7alpha-hydroxy-3-oxo-4-cholestenoic acid (BioDeep_00001869075)

Main id: BioDeep_00000011650

 


代谢物信息卡片


7alpha-hydroxy-3-oxo-4-cholestenoic acid

化学式: C27H42O4 (430.3083)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CCCC(C)C(=O)O)C1CCC2C1(CCC3C2C(CC4=CC(=O)CCC34C)O)C
InChI: InChI=1S/C27H42O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h14,16-17,20-24,29H,5-13,15H2,1-4H3,(H,30,31)/t16-,17?,20-,21+,22+,23-,24+,26+,27-/m1/s1

描述信息

A cholestanoid that is cholest-4-en-26-oic acid substituted by an alpha-hydroxy group at position 7 and an oxo group at position 3. It is an intermediate metabolite in the bile acid synthesis.

同义名列表

2 个代谢物同义名

7alpha-hydroxy-3-oxo-4-cholestenoic acid; 7alpha-Hydroxy-3-oxo-4-cholestenoate



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ALB, CALCRL, RBFOX3, SMAD2
Peripheral membrane protein 1 CYP27A1
Endoplasmic reticulum membrane 2 CYP7B1, HMGCR
Mitochondrion membrane 1 CYP27A1
Nucleus 4 ALB, NAXE, RBFOX3, SMAD2
cytosol 4 ALB, GPT, NAXE, SMAD2
centrosome 1 ALB
nucleoplasm 1 SMAD2
Cell membrane 2 CALCRL, FFAR1
Multi-pass membrane protein 4 CALCRL, CYP7B1, FFAR1, HMGCR
Golgi apparatus 1 ALB
Golgi membrane 1 INS
mitochondrial inner membrane 1 CYP27A1
Lysosome 1 CALCRL
endosome 1 CALCRL
plasma membrane 2 CALCRL, FFAR1
Membrane 3 CYP7B1, HMGCR, SMAD2
extracellular exosome 3 ALB, GPT, NAXE
endoplasmic reticulum 3 ALB, CALCRL, HMGCR
extracellular space 3 ALB, INS, NAXE
mitochondrion 2 CYP27A1, NAXE
protein-containing complex 2 ALB, SMAD2
Microsome membrane 1 CYP7B1
Secreted 3 ALB, INS, NAXE
extracellular region 3 ALB, INS, NAXE
mitochondrial matrix 2 CYP27A1, NAXE
anchoring junction 1 ALB
transcription regulator complex 1 SMAD2
perikaryon 1 RBFOX3
Mitochondrion inner membrane 1 CYP27A1
peroxisomal membrane 1 HMGCR
ciliary basal body 1 ALB
cilium 1 NAXE
chromatin 1 SMAD2
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 INS
cell body 1 NAXE
Peroxisome membrane 1 HMGCR
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
heteromeric SMAD protein complex 1 SMAD2
SMAD protein complex 1 SMAD2
CGRP receptor complex 1 CALCRL
adrenomedullin receptor complex 1 CALCRL
activin responsive factor complex 1 SMAD2
ciliary transition fiber 1 ALB
homomeric SMAD protein complex 1 SMAD2


文献列表

  • Ahmed A Saeed, Erik Edström, Irina Pikuleva, Gösta Eggertsen, Ingemar Björkhem. On the importance of albumin binding for the flux of 7α-hydroxy-3-oxo-4-cholestenoic acid in the brain. Journal of lipid research. 2017 02; 58(2):455-459. doi: 10.1194/jlr.p073403. [PMID: 27956474]
  • Ahmed Saeed, Federico Floris, Ulla Andersson, Irina Pikuleva, Anita Lövgren-Sandblom, Maria Bjerke, Martin Paucar, Anders Wallin, Per Svenningsson, Ingemar Björkhem. 7α-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier. Journal of lipid research. 2014 Feb; 55(2):313-8. doi: 10.1194/jlr.p044982. [PMID: 24319290]
  • Steve Meaney, Maura Heverin, Ute Panzenboeck, Lena Ekström, Magnus Axelsson, Ulla Andersson, Ulf Diczfalusy, Irina Pikuleva, John Wahren, Wolfgang Sattler, Ingemar Björkhem. Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid. Journal of lipid research. 2007 Apr; 48(4):944-51. doi: 10.1194/jlr.m600529-jlr200. [PMID: 17251592]
  • Steve Meaney, Amir Babiker, Dieter Lütjohann, Ulf Diczfalusy, Magnus Axelson, Ingemar Björkhem. On the origin of the cholestenoic acids in human circulation. Steroids. 2003 Sep; 68(7-8):595-601. doi: 10.1016/s0039-128x(03)00081-3. [PMID: 12957664]
  • K Nagata, Y Seyama, T Shimizu. Changes in the level of 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid after subarachnoid hemorrhage. Neurologia medico-chirurgica. 1995 May; 35(5):294-7. doi: 10.2176/nmc.35.294. [PMID: 7623950]
  • K Nagata, K Takakura, T Asano, Y Seyama, H Hirota, N Shigematsu, I Shima, T Kasama, T Shimizu. Identification of 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in chronic subdural hematoma. Biochimica et biophysica acta. 1992 Jun; 1126(2):229-36. doi: 10.1016/0005-2760(92)90295-7. [PMID: 1627627]
  • M Axelson, B Mörk, A Aly, O Wisén, J Sjövall. Concentrations of cholestenoic acids in plasma from patients with liver disease. Journal of lipid research. 1989 Dec; 30(12):1877-82. doi: . [PMID: 2621414]
  • M Axelson, B Mörk, A Aly, G Walldius, J Sjövall. Concentrations of cholestenoic acids in plasma from patients with reduced intestinal reabsorption of bile acids. Journal of lipid research. 1989 Dec; 30(12):1883-7. doi: . [PMID: 2621415]
  • M Axelson, B Mörk, J Sjövall. Occurrence of 3 beta-hydroxy-5-cholestenoic acid, 3 beta,7 alpha-dihydroxy-5-cholestenoic acid, and 7 alpha-hydroxy-3-oxo-4-cholestenoic acid as normal constituents in human blood. Journal of lipid research. 1988 May; 29(5):629-41. doi: 10.1016/s0022-2275(20)38509-6. [PMID: 3411238]