Neurokinin A (BioDeep_00000181638)
human metabolite blood metabolite
代谢物信息卡片
3-(2-{6-amino-2-[2-amino-3-(1H-imidazol-5-yl)propanamido]hexanamido}-3-hydroxybutanamido)-3-({1-[(1-{[1-({[(1-{[1-carbamoyl-3-(methylsulfanyl)propyl]carbamoyl}-3-methylbutyl)carbamoyl]methyl}carbamoyl)-2-methylpropyl]carbamoyl}-2-phenylethyl)carbamoyl]-2-hydroxyethyl}carbamoyl)propanoic acid
化学式: C50H80N14O14S (1132.5699)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N
InChI: InChI=1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)
描述信息
D018377 - Neurotransmitter Agents > D015320 - Tachykinins
同义名列表
5 个代谢物同义名
3-(2-{6-amino-2-[2-amino-3-(1H-imidazol-5-yl)propanamido]hexanamido}-3-hydroxybutanamido)-3-({1-[(1-{[1-({[(1-{[1-carbamoyl-3-(methylsulfanyl)propyl]carbamoyl}-3-methylbutyl)carbamoyl]methyl}carbamoyl)-2-methylpropyl]carbamoyl}-2-phenylethyl)carbamoyl]-2-hydroxyethyl}carbamoyl)propanoic acid; Neurokinin alpha; NEUROKININ A; Neuromedin L; Substance K
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 55582
- HMDB: HMDB0255556
- ChEMBL: CHEMBL3969255
- Wikipedia: Neurokinin A
- MeSH: Neurokinin A
- chemspider: 50189
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wioleta Czelejewska, Agata Zmijewska, Mariusz Dziekonski, Stanislaw Okrasa. The role of neurokinin A and its receptor in the regulation of prolactin secretion by the anterior pituitary of cyclic pigs.
Reproduction in domestic animals = Zuchthygiene.
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2018 09; 391(9):907-914. doi:
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Pancreas.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jul; 103(?):1-8. doi:
10.1016/j.biopha.2018.04.011. [PMID: 29635121] - Nadia M J Rupniak, Mary Katofiasc, Lesley Marson, Karl B Thor. NK2 and NK1 receptor-mediated effects of NKA and analogs on colon, bladder, and arterial pressure in anesthetized dogs.
Naunyn-Schmiedeberg's archives of pharmacology.
2018 03; 391(3):299-308. doi:
10.1007/s00210-017-1458-0. [PMID: 29279967] - F Aura Kullmann, M Katofiasc, K B Thor, Lesley Marson. Pharmacodynamic evaluation of Lys5, MeLeu9, Nle10-NKA(4-10) prokinetic effects on bladder and colon activity in acute spinal cord transected and spinally intact rats.
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2017 Feb; 390(2):163-173. doi:
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PloS one.
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Pulmonary pharmacology & therapeutics.
2008; 21(3):522-32. doi:
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Acta physiologica Scandinavica.
1998 Nov; 164(3):317-23. doi:
10.1046/j.1365-201x.1998.00458.x. [PMID: 9853020] - P Duval, V Lenoir, B Kerdelhue. Ovarian steroid modulation of neurokinin contents in hypothalamus, pituitary, trigeminal nucleus, and cervical spinal cord of the ovariectomized female rat.
Journal of neuroendocrinology.
1998 Nov; 10(11):823-8. doi:
10.1046/j.1365-2826.1998.00267.x. [PMID: 9831258] - A Asztély, G Havel, J Ekström. Vascular protein leakage in the rat parotid gland elicited by reflex stimulation, parasympathetic nerve stimulation and administration of neuropeptides.
Regulatory peptides.
1998 Oct; 77(1-3):113-20. doi:
10.1016/s0167-0115(98)00121-9. [PMID: 9809804] - D L Mohyi, B Kerdelhué, V Lenoir, P Kolm, H W Jones, G S Jones. Plasma substance-P and substance-K and gonadal steroids in relation to the gonadotropin surge in normal human reproductive cycles.
Journal of assisted reproduction and genetics.
1998 Oct; 15(9):547-51. doi:
10.1023/a:1022534204239. [PMID: 9822983] - H H Chen, H P Kuo. Effect of sensory neuropeptides on mucus secretion from cultured goblet cells.
Changgeng yi xue za zhi.
1998 Sep; 21(3):283-90. doi:
NULL. [PMID: 9849009] - E Haker, E Theodorsson, T Lundeberg. An experimental model of tennis elbow in rats: a study of the contribution of the nervous system.
Inflammation.
1998 Aug; 22(4):435-44. doi:
10.1023/a:1022377001084. [PMID: 9675613] - M Tramontana, R Patacchini, S Giuliani, A Lippi, A Lecci, P Santicioli, M Criscuoli, C A Maggi. Characterization of the antibronchoconstrictor activity of MEN 11420, a tachykinin NK2 receptor antagonist, in guinea-pigs.
European journal of pharmacology.
1998 Jul; 352(2-3):279-88. doi:
10.1016/s0014-2999(98)00376-8. [PMID: 9716365] - M Bakke, J W Hu, B J Sessle. Involvement of NK-1 and NK-2 tachykinin receptor mechanisms in jaw muscle activity reflexly evoked by inflammatory irritant application to the rat temporomandibular joint.
Pain.
1998 Apr; 75(2-3):219-27. doi:
10.1016/s0304-3959(97)00223-6. [PMID: 9583757] - D A Bereiter, D F Bereiter, B H Tonnessen, D B Maclean. Selective blockade of substance P or neurokinin A receptors reduces the expression of c-fos in trigeminal subnucleus caudalis after corneal stimulation in the rat.
Neuroscience.
1998 Mar; 83(2):525-34. doi:
10.1016/s0306-4522(97)00433-8. [PMID: 9460760] - P M Hellström, M Thollander, E Theodorsson. Nociceptive inhibition of migrating myoelectric complex by nitric oxide and monoaminergic pathways in the rat.
The American journal of physiology.
1998 03; 274(3):G480-6. doi:
10.1152/ajpgi.1998.274.3.g480. [PMID: 9530148] - G A Sarosi, B C Kimball, D C Barnhart, W Zhang, M W Mulholland. Tachykinin neuropeptide-evoked intracellular calcium transients in cultured guinea pig myenteric neurons.
Peptides.
1998; 19(1):75-84. doi:
10.1016/s0196-9781(97)00271-4. [PMID: 9437739] - P Holzer. Neurogenic vasodilatation and plasma leakage in the skin.
General pharmacology.
1998 Jan; 30(1):5-11. doi:
10.1016/s0306-3623(97)00078-5. [PMID: 9457475] - H Sann, F K Pierau. Efferent functions of C-fiber nociceptors.
Zeitschrift fur Rheumatologie.
1998; 57 Suppl 2(?):8-13. doi:
10.1007/s003930050226. [PMID: 10025074] - J C Emms, D F Rogers. Cigarette smoke-inhibition of neurogenic bronchoconstriction in guinea-pigs in vivo: involvement of exogenous and endogenous nitric oxide.
British journal of pharmacology.
1997 Oct; 122(4):779-85. doi:
10.1038/sj.bjp.0701440. [PMID: 9375977] - P M Hellström, A al-Saffar, T Ljung, E Theodorsson. Endotoxin actions on myoelectric activity, transit, and neuropeptides in the gut. Role of nitric oxide.
Digestive diseases and sciences.
1997 Aug; 42(8):1640-51. doi:
10.1023/a:1018897028463. [PMID: 9286229] - A Uribe, M Kapraali, M Alam, C Söderman, E Theodorsson. Indomethacin influences regulatory peptides and increases DNA synthesis in the gastrointestinal tract of the rat.
European journal of gastroenterology & hepatology.
1997 Jul; 9(7):665-73. doi:
10.1097/00042737-199707000-00004. [PMID: 9262974] - E M Kudlacz, R W Knippenberg, S A Shatzer, J H Kehne, T C McCloskey, T P Burkholder. The peripheral NK-1/NK-2 receptor antagonist MDL 105,172A inhibits tachykinin-mediated respiratory effects in guinea-pigs.
Journal of autonomic pharmacology.
1997 Apr; 17(2):109-19. doi:
10.1046/j.1365-2680.1997.00446.x. [PMID: 9234081] - H Goodis, K Saeki. Identification of bradykinin, substance P, and neurokinin A in human dental pulp.
Journal of endodontics.
1997 Apr; 23(4):201-4. doi:
10.1016/s0099-2399(97)80045-3. [PMID: 9594764] - Y D Yuan, R Couture. Renal effects of intracerebroventricularly injected tachykinins in the conscious saline-loaded rat: receptor characterization.
British journal of pharmacology.
1997 Mar; 120(5):785-96. doi:
10.1038/sj.bjp.0700972. [PMID: 9138683] - S Evangelista, S Paoli, A Giachetti, S Manzini. Involvement of tachykinin NK1 receptors in plasma protein extravasation induced by tachykinins in the guinea pig upper airways.
Neuropeptides.
1997 Feb; 31(1):65-70. doi:
10.1016/s0143-4179(97)90022-6. [PMID: 9574840] - E Haker, E Theodorsson, T Lundeberg. An experimental study of the neurogenic and the immunological contribution to 'tennis elbow' in rats.
Inflammation.
1997 Feb; 21(1):35-44. doi:
10.1023/a:1027386724444. [PMID: 9179620] - F Zheng, S N Lawson. Neurokinin A in rat renal afferent neurons and in nerve fibres within smooth muscle and epithelium of rat and guinea-pig renal pelvis.
Neuroscience.
1997 Feb; 76(4):1245-55. doi:
10.1016/s0306-4522(96)00441-1. [PMID: 9027883] - I Bileviciute, E Theodorsson, T Lundeberg. Is the pretreatment effect of low dose Freund's adjuvant on adjuvant arthritis due to an activation of the nervous system?.
Neuropeptides.
1996 Oct; 30(5):405-11. doi:
10.1016/s0143-4179(96)90001-3. [PMID: 8923499] - D Pisera, A De Laurentiis, B Duvilanski, M Lasaga, M C Díaz, A Seilicovich. Neurokinin A affects the tubero-hypophyseal gabaergic system.
Neuroreport.
1996 Sep; 7(13):2236-40. doi:
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Journal of neuroscience research.
1996 Sep; 45(5):598-609. doi:
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British journal of pharmacology.
1996 Aug; 118(7):1567-9. doi:
10.1111/j.1476-5381.1996.tb15576.x. [PMID: 8842416] - H Inoue, N Nagata, Y Koshihara. Involvement of tachykinin receptors in oedema formation and plasma extravasation induced by substance P, neurokinin A, and neurokinin B in mouse ear.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
1996 Jul; 45(7):316-23. doi:
10.1007/bf02252943. [PMID: 8841832] - J Carleson, P Alstergren, A Appelgren, B Appelgren, S Kopp, G R Srinivasan, E Theodorsson, T Lundeberg. Effects of adjuvant on neuropeptide-like immunoreactivity in experimentally induced temporomandibular arthritis in rats.
Archives of oral biology.
1996 Jul; 41(7):705-12. doi:
10.1016/s0003-9969(96)00027-1. [PMID: 9015573] - H Sann, R Friedrich, F K Pierau. Substance P and calcitonin gene-related peptide in the chicken skin: distribution and cardiovascular effects.
Neuropeptides.
1996 Jun; 30(3):273-81. doi:
10.1016/s0143-4179(96)90073-6. [PMID: 8819151] - E M Kudlacz, S A Shatzer, R W Knippenberg, D E Logan, M Poirot, P L van Giersbergen, T P Burkholder. In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist.
The Journal of pharmacology and experimental therapeutics.
1996 May; 277(2):840-51. doi:
. [PMID: 8627566] - M Lördal, A Hällgren, O Nylander, P M Hellström. Tachykinins increase vascular permeability in the gastrointestinal tract of the rat.
Acta physiologica Scandinavica.
1996 Apr; 156(4):489-94. doi:
10.1046/j.1365-201x.1996.457174000.x. [PMID: 8732255] - J Carleson, P Alstergren, A Appelgren, B Appelgren, S Kopp, E Theodorsson, T Lundeberg. A model for the study of experimentally induced temporomandibular arthritis in rats: the effect of human recombinant interleukin-1 alpha on neuropeptide-like immunoreactivity.
Journal of orofacial pain.
1996; 10(1):9-14. doi:
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Life sciences.
1996; 59(15):1193-201. doi:
10.1016/0024-3205(96)00309-8. [PMID: 8845005] - M Bergstrom, E Theodorsson, I Norheim, K Oberg. Immunoreactive tachykinins in 24-h collections of urine from patients with carcinoid tumours: characterization and correlation with plasma concentrations.
Scandinavian journal of clinical and laboratory investigation.
1995 Dec; 55(8):679-89. doi:
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Endocrine research.
1995 Nov; 21(4):757-67. doi:
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The Journal of pharmacy and pharmacology.
1995 Oct; 47(10):846-51. doi:
10.1111/j.2042-7158.1995.tb05752.x. [PMID: 8583354] - V Gallai, P Sarchielli, A Floridi, M Franceschini, M Codini, G Glioti, A Trequattrini, R Palumbo. Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally.
Cephalalgia : an international journal of headache.
1995 Oct; 15(5):384-90. doi:
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