Devazepide (BioDeep_00001028383)
代谢物信息卡片
Devazepide
化学式: C25H20N4O2 (408.158618)
中文名称: 地伐西匹
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C2=CC=CC=C2C(=NC(C1=O)NC(=O)C3=CC4=CC=CC=C4N3)C5=CC=CC=C5
InChI: InChI=1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders[1].
同义名列表
3 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:4460
- PubChem: 443375
- ChEMBL: CHEMBL9506
- MeSH: Devazepide
- CAS: 103420-77-5
- RefMet: Devazepide
- medchemexpress: HY-106301
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Helen H Wang, Piero Portincasa, David Q-H Wang. The cholecystokinin-1 receptor antagonist devazepide increases cholesterol cholelithogenesis in mice.
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Brain research.
1996 Oct; 737(1-2):83-91. doi:
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International journal of pancreatology : official journal of the International Association of Pancreatology.
1996 Oct; 20(2):109-18. doi:
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The Journal of surgical research.
1996 Aug; 64(2):170-5. doi:
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Scandinavian journal of gastroenterology.
1996 Jul; 31(7):723-32. doi:
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British journal of pharmacology.
1996 May; 118(2):400-6. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
1996 Apr; 93(9):4415-20. doi:
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The Journal of surgical research.
1996 Feb; 61(1):256-9. doi:
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World journal of surgery.
1996 Feb; 20(2):221-7. doi:
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Regulatory peptides.
1995 Nov; 59(3):297-302. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
1995 Oct; 92(22):10312-6. doi:
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Archives of physiology and biochemistry.
1995 Aug; 103(4):410-5. doi:
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Pancreas.
1995 Aug; 11(2):179-84. doi:
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Hepatology (Baltimore, Md.).
1995 Jul; 22(1):325-31. doi:
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Gastroenterology.
1995 Jul; 109(1):231-8. doi:
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Pancreas.
1995 Jul; 11(1):86-94. doi:
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Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.
1995 Jun; 111(2):257-63. doi:
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The American journal of physiology.
1995 Apr; 268(4 Pt 1):G605-12. doi:
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The Journal of surgical research.
1995 Feb; 58(2):149-58. doi:
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The American journal of physiology.
1995 Jan; 268(1 Pt 2):R135-41. doi:
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The American journal of physiology.
1994 Dec; 267(6 Pt 1):G960-5. doi:
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Anticancer research.
1994 Nov; 14(6B):2611-6. doi:
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General pharmacology.
1994 Nov; 25(7):1337-40. doi:
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Biochimica et biophysica acta.
1994 Oct; 1224(1):127-38. doi:
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Journal of medicinal chemistry.
1994 Oct; 37(21):3639-54. doi:
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The American journal of physiology.
1994 Oct; 267(4 Pt 1):G625-9. doi:
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Gastroenterology.
1994 Aug; 107(2):525-31. doi:
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Annals of clinical and laboratory science.
1994 Jul; 24(4):346-54. doi:
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International journal of pancreatology : official journal of the International Association of Pancreatology.
1994 Jun; 15(3):215-22. doi:
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Pancreas.
1994 May; 9(3):309-15. doi:
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