N-Ethylglycine (BioDeep_00000001862)

   

human metabolite Endogenous Chemicals and Drugs natural product


代谢物信息卡片


2-(ethylamino)acetic acid

化学式: C4H9NO2 (103.0633254)
中文名称: N-乙基甘氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.27%

分子结构信息

SMILES: CCNCC(=O)O
InChI: InChI=1S/C4H9NO2/c1-2-5-3-4(6)7/h5H,2-3H2,1H3,(H,6,7)

描述信息

N-Ethylglycine, also known as EG, belongs to the family of compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). N-ethylglyicne is a known metabolite of the anesthesia drug lidocaine (PMID: 25932687). N-ethylglyicne is also an endogenously produced metabolite and appears in normal subjects’ urine in small amounts, but its presence is significantly higher in patients with metastatic bone disease (PMID: 16962088). Research has shown that it is lidocaine’s metabolites, n-ethylglycine and monoethylglycinexylidide inhibit GlyT1-mediated uptake of glycine. N-ethylglycine acts as a substrate for the glycine transporter GlyT1 (PMID: 22133759, 25932687).

同义名列表

5 个代谢物同义名

2-(ethylamino)acetic acid; 2-Ethylaminoacetic acid; (Ethylammonio)acetate; N-Ethylglycine; EtGly



数据库引用编号

19 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Robert Werdehausen, David Kremer, Timo Brandenburger, Lukas Schlösser, Janusz Jadasz, Patrick Küry, Inge Bauer, Carmen Aragón, Volker Eulenburg, Henning Hermanns. Lidocaine metabolites inhibit glycine transporter 1: a novel mechanism for the analgesic action of systemic lidocaine?. Anesthesiology. 2012 Jan; 116(1):147-58. doi: 10.1097/aln.0b013e31823cf233. [PMID: 22133759]
  • F Bianchi, S Dugheri, M Musci, A Bonacchi, E Salvadori, G Arcangeli, V Cupelli, M Lanciotti, L Masieri, S Serni, M Carini, M Careri, A Mangia. Fully automated solid-phase microextraction-fast gas chromatography-mass spectrometry method using a new ionic liquid column for high-throughput analysis of sarcosine and N-ethylglycine in human urine and urinary sediments. Analytica chimica acta. 2011 Nov; 707(1-2):197-203. doi: 10.1016/j.aca.2011.09.015. [PMID: 22027139]
  • Yasuto Tsuruta, Maya Matsumoto, Hirofumi Inoue, Sayaka Munemura, Shigeru Yamano, Haruo Iguchi. Determination of N-ethylglycine in urine of cancer patients with metastatic bone disease by HPLC using 4-(5,6-dimethoxy-2-phthalimidinyl)-2-methoxyphenylsulfonyl chloride as a fluorescent labeling reagent. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2008 Dec; 24(12):1629-31. doi: 10.2116/analsci.24.1629. [PMID: 19075476]
  • Yasuto Tsuruta, Maya Matsumoto, Hirofumi Inoue, Sayaka Munemura, Takashi Ishizu, Shigeru Yamano, Haruo Iguchi. Identification of N-ethylglycine in urine of cancer patients with metastatic bone disease. Clinica chimica acta; international journal of clinical chemistry. 2007 Feb; 376(1-2):226-8. doi: 10.1016/j.cca.2006.07.023. [PMID: 16962088]