Octreotide (BioDeep_00000019544)

human metabolite blood metabolite Chemicals and Drugs Toxin Volatile Flavor Compounds

代谢物信息卡片

化学式: C49H66N10O10S2 (1018.4404576000002)
中文名称: 醋酸奥曲肽
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)NC(=O)C(CC5=CC=CC=C5)N)C(=O)NC(CO)C(C)O)O
InChI: InChI=1S/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)

描述信息

Octreotide is only found in individuals that have used or taken this drug. It is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.Octreotide binds to somatostatin receptors. These receptors are coupled via pertussis toxin sensitive G proteins which lead to inhibition of adenylyl cyclase. Octreotide binding to these receptors also stimulates phosphotyrosine phosphatase and activation of the Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
H - Systemic hormonal preparations, excl. sex hormones and insulins > H01 - Pituitary and hypothalamic hormones and analogues > H01C - Hypothalamic hormones > H01CB - Somatostatin and analogues
D005765 - Gastrointestinal Agents
D000970 - Antineoplastic Agents
Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly[1][2].

同义名列表

18 个代谢物同义名

(4R,7S,10S,13R,16S,19R)-19-{[(2R)-2-amino-1-hydroxy-3-phenylpropylidene]amino}-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-6,9,12,15,18-pentahydroxy-7-(1-hydroxyethyl)-13-[(1H-indol-3-yl)methyl]-1,2-dithia-5,8,11,14,17-pentaazacycloicosa-5,8,11,14,17-pentaene-4-carboximidate; (4R,7S,10S,13R,16S,19R)-19-[(2R)-2-amino-3-phenylpropanamido]-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide; Octreotide acetate salt; Octreotida [Spanish]; Octreotide acetate; Compound 201 995; Compound 201-995; Compound 201995; Sandoz 201 995; Sandoz 201-995; Sandoz 201995; Sandostatine; Sandostatin; Octreotide; Octrotide; Mycapssa; SMS 201-995; Octreotide

数据库引用编号

17 个数据库交叉引用编号

KEGG: C07306
PubChem: 6400441
PubChem: 383414
HMDB: HMDB0014262
ChEMBL: CHEMBL3182554
ChEMBL: CHEMBL262746
Wikipedia: Octreotide
MeSH: Octreotide
chemspider: 10482007
CAS: 1240797-41-4
CAS: 83150-76-9
PMhub: MS000019511
ChEBI: CHEBI:7726
PubChem: 9514
NIKKAJI: J23.724H
medchemexpress: HY-P0036
KNApSAcK: 7726

分类词条

Oligopeptides

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Sara Heebøll, Jeyanthini Risikesan, Steffen Ringgaard, Indumathi Kumarathas, Thomas D Sandahl, Henning Grønbæk, Esben Søndergaard, Søren Nielsen. Impaired Glucagon-Mediated Suppression of VLDL-Triglyceride Secretion in Individuals With Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD). Diabetes. 2022 11; 71(11):2402-2411. doi: 10.2337/db22-0313. [PMID: 36001750]
Leila Deilami-Nezhad, Leila Moghaddam-Banaem, Mahdi Sadeghi. The preparation, biodistribution, and human's absorbed dose evaluation of Radio-Scandium-HYNIC-TOC for somatostatin-receptor-positive neuroendocrine tumors therapy by animal study. Nuclear medicine communications. 2022 Aug; 43(8):881-891. doi: 10.1097/mnm.0000000000001586. [PMID: 35660705]
Priscilla Guglielmo, Fiammetta Pesella, Alida Sartorello, Badr El Khouzai, Sara Berti, Simona Muccioli, Michele Gregianin. Metastasis From Clear Cell Renal Cell Carcinoma Mimicking Well-Differentiated Pancreatic Neuroendocrine Tumor at 18F-FDG and 68Ga-DOTATOC PET/CT. Clinical nuclear medicine. 2022 Jul; 47(7):e498-e499. doi: 10.1097/rlu.0000000000004151. [PMID: 35675141]
Asmaa A Khalifa, Nahed H El Sokkary, Samar S Elblehi, Mohamed A Diab, Mennatallah A Ali. Potential cardioprotective effect of octreotide via NOXs mitigation, mitochondrial biogenesis and MAPK/Erk1/2/STAT3/NF-kβ pathway attenuation in isoproterenol-induced myocardial infarction in rats. European journal of pharmacology. 2022 Jun; 925(?):174978. doi: 10.1016/j.ejphar.2022.174978. [PMID: 35500641]
Heying Duan, Valentina Ferri, George Albert Fisher, Shagufta Shaheen, Guido Alejandro Davidzon, Andrei Iagaru, Carina Mari Aparici. Evaluation of Liver and Renal Toxicity in Peptide Receptor Radionuclide Therapy for Somatostatin Receptor Expressing Tumors: A 2-Year Follow-Up. The oncologist. 2022 Jun; 27(6):447-452. doi: 10.1093/oncolo/oyab072. [PMID: 35641196]
Kevin C J Yuen, Susan L Samson. Oral Octreotide: A Review of Recent Clinical Trials and Practical Recommendations for Its Use in the Treatment of Patients With Acromegaly. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2022 Jun; 28(6):637-645. doi: 10.1016/j.eprac.2022.04.009. [PMID: 35452815]
Ivana Capuano, Pasquale Buonanno, Eleonora Riccio, Manuela Rizzo, Antonio Pisani. Tolvaptan vs. somatostatin in the treatment of ADPKD: A review of the literature. Clinical nephrology. 2022 Mar; 97(3):131-140. doi: 10.5414/cn110510. [PMID: 34846296]
Caroline Boursier, Elodie Chevalier, Laura Filippetti, Laetitia Imbert, Veronique Roch, Olivier Huttin, Marine Claudin, Pierre-Yves Marie. 68Ga-DOTATOC digital-PET imaging of inflammatory cell infiltrates in myocarditis following COVID-19 vaccination. European journal of nuclear medicine and molecular imaging. 2022 03; 49(4):1433-1434. doi: 10.1007/s00259-021-05609-4. [PMID: 34746968]
Libuse Tauchmanova, Astrid Breitschaft, Geoffrey Holder, Kevin Tianxiang Han, Somesh Choudhury, Christelle Darstein, Michaela Paul, Eric Drutinus, Germo Gericke, Herbert A Schmid, Alberto M Pedroncelli. Combination of pasireotide and octreotide: effects on GH and IGF-I secretion and glucose metabolism in healthy volunteers. Endocrine. 2022 Feb; 75(2):537-548. doi: 10.1007/s12020-021-02908-6. [PMID: 34741720]
Priscilla Guglielmo, Simona Muccioli, Sara Berti, Alida Sartorello, Fiammetta Pesella, Michele Gregianin. Detection of Unilateral Axillary Nodal Uptake Both at 68Ga-DOTATOC and 18F-FDG PET/CT After 1 Week From COVID-19 Vaccine. Clinical nuclear medicine. 2022 Feb; 47(2):e123-e124. doi: 10.1097/rlu.0000000000003918. [PMID: 34524165]
Bilal Kovan, Zeynep Gözde Özkan, Bayram Demir, Duygu Tunçman, Emine Göknur Işik, Duygu Has Şimşek, Fikret Büyükkaya, Cüneyt Türkmen, Yasemin Şanli. An Analysis for Therapeutic Doses of Patients with Neuroendocrine Tumor Treated with Lutetium 177 (177Lu)-DOTATATE. Cancer biotherapy & radiopharmaceuticals. 2022 Feb; 37(1):17-22. doi: 10.1089/cbr.2021.0071. [PMID: 34134512]
Wenying Hao, Longfan Piao, Maojie Sun, Fanzhuo Zeng. Clinical effect of combination of octreotide and omeprazole in children with acute upper gastrointestinal bleeding and the levels of serum creatinine and serum urea nitrogen. Pakistan journal of pharmaceutical sciences. 2022 Jan; 35(1(Special)):343-347. doi: NULL. [PMID: 35236645]
Marie Lambert, Lawrence Dierickx, Séverine Brillouet, Frédéric Courbon, Etienne Chatelut. Comparison of Two Types of Amino Acid Solutions on 177Lu-Dotatate Pharmacokinetics and Pharmacodynamics in Patients with Metastatic Gastroenteropancreatic Neuroendocrine Tumors. Current radiopharmaceuticals. 2022; 15(2):164-172. doi: 10.2174/1874471015666211228123525. [PMID: 35105299]
Jeremy Fabes, Gareth Ambler, Bina Shah, Norman R Williams, Daniel Martin, Brian R Davidson, Michael Spiro. Protocol for a prospective double-blind, randomised, placebo-controlled feasibility trial of octreotide infusion during liver transplantation. BMJ open. 2021 12; 11(12):e055864. doi: 10.1136/bmjopen-2021-055864. [PMID: 34857585]
Clemens Kratochwil, Leonidas Apostolidis, Hendrik Rathke, Christos Apostolidis, Felix Bicu, Frank Bruchertseifer, Peter L Choyke, Uwe Haberkorn, Frederik L Giesel, Alfred Morgenstern. Dosing 225Ac-DOTATOC in patients with somatostatin-receptor-positive solid tumors: 5-year follow-up of hematological and renal toxicity. European journal of nuclear medicine and molecular imaging. 2021 12; 49(1):54-63. doi: 10.1007/s00259-021-05474-1. [PMID: 34448031]
Bing Han, Huan Tang, Qiming Liang, Ming Zhu, Yizhuo Xie, Jinglin Chen, Qianwen Li, Juan Jia, Yan Li, Zhihui Ren, Dengli Cong, Xiaofeng Yu, Dayun Sui, Jin Pei. Preparation of long-acting microspheres loaded with octreotide for the treatment of portal hypertensive. Drug delivery. 2021 Dec; 28(1):719-732. doi: 10.1080/10717544.2021.1898702. [PMID: 33825592]
Michal Pudis, José Luis Vercher Conejero, Juan José Martín Marcuartu, Montserrat Cortés Romera. 68Ga-DOTATOC-avid lymphadenopathies induced from COVID-19 mRNA vaccination. Japanese journal of clinical oncology. 2021 12; 51(12):1765. doi: 10.1093/jjco/hyab129. [PMID: 34363083]
Anna Sowa-Staszczak, Marta Opalińska, Anna Kurzyńska, Karolina Morawiec-Sławek, Aleksandra Gilis-Januszewska, Joanna Palen-Tytko, Helena Olearska, Alicja Hubalewska-Dydejczyk. Self-Administration of Long-Acting Somatostatin Analogues in NET Patients-Does It Affect the Clinical Outcome?. Medicina (Kaunas, Lithuania). 2021 Nov; 57(12):. doi: 10.3390/medicina57121287. [PMID: 34946232]
Manjiri Pramod Karlekar, Vijaya Sarathi, Sneha Arya, Sarah E Flanagan, Virendra Patil, Anurag Lila, Nalini Shah, Tushar Bandgar. Octreotide-LAR is a Useful Alternative for the Management of Diazoxide-Responsive Congenital Hyperinsulinism. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2021 Nov; 53(11):723-729. doi: 10.1055/a-1654-8542. [PMID: 34740273]
Noémie Worbe, Louise Damian, Véronique Le Cam-Duchez, Hervé Levesque, Pierre Michel, Elske Quak. Hemorrhagic disseminated intravascular coagulation after 177Lu-Dotatate in metastatic midgut neuroendocrine tumor: A case report. Medicine. 2021 Oct; 100(40):e27455. doi: 10.1097/md.0000000000027455. [PMID: 34622868]
Narges K Tafreshi, Darpan N Pandya, Christopher J Tichacek, Mikalai M Budzevich, Zhen Wang, Jordan N Reff, Robert W Engelman, David C Boulware, Alberto A Chiappori, Jonathan R Strosberg, Haitao Ji, Thaddeus J Wadas, Ghassan El-Haddad, David L Morse. Preclinical evaluation of [225Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms. European journal of nuclear medicine and molecular imaging. 2021 10; 48(11):3408-3421. doi: 10.1007/s00259-021-05315-1. [PMID: 33772332]
Jeongin Yoo, Se Hyung Kim, Sun Kyung Jeon, Jae Seok Bae, Joon Koo Han. Added value of [68Ga]Ga-DOTA-TOC PET/CT for characterizing pancreatic neuroendocrine neoplasms: a comparison with contrast-enhanced CT and/or MRI in a large study cohort. European radiology. 2021 Oct; 31(10):7734-7745. doi: 10.1007/s00330-021-07859-0. [PMID: 33787974]
Wouter T Zandee, Tessa Brabander, Anela Blažević, Noémie S Minczeles, Richard A Feelders, Wouter W de Herder, Johannes Hofland. Peptide Receptor Radionuclide Therapy With 177Lu-DOTATATE for Symptomatic Control of Refractory Carcinoid Syndrome. The Journal of clinical endocrinology and metabolism. 2021 08; 106(9):e3665-e3672. doi: 10.1210/clinem/dgab289. [PMID: 33942075]
Jacob Luty, LesleAnn Hayward, Melanie Jackson, P Barton Duell. Severe respiratory failure in a patient with COVID-19 and acromegaly: rapid improvement after adding octreotide. BMJ case reports. 2021 Aug; 14(8):. doi: 10.1136/bcr-2021-243900. [PMID: 34404661]
Theresa P Devasia, Yuni K Dewaraja, Kirk A Frey, Ka Kit Wong, Matthew J Schipper. A Novel Time-Activity Information-Sharing Approach Using Nonlinear Mixed Models for Patient-Specific Dosimetry with Reduced Imaging Time Points: Application in SPECT/CT After 177Lu-DOTATATE. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2021 08; 62(8):1118-1125. doi: 10.2967/jnumed.120.256255. [PMID: 33443063]
Caitlin Reilly, Alastair J Gemmell, Ian M McLaughlin, Robert Fleming, Nicholas Reed, David McIntosh, Alice Nicol. Characterisation of 99mTc EDDA/HYNIC-TOC (Tektrotyd) physiological and neuroendocrine tumour uptake using SPECT/CT standardised uptake values: initial experience. Nuclear medicine communications. 2021 Aug; 42(8):935-939. doi: 10.1097/mnm.0000000000001416. [PMID: 33741866]
Heribert Hänscheid, Philipp E Hartrampf, Andreas Schirbel, Andreas K Buck, Constantin Lapa. Intraindividual comparison of [177Lu]Lu-DOTA-EB-TATE and [177Lu]Lu-DOTA-TOC. European journal of nuclear medicine and molecular imaging. 2021 07; 48(8):2566-2572. doi: 10.1007/s00259-020-05177-z. [PMID: 33452632]
Lowell B Anthony, Thomas M O'Dorisio. Opportunities to Improve Symptom Control with Somatostatin Congeners in GEP-NETs: A Review of Key Issues. The oncologist. 2021 07; 26(7):e1171-e1178. doi: 10.1002/onco.13847. [PMID: 34097784]
Dimitrios Papantoniou, Malin Grönberg, Kalle Landerholm, Staffan Welin, Barbara Ziolkowska, Dennis Nordvall, Eva Tiensuu Janson. Assessment of hormonal levels as prognostic markers and of their optimal cut-offs in small intestinal neuroendocrine tumours grade 2. Endocrine. 2021 06; 72(3):893-904. doi: 10.1007/s12020-020-02534-8. [PMID: 33244704]
Joseph Bennett, Mark T Cunningham, Christin Howard, Marc Hoffmann, Fred V Plapp. Acquired factor V inhibitor in the setting of coronavirus disease 2019 infection. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2021 Jun; 32(4):294-297. doi: 10.1097/mbc.0000000000001009. [PMID: 33443928]
Peng Li, Leigh Ford, Shadabul Haque, Mitchell P McInerney, Hywel D Williams, Peter J Scammells, Philip E Thompson, Vincent Jannin, Christopher J H Porter, Hassan Benameur, Colin W Pouton. Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide. Pharmaceutical research. 2021 Jun; 38(6):1125-1137. doi: 10.1007/s11095-021-03063-3. [PMID: 34100217]
Chuandong Sun, Zhu Li, Zheng Shi, Guichen Li. Current diagnosis and treatment of acute pancreatitis in China: a real-world, multicenter study. BMC gastroenterology. 2021 May; 21(1):210. doi: 10.1186/s12876-021-01799-1. [PMID: 33964868]
Federico Veracierto, Nicolas Sanchez, Leandro Mosna, Diego Herrera Vegas, Roberto Salgado. Management of Chylous Ascites After Laparoscopic Nephrectomy for Living Kidney Donor: A Case Report and Literature Review. Transplantation proceedings. 2021 May; 53(4):1251-1256. doi: 10.1016/j.transproceed.2020.10.024. [PMID: 33288311]
Hao-Nan Yu, Ling Liu, Qiu-Song Chen, Qing He, Yan-Sheng Li, Ying Wang, Shuo Gao. Comparison of 18 F-FDG PET/CT and 68 Ga-DOTATATE PET/CT in the Targeted Imaging of Culprit Tumors Causing Osteomalacia. Orthopaedic surgery. 2021 May; 13(3):791-798. doi: 10.1111/os.12980. [PMID: 33709632]
Dina Zakaria Mohamed, Alaa El-Din El-Sayed El-Sisi, Samia Salim Sokar, Abdelhadi Mohamed Shebl, Sally El-Sayed Abu-Risha. Targeting autophagy to modulate hepatic ischemia/reperfusion injury: A comparative study between octreotide and melatonin as autophagy modulators through AMPK/PI3K/AKT/mTOR/ULK1 and Keap1/Nrf2 signaling pathways in rats. European journal of pharmacology. 2021 Apr; 897(?):173920. doi: 10.1016/j.ejphar.2021.173920. [PMID: 33571535]
Esmail Jafari, Abdul Latif Amini, Hojjat Ahmadzadehfar, Dara Bagheri, Majid Assadi. Cardiotoxicity and cardiac monitoring following the use of radiotheranostics agents including 177Lu-PSMA for prostate cancer and 177Lu-DOTATATE for neuroendocrine tumors. Nuklearmedizin. Nuclear medicine. 2021 Apr; 60(2):99-105. doi: 10.1055/a-1332-8230. [PMID: 33461224]
Esmail Jafari, Hojjat Ahmadzadehfar, Dara Bagheri, Abdullatif Amini, Majid Assadi. Assessment of early oxidative stress following the use of radiotheranostics agents 177Lu-PSMA for prostate cancer and 177Lu-DOTATATE for neuroendocrine tumors; radioprotective effect of vitamin C. Nuclear medicine communications. 2021 Mar; 42(3):325-331. doi: 10.1097/mnm.0000000000001327. [PMID: 33306634]
Jakob Albrecht, Samantha Exner, Carsten Grötzinger, Sonal Prasad, Frank Konietschke, Nicola Beindorff, Anja A Kühl, Vikas Prasad, Winfried Brenner, Eva J Koziolek. Multimodal Imaging of 2-Cycle PRRT with 177Lu-DOTA-JR11 and 177Lu-DOTATOC in an Orthotopic Neuroendocrine Xenograft Tumor Mouse Model. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2021 03; 62(3):393-398. doi: 10.2967/jnumed.120.250274. [PMID: 32859703]
Sarit T Kipnis, Matthew Hung, Shria Kumar, Jason M Heckert, Hwan Lee, Bonita Bennett, Michael C Soulen, Daniel A Pryma, David A Mankoff, David C Metz, Jennifer R Eads, Bryson W Katona. Laboratory, Clinical, and Survival Outcomes Associated With Peptide Receptor Radionuclide Therapy in Patients With Gastroenteropancreatic Neuroendocrine Tumors. JAMA network open. 2021 03; 4(3):e212274. doi: 10.1001/jamanetworkopen.2021.2274. [PMID: 33755166]
Geza Vass, Ria Evans Fry, Charles C Roehr. Should Newborns with Refractory Chylothorax Be Tried on Higher Dose of Octreotide?. Neonatology. 2021; 118(1):122-126. doi: 10.1159/000512461. [PMID: 33494092]
Jules Zhang-Yin, Nadine Guilabert, Thierry Kiffel, Françoise Montravers, Phillip Calais, Jean Lumbroso, Jean-Noël Talbot. Patient external dose rate after 177Lu-DOTATATE therapy: factors affecting its decrease and predictive value. International journal of medical sciences. 2021; 18(12):2725-2735. doi: 10.7150/ijms.58680. [PMID: 34104105]
Conor F Murphy, Nicholas Stratford, Neil G Docherty, Brendan Moran, Jessie A Elliott, Marie-Louise Healy, Jason P McMorrow, Narayanasamy Ravi, Anthony P Goldstone, John V Reynolds, Carel W le Roux. A Pilot Study of Gut-Brain Signaling After Octreotide Therapy for Unintentional Weight Loss After Esophagectomy. The Journal of clinical endocrinology and metabolism. 2021 01; 106(1):e204-e216. doi: 10.1210/clinem/dgaa697. [PMID: 33000149]
Luis David Jiménez-Franco, Gerhard Glatting, Vikas Prasad, Wolfgang A Weber, Ambros J Beer, Peter Kletting. Effect of Tumor Perfusion and Receptor Density on Tumor Control Probability in 177Lu-DOTATATE Therapy: An In Silico Analysis for Standard and Optimized Treatment. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2021 01; 62(1):92-98. doi: 10.2967/jnumed.120.245068. [PMID: 32646878]
Yanxia Gao, Linlin Hou, Yibo Wang, Shigong Guo, Ding Yuan, Ya'nan Jiang, Guoyu Duan, Yan Zhang, Zhigao Xu, Lu Che, Changhua Sun, Sujuan Li, Shoutao Zhang, Tongwen Sun, Yi Li. Octreotide alleviates pancreatic damage caused by paraquat in rats by reducing inflammatory responses and oxidative stress. Environmental toxicology and pharmacology. 2020 Nov; 80(?):103456. doi: 10.1016/j.etap.2020.103456. [PMID: 32673753]
Afshar Zomorrodi, Alireza Farshi. A Massive Chylous Ascites With Severe Morbidity After Laparoscopic Donor Nephrectomy and Successful Treatment With Total Parenteral Nutrition and Octreotide. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 2020 11; 18(6):729-731. doi: 10.6002/ect.2018.0309. [PMID: 31615378]
Ahmed A H Abdellatif, Robert Hennig, Klaus Pollinger, Hesham M Tawfeek, Abdellatif Bouazzaoui, Achim Goepferich. Fluorescent Nanoparticles Coated with a Somatostatin Analogue Target Blood Monocyte for Efficient Leukaemia Treatment. Pharmaceutical research. 2020 Oct; 37(11):217. doi: 10.1007/s11095-020-02938-1. [PMID: 33037505]
Rosalba Mansi, Guillaume Pierre Nicolas, Luigi Del Pozzo, Karim Alexandre Abid, Eric Grouzmann, Melpomeni Fani. Evaluation of a New 177Lu-Labeled Somatostatin Analog for the Treatment of Tumors Expressing Somatostatin Receptor Subtypes 2 and 5. Molecules (Basel, Switzerland). 2020 Sep; 25(18):. doi: 10.3390/molecules25184155. [PMID: 32932783]
Ahmad Pourahadi, Saeed Nojavan, Saied Saeed Hosseiny Davarani. Gel-electromembrane extraction of peptides: Determination of five hypothalamic agents in human plasma samples. Talanta. 2020 Sep; 217(?):121025. doi: 10.1016/j.talanta.2020.121025. [PMID: 32498910]
Walaa Alshafie, Yingzhou Edward Pan, Hans-Jürgen Kreienkamp, Thomas Stroh. Characterization of agonist-dependent somatostatin receptor subtype 2 trafficking in neuroendocrine cells. Endocrine. 2020 09; 69(3):655-669. doi: 10.1007/s12020-020-02329-x. [PMID: 32383089]
Giovanni Paganelli, Lisa Bodei, Irvin Modlin. A metastatic tumor is no different to a viral pandemic: lessons learnt from COVID-19 may teach us to change the PRRT paradigm. European journal of nuclear medicine and molecular imaging. 2020 09; 47(10):2223-2226. doi: 10.1007/s00259-020-04904-w. [PMID: 32564170]
Mark Lubberink, Helena Wilking, Amalia Öst, Ezgi Ilan, Mattias Sandström, Camilla Andersson, Katarzyna Fröss-Baron, Irina Velikyan, Anders Sundin. In Vivo Instability of 177Lu-DOTATATE During Peptide Receptor Radionuclide Therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2020 09; 61(9):1337-1340. doi: 10.2967/jnumed.119.237818. [PMID: 32005767]
Berta Pérez Martín, Elisa Rodríguez Martínez, Iván Baamonde de la Torre, Natalia Suárez Pazos, Manuel Díaz Tie. Gastric Antral Vascular Ectasia Refractory to Endoscopic Treatment. Cirugia espanola. 2020 Aug; 98(7):416-418. doi: 10.1016/j.ciresp.2019.11.001. [PMID: 31812265]
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