27-Hydroxycholesterol (BioDeep_00000014448)

 

Secondary id: BioDeep_00000010789, BioDeep_00000636693

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(1S,2R,5S,10S,11S,14R,15R)-14-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol

化学式: C27H46O2 (402.3498)
中文名称: 27-羟基胆固醇, 胆固醇-(25R)-5-烯-3β,27-二醇
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 30.14%

Reviewed

Last reviewed on 2024-09-29.

Cite this Page

27-Hydroxycholesterol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/27-hydroxycholesterol (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000014448). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@]([H])([C@]([H])(C)CCC[C@@H](C)CO)CC[C@@]4([H])[C@]3([H])CC=C2C[C@@H](O)C1
InChI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

描述信息

27-Hydroxycholesterol (27-HC), also known as (25R)-cholest-5-ene-3β,26-diol or by its conventional name 26-hydroxycholesterol, is an oxygenated derivative of cholesterol and a major oxysterol in circulation (PMID: 7749852). 27-Hydroxycholesterol is the product of the enzyme sterol 27-hydroxylase. The enzyme is critical for the degradation of the steroid side-chain and a genetic deficiency of the enzyme leads to reduced formation of bile acids in humans. There is a correlation between 27-hydroxycholesterol and cholesterol in the circulation, and females have lower levels of 27-hydroxycholesterol than males. A strong correlation is observed between circulating levels of 27-hydroxycholesterol and cholesterol, in both healthy subjects and subjects with hypercholesterolemia and documented atherosclerosis. 27-Hydroxycholesterol is metabolized by an oxysterol 7alpha-hydroxylase in the liver. Changes in the activity of this enzyme may lead to the accumulation of 27-hydroxycholesterol in the circulation. It has been reported that patients with a genetic deficiency of oxysterol 7alpha-hydroxylase in the liver had markedly increased levels of 27-hydroxycholesterol in the circulation. However, under normal conditions and in the absence of liver or kidney disease, changes in the levels of 27-hydroxycholesterol in the circulation are likely to be caused by changes in the rate of synthesis of these steroids rather than by the rate of metabolism. There are three possible explanations for the high concentrations of 27-hydroxycholesterol found in the circulation of three subjects with atherosclerosis: (1) increased expression of sterol 27-hydroxylase owing to a genetic factor or some other factor completely unrelated to atherosclerosis, (2) the extrahepatic sterol 27-hydroxylase may be up-regulated by circulating factors (e.g. cytokines) that are directly or indirectly related to the development of atherosclerosis, and (3) the high amounts of cholesterol accumulating in macrophages in some patients with atherosclerosis may result in an increased flux of 27-hydroxycholesterol from the macrophages to the circulation. Since there is a close relation between levels of cholesterol and 27-hydroxycholesterol in the circulation, the possibility must be considered that the flux of 27-hydroxycholesterol into the brain may be part of the yet unexplained link between hypercholesterolemia and Alzheimers disease. 27-Hydroxysterol is the most dominant oxysterol in human atheromas where it may reflect a mechanism for eliminating excessive cholesterol, and thus have a protective role. Hypercholesterolemia and chronic low-grade immunological activation are pivotal in the development of atherosclerosis. However, the interconnections between these two factors are not well known. The CD40 system, as measured by the plasma level of soluble CD40 (sCD40), is associated with cholesterol metabolism in hypercholesterolemic patients. When combined, a decreased cholesterol synthesis rate and increased levels of 27-hydroxycholesterol may be a consequence of high levels of cellular cholesterol, and therefore be related to sCD40. However, sCD40 had no significant correlation with total plasma cholesterol. This suggests that the cellular cholesterol synthesis rate and 27-hydroxycholesterol production are more importantly linked with the plasma levels of sCD40 than total cholesterol (PMID: 16081359, 17012138, 11504730, 9144161).
27-hydroxycholesterol is an oxygenated derivative of cholesterol and a major oxysterol in circulation. 27-hydroxycholesterol is the product of the enzyme sterol 27-hydroxylase. The enzyme is critical for degradation of the steroid side-chain and a genetic deficiency of the enzyme leads to reduced formation of bile acids in humans. There is a correlation between 27-hydroxycholesterol and cholesterol in the circulation, and females have lower levels of 27-hydroxycholesterol than males. A strong correlation is observed between circulating levels of 27-hydroxycholesterol and cholesterol, in both healthy subjects and subjects with hypercholesterolemia and documented atherosclerosis. 27-hydroxycholesterol is metabolized by an oxysterol 7a-hydroxylase in the liver, and changes in the activity of this enzyme may lead to accumulation of 27-hydroxycholesterol in the circulation. It has been reported that patients with a genetic deficiency of oxysterol 7a-hydroxylase in the liver had markedly increased levels of 27-hydroxycholesterol in the circulation. Under normal conditions, however, and in the absence of liver or kidney disease, changes in the levels of 27-hydroxycholesterol in the circulation are likely to be caused by changes in the rate of synthesis of these steroids rather than by the rate of metabolism. Three possible explanations for the high concentrations of 27-hydroxycholesterol found in the circulation of the three subjects with atherosclerosis could be: 1) Increased expression of sterol 27-hydroxylase owing to a genetic factor or some other factor completely unrelated to atherosclerosis. 2) The extrahepatic sterol 27-hydroxylase may be up-regulated by circulating factors (e.g. cytokines) that are directly or indirectly related to the development of atherosclerosis. 3) The high amounts of cholesterol accumulating in macrophages in some patients with atherosclerosis may result in increased flux of 27-hydroxycholesterol from the macrophages to the circulation.
(25R)-cholest-5-ene-3beta,26-diol is a 26-hydroxycholesterol in which the 25-position has R-configuration. It has a role as an apoptosis inducer, a neuroprotective agent, a human metabolite and a mouse metabolite. It is functionally related to a cholesterol.
27-Hydroxycholesterol is an endogenous metabolite of cholesterol produced by the hydroxylation of the carbon at position 27 by the enzyme sterol 26-hydroxylase, mitochondrial (CYP27A1). Some neoplasms produce excess of 27-hydroxycholesterol (27HC) or inhibit its catabolism, and high cholesterol levels are correlated with elevated levels of 27HC; under these conditions, 27HC may have deleterious selective estrogen receptor modulator (SERM) and liver X receptor (LXR) agonistic activities. As a SERM, 27HC binds to and prevents the activation of estrogen receptors (ERs) in the vasculature. This prevents ER-mediated vasodilation and abrogates the cardiovascular protective effects of estrogen. However, 27HC binds to and activates ERs and LXRs in breast tissue, which stimulates ER-dependent breast cancer cell growth and metastasis.
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.
27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor.

同义名列表

59 个代谢物同义名

(3S,8S,9S,10R,13R,14S,17R)-17-((2R,6R)-7-Hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol; (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; (3S,8S,9S,10R,13R,14S,17R)-17-[(1R,5R)-6-hydroxy-1,5-dimethyl-hexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; (1S,2R,5S,10S,11S,14R,15R)-14-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol; (1S,2R,5S,10S,11S,14R,15R)-14-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadec-7-en-5-ol; CHOLEST-5-ENE-3,26-DIOL, (3.BETA.,25R)-; (3.BETA.,25R)-CHOLEST-5-ENE-3,26-DIOL; cholest-5-ene-3,26-diol, (3beta,25R)-; CHOLEST-5-ENE-3.BETA.,26-DIOL, (25R)-; Cholest-5-ene-3,26,diol, (3beta,25R)-; cholest-5-ene-3 beta,26-diol, (25R)-; (3 beta,25R)-cholest-5-ene-3,26-diol; Cholest-5-ene-3beta,26-diol, (25R)-; (3beta,25R)-cholest-5-ene-3,26-diol; (3beta,25R)-Cholest-5-ene-3,26,diol; (25R)-CHOLEST-5-ENE-3.BETA.,26-DIOL; (25R)-cholest-5-ene-3 beta,26-diol; (25R)-Cholest-5-ene-3beta,26-diol; (3?,25R)-Cholest-5-ene-3,26-diol; (3-beta)-cholest-5-ene-3,26-diol; (3b,25R)-Cholest-5-ene-3,26-diol; cholest-(25R)-5-en-3beta,26-diol; (3Β,25R)-cholest-5-ene-3,26-diol; (-)-(25R)-26-HYDROXYCHOLESTEROL; (3beta)-Cholest-5-ene-3,26-diol; (25R)-Cholest-5-ene-3β,26-diol; 5-,25r-Cholesten-3beta,26-diol; (25R)-Cholest-5-ene-3b,26-diol; 26-HYDROXYCHOLESTEROL, (25R)-; (3Β)-cholest-5-ene-3,26-diol; cholest-5-ene-3 beta,27-diol; 26-hydroxycholesterol, (25R); Cholest-5-ene-3-beta,27-diol; Cholest-5-ene-3-beta,26-diol; 25(R)-27-hydroxy Cholesterol; Cholest-5-ene-3beta,27-diol; 27-hydroxy-cholesterol(25R); Cholest-5-ene-3beta,26-diol; 5-cholestene-3 beta,27-diol; FYHRJWMENCALJY-YSQMORBQSA-N; (25R)-26-hydroxycholesterol; 5-cholestene-3beta,27-diol; 26-hydroxycholesterol(25R); Cholest-5-ene-3-b,27-diol; Cholest-5-ene-3b,27-diol; Cholest-5-ene-3β,26-diol; Cholest-5-ene-3β,27-diol; 5-Cholestene-3b,27-diol; 5-Cholestene-3β,27-diol; 26-Hydroxycholesterol; 27-Hydroxycholesterol; UNII-6T2NA6P5SQ; 6T2NA6P5SQ; ST 27:1;O2; 27 OHC; 27 HC; 27HC; 27-OHC; Cholest-5-ene-3beta,26-diol



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

56 个相关的代谢反应过程信息。

Reactome(33)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(22)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Kailin Jiao, Keke Yang, Jie Wang, Yifan Ni, Chunyan Hu, Jiao Liu, Ming Zhou, Jin Zheng, Zhong Li. 27-Hydroxycholesterol induces liver fibrosis via down-regulation of trimethylation of histone H3 at lysine 27 by activating oxidative stress; effect of nutrient interventions. Free radical biology & medicine. 2024 Jan; 210(?):462-477. doi: 10.1016/j.freeradbiomed.2023.11.043. [PMID: 38056577]
  • Mindy C DeRouen, Juan Yang, Yuqing Li, Adrian A Franke, Anne N Tome, Kami K White, Brenda Y Hernandez, Yurii Shvetsov, Veronica Setiawan, Anna H Wu, Lynne R Wilkens, Loïc Le Marchand, Lenora W M Loo, Iona Cheng. Circulating 27-hydroxycholesterol, lipids, and steroid hormones in breast cancer risk: a nested case-control study of the Multiethnic Cohort Study. Breast cancer research : BCR. 2023 08; 25(1):95. doi: 10.1186/s13058-023-01693-6. [PMID: 37580793]
  • Ahmed Hjazi, Maria Ahsan, Mohammed I Alghamdi, A K Kareem, Dahlia N Al-Saidi, Maytham T Qasim, Rosario Mireya Romero-Parra, Rahman S Zabibah, Andrés Alexis Ramírez-Coronel, Yasser Fakri Mustafa, Seyed Reza Hosseini-Fard, Sajad Karampoor, Rasoul Mirzaei. Unraveling the impact of 27-hydroxycholesterol in autoimmune diseases: Exploring promising therapeutic approaches. Pathology, research and practice. 2023 Aug; 248(?):154737. doi: 10.1016/j.prp.2023.154737. [PMID: 37542860]
  • Tao Wang, Xiaona Zhang, Yushan Wang, Wen Liu, Lijing Wang, Ling Hao, Mengwei Ju, Rong Xiao. High cholesterol and 27-hydroxycholesterol contribute to phosphorylation of tau protein by impairing autophagy causing learning and memory impairment in C57BL/6J mice. The Journal of nutritional biochemistry. 2022 08; 106(?):109016. doi: 10.1016/j.jnutbio.2022.109016. [PMID: 35447319]
  • Fiorella Biasi, Valerio Leoni, Paola Gamba, Khouloud Sassi, Gérard Lizard, Giuseppe Poli. Role of 27-hydroxycholesterol and its metabolism in cancer progression: Human studies. Biochemical pharmacology. 2022 02; 196(?):114618. doi: 10.1016/j.bcp.2021.114618. [PMID: 34023292]
  • Dayea Kim, Kwang Min Lee, Chanhee Lee, Yeon Suk Jo, Muradillaeva Shakhnoza Muradillaevna, Jae Ho Kim, Jong Hyuk Yoon, Parkyong Song. Pathophysiological role of 27-hydroxycholesterol in human diseases. Advances in biological regulation. 2022 01; 83(?):100837. doi: 10.1016/j.jbior.2021.100837. [PMID: 34774482]
  • Dieter Lütjohann, Frans Stellaard, Bediha Bölükbasi, Anja Kerksiek, Klaus G Parhofer, Ulrich Laufs. Anti-PCSK 9 antibodies increase the ratios of the brain-specific oxysterol 24S-hydroxycholesterol to cholesterol and to 27-hydroxycholesterol in the serum. British journal of clinical pharmacology. 2021 11; 87(11):4252-4261. doi: 10.1111/bcp.14841. [PMID: 33792095]
  • Wen Liu, Binita Chakraborty, Rachid Safi, Dmitri Kazmin, Ching-Yi Chang, Donald P McDonnell. Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer. Nature communications. 2021 08; 12(1):5103. doi: 10.1038/s41467-021-25354-4. [PMID: 34429409]
  • Cristina Parrado-Fernandez, Valerio Leoni, Ahmed Saeed, Patricia Rodriguez-Rodriguez, Anna Sandebring-Matton, Carmen M Córdoba-Beldad, Paula Bueno, Chaitanya Chakravarthi Gali, Ute Panzenboeck, Angel Cedazo-Minguez, Ingemar Björkhem. Sex difference in flux of 27-hydroxycholesterol into the brain. British journal of pharmacology. 2021 08; 178(16):3194-3204. doi: 10.1111/bph.15353. [PMID: 33345295]
  • Lucio Boglione, Claudio Caccia, Andrea Civra, Jessica Cusato, Antonio D'Avolio, Fiorella Biasi, David Lembo, Giovanni Di Perri, Giuseppe Poli, Valerio Leoni. Trend of 25-hydroxycholesterol and 27-hydroxycholesterol plasma levels in patients affected by active chronic hepatitis B virus infection and inactive carriers. The Journal of steroid biochemistry and molecular biology. 2021 06; 210(?):105854. doi: 10.1016/j.jsbmb.2021.105854. [PMID: 33631373]
  • Michael N Passarelli, Bonne M Thompson, Jeffrey G McDonald, Dale C Snover, Thomas J Palys, Judy R Rees, Elizabeth L Barry, John A Baron. Circulating 27-hydroxycholesterol and Risk of Colorectal Adenomas and Serrated Polyps. Cancer prevention research (Philadelphia, Pa.). 2021 04; 14(4):479-488. doi: 10.1158/1940-6207.capr-20-0414. [PMID: 33408073]
  • Ken-Ichiro Konishi, Tatsuki Mizuochi, Hajime Takei, Ryosuke Yasuda, Hirotaka Sakaguchi, Jun Ishihara, Yugo Takaki, Masahiro Kinoshita, Naoki Hashizume, Suguru Fukahori, Hiromichi Shoji, Go Miyano, Koichiro Yoshimaru, Toshiharu Matsuura, Yukihiro Sanada, Takahisa Tainaka, Hiroo Uchida, Yumiko Kubo, Hiromu Tanaka, Hideyuki Sasaki, Tsuyoshi Murai, Jun Fujishiro, Yushiro Yamashita, Masaki Nio, Hiroshi Nittono, Akihiko Kimura. A Japanese prospective multicenter study of urinary oxysterols in biliary atresia. Scientific reports. 2021 03; 11(1):4986. doi: 10.1038/s41598-021-84445-w. [PMID: 33654186]
  • Tabea Jahn, Christopher Clark, Anja Kerksiek, Piotr Lewczuk, Dieter Lütjohann, Julius Popp. Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer's cerebral pathology and clinical disease progression. The Journal of steroid biochemistry and molecular biology. 2021 01; 205(?):105785. doi: 10.1016/j.jsbmb.2020.105785. [PMID: 33171206]
  • Masaya Matsubayashi, Yoshihiko M Sakaguchi, Yoshiki Sahara, Hitoki Nanaura, Sotaro Kikuchi, Arvand Asghari, Linh Bui, Shinko Kobashigawa, Mari Nakanishi, Riko Nagata, Takeshi K Matsui, Genro Kashino, Masatoshi Hasegawa, Shin Takasawa, Masahiro Eriguchi, Kazuhiko Tsuruya, Shushi Nagamori, Kazuma Sugie, Takahiko Nakagawa, Minoru Takasato, Michihisa Umetani, Eiichiro Mori. 27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 01; 35(1):e21262. doi: 10.1096/fj.202002077r. [PMID: 33368618]
  • Maria Szomek, Laust Moesgaard, Peter Reinholdt, Sophia Bell Haarhøj Hald, Daniel Petersen, Kathiresan Krishnan, Douglas F Covey, Jacob Kongsted, Daniel Wüstner. Membrane organization and intracellular transport of a fluorescent analogue of 27-hydroxycholesterol. Chemistry and physics of lipids. 2020 11; 233(?):105004. doi: 10.1016/j.chemphyslip.2020.105004. [PMID: 33137329]
  • Akira Abe, Miki Hiraoka, Fumiko Matsuzawa, Sei-Ichi Aikawa, Youichi Niimura. Esterification of side-chain oxysterols by lysosomal phospholipase A2. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 10; 1865(10):158787. doi: 10.1016/j.bbalip.2020.158787. [PMID: 32777483]
  • Alessandro Marcello, Andrea Civra, Rafaela Milan Bonotto, Lais Nascimento Alves, Sreejith Rajasekharan, Chiara Giacobone, Claudio Caccia, Roberta Cavalli, Marco Adami, Paolo Brambilla, David Lembo, Giuseppe Poli, Valerio Leoni. The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients. Redox biology. 2020 09; 36(?):101682. doi: 10.1016/j.redox.2020.101682. [PMID: 32810737]
  • Tom Houben, Albert V Bitorina, Yvonne Oligschlaeger, Mike Lj Jeurissen, Sander Rensen, S Eleonore Köhler, Marit Westerterp, Dieter Lütjohann, Jan Theys, Andrea Romano, Jogchum Plat, Ronit Shiri-Sverdlov. Sex-opposed inflammatory effects of 27-hydroxycholesterol are mediated via differences in estrogen signaling. The Journal of pathology. 2020 08; 251(4):429-439. doi: 10.1002/path.5477. [PMID: 32472585]
  • Ying Wang, Yu An, Weiwei Ma, Huiyan Yu, Yanhui Lu, Xiaona Zhang, Yushan Wang, Wen Liu, Tao Wang, Rong Xiao. 27-Hydroxycholesterol contributes to cognitive deficits in APP/PS1 transgenic mice through microbiota dysbiosis and intestinal barrier dysfunction. Journal of neuroinflammation. 2020 Jun; 17(1):199. doi: 10.1186/s12974-020-01873-7. [PMID: 32593306]
  • Shweta Dambal, Mahmoud Alfaqih, Sergio Sanders, Erick Maravilla, Adela Ramirez-Torres, Gloria C Galvan, Mariana Reis-Sobreiro, Mirja Rotinen, Lucy M Driver, Matthew S Behrove, Tijana Jovanovic Talisman, Junhee Yoon, Sungyong You, James Turkson, Jen-Tsan Chi, Michael R Freeman, Everardo Macias, Stephen J Freedland. 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells. Molecular cancer research : MCR. 2020 05; 18(5):671-684. doi: 10.1158/1541-7786.mcr-19-0974. [PMID: 32019810]
  • Antonina Germano, Daniela Rossin, Valerio Leoni, Noemi Iaia, Laura Saba, Vittoria Basile, Soraya Puglisi, Claudio Caccia, Giuseppe Poli, Fiorella Biasi, Massimo Terzolo. Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma. Cells. 2020 04; 9(4):. doi: 10.3390/cells9040885. [PMID: 32260362]
  • Andrea Civra, Mara Colzani, Valeria Cagno, Rachele Francese, Valerio Leoni, Giancarlo Aldini, David Lembo, Giuseppe Poli. Modulation of cell proteome by 25-hydroxycholesterol and 27-hydroxycholesterol: A link between cholesterol metabolism and antiviral defense. Free radical biology & medicine. 2020 03; 149(?):30-36. doi: 10.1016/j.freeradbiomed.2019.08.031. [PMID: 31525455]
  • Charlotte Le Cornet, Britta Walter, Disorn Sookthai, Theron S Johnson, Tilman Kühn, Ester Herpel, Rudolf Kaaks, Renée T Fortner. Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-β, and ERβ: results from the EPIC-Heidelberg cohort. Breast cancer research : BCR. 2020 02; 22(1):23. doi: 10.1186/s13058-020-1253-6. [PMID: 32075687]
  • Charlotte Le Cornet, Theron S Johnson, Da-Lin Lu, Rudolf Kaaks, Renée Turzanski Fortner. Association between lifestyle, dietary, reproductive, and anthropometric factors and circulating 27-hydroxycholesterol in EPIC-Heidelberg. Cancer causes & control : CCC. 2020 Feb; 31(2):181-192. doi: 10.1007/s10552-019-01259-y. [PMID: 31938951]
  • Lin Xiao, Gang Luo, Xiaoping Guo, Chunjie Jiang, Hongmei Zeng, Feng Zhou, Yanyan Li, Jiasheng Yu, Ping Yao. Macrophage iron retention aggravates atherosclerosis: Evidence for the role of autocrine formation of hepcidin in plaque macrophages. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 02; 1865(2):158531. doi: 10.1016/j.bbalip.2019.158531. [PMID: 31666189]
  • Ulrich Pecks, Verena Bornemann, Anika Klein, Laura Segger, Nicolai Maass, Ibrahim Alkatout, Christel Eckmann-Scholz, Mohamed Elessawy, Dieter Lütjohann. Estimating fetal cholesterol synthesis rates by cord blood analysis in intrauterine growth restriction and normally grown fetuses. Lipids in health and disease. 2019 Oct; 18(1):185. doi: 10.1186/s12944-019-1117-1. [PMID: 31653257]
  • Arvand Asghari, Tomonori Ishikawa, Shiro Hiramitsu, Wan-Ru Lee, Junko Umetani, Linh Bui, Kenneth S Korach, Michihisa Umetani. 27-Hydroxycholesterol Promotes Adiposity and Mimics Adipogenic Diet-Induced Inflammatory Signaling. Endocrinology. 2019 10; 160(10):2485-2494. doi: 10.1210/en.2019-00349. [PMID: 31386147]
  • Giovanna Revilla, Monica de Pablo Pons, Lucía Baila-Rueda, Annabel García-León, David Santos, Ana Cenarro, Marcelo Magalhaes, R M Blanco, Antonio Moral, José Ignacio Pérez, Gerard Sabé, Cintia González, Victoria Fuste, Enrique Lerma, Manuel Dos Santos Faria, Alberto de Leiva, Rosa Corcoy, Joan Carles Escolà-Gil, Eugenia Mato. Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness. Scientific reports. 2019 07; 9(1):10260. doi: 10.1038/s41598-019-46727-2. [PMID: 31311983]
  • Kelly Fellows Maxwell, Sonia Bhattacharya, Mary Lou Bodziak, Dejan Jakimovski, Jesper Hagemeier, Richard W Browne, Bianca Weinstock-Guttman, Robert Zivadinov, Murali Ramanathan. Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study. Journal of lipid research. 2019 07; 60(7):1190-1198. doi: 10.1194/jlr.m089664. [PMID: 31085627]
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