Methsuximide (BioDeep_00000018127)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C12H13NO2 (203.0946)
中文名称: 甲琥胺
谱图信息:
最多检出来源 Homo sapiens(blood) 5.21%
分子结构信息
SMILES: CC1(CC(=O)N(C1=O)C)C2=CC=CC=C2
InChI: InChI=1S/C12H13NO2/c1-12(9-6-4-3-5-7-9)8-10(14)13(2)11(12)15/h3-7H,8H2,1-2H3
描述信息
Methsuximide is only found in individuals that have used or taken this drug. It is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin. [Wikipedia]Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AD - Succinimide derivatives
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
同义名列表
24 个代谢物同义名
alpha-Methyl-alpha-phenyl N-methyl succinimide; N-Methyl-alpha-methyl-alpha-phenylsuccinimide; (RS)-1,3-Dimethyl-3-phenyl-2,5-pyrrolidindion; 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione; 1,3-Dimethyl-3-phenyl-2,5-pyrrolidinedione; 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine; 1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dione; Warner-lambert brand OF methsuximide; Parke david brand OF methsuximide; N,2-Dimethyl-2-phenylsuccinimide; 1,3-Dimethyl-3-phenylsuccinimide; Pfizer brand OF methsuximide; Methsuximide, (+-)-isomer; Methsuximide, (+)-isomer; Methsuximide, (-)-isomer; alpha-Methylphensuximide; Metosuccimmide; METHSUXIMIDE; Metsuccimide; Methsuximid; Mesuximide; Petinutin; Mesuximid; Celontin
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:6846
- PubChem: 6476
- HMDB: HMDB0015611
- DrugBank: DB05246
- ChEMBL: CHEMBL697
- Wikipedia: Mesuximide
- chemspider: 6231
- CAS: 77-41-8
- PMhub: MS000002707
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Robert Hoepner, Theodor W May, Bernhard Rambeck, Helga Ottenottebrock, Rainer Valentin, Christian Brandt. Symptoms and course of intoxication with mesuximide--a case report.
Epilepsy & behavior : E&B.
2012 Sep; 25(1):129-30. doi:
10.1016/j.yebeh.2012.06.011. [PMID: 22818365] - F M Besag, D J Berry, M Vasey. Methsuximide reduces valproic acid serum levels.
Therapeutic drug monitoring.
2001 Dec; 23(6):694-7. doi:
10.1097/00007691-200112000-00017. [PMID: 11802106] - M Sigler, H M Strassburg, H E Boenigk. Effective and safe but forgotten: methsuximide in intractable epilepsies in childhood.
Seizure.
2001 Mar; 10(2):120-4. doi:
10.1053/seiz.2000.0467. [PMID: 11407955] - F M Besag, D J Berry, F Pool. Methsuximide lowers lamotrigine blood levels: A pharmacokinetic antiepileptic drug interaction.
Epilepsia.
2000 May; 41(5):624-7. doi:
10.1111/j.1528-1157.2000.tb00218.x. [PMID: 10802770] - N Wad, B Bourgeois, G Krämer. Serum protein binding of desmethyl-methsuximide.
Clinical neuropharmacology.
1999 Jul; 22(4):239-40. doi:
NULL. [PMID: 10442255] - T W May, B Rambeck, U Jürgens. Influence of oxcarbazepine and methsuximide on lamotrigine concentrations in epileptic patients with and without valproic acid comedication: results of a retrospective study.
Therapeutic drug monitoring.
1999 Apr; 21(2):175-81. doi:
10.1097/00007691-199904000-00007. [PMID: 10217337] - D Battino, M Estienne, G Avanzini. Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide.
Clinical pharmacokinetics.
1995 Oct; 29(4):257-86. doi:
10.2165/00003088-199529040-00005. [PMID: 8549027] - G O Rankin, V J Teets, D W Nicoll, P I Brown. Acute effects of the antiepileptic succinimides on the urinary tract and potentiation of phensuximide-induced urotoxicity by phenobarbital.
Journal of applied toxicology : JAT.
1990 Jun; 10(3):203-9. doi:
10.1002/jat.2550100311. [PMID: 2380483] - T R Browne, R G Feldman, R A Buchanan, N C Allen, L Fawcett-Vickers, G K Szabo, G F Mattson, S E Norman, D J Greenblatt. Methsuximide for complex partial seizures: efficacy, toxicity, clinical pharmacology, and drug interactions.
Neurology.
1983 Apr; 33(4):414-8. doi:
10.1212/wnl.33.4.414. [PMID: 6403891] - G K Szabo, T R Browne. Improved isocratic liquid-chromatographic simultaneous measurement of phenytoin, phenobarbital, primidone, carbamazepine, ethosuximide, and N-desmethylmethsuximide in serum.
Clinical chemistry.
1982 Jan; 28(1):100-4. doi:
. [PMID: 6895720] - B J Wilder, R A Buchanan. Methsuximide for refractory complex partial seizures.
Neurology.
1981 Jun; 31(6):741-4. doi:
10.1212/wnl.31.6.741. [PMID: 6894634] - M Riedmann, B Rambeck, J W Meijer. Quantitative simultaneous determination of eight common antiepileptic drugs and metabolites by liquid chromatography.
Therapeutic drug monitoring.
1981; 3(4):397-413. doi:
10.1097/00007691-198104000-00010. [PMID: 6895956] - R Varma. Therapeutic monitoring of anticonvulsant drugs in psychiatric patients: rapid, simultaneous gas-chromatographic determination of six commonly used anticonvulsants without interference from other drugs.
Biochemistry and experimental biology.
1978; 14(4):311-8. doi:
. [PMID: 583395] - B Fleischer. Localization of some glycolipid glycosylating enzymes in the Golgi apparatus of rat kidney.
Journal of supramolecular structure.
1977; 7(1):79-89. doi:
10.1002/jss.400070108. [PMID: 24139] - J G MILLICHAP, J D JONES. ACID-BASE, ELECTROLYTE, AND AMINO-ACID METABOLISM IN CHILDREN WITH PETIT MAL. ETIOLOGIC SIGNIFICANCE AND MODIFICATION BY ANTICONVULSANT DRUGS AND THE KETOGENIC DIET.
Epilepsia.
1964 Sep; 5(?):239-55. doi:
10.1111/j.1528-1157.1964.tb03331.x. [PMID: 14232248]
