Rolipram (BioDeep_00000183006)
human metabolite blood metabolite
代谢物信息卡片
3-[3-(cyclopentyloxy)-4-methoxyphenyl]-3,4-dihydro-2H-pyrrol-5-ol
化学式: C16H21NO3 (275.1521)
中文名称: 咯利普兰
谱图信息:
最多检出来源 Homo sapiens(blood) 25.73%
分子结构信息
SMILES: COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
InChI: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
描述信息
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058988 - Phosphodiesterase 4 Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:104872
- PubChem: 5092
- HMDB: HMDB0257294
- DrugBank: DB01954
- ChEMBL: CHEMBL63
- Wikipedia: Rolipram
- MeSH: Rolipram
- chemspider: 4913
- CAS: 85416-74-6
- CAS: 61413-54-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Leila Gobejishvili, Walter E Rodriguez, Philip Bauer, Yali Wang, Chirag Soni, Todd Lydic, Shirish Barve, Craig McClain, Claudio Maldonado. Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis.
Drug design, development and therapy.
2022; 16(?):1301-1309. doi:
10.2147/dddt.s355796. [PMID: 35535222] - Divjot Virk, Amit Kumar, Amteshwar Singh Jaggi, Nirmal Singh. Ameliorative role of rolipram, PDE-4 inhibitor, against sodium arsenite-induced vascular dementia in rats.
Environmental science and pollution research international.
2021 Nov; 28(44):63250-63262. doi:
10.1007/s11356-021-15189-3. [PMID: 34226994] - Likang Wu, Lei Xu, Yu Chen, Guohua Xu, Qunfeng Guo, Depeng Meng, Jianping Fan, Guoqiang Song, Peng Xu. Rolipram plays an anti-fibrotic effect in ligamentum flavum fibroblasts by inhibiting the activation of ERK1/2.
BMC musculoskeletal disorders.
2021 Sep; 22(1):818. doi:
10.1186/s12891-021-04712-9. [PMID: 34556093] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Zafer Sahin, Sevde Nur Biltekin, Leyla Yurttas, Barkin Berk, Yağmur Özhan, Hande Sipahi, Zhan-Guo Gao, Kenneth A Jacobson, Şeref Demirayak. Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition.
European journal of medicinal chemistry.
2021 Feb; 212(?):113125. doi:
10.1016/j.ejmech.2020.113125. [PMID: 33422981] - Chia-Chih Liao, Huang-Ping Yu, Shih-Chun Yang, Ahmed Alalaiwe, You-Shan Dai, Fu-Chao Liu, Jia-You Fang. Multifunctional lipid-based nanocarriers with antibacterial and anti-inflammatory activities for treating MRSA bacteremia in mice.
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2021 Feb; 19(1):48. doi:
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PloS one.
2021; 16(6):e0253269. doi:
10.1371/journal.pone.0253269. [PMID: 34138962] - Lirlândia P Sousa, Vanessa Pinho, Mauro M Teixeira. Harnessing inflammation resolving-based therapeutic agents to treat pulmonary viral infections: What can the future offer to COVID-19?.
British journal of pharmacology.
2020 09; 177(17):3898-3904. doi:
10.1111/bph.15164. [PMID: 32557557] - Xiaying Lu, Juan Wang, Xiaohuan Chen, Yong Jiang, Zhixing K Pan. Rolipram Protects Mice from Gram-negative Bacterium Escherichia coli-induced Inflammation and Septic Shock.
Scientific reports.
2020 01; 10(1):175. doi:
10.1038/s41598-019-56899-6. [PMID: 31932743] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Maarten Ooms, Tetsuya Tsujikawa, Talakad G Lohith, Sanché N Mabins, Sami S Zoghbi, Akiko Sumitomo, Hanna Jaaro-Peled, Yasuyuki Kimura, Sanjay Telu, Victor W Pike, Toshifumi Tomoda, Robert B Innis, Akira Sawa, Masahiro Fujita. [11C](R)-Rolipram positron emission tomography detects DISC1 inhibition of phosphodiesterase type 4 in live Disc1 locus-impaired mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2019 07; 39(7):1306-1313. doi:
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2018 11; 38(11):2033-2040. doi:
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Innate immunity.
2018 11; 24(8):501-512. doi:
10.1177/1753425918809155. [PMID: 30409089] - Zhuoran Wang, Yaru Liang, Lu Zhang, Nannan Zhang, Qingfei Liu, Zhao Wang. Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder.
Aging.
2018 09; 10(9):2394-2406. doi:
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Molecular imaging and biology.
2018 08; 20(4):615-622. doi:
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European journal of medicinal chemistry.
2018 Jan; 144(?):758-766. doi:
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General physiology and biophysics.
2018 Jan; 37(1):1-12. doi:
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Life sciences.
2017 Mar; 173(?):11-19. doi:
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Medicinal chemistry (Shariqah (United Arab Emirates)).
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Oncotarget.
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2016 08; 13(1):197. doi:
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Toxicology and applied pharmacology.
2016 May; 298(?):9-18. doi:
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Phytotherapy research : PTR.
2016 Jan; 30(1):144-51. doi:
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Brain research.
2015 Oct; 1622(?):279-91. doi:
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American journal of physiology. Cell physiology.
2015 Sep; 309(6):C415-24. doi:
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Journal of veterinary pharmacology and therapeutics.
2015 Jun; 38(3):290-6. doi:
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2015 Jan; 746(?):138-47. doi:
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Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2014 Jul; 89(5):388-92. doi:
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Shock (Augusta, Ga.).
2014 Jun; 41(6):537-45. doi:
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Journal of natural products.
2014 Apr; 77(4):955-62. doi:
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PloS one.
2014; 9(1):e87239. doi:
10.1371/journal.pone.0087239. [PMID: 24466344] - Joseph H Holthoff, Zhen Wang, Naeem K Patil, Neriman Gokden, Philip R Mayeux. Rolipram improves renal perfusion and function during sepsis in the mouse.
The Journal of pharmacology and experimental therapeutics.
2013 Nov; 347(2):357-64. doi:
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Thyroid : official journal of the American Thyroid Association.
2013 Nov; 23(11):1484-9. doi:
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Rapid communications in mass spectrometry : RCM.
2013 May; 27(9):993-1004. doi:
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Urology.
2012 Dec; 80(6):1390.e1-6. doi:
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Toxicology and applied pharmacology.
2012 Sep; 263(2):251-8. doi:
10.1016/j.taap.2012.06.017. [PMID: 22763362] - Yueh-Chen Lin, Roger H Adamson, Joyce F Clark, Rolf K Reed, Fitz-Roy E Curry. Phosphodiesterase 4 inhibition attenuates plasma volume loss and transvascular exchange in volume-expanded mice.
The Journal of physiology.
2012 Jan; 590(2):309-22. doi:
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Journal of biomedical science.
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Free radical biology & medicine.
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Immunopharmacology and immunotoxicology.
2011 Mar; 33(1):55-63. doi:
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NeuroImage.
2011 Feb; 54(3):1903-9. doi:
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The Journal of physiology.
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Clinical hemorheology and microcirculation.
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The Biochemical journal.
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Microbial pathogenesis.
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Journal of ethnopharmacology.
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Fundamental & clinical pharmacology.
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Journal of immunology (Baltimore, Md. : 1950).
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British journal of pharmacology.
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Antimicrobial agents and chemotherapy.
2009 Jan; 53(1):216-22. doi:
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Neurobiology of learning and memory.
2008 Oct; 90(3):569-75. doi:
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Urology.
2008 Oct; 72(4):743-8. doi:
10.1016/j.urology.2008.04.013. [PMID: 18554698] - Miran Kenk, Michael Greene, Mireille Lortie, Robert A Dekemp, Rob S Beanlands, Jean N Dasilva. Use of a column-switching high-performance liquid chromatography method to assess the presence of specific binding of (R)- and (S)-[(11)C]rolipram and their labeled metabolites to the phosphodiesterase-4 enzyme in rat plasma and tissues.
Nuclear medicine and biology.
2008 May; 35(4):515-21. doi:
10.1016/j.nucmedbio.2008.01.004. [PMID: 18482689] - Wenkuan Xin, Tuan M Tran, Wito Richter, Richard B Clark, Thomas C Rich. Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling.
The Journal of general physiology.
2008 Apr; 131(4):349-64. doi:
10.1085/jgp.200709881. [PMID: 18347080] - Songwei Wu, Hairu Chen, Mikhail F Alexeyev, Judy A C King, Timothy M Moore, Troy Stevens, Ronald D Balczon. Microtubule motors regulate ISOC activation necessary to increase endothelial cell permeability.
The Journal of biological chemistry.
2007 Nov; 282(48):34801-8. doi:
10.1074/jbc.m704522200. [PMID: 17921144] - P Kalk, B Eggert, K Relle, M Godes, S Heiden, Y Sharkovska, Y Fischer, D Ziegler, G-W Bielenberg, B Hocher. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure.
British journal of pharmacology.
2007 Aug; 151(7):1025-32. doi:
10.1038/sj.bjp.0707319. [PMID: 17558436] - K Rutten, C Lieben, L Smits, A Blokland. The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat.
Psychopharmacology.
2007 Jun; 192(2):275-82. doi:
10.1007/s00213-006-0697-4. [PMID: 17265077] - David G McEwan, Valerie G Brunton, George S Baillie, Nicholas R Leslie, Miles D Houslay, Margaret C Frame. Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase.
Cancer research.
2007 Jun; 67(11):5248-57. doi:
10.1158/0008-5472.can-07-0097. [PMID: 17545604] - N Bonnet, P Bernard, H Beaupied, J C Bizot, F Trovero, D Courteix, C L Benhamou. Various effects of antidepressant drugs on bone microarchitectecture, mechanical properties and bone remodeling.
Toxicology and applied pharmacology.
2007 May; 221(1):111-8. doi:
10.1016/j.taap.2007.02.005. [PMID: 17383703] - S Erdogan, S Celik, O Aslantas, T Kontas, S Ocak. Elevated cAMP levels reverse Brucella melitensis-induced lipid peroxidation and stimulate IL-10 transcription in rats.
Research in veterinary science.
2007 Apr; 82(2):181-6. doi:
10.1016/j.rvsc.2006.07.008. [PMID: 17014875] - Allen J Duplantier, Elizabeth L Bachert, John B Cheng, Victoria L Cohan, Teresa H Jenkinson, Kenneth G Kraus, Michael W McKechney, Joann D Pillar, John W Watson. SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase.
Journal of medicinal chemistry.
2007 Jan; 50(2):344-9. doi:
10.1021/jm060904g. [PMID: 17228876] - Thomas C Rich, Wenkuan Xin, Celine Mehats, Kathryn A Hassell, Leslie A Piggott, Xuan Le, Jeffrey W Karpen, Marco Conti. Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells.
American journal of physiology. Cell physiology.
2007 Jan; 292(1):C319-31. doi:
10.1152/ajpcell.00121.2006. [PMID: 16899551] - Eduard Stefan, Burkhard Wiesner, George S Baillie, Rustam Mollajew, Volker Henn, Dorothea Lorenz, Jens Furkert, Katja Santamaria, Pavel Nedvetsky, Christian Hundsrucker, Michael Beyermann, Eberhard Krause, Peter Pohl, Irene Gall, Andrew N MacIntyre, Sebastian Bachmann, Miles D Houslay, Walter Rosenthal, Enno Klussmann. Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.
Journal of the American Society of Nephrology : JASN.
2007 Jan; 18(1):199-212. doi:
10.1681/asn.2006020132. [PMID: 17135396] - Kouya Yamaki, Xiaojuan Li, Md Aslam Hossain, A H M Khurshid Alam, Shinji Taneda, Rie Yanagisawa, Hirohisa Takano, Shin Yoshino. Difference in preventive effects between the phosphodiesterase iv inhibitor rolipram and anti-arthritic drugs on antigen-induced arthritis in mice.
Immunological investigations.
2007; 36(2):131-45. doi:
10.1080/08820130600746008. [PMID: 17365015] - C S Moore, N Earl, R Frenette, A Styhler, J A Mancini, D W Nicholson, A L O Hebb, T Owens, G S Robertson. Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis.
The Journal of pharmacology and experimental therapeutics.
2006 Oct; 319(1):63-72. doi:
10.1124/jpet.106.106096. [PMID: 16809479] - Eisei Sohara, Tatemitsu Rai, Sung-Sen Yang, Keiko Uchida, Kosaku Nitta, Shigeru Horita, Mayuko Ohno, Akihiro Harada, Sei Sasaki, Shinichi Uchida. Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation.
Proceedings of the National Academy of Sciences of the United States of America.
2006 Sep; 103(38):14217-22. doi:
10.1073/pnas.0602331103. [PMID: 16968783] - Carey L Medin, Alan L Rothman. Cell type-specific mechanisms of interleukin-8 induction by dengue virus and differential response to drug treatment.
The Journal of infectious diseases.
2006 Apr; 193(8):1070-7. doi:
10.1086/502630. [PMID: 16544247] - Jingfei Cheng, Michael A Thompson, Henry J Walker, Catherine E Gray, Gina M Warner, Wei Zhou, Joseph P Grande. Lixazinone stimulates mitogenesis of Madin-Darby canine kidney cells.
Experimental biology and medicine (Maywood, N.J.).
2006 Mar; 231(3):288-95. doi:
10.1177/153537020623100308. [PMID: 16514175] - Xiang Li, Elaine Huston, Martin J Lynch, Miles D Houslay, George S Baillie. Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.
The Biochemical journal.
2006 Mar; 394(Pt 2):427-35. doi:
10.1042/bj20051560. [PMID: 16356165] - Daisuke Harada, Yukihito Tsukumo, Yuko Takashima, Haruhiko Manabe. Effect of orally administered rolipram, a phosphodiesterase 4 inhibitor, on a mouse model of the dermatitis caused by 2,4,6-trinitro-1-chlorobenzene (TNCB)-repeated application.
European journal of pharmacology.
2006 Feb; 532(1-2):128-37. doi:
10.1016/j.ejphar.2005.12.005. [PMID: 16442096] - Shoji Nishiyama, Masahiko Okudaira, Noboru Saito. Mechanisms of rolipram-induced increase in the incidence of mammary adenocarcinoma: histopathological study of a 104-week oral carcinogenicity study in female Sprague-Dawley rats.
Archives of toxicology.
2006 Feb; 80(2):88-97. doi:
10.1007/s00204-005-0016-6. [PMID: 16167140] - Su-Jane Wang. An investigation into the effect of the type IV phosphodiesterase inhibitor rolipram in the modulation of glutamate release from rat prefrontocortical nerve terminals.
Synapse (New York, N.Y.).
2006 Jan; 59(1):41-50. doi:
10.1002/syn.20212. [PMID: 16247764] - Masaki Hamamoto, Michiharu Suga, Yuzo Takahashi, Yukio Sato, Shuji Inamori, Toshikatsu Yagihara, Takeshi Nakatani, Soichiro Kitamura. Suppressive effect of phosphodiesterase type 4 inhibition on systemic inflammatory responses after cardiopulmonary bypass.
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs.
2006; 9(3):144-8. doi:
10.1007/s10047-006-0335-2. [PMID: 16998698] - Zheng Huang, Joseph A Mancini. Phosphodiesterase 4 inhibitors for the treatment of asthma and COPD.
Current medicinal chemistry.
2006; 13(27):3253-62. doi:
10.2174/092986706778773040. [PMID: 17168849] - Mina Ahloulay, Lise Bankir, Claire Lugnier, Alain Le Bec, Odile Poirel, Richard Moreau, Didier Lebrec. Cyclic AMP-phosphodiesterases inhibitor improves sodium excretion in rats with cirrhosis and ascites.
Liver international : official journal of the International Association for the Study of the Liver.
2005 Apr; 25(2):403-9. doi:
10.1111/j.1478-3231.2005.01034.x. [PMID: 15780066] - Anthony P Barnes, Gabriel Livera, Pingbo Huang, Chuanwen Sun, Wanda K O'Neal, Marco Conti, M Jackson Stutts, Sharon L Milgram. Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium.
The Journal of biological chemistry.
2005 Mar; 280(9):7997-8003. doi:
10.1074/jbc.m407521200. [PMID: 15611099] - Tamotsu Matsuhashi, Michiro Otaka, Masaru Odashima, Mario Jin, Koga Komatsu, Noriaki Konishi, Isao Wada, Toshihiro Sato, Youhei Horikawa, Reina Ohba, Jinko Oyake, Natsumi Hatakeyama, Sumio Watanabe. Specific type IV phosphodiesterase inhibitor ameliorates thioacetamide-induced liver injury in rats.
Journal of gastroenterology and hepatology.
2005 Jan; 20(1):135-40. doi:
10.1111/j.1440-1746.2004.03512.x. [PMID: 15610458] - Bärbel Lange-Sperandio, Michael S Forbes, Barbara Thornhill, Mark D Okusa, Joel Linden, Robert L Chevalier. A2A adenosine receptor agonist and PDE4 inhibition delays inflammation but fails to reduce injury in experimental obstructive nephropathy.
Nephron. Experimental nephrology.
2005; 100(3):e113-23. doi:
10.1159/000085057. [PMID: 15824514] - Akiko Okayama, Keiichi Mikasa, Norio Matsui, Nobutaka Higashi, Mamiko Miyamoto, Eiji Kita. An interventional approach to block brain damage caused by Shiga toxin-producing Escherichia coli infection, by use of a combination of phosphodiesterase inhibitors.
The Journal of infectious diseases.
2004 Dec; 190(12):2129-36. doi:
10.1086/425982. [PMID: 15551211] - Juan M Alarcón, Gaël Malleret, Khalid Touzani, Svetlana Vronskaya, Shunsuke Ishii, Eric R Kandel, Angel Barco. Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.
Neuron.
2004 Jun; 42(6):947-59. doi:
10.1016/j.neuron.2004.05.021. [PMID: 15207239] - Antonio Maurizio Vignola. PDE4 inhibitors in COPD--a more selective approach to treatment.
Respiratory medicine.
2004 Jun; 98(6):495-503. doi:
10.1016/j.rmed.2003.12.012. [PMID: 15191033] - Hoda E Mohamed, Mervat E Asker, Sousou I Ali, Tamer M Abd el-Fattah. Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4.
The Journal of pharmacy and pharmacology.
2004 Jun; 56(6):757-68. doi:
10.1211/0022357023565. [PMID: 15231041] - Raymond Quigley, Sumana Chakravarty, Michel Baum. Antidiuretic hormone resistance in the neonatal cortical collecting tubule is mediated in part by elevated phosphodiesterase activity.
American journal of physiology. Renal physiology.
2004 Feb; 286(2):F317-22. doi:
10.1152/ajprenal.00122.2003. [PMID: 14644747] - Jost Leemhuis, Stephanie Boutillier, Holger Barth, Thomas J Feuerstein, Carsten Brock, Bernd Nürnberg, Klaus Aktories, Dieter K Meyer. Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites.
The Journal of biological chemistry.
2004 Jan; 279(1):585-96. doi:
10.1074/jbc.m307066200. [PMID: 14578357] - Tetsuji Itoh, Kohji Abe, Miwa Tokumura, Masahito Horiuchi, Osamu Inoue, Nobuhiro Ibii. Different regulation of adenylyl cyclase and rolipram-sensitive phosphodiesterase activity on the frontal cortex and hippocampus in learned helplessness rats.
Brain research.
2003 Nov; 991(1-2):142-9. doi:
10.1016/j.brainres.2003.08.007. [PMID: 14575886] - Rossana Estellés, Javier López-Martín, Lara Milian, José-Enrique O'Connor, Magdalena Martínez-Losa, Miguel Cerdá-Nicolás, Edet M Anam, María Dolores Ivorra, Andrew C Issekutz, Julio Cortijo, Esteban J Morcillo, Maria Amparo Blázquez, Maria-Jesús Sanz. Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo.
British journal of pharmacology.
2003 Nov; 140(6):1057-67. doi:
10.1038/sj.bjp.0705525. [PMID: 14559857] - Bryan R Cobb, Lijuan Fan, Timea E Kovacs, Eric J Sorscher, John P Clancy. Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells.
American journal of respiratory cell and molecular biology.
2003 Sep; 29(3 Pt 1):410-8. doi:
10.1165/rcmb.2002-0247oc. [PMID: 12714375] - Koh-hei Masumoto, Atsuko Fujioka, Ken-ichi Nakahama, Shin-Ichi T Inouye, Yasufumi Shigeyoshi. Effect of phosphodiesterase type 4 on circadian clock gene Per1 transcription.
Biochemical and biophysical research communications.
2003 Jul; 306(3):781-5. doi:
10.1016/s0006-291x(03)01048-9. [PMID: 12810087] - George S Baillie, Arvind Sood, Ian McPhee, Irene Gall, Stephen J Perry, Robert J Lefkowitz, Miles D Houslay. beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
Proceedings of the National Academy of Sciences of the United States of America.
2003 Feb; 100(3):940-5. doi:
10.1073/pnas.262787199. [PMID: 12552097] - Donna D Gale, Peter Hofer, Domenico Spina, Esther A Seeds, Katherine H Banner, Selina Harrison, Gary Douglas, Tatsui Matsumoto, Clive P Page, Richard H Wong, Stephan Jordan, Forrest Smith, Nandini Banik, Perry V Halushka, David Cavalla, Yakov Rotshteyn, Donald J Kyle, Ronald M Burch, Mark Chasin. Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294.
Pulmonary pharmacology & therapeutics.
2003; 16(2):97-104. doi:
10.1016/s1094-5539(02)00175-x. [PMID: 12670778] - Taku Murata, Toshifumi Sugatani, Kasumi Shimizu, Vincent C Manganiello, Toshiro Tagawa. Effect of the phosphodiesterase 4 inhibitor, rolipram, on retinoic acid-increased alkaline phosphatase activity in the mouse fibroblastic C3H10T1/2 cell line.
Archives of oral biology.
2003 Jan; 48(1):63-7. doi:
10.1016/s0003-9969(02)00166-8. [PMID: 12615143] - Weidong Wang, Chunling Li, Tae-Hwan Kwon, Mark A Knepper, Jørgen Frøkiaer, Søren Nielsen. AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors.
American journal of physiology. Renal physiology.
2002 Dec; 283(6):F1313-25. doi:
10.1152/ajprenal.00040.2002. [PMID: 12388409]
