Nicotinuric acid (BioDeep_00000001394)

 

Secondary id: BioDeep_00000405551

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Volatile Flavor Compounds


代谢物信息卡片


2-[(pyridin-3-yl)formamido]acetic acid

化学式: C8H8N2O3 (180.0534898)
中文名称: N-烟酰甘氨酸, 酰基甘氨酸, 烟酰甘氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.44%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Nicotinuric acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/nicotinuric_acid (retrieved 2024-11-22) (BioDeep RN: BioDeep_00000001394). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CC(=CN=C1)C(=O)NCC(=O)O
InChI: InChI=1S/C8H8N2O3/c11-7(12)5-10-8(13)6-2-1-3-9-4-6/h1-4H,5H2,(H,10,13)(H,11,12)

描述信息

Nicotinuric acid is an acylglycine. Acylglycines are normally minor metabolites of fatty acids. However, the excretion of certain acylglycines is increased in several inborn errors of metabolism. In certain cases, the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acylglycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction acyl-CoA + glycine <-> CoA + N-acylglycine. Nicotinuric acid is the major detoxification product of nicotinic acid. It may serve as a simple quantitative index of hepatic biotransformation of nicotinic acid (PMID:3243933).
Nicotinuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:
Nicotinuric acid is an acyl glycine. Nicotinuric acid is a metabolite of nicotinic acid.

同义名列表

20 个代谢物同义名

2-[(pyridin-3-yl)formamido]acetic acid; N-(3-Pyridinylcarbonyl)-(9ci)-glycine; Nicotinuric acid, monosodium salt; N-(3-Pyridinylcarbonyl)-glycine; N-(Pyridin-3-ylcarbonyl)glycine; N-Nicotinoyl-(8ci)-glycine; N-nicotinoyl-Glycine; N-Nicotinuric acid; Nicotinoyl-glycine; N-Nicotinylglycine; Nicotinoylglycine; Nicotinuric acid; Nicotinylglycine; Nicotinic acid; N-Nicotinurate; Nicotinurate; nicotinate; Nicotinuric acid; Nicotinurate; Nicotinuric acid



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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  • Chun-Feng Huang, Mei-Ling Cheng, Chun-Ming Fan, Chuang-Ye Hong, Ming-Shi Shiao. Nicotinuric acid: a potential marker of metabolic syndrome through a metabolomics-based approach. Diabetes care. 2013 Jun; 36(6):1729-31. doi: 10.2337/dc12-1067. [PMID: 23275373]
  • Alastair B Ross, Emma Pere-Trépat, Ivan Montoliu, Francois-Pierre J Martin, Sebastiano Collino, Sofia Moco, Jean-Philippe Godin, Marilyn Cléroux, Philippe A Guy, Isabelle Breton, Rodrigo Bibiloni, Anita Thorimbert, Isabelle Tavazzi, Lionel Tornier, Aude Bebuis, Stephen J Bruce, Maurice Beaumont, Laurent-Bernard Fay, Sunil Kochhar. A whole-grain-rich diet reduces urinary excretion of markers of protein catabolism and gut microbiota metabolism in healthy men after one week. The Journal of nutrition. 2013 Jun; 143(6):766-73. doi: 10.3945/jn.112.172197. [PMID: 23616503]
  • Man Liu, Dan Zhang, Xiaolin Wang, Lina Zhang, Jing Han, Man Yang, Xue Xiao, Yanan Zhang, Huichen Liu. Simultaneous quantification of niacin and its three main metabolites in human plasma by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Sep; 904(?):107-14. doi: 10.1016/j.jchromb.2012.07.030. [PMID: 22884475]
  • Yang Sun, Zeqin Lian, Chunying Jiang, Yinghong Wang, Haibo Zhu. Beneficial metabolic effects of 2',3',5'-tri-acetyl-N6- (3-hydroxylaniline) adenosine in the liver and plasma of hyperlipidemic hamsters. PloS one. 2012; 7(3):e32115. doi: 10.1371/journal.pone.0032115. [PMID: 22470419]
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  • Teddy Kosoglou, Yali Zhu, Paul Statkevich, Ilias Triantafyllou, William Taggart, Fengjuan Xuan, Kenneth T Kim, David L Cutler. Assessment of potential pharmacokinetic interactions of ezetimibe/simvastatin and extended-release niacin tablets in healthy subjects. European journal of clinical pharmacology. 2011 May; 67(5):483-92. doi: 10.1007/s00228-010-0955-6. [PMID: 21120461]
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  • Ines Reiche, Sabine Westphal, Jens Martens-Lobenhoffer, Uwe Tröger, Claus Luley, Stefanie M Bode-Böger. Pharmacokinetics and dose recommendations of Niaspan® in chronic kidney disease and dialysis patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2011 Jan; 26(1):276-82. doi: 10.1093/ndt/gfq344. [PMID: 20562093]
  • Lei Wang, Yong-ping Qin, Xiao-li Gong, Feng Nan, Jin Xiang, Qin Yu, Mao-zhi Liang. [Determination of nicacid and its metabolites in human plasma by HPLC-MS/MS]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2010 Nov; 41(6):1051-4. doi: . [PMID: 21265114]
  • Jaswanth Kumar Inamadugu, Rajasekhar Damaramadugu, Ramesh Mullangi, Venkateswarlu Ponneri. Simultaneous determination of niacin and its metabolites--nicotinamide, nicotinuric acid and N-methyl-2-pyridone-5-carboxamide--in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. Biomedical chromatography : BMC. 2010 Oct; 24(10):1059-74. doi: 10.1002/bmc.1406. [PMID: 20853461]
  • Devita Surjana, Gary M Halliday, Diona L Damian. Role of nicotinamide in DNA damage, mutagenesis, and DNA repair. Journal of nucleic acids. 2010 Jul; 2010(?):. doi: 10.4061/2010/157591. [PMID: 20725615]
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  • Tsutomu Fukuwatari, Hideko Wada, Ryuzo Sasaki, Katsumi Shibata. Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats. Bioscience, biotechnology, and biochemistry. 2004 Jan; 68(1):44-50. doi: 10.1271/bbb.68.44. [PMID: 14745162]
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