5-(3-Methoxyphenyl)-3-(1-phenylethylamino)-1-[4-(trifluoromethyl)phenyl]pyrrolidin-2-one (BioDeep_00000185310)
human metabolite blood metabolite
代谢物信息卡片
化学式: C26H25F3N2O2 (454.1868)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CC(C1=CC=CC=C1)NC2CC(N(C2=O)C3=CC=C(C=C3)C(F)(F)F)C4=CC(=CC=C4)OC
InChI: InChI=1S/C26H25F3N2O2/c1-17(18-7-4-3-5-8-18)30-23-16-24(19-9-6-10-22(15-19)33-2)31(25(23)32)21-13-11-20(12-14-21)26(27,28)29/h3-15,17,23-24,30H,16H2,1-2H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Garth E Terry, Jussi Hirvonen, Jeih-San Liow, Nicholas Seneca, Johannes T Tauscher, John M Schaus, Lee Phebus, Christian C Felder, Cheryl L Morse, Victor W Pike, Christer Halldin, Robert B Innis. Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography.
European journal of nuclear medicine and molecular imaging.
2010 Aug; 37(8):1499-506. doi:
10.1007/s00259-010-1411-7. [PMID: 20333514] - Garth E Terry, Jussi Hirvonen, Jeih-San Liow, Sami S Zoghbi, Robert Gladding, Johannes T Tauscher, John M Schaus, Lee Phebus, Christian C Felder, Cheryl L Morse, Sean R Donohue, Victor W Pike, Christer Halldin, Robert B Innis. Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2010 Jan; 51(1):112-20. doi:
10.2967/jnumed.109.067074. [PMID: 20008988] - Garth E Terry, Jeih-San Liow, Sami S Zoghbi, Jussi Hirvonen, Amanda G Farris, Alicja Lerner, Johannes T Tauscher, John M Schaus, Lee Phebus, Christian C Felder, Cheryl L Morse, Jinsoo S Hong, Victor W Pike, Christer Halldin, Robert B Innis. Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand.
NeuroImage.
2009 Nov; 48(2):362-70. doi:
10.1016/j.neuroimage.2009.06.059. [PMID: 19573609] - Garth Terry, Jeih-San Liow, Eyassu Chernet, Sami S Zoghbi, Lee Phebus, Christian C Felder, Johannes Tauscher, John M Schaus, Victor W Pike, Christer Halldin, Robert B Innis. Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents.
NeuroImage.
2008 Jul; 41(3):690-8. doi:
10.1016/j.neuroimage.2008.03.004. [PMID: 18456516] - Fumihiko Yasuno, Amira K Brown, Sami S Zoghbi, Joseph H Krushinski, Eyassu Chernet, Johannes Tauscher, John M Schaus, Lee A Phebus, Amy K Chesterfield, Christian C Felder, Robert L Gladding, Jinsoo Hong, Christer Halldin, Victor W Pike, Robert B Innis. The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2008 Jan; 33(2):259-69. doi:
10.1038/sj.npp.1301402. [PMID: 17392732]
