N-(3,5-Dichlorophenyl)-2-hydroxysuccinimide (BioDeep_00000172674)

   

human metabolite blood metabolite


代谢物信息卡片


1-(3,5-dichlorophenyl)-3-hydroxypyrrolidine-2,5-dione

化学式: C10H7Cl2NO3 (258.9802972)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 88.73%

分子结构信息

SMILES: C1C(C(=O)N(C1=O)C2=CC(=CC(=C2)Cl)Cl)O
InChI: InChI=1S/C10H7Cl2NO3/c11-5-1-6(12)3-7(2-5)13-9(15)4-8(14)10(13)16/h1-3,8,14H,4H2

描述信息

同义名列表

3 个代谢物同义名

1-(3,5-dichlorophenyl)-3-hydroxypyrrolidine-2,5-dione; N-(3,5-Dichlorophenyl)-2-hydroxysuccinimide; NDHS



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gary O Rankin, Suk K Hong, Dianne K Anestis, John G Ball, Monica A Valentovic, Vincent A Graffeo. Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats. Toxicology. 2012 Oct; 300(1-2):92-9. doi: 10.1016/j.tox.2012.06.003. [PMID: 22706168]
  • Gary O Rankin, Dianne K Anestis, Monica A Valentovic, Hang Sun, William E Triest. Nephrotoxicity induced by the R- and S-enantiomers of N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and their sulfate conjugates in male Fischer 344 rats. Toxicology. 2007 Oct; 240(1-2):38-47. doi: 10.1016/j.tox.2007.07.013. [PMID: 17728037]
  • Donghui Cui, Gary O Rankin, Peter J Harvison. Metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in rats: evidence for bioactivation through alcohol-O-glucuronidation and O-sulfation. Chemical research in toxicology. 2005 Jun; 18(6):991-1003. doi: 10.1021/tx0496587. [PMID: 15962934]
  • Gary O Rankin, Suk K Hong, Dianne K Anestis, Travis T Henderson, John G Ball, Monica A Valentovic, Patrick I Brown. Effect of three n-acetylamino acids on N-(3,5-dichlorophenyl)succinimide (NDPS) and ndps metabolite nephrotoxicity in Fischer 344 rats. Journal of toxicology and environmental health. Part A. 2002 Apr; 65(7):539-56. doi: 10.1080/15287390252807993. [PMID: 11939711]
  • S K Hong, D K Anestis, M A Valentovic, J G Ball, P I Brown, G O Rankin. Gender differences in the potentiation of N-(3,5-dichlorophenyl)succinimide metabolite nephrotoxicity by phenobarbital. Journal of toxicology and environmental health. Part A. 2001 Oct; 64(3):241-56. doi: 10.1080/15287390152543717. [PMID: 11594702]
  • S K Hong, D K Anestis, J G Ball, M A Valentovic, P I Brown, G O Rankin. Sodium sulfate potentiates N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in the Fischer 344 rat. Toxicology. 1999 Nov; 138(3):165-74. doi: 10.1016/s0300-483x(99)00102-x. [PMID: 10593507]
  • S K Hong, D K Anestis, M A Valentovic, J G Ball, P I Brown, R T Wang, G O Rankin. Gender differences in acute N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in Fischer 344 rats. Journal of toxicology and environmental health. Part A. 1998 Aug; 54(8):613-32. doi: 10.1080/009841098158647. [PMID: 9726783]
  • G O Rankin, H C Shih, S K Hong, D W Nicoll, D K Anestis, J G Ball, P I Brown, M A Valentovic. Role of chloride groups in the nephrotoxic potential of N-(3,5-dichlorophenyl)-2-hydroxysuccinimide, an oxidative metabolite of N-(3,5-dichlorophenyl)succinimide. Toxicology letters. 1995 Jun; 78(1):49-56. doi: 10.1016/0378-4274(94)03232-v. [PMID: 7604399]
  • K W Beers, D W Nicoll, D K Anestis, P I Brown, G O Rankin. Effect of microsomal enzyme modulators on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS)-induced nephrotoxicity in the Fischer 344 rat. Toxicology. 1993 Nov; 84(1-3):141-55. doi: 10.1016/0300-483x(93)90113-7. [PMID: 8266334]
  • K W Beers, G O Rankin. Effect of N-(3,5-dichlorophenyl)-2-hydroxysuccinimide on renal function and hemodynamics in the anesthetized rat. Toxicology. 1993 Apr; 79(2):139-48. doi: 10.1016/0300-483x(93)90127-e. [PMID: 8497867]
  • G O Rankin, V J Teets, D W Nicoll, P I Brown. Effect of buthionine sulfoximine on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid nephrotoxicity. Toxicology letters. 1991 Aug; 57(3):297-308. doi: 10.1016/0378-4274(91)90204-j. [PMID: 1882389]
  • G O Rankin, M A Valentovic, V J Teets, D W Nicoll, D K Anestis, P I Brown. Effect of autacoid modulation on N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity. Toxicology. 1991; 70(3):327-44. doi: 10.1016/0300-483x(91)90007-n. [PMID: 1771640]