Oxydemeton-methyl (BioDeep_00000001813)

 

Secondary id: BioDeep_00001867772

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


Phosphorothioic acid, S-(2-(ethylsulphinyl)ethyl) O,O-dimethyl ester

化学式: C6H15O4PS2 (246.01493599999998)
中文名称: 砜吸磷
谱图信息: 最多检出来源 Homo sapiens(blood) 85.71%

分子结构信息

SMILES: CCS(=O)CCSP(=O)(OC)OC
InChI: InChI=1S/C6H15O4PS2/c1-4-13(8)6-5-12-11(7,9-2)10-3/h4-6H2,1-3H3

描述信息

D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals

同义名列表

19 个代谢物同义名

Phosphorothioic acid, S-(2-(ethylsulphinyl)ethyl) O,O-dimethyl ester; Phosphorothioic acid, S-(2-(ethylsulfinyl)ethyl) O,O-dimethyl ester; Phosphorothioate, S-(2-(ethylsulphinyl)ethyl) O,O-dimethyl ester; Phosphorothioate, S-(2-(ethylsulfinyl)ethyl) O,O-dimethyl ester; S-[2-(Ethylsulphinyl)ethyl] O,O-dimethyl thiophosphoric acid; S-[2-(Ethylsulfinyl)ethyl] O,O-dimethyl thiophosphoric acid; O,O-Dimethyl S-(2-(ethylsulfinyl)ethyl)phosphorothioate; dimethyl {[2-(ethanesulfinyl)ethyl]sulfanyl}phosphonate; S-[2-(Ethylsulphinyl)ethyl] O,O-dimethyl thiophosphate; 1-Dimethoxyphosphorylsulphanyl-2-ethylsulphinylethane; S-[2-(Ethylsulfinyl)ethyl] O,O-dimethyl thiophosphate; Methylmercaptophos oxide; Oxydemeton methyl; OXYDEMETON-METHYL; OXDEMETONMETHYL; Methyl demeton; Metasystox-R; Metasystox; Oxydemeton-methyl



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Harald John, Markus Siegert, Florian Eyer, Franz Worek, Horst Thiermann, Andreas Kranawetvogl. Novel cysteine- and albumin-adduct biomarkers to prove human poisoning with the pesticide oxydemeton-S-methyl. Toxicology letters. 2018 Sep; 294(?):122-134. doi: 10.1016/j.toxlet.2018.05.023. [PMID: 29777832]
  • Fatemeh Ganjeizadeh Rohani, Vahideh Mahdavi, M Mehdi Aminaei. Investigation on diazinon and oxydemeton-methyl residues in cucumbers grown in Kerman greenhouses. Environmental monitoring and assessment. 2014 Jul; 186(7):3995-9. doi: 10.1007/s10661-014-3674-0. [PMID: 24526616]
  • Maryse F Bouchard, Jonathan Chevrier, Kim G Harley, Katherine Kogut, Michelle Vedar, Norma Calderon, Celina Trujillo, Caroline Johnson, Asa Bradman, Dana Boyd Barr, Brenda Eskenazi. Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environmental health perspectives. 2011 Aug; 119(8):1189-95. doi: 10.1289/ehp.1003185. [PMID: 21507776]
  • Asa Bradman, Rosemary Castorina, Dana Boyd Barr, Jonathan Chevrier, Martha E Harnly, Ellen A Eisen, Thomas E McKone, Kim Harley, Nina Holland, Brenda Eskenazi. Determinants of organophosphorus pesticide urinary metabolite levels in young children living in an agricultural community. International journal of environmental research and public health. 2011 04; 8(4):1061-83. doi: 10.3390/ijerph8041061. [PMID: 21695029]
  • Kim G Harley, Karen Huen, Raul Aguilar Schall, Nina T Holland, Asa Bradman, Dana Boyd Barr, Brenda Eskenazi. Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women. PloS one. 2011; 6(8):e23923. doi: 10.1371/journal.pone.0023923. [PMID: 21904599]
  • Brenda Eskenazi, Karen Huen, Amy Marks, Kim G Harley, Asa Bradman, Dana Boyd Barr, Nina Holland. PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero. Environmental health perspectives. 2010 Dec; 118(12):1775-81. doi: 10.1289/ehp.1002234. [PMID: 21126941]
  • Amy R Marks, Kim Harley, Asa Bradman, Katherine Kogut, Dana Boyd Barr, Caroline Johnson, Norma Calderon, Brenda Eskenazi. Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study. Environmental health perspectives. 2010 Dec; 118(12):1768-74. doi: 10.1289/ehp.1002056. [PMID: 21126939]
  • Harald John, Florian Eyer, Thomas Zilker, Horst Thiermann. High-performance liquid-chromatographic tandem-mass spectrometric methods for atropinesterase-mediated enantioselective and chiral determination of R- and S-hyoscyamine in plasma. Analytica chimica acta. 2010 Nov; 680(1-2):32-40. doi: 10.1016/j.aca.2010.09.018. [PMID: 20969988]
  • H Thiermann, T Zilker, F Eyer, N Felgenhauer, P Eyer, F Worek. Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients. Toxicology letters. 2009 Dec; 191(2-3):297-304. doi: 10.1016/j.toxlet.2009.09.013. [PMID: 19793545]
  • Jan Wilko Schrickel, Thorsten Lewalter, Berndt Lüderitz, Georg Nickenig, Hans-Ulrich Klehr, Christian Rabe. Recovery from ultra-high dose organophosphate poisoning after "in-the-field" antidote treatment: potential lessons for civil defense. The Journal of emergency medicine. 2009 Oct; 37(3):279-82. doi: 10.1016/j.jemermed.2007.11.006. [PMID: 18281183]
  • Florian Eyer, Franz Worek, Peter Eyer, Norbert Felgenhauer, Mike Haberkorn, Thomas Zilker, Horst Thiermann. Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness. Clinical toxicology (Philadelphia, Pa.). 2009 Sep; 47(8):798-806. doi: 10.1080/15563650903206828. [PMID: 19778163]
  • Horst Thiermann, Franz Worek, Peter Eyer, Florian Eyer, Norbert Felgenhauer, Thomas Zilker. Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships. Clinical toxicology (Philadelphia, Pa.). 2009 Sep; 47(8):807-13. doi: 10.1080/15563650903206836. [PMID: 19778190]
  • A K Gottzein, F Musshoff, E Doberentz, B Madea. Combined suicide by oxydemeton-methyl (Metasystox) ingestion and hanging. Forensic science international. 2009 Aug; 189(1-3):e21-5. doi: 10.1016/j.forsciint.2009.04.006. [PMID: 19428202]
  • Michael Eddleston, Peter Eyer, Franz Worek, Edmund Juszczak, Nicola Alder, Fahim Mohamed, Lalith Senarathna, Ariyasena Hittarage, Shifa Azher, K Jeganathan, Shaluka Jayamanne, Ludwig von Meyer, Andrew H Dawson, Mohamed Hussain Rezvi Sheriff, Nick A Buckley. Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial. PLoS medicine. 2009 Jun; 6(6):e1000104. doi: 10.1371/journal.pmed.1000104. [PMID: 19564902]
  • Eiji Ueno, Yuka Kabashima, Harumi Oshima, Tsutomu Ohno, Satoru Nemoto, Tamio Maitani. [Analysis of demeton-S-methyl, oxydemeton-methyl and demeton-S-methylsulfone in agricultural products by LC-MS]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan. 2009 Apr; 50(2):64-9. doi: 10.3358/shokueishi.50.64. [PMID: 19436153]
  • M Ghadamyari, K Talebi, H Mizuno, Y Kono. Oxydemeton-methyl resistance, mechanisms, and associated fitness cost in green peach aphids (Hemiptera: Aphididae). Journal of economic entomology. 2008 Aug; 101(4):1432-8. doi: 10.1603/0022-0493(2008)101[1432:ormaaf]2.0.co;2. [PMID: 18767757]
  • Brenda Eskenazi, Amy R Marks, Asa Bradman, Kim Harley, Dana B Barr, Caroline Johnson, Norma Morga, Nicholas P Jewell. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environmental health perspectives. 2007 May; 115(5):792-8. doi: 10.1289/ehp.9828. [PMID: 17520070]
  • Asa Bradman, Robin M Whyatt. Characterizing exposures to nonpersistent pesticides during pregnancy and early childhood in the National Children's Study: a review of monitoring and measurement methodologies. Environmental health perspectives. 2005 Aug; 113(8):1092-9. doi: 10.1289/ehp.7769. [PMID: 16079084]
  • Larry L Needham. Assessing exposure to organophosphorus pesticides by biomonitoring in epidemiologic studies of birth outcomes. Environmental health perspectives. 2005 Apr; 113(4):494-8. doi: 10.1289/ehp.7490. [PMID: 15811842]
  • Brenda Eskenazi, Kim Harley, Asa Bradman, Erin Weltzien, Nicholas P Jewell, Dana B Barr, Clement E Furlong, Nina T Holland. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environmental health perspectives. 2004 Jul; 112(10):1116-24. doi: 10.1289/ehp.6789. [PMID: 15238287]
  • O Volk, S Reith, C Saehn, P Haars, D Bach, H G Klues. [Attempted suicide by intravenous injection of metasystox]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS. 2002 May; 37(5):280-3. doi: 10.1055/s-2002-30127. [PMID: 12015685]
  • Lea Pogacnik, Mladen Franko. Validation of different commercially available cholinesterases for pesticide toxicity test. Annali di chimica. 2002 Jan; 92(1-2):93-101. doi: . [PMID: 11993279]
  • L Pogacnik, M Franko. Optimisation of FIA system for detection of organophosphorus and carbamate pesticides based on cholinesterase inhibition. Talanta. 2001 May; 54(4):631-41. doi: 10.1016/s0039-9140(01)00314-9. [PMID: 18968286]
  • H Thiermann, L Szinicz, F Eyer, F Worek, P Eyer, N Felgenhauer, T Zilker. Modern strategies in therapy of organophosphate poisoning. Toxicology letters. 1999 Jun; 107(1-3):233-9. doi: 10.1016/s0378-4274(99)00052-1. [PMID: 10414801]
  • H Thiermann, U Mast, R Klimmek, P Eyer, A Hibler, R Pfab, N Felgenhauer, T Zilker. Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients. Human & experimental toxicology. 1997 Aug; 16(8):473-80. doi: 10.1177/096032719701600809. [PMID: 9292288]
  • R B Raizada, M K Srivastava, R P Singh, R A Kaushal, K P Gupta, T S Dikshith. Interaction of technical hexachlorocyclohexane and oxydemeton methyl 25 EC to female rats after dermal application. Indian journal of experimental biology. 1993 Feb; 31(2):142-6. doi: NULL. [PMID: 7684724]
  • G R Clemens, R E Hartnagel, J J Bare, J H Thyssen. Teratological, neurochemical, and postnatal neurobehavioral assessment of METASYSTOX-R, an organophosphate pesticide in the rat. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1990 Jan; 14(1):131-43. doi: 10.1016/0272-0590(90)90239-g. [PMID: 2307312]
  • H Gellhaus, E Hausmann, H H Wellhöner. Fast determination of demeton-S-methylsulfoxide (Metasystox R) in blood plasma. Journal of analytical toxicology. 1989 Nov; 13(6):330-2. doi: 10.1093/jat/13.6.330. [PMID: 2607761]
  • J H van Vuren. The effects of toxicants on the haematology of Labeo umbratus (Teleostei: Cyprinidae). Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 1986; 83(1):155-9. doi: 10.1016/0742-8413(86)90029-0. [PMID: 2869891]
  • K Tayyaba, M Hasan. Vitamin E protects against metasystox-induced adverse effect on lipid metabolism in the rat brain and spinal cord. Acta pharmacologica et toxicologica. 1985 Sep; 57(3):190-6. doi: 10.1111/bcpt.1985.57.3.190. [PMID: 4061100]
  • F Islam, K Tayyaba, M Hasan. Organophosphate metasystox-induced increment of lipase activity and lipid peroxidation in cerebral hemisphere: diminution of lipids in discrete areas of the rat brain. Acta pharmacologica et toxicologica. 1983 Aug; 53(2):121-4. doi: 10.1111/j.1600-0773.1983.tb01878.x. [PMID: 6624479]
  • A Chopra, P K Gopal, S P Ahuja. Effects of Metasystox-R and Lebaycid on lipid metabolism in various organs of chicks (Gallus domesticus). Zentralblatt fur Veterinarmedizin. Reihe A. 1980 Feb; 27(1):54-64. doi: 10.1111/j.1439-0442.1980.tb01668.x. [PMID: 6774521]
  • A Chopra, S P Ahuja, P P Gupta, S K Nagpal. Histopathological and lipid changes in various organs of chicks (Gallus domesticus) caused by acute and chronic toxicity of metasytox-R and lebaycid. Zentralblatt fur Veterinarmedizin. Reihe A. 1979 Dec; 26(10):822-34. doi: 10.1111/j.1439-0442.1979.tb01368.x. [PMID: 121503]