiago R Leal-Noval, Gábor Nardai, Giuseppe Nardi, Anders Östlund, Herbert Schöchl. Variations and obstacles in the use of coagulation factor concentrates for major trauma bleeding across Europe: outcomes from a European expert meeting.
European journal of trauma and emergency surgery : official publication of the European Trauma Society.
2022 Apr; 48(2):763-774. doi:
10.1007/s00068-020-01563-2. [PMID: 33399876] - Zhi-Yao Zou, Li-Xian He, Yun-Tai Yao. Tranexamic acid reduces postoperative blood loss in Chinese pediatric patients undergoing cardiac surgery: A PRISMA-compliant systematic review and meta-analysis.
Medicine.
2022 Mar; 101(9):e28966. doi:
10.1097/md.0000000000028966. [PMID: 35244062] - Jesse Qiao, Bradford Ray, Frank Wians, Jude Abadie. Transfusion management of trauma from the 2019 El Paso mass shooting incident.
Vox sanguinis.
2022 Mar; 117(3):299-312. doi:
10.1111/vox.13206. [PMID: 34558091] - Nicola Sandler, Heidi Ho, Dominik F Draxler, Christopher R Bain, Julian A Smith, Carl J Hauser, Russell L Gruen, Paul S Myles, Robert L Medcalf. Characterisation of Plasma Mitochondrial DNA, MMP-9 and Neutrophil Elastase in Patients Undergoing Coronary Artery Bypass Grafting: Effects of Tranexamic Acid and Postoperative Pneumonia.
Heart, lung & circulation.
2022 Mar; 31(3):439-446. doi:
10.1016/j.hlc.2021.08.008. [PMID: 34627673] - Qing-Yi Zhang, Kai Huang, Shi-Jiu Yin, Mi-Ye Wang, Ren Liao, Hui-Qi Xie, Jing Yang, Yi Zeng. Hypotensive Anesthesia Combined with Tranexamic Acid Reduces Perioperative Blood Loss in Simultaneous Bilateral Total Hip Arthroplasty: A Retrospective Cohort Study.
Orthopaedic surgery.
2022 Mar; 14(3):555-565. doi:
10.1111/os.13200. [PMID: 35142043] - Mohamed Mahmoud Gamea, Doha Ali Kamal, Ahmed Atef Donia, Doaa Salah Hegab. Comparative study between topical tranexamic acid alone versus its combination with autologous platelet rich plasma for treatment of melasma.
The Journal of dermatological treatment.
2022 Mar; 33(2):798-804. doi:
10.1080/09546634.2020.1781755. [PMID: 32567984] - Ankur Kumar Jindal, Prabal Barman, Sanchi Chawla, Anit Kaur, Rahul Tyagi, Pooja Sikka, Seema Chopra, Shalvi Mahajan, Hilary Longhurst, Surjit Singh. Management of pregnancy in hereditary angioedema in a resource constrained setting: Our experience at Chandigarh, North India.
Immunobiology.
2022 03; 227(2):152175. doi:
10.1016/j.imbio.2022.152175. [PMID: 35016112] - Seyit Ali Gümüştaş, Zekeriya Ersin Çelen, Tolga Onay, Mehmet Süleyman Abul, Hüseyin Bilgehan Çevik. The efficiency and safety of intravenous tranexamic acid administration in open reduction and internal fixation of pelvic and acetabular fractures.
European journal of trauma and emergency surgery : official publication of the European Trauma Society.
2022 Feb; 48(1):351-356. doi:
10.1007/s00068-021-01624-0. [PMID: 33641043] - Enshi Wang, Xin Yuan, Yang Wang, Weinan Chen, Xingtong Zhou, Shengshou Hu, Su Yuan. Blood conservation outcomes and safety of tranexamic acid in coronary artery bypass graft surgery.
International journal of cardiology.
2022 02; 348(?):50-56. doi:
10.1016/j.ijcard.2021.12.017. [PMID: 34920046] - Gianluca Maresca, Justine Royle, James Fergus Donaldson. Tranexamic acid-induced ureteric clot obstruction in a patient with urothelial cell carcinoma resulting in upper urinary tract perforation.
BMJ case reports.
2022 Jan; 15(1):. doi:
10.1136/bcr-2021-247334. [PMID: 35039376] - Fei Ma, Shujing Sui, Zhiyuan Yang, Tong Ye, Lei Yang, Peng Han, Hui Gan, Zhuona Wu, Ruolan Gu, Xiaoxia Zhu, Fei Li, Zhiyun Meng, Zhiping Jiang, Guifang Dou. Evaluation of Novel Tranexamic Acid/Montmorillonite Intercalation Composite, as a New Type of Hemostatic Material.
BioMed research international.
2022; 2022(?):3963681. doi:
10.1155/2022/3963681. [PMID: 35265711] - Aránzazu González Osuna, Luisa Fernanda Rojas, Claudia Lamas, Xavier Aguilera Roig, Francesc Pla-Junca, Sebastián Videla, Mª José Martínez-Zapata, Marta Valle. Population Pharmacokinetics of Intra-articular and Intravenous Administration of Tranexamic Acid in Patients Undergoing Total Knee Replacement.
Clinical pharmacokinetics.
2022 01; 61(1):83-95. doi:
10.1007/s40262-021-01043-9. [PMID: 34255299] - Sara R Fernandes, Luisa Barreiros, Paula Sá, Manuel Miró, Marcela A Segundo. Automatic and renewable micro-solid-phase extraction based on bead injection lab-on-valve system for determination of tranexamic acid in urine by UHPLC coupled with tandem mass spectrometry.
Analytical and bioanalytical chemistry.
2022 Jan; 414(1):649-659. doi:
10.1007/s00216-021-03606-y. [PMID: 34410441] - Carlos A Batagello, Fabio C Vicentini, Manoj Monga, Aaron W Miller, Giovanni S Marchini, Fabio C M Torricelli, Alexandre Danilovic, Rafael F Coelho, Miguel Srougi, Willian C Nahas, Eduardo Mazzucchi. Tranexamic acid in patients with complex stones undergoing percutaneous nephrolithotomy: a randomised, double-blinded, placebo-controlled trial.
BJU international.
2022 01; 129(1):35-47. doi:
10.1111/bju.15378. [PMID: 33630393] - Jue-Fu Cheng, Wen-Qiang Qian, Mumingjiang Yishake, Jin-Wen Shen. Comment on article by Shodipo et al.: comparison of single versus double tranexamic acid dose regimens in reducing post-operative blood loss following intramedullary nailing of femoral fracture nonunions.
International orthopaedics.
2022 01; 46(1):153-154. doi:
10.1007/s00264-021-05248-2. [PMID: 34674020] - Alexandros Rampotas, Edmund Watson, Kieran Burton, Quentin A Hill, Sue Pavord. A real-world study of immune thrombocytopenia management during the COVID-19 pandemic in the UK.
British journal of haematology.
2022 01; 196(2):351-355. doi:
10.1111/bjh.17804. [PMID: 34448203] - Zhicheng Pan, Ting Xu. Comment on Shodipo et al.: comparison of single versus double tranexamic acid dose regimens in reducing post-operative blood loss following intramedullary nailing of femoral fracture nonunions.
International orthopaedics.
2022 01; 46(1):103-104. doi:
10.1007/s00264-021-05251-7. [PMID: 34686890] - Musarrat Hussain Raza, Nadia Iftikhar, Ayesha Anwar, Asher Ahmed Mashhood, Shahan Tariq, Muhammad Ammar Bin Hamid. Split-Face Comparative Analysis Of Micro-Needling With Tranexamic Acid Vs Vitamin C Serum In Melasma.
Journal of Ayub Medical College, Abbottabad : JAMC.
2022 Jan; 34(1):169-172. doi:
10.55519/jamc-01-9840. [PMID: 35466647] - Rashmi Sarkar, Meghna Gupta. Platelet-Rich Plasma in Melasma-A Systematic Review.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].
2022 01; 48(1):131-134. doi:
10.1097/dss.0000000000003266. [PMID: 34904579] - Håkon Kvåle Bakke, Ole Martin Fuskevåg, Erik Waage Nielsen, Erik Sveberg Dietrichs. Intramuscular uptake of tranexamic acid during haemorrhagic shock in a swine model.
Scandinavian journal of trauma, resuscitation and emergency medicine.
2021 Dec; 29(1):171. doi:
10.1186/s13049-021-00983-2. [PMID: 34922577] - Alireza Negahi, Taher Teimoury, Yousef Alimohamadi, Mohammad Vaziri, Mohsen Khaleghian. The effect of early tranexamic acid on bleeding, blood product consumption, mortality and length of hospital stay in trauma cases with hemorrhagic shock: a randomized clinical trial.
Journal of preventive medicine and hygiene.
2021 Dec; 62(4):E958-E965. doi:
10.15167/2421-4248/jpmh2021.62.4.2186. [PMID: 35603236] - J J Peña Borras, A Pajares Moncho, J Puig, E Mateo Rodríguez, C López Forte, L Peña Pérez, J Moreno Pachón, T Gabaldón Conejos, J Pérez Artacho, C Ferrer Gómez, A Férez Martí, M López Cantero, J de Andrés Ibáñez. Tranexamic acid in cardiac surgery: Are low doses enough?.
Revista espanola de anestesiologia y reanimacion.
2021 12; 68(10):576-583. doi:
10.1016/j.redare.2021.02.005. [PMID: 34857506] - Chen-Xi Xue, Yun-Feng Yao, Hao Lv, Li Cheng, Jue-Hua Jing. Efficacy and Safety of Postoperative Intravenous Tranexamic Acid in Total Knee Arthroplasty: A Prospective Randomized Controlled Study.
Orthopaedic surgery.
2021 Dec; 13(8):2227-2235. doi:
10.1111/os.13045. [PMID: 34668331] - Juan Duchesne, Sharven Taghavi, Scott Ninokawa, Charles Harris, Rebecca Schroll, Patrick McGrew, Clifton McGinness, Robert Reily, Chrissy Guidry, Danielle Tatum. After 800 Mtp Events, Mortality Due to Hemorrhagic Shock Remains High and Unchanged Despite Several In-Hospital Hemorrhage Control Advancements.
Shock (Augusta, Ga.).
2021 12; 56(1S):70-78. doi:
10.1097/shk.0000000000001817. [PMID: 34048424] - Hervé Hourlier, Peter Fennema. Application of an adjusted patient blood management protocol in patients undergoing elective total hip arthroplasty: towards a zero-percent transfusion rate in renal patients-results from an observational cohort study.
Journal of orthopaedic surgery and research.
2021 Nov; 16(1):697. doi:
10.1186/s13018-021-02846-z. [PMID: 34838063] - Jong-Keun Kim, Jae-Young Park, Do Yoon Lee, Du Hyun Ro, Hyuk-Soo Han, Myung Chul Lee. Optimal dose of topical tranexamic acid considering efficacy and safety in total knee arthroplasty: a randomized controlled study.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA.
2021 Oct; 29(10):3409-3417. doi:
10.1007/s00167-020-06241-9. [PMID: 32869124] - Qingyi Zhang, Shijiu Yin, Kai Huang, Miye Wang, Huiqi Xie, Ren Liao, Yi Zeng, Jing Yang. [Effectiveness and safety of tranexamic acid combined with intraoperative controlled hypotension on reducing perioperative blood loss in primary total hip arthroplasty].
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery.
2021 Sep; 35(9):1133-1140. doi:
10.7507/1002-1892.202103230. [PMID: 34523278] - Zoe Kane, Roberto Picetti, Alison Wilby, Joseph F Standing, Stanislas Grassin-Delyle, Ian Roberts, Haleema Shakur-Still. Physiologically based modelling of tranexamic acid pharmacokinetics following intravenous, intramuscular, sub-cutaneous and oral administration in healthy volunteers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Sep; 164(?):105893. doi:
10.1016/j.ejps.2021.105893. [PMID: 34087356] - M C Punt, M L Waning, E P Mauser-Bunschoten, M J H A Kruip, J Eikenboom, L Nieuwenhuizen, A B U Makelburg, M H E Driessens, J J Duvekot, M Peters, J M Middeldorp, K W M Bloemenkamp, R E G Schutgens, A T Lely, K P M van Galen. Maternal and neonatal bleeding complications in relation to peripartum management in hemophilia carriers: A systematic review.
Blood reviews.
2021 09; 49(?):100826. doi:
10.1016/j.blre.2021.100826. [PMID: 33775466] - Michael J R Desborough, Samya Obaji, Gillian C Lowe, Carolyn Doree, Will Thomas. Management of surgery, menorrhagia and child-birth for patients with unclassified bleeding disorders: a systematic review of cohort studies.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2021 Sep; 32(6):366-372. doi:
10.1097/mbc.0000000000001045. [PMID: 33973892] - Sebastian Imach, Arasch Wafaisade, Rolf Lefering, Andreas Böhmer, Mark Schieren, Victor Suárez, Matthias Fröhlich. The impact of prehospital tranexamic acid on mortality and transfusion requirements: match-pair analysis from the nationwide German TraumaRegister DGU®.
Critical care (London, England).
2021 08; 25(1):277. doi:
10.1186/s13054-021-03701-7. [PMID: 34348782] - Ebtehal F Anwer, Deena A M Nour El-Deen, Mahmoud A Omar. Design and strategy for spectrofluorimetric determination of tranexamic acid in its authentic form and pharmaceutical preparations: application to spiked human plasma.
Luminescence : the journal of biological and chemical luminescence.
2021 Aug; 36(5):1327-1334. doi:
10.1002/bio.4068. [PMID: 33955136] - Roy Nadler, Avishai M Tsur, Ari M Lipsky, Avi Benov, Alex Sorkin, Elon Glassberg, Jacob Chen. Trends in combat casualty care following the publication of clinical practice guidelines.
The journal of trauma and acute care surgery.
2021 08; 91(2S Suppl 2):S194-S200. doi:
10.1097/ta.0000000000003280. [PMID: 34039926] - N Mete Gökmen, O Kuman Tunçel, G Boğatekin, G Bulut, S Demir, A Gelincik, C Tunakan Dalgıç, D Mungan. Psychiatric and Clinical Characteristics of Hereditary Angioedema Patients Who Experienced Attacks During COVID-19.
Journal of investigational allergology & clinical immunology.
2021 Jul; 31(4):356-357. doi:
10.18176/jiaci.0701. [PMID: 33949951] - Thushara Madathil, Rakhi Balachandran, Brijesh P Kottayil, K R Sundaram, Suresh G Nair. Comparison of efficacy of two different doses of tranexamic acid in prevention of post operative blood loss in patients with congenital cyanotic heart disease undergoing cardiac surgery.
Annals of cardiac anaesthesia.
2021 Jul; 24(3):339-344. doi:
10.4103/aca.aca_162_20. [PMID: 34269265] - Taylor N Anderson, David H Farrell, Susan E Rowell. Fibrinolysis in Traumatic Brain Injury: Diagnosis, Management, and Clinical Considerations.
Seminars in thrombosis and hemostasis.
2021 Jul; 47(5):527-537. doi:
10.1055/s-0041-1722970. [PMID: 33878779] - Homa K Ahmadzia, Naomi L C Luban, Shuhui Li, Dong Guo, Adam Miszta, Jogarao V S Gobburu, Jeffrey S Berger, Andra H James, Alisa S Wolberg, John van den Anker. Optimal use of intravenous tranexamic acid for hemorrhage prevention in pregnant women.
American journal of obstetrics and gynecology.
2021 07; 225(1):85.e1-85.e11. doi:
10.1016/j.ajog.2020.11.035. [PMID: 33248975] - Pengzhi Shi, Junwu Wang, Tongchuan Cai, Dong Chen, Shuguang Wang, Xinmin Feng, Yongxiang Wang, Wenjie Zhang, Liang Zhang. Safety and Efficacy of Topical Administration of Tranexamic Acid in High-Risk Patients Undergoing Posterior Lumbar Interbody Fusion Surgery.
World neurosurgery.
2021 07; 151(?):e621-e629. doi:
10.1016/j.wneu.2021.04.088. [PMID: 33940262] - Lloyd M Halpern, William E Bronson, Clark J Kogan. A New Low Dose of Tranexamic Acid for Decreasing the Rate of Blood Loss in Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis.
Journal of pediatric orthopedics.
2021 Jul; 41(6):333-337. doi:
10.1097/bpo.0000000000001820. [PMID: 33826563] - José Luiz de Faria, Josué da Silva Brito, Louise Teixeira Costa E Silva, Christiano Tadeu Sanches Mattos Kilesse, Nicolli Bellotti de Souza, Carlos Umberto Pereira, Eberval Gadelha Figueiredo, Nícollas Nunes Rabelo. Tranexamic acid in Neurosurgery: a controversy indication-review.
Neurosurgical review.
2021 Jun; 44(3):1287-1298. doi:
10.1007/s10143-020-01324-0. [PMID: 32556832] - Dominik Stämpfli, Stefan Weiler, Carolyn F Weiniger, Andrea M Burden, Michael Heesen. Renal ischemic adverse drug events related to tranexamic acid in women of child-bearing age: an analysis of pharmacovigilance data.
European journal of clinical pharmacology.
2021 Jun; 77(6):913-919. doi:
10.1007/s00228-020-03064-y. [PMID: 33341923] - Charithani B Keragala, Robert L Medcalf. Plasminogen: an enigmatic zymogen.
Blood.
2021 05; 137(21):2881-2889. doi:
10.1182/blood.2020008951. [PMID: 33735914] - Bing-Xin Kang, Hui Xu, Chen-Xin Gao, Sheng Zhong, Jing Zhang, Jun Xie, Song-Tao Sun, Ying-Hui Ma, Xi-Rui Xu, Chi Zhao, Wei-Tao Zhai, Lian-Bo Xiao, Xiao-Jun Gao. Multiple intravenous tranexamic acid doses in total knee arthroplasty in patients with rheumatoid arthritis: a randomized controlled study.
BMC musculoskeletal disorders.
2021 May; 22(1):425. doi:
10.1186/s12891-021-04307-4. [PMID: 33962594] - Oyindamola Ajewole, Mosopefoluwa Lanlokun, Stevenson Dimanche, Timothy Craig. Short-term prophylaxis for children and adolescents with hereditary angioedema.
Allergy and asthma proceedings.
2021 05; 42(3):205-213. doi:
10.2500/aap.2021.42.210006. [PMID: 33980333] - Maryam Mumtaz, Tahir Hassan Chandio, Mohammad Khurram Shahzad, Nazia Hanif, Sarah Anwar, Saira Rafique. Comparing the Efficacy of Patelet-rich Plasma (PRP) versus Tranexamic Acid (4mg/mL) as Intradermal Treatments of Melasma.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2021 May; 30(5):502-505. doi:
10.29271/jcpsp.2021.05.502. [PMID: 34027858] - Mengzhen Xing, Xue Wang, Lichun Zhao, Zequan Zhou, Han Liu, Baorui Wang, Aguo Cheng, Suohui Zhang, Yunhua Gao. Novel dissolving microneedles preparation for synergistic melasma therapy: Combined effects of tranexamic acid and licorice extract.
International journal of pharmaceutics.
2021 May; 600(?):120406. doi:
10.1016/j.ijpharm.2021.120406. [PMID: 33711468] - Panagiotis Touzopoulos, Konstantinos Arvanitidis, Eirini Filidou, Konstantinos Tilkeridis, Michael Karanikas, George Kolios, Athanasios Ververidis. Is serum gentamicin concentration modified with autologous cell-saved blood transfusion after total knee arthroplasty using tranexamic acid? A randomised control trial.
Orthopaedics & traumatology, surgery & research : OTSR.
2021 05; 107(3):102794. doi:
10.1016/j.otsr.2020.102794. [PMID: 33333277] - Philipp Groene, Sophia R Sappel, Thomas Saller, Tobias Nitschke, Paula A Sa, Alexander Paulus, Daniel Chappell, Simon T Schäfer. Functional testing of tranexamic acid effects in patients undergoing elective orthopaedic surgery.
Journal of thrombosis and thrombolysis.
2021 May; 51(4):989-996. doi:
10.1007/s11239-020-02272-8. [PMID: 32918670] - Shenqi Zhang, Fengyan Wang, Chengbin Wang, Pengfei Chu, Lei Shi, Qingyun Xue. Are The Applications of Tranexamic Acid in Reverse Hybrid Total Knee Arthroplasty (TKA) The Same as Those in Fully Cemented TKA?: A Randomized Controlled Trial.
Advances in therapy.
2021 05; 38(5):2542-2557. doi:
10.1007/s12325-021-01719-5. [PMID: 33830462] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Dominik F Draxler, Saffanah Zahra, Isaac Goncalves, Huyen Tran, Gryselda Hanafi, Heidi Ho, Charithani B Keragala, Anton Ilich, Nigel S Key, Paul S Myles, Robert L Medcalf. Tranexamic acid rapidly inhibits fibrinolysis, yet transiently enhances plasmin generation in vivo.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2021 Apr; 32(3):172-179. doi:
10.1097/mbc.0000000000001008. [PMID: 33443933] - Kazumasa Iwamoto, Beverley Yamamoto, Isao Ohsawa, Daisuke Honda, Takahiko Horiuchi, Akira Tanaka, Atsushi Fukunaga, Junichi Maehara, Kouhei Yamashita, Tomoyuki Akita, Michihiro Hide. The diagnosis and treatment of hereditary angioedema patients in Japan: A patient reported outcome survey.
Allergology international : official journal of the Japanese Society of Allergology.
2021 Apr; 70(2):235-243. doi:
10.1016/j.alit.2020.09.008. [PMID: 33168485] - Nikita Looby, Tijana Vasiljevic, Nathaly Reyes-Garcés, Anna Roszkowska, Barbara Bojko, Marcin Wąsowicz, Angela Jerath, Janusz Pawliszyn. Therapeutic drug monitoring of tranexamic acid in plasma and urine of renally impaired patients using solid phase microextraction.
Talanta.
2021 Apr; 225(?):121945. doi:
10.1016/j.talanta.2020.121945. [PMID: 33592700] - Derek B Asserson, David E Sahar. Can Tranexamic Acid Be Safely Administered during Microsurgery in the Era of COVID-19?.
Plastic and reconstructive surgery.
2021 03; 147(3):573e-574e. doi:
10.1097/prs.0000000000007665. [PMID: 33395008] - Yong Yang, Zheng Wang, Faxuan Wang, Xin Zhao, Kaijie Yang, Jinlong He, Yun Jin, Haibo Yang, Dong Ding, Qunhua Jin. Prospective, randomised, controlled study on the efficacy and safety of different strategies of tranexamic acid with total blood loss, blood transfusion rate and thrombogenic biomarkers in total knee arthroplasty: study protocol.
BMJ open.
2021 02; 11(2):e038399. doi:
10.1136/bmjopen-2020-038399. [PMID: 33637540] - Mahmoud A Omar, Ebtehal F Anwer, Deena A M Nour El-Deen. Derivatization of tranexamic acid for its rapid spectrofluorimetric determination in pure form and pharmaceutical formulations: Application in human plasma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Feb; 247(?):119111. doi:
10.1016/j.saa.2020.119111. [PMID: 33161264] - Huixu Ma, Hairuo Wang, Xiaotao Long, Zexiang Xu, Xiaohua Chen, Mingjin Li, Tao He, Wei Wang, Lei Liu, Xi Liu. Early intravenous tranexamic acid intervention reduces post-traumatic hidden blood loss in elderly patients with intertrochanteric fracture: a randomized controlled trial.
Journal of orthopaedic surgery and research.
2021 Feb; 16(1):106. doi:
10.1186/s13018-020-02166-8. [PMID: 33536047] - Zhen-Feng Zhou, Wen Zhai, Li-Na Yu, Kai Sun, Li-Hong Sun, Xiu-Fang Xing, Min Yan. Comparison of the in-vivo effect of two tranexamic acid doses on fibrinolysis parameters in adults undergoing valvular cardiac surgery with cardiopulmonary bypass - a pilot investigation.
BMC anesthesiology.
2021 02; 21(1):33. doi:
10.1186/s12871-021-01234-8. [PMID: 33530942] - Nir Tsur, Avi Benov, Roy Nadler, Avishai M Tsur, Yuval Glick, Irina Radomislensky, Shlomi Abuhasira, Aviram Mizrachi, Jacob Chen. Neck injuries - israel defense forces 20 years' experience.
Injury.
2021 Feb; 52(2):274-280. doi:
10.1016/j.injury.2020.09.042. [PMID: 32972724] - Bing-Xin Kang, Yu-Lin Li, Hui Xu, Chen-Xin Gao, Sheng Zhong, Jing Zhang, Jun Xie, Song-Tao Sun, Xi-Rui Xu, Chi Zhao, Ying-Hui Ma, Wei-Tao Zhai, Lian-Bo Xiao, Xiao-Xue Hu. Effect of Multiple Doses of Intravenous Tranexamic Acid on Perioperative Blood Loss in Total Knee Arthroplasty: A Randomized Controlled Study.
Orthopaedic surgery.
2021 Feb; 13(1):126-133. doi:
10.1111/os.12850. [PMID: 33295133] - Ivan D da Silva Souza, Lorraine Lampe, Daniel Winn. New topical tranexamic acid derivative for the improvement of hyperpigmentation and inflammation in the sun-damaged skin.
Journal of cosmetic dermatology.
2021 Feb; 20(2):561-565. doi:
10.1111/jocd.13545. [PMID: 32588531] - Sigismond Lasocki, Thibault Loupec, Elsa Parot-Schinkel, Bruno Vielle, Marc Danguy des Déserts, Antoine Roquilly, Maria Lahlou-Casulli, Vincent Collange, Olivier Desebbe, Alexis Duchalais, Bertrand Drugeon, Pierre Bouzat, Delphine Garrigue, Benjamin Mounet, Franck Hamard, Jean-Stéphane David, Maxime Leger, Emmanuel Rineau. Study protocol for a multicentre, 2×2 factorial, randomised, controlled trial evaluating the interest of intravenous iron and tranexamic acid to reduce blood transfusion in hip fracture patients (the HiFIT study).
BMJ open.
2021 01; 11(1):e040273. doi:
10.1136/bmjopen-2020-040273. [PMID: 33455926] - Josko Ivica, Jeannette Gauthier, Patricia Power, André Lamy, Murray Potter. Analysis of serum tranexamic acid in patients undergoing open heart surgery.
Clinical biochemistry.
2021 Jan; 87(?):74-78. doi:
10.1016/j.clinbiochem.2020.10.010. [PMID: 33188769] - Adam Miszta, Homa K Ahmadzia, Naomi L C Luban, Shuhui Li, Dong Guo, Lori A Holle, Jeffrey S Berger, Andra H James, Jogarao V S Gobburu, John van den Anker, Bas de Laat, Alisa S Wolberg. Application of a plasmin generation assay to define pharmacodynamic effects of tranexamic acid in women undergoing cesarean delivery.
Journal of thrombosis and haemostasis : JTH.
2021 01; 19(1):221-232. doi:
10.1111/jth.15114. [PMID: 33001565] - Shaoyun Zhang, Jinwei Xie, Guorui Cao, Yiting Lei, Qiang Huang, Fuxing Pei. Six-Dose Intravenous Tranexamic Acid Regimen Further Inhibits Postoperative Fibrinolysis and Reduces Hidden Blood Loss following Total Knee Arthroplasty.
The journal of knee surgery.
2021 Jan; 34(2):224-232. doi:
10.1055/s-0039-1694768. [PMID: 31434149] - Tai Guo, Wenxia Xuan, Haoyu Feng, Junjie Wang, Xun Ma. The Efficacy and Safety of Topical Tranexamic Acid for Spinal Surgery.
Current pharmaceutical design.
2021; 27(44):4496-4503. doi:
10.2174/1381612827666210713160016. [PMID: 34259138] - Yun-Tai Yao, Li-Xian He, Jie-Chao Tan. The effect of tranexamic acid on the values of activated clotting time in patients undergoing cardiac surgery: A PRISMA-compliant systematic review and meta-analysis.
Journal of clinical anesthesia.
2020 Dec; 67(?):110020. doi:
10.1016/j.jclinane.2020.110020. [PMID: 32889412] - Akbar Dorgalaleh, Mohammad Reza Baghaipour, Shadi Tabibian, Farid Ghazizadeh, Ali Dabbagh, Gholamreza Bahoush, Mohammad Jazebi, Mehran Bahraini, Alieh Fazeli, Nazanin Baghaipour, Forough Yousefi. Gastrointestinal bleeding in a newborn infant with congenital factor X deficiency and COVID-19-A common clinical feature between a rare disorder and a new, common infection.
International journal of laboratory hematology.
2020 12; 42(6):e277-e279. doi:
10.1111/ijlh.13318. [PMID: 32845081] - Iyabo O Muse, Elilary Montilla, Konrad I Gruson, Jay Berger. Perioperative management of patients with hip fractures and COVID-19: A single institution's early experiences.
Journal of clinical anesthesia.
2020 Dec; 67(?):110017. doi:
10.1016/j.jclinane.2020.110017. [PMID: 32836189] - Christopher D Barrett, Navin Vigneshwar, Hunter B Moore, Arsen Ghasabyan, James Chandler, Ernest E Moore, Michael B Yaffe. Tranexamic acid is associated with reduced complement activation in trauma patients with hemorrhagic shock and hyperfibrinolysis on thromboelastography.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2020 Dec; 31(8):578-582. doi:
10.1097/mbc.0000000000000938. [PMID: 32732500] - Evander Meneses, Dessy Boneva, Mark McKenney, Adel Elkbuli. Massive transfusion protocol in adult trauma population.
The American journal of emergency medicine.
2020 12; 38(12):2661-2666. doi:
10.1016/j.ajem.2020.07.041. [PMID: 33071074]