PD 123177 (BioDeep_00001878178)
Main id: BioDeep_00000010769
代谢物信息卡片
1-[(4-Amino-3-methylphenyl)methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid
化学式: C29H28N4O3 (480.2161298)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC(=C1)CN2C=NC3=C2CC(N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N
InChI: InChI=1S/C29H28N4O3/c1-19-14-20(12-13-23(19)30)16-32-18-31-24-17-33(26(29(35)36)15-25(24)32)28(34)27(21-8-4-2-5-9-21)22-10-6-3-7-11-22/h2-14,18,26-27H,15-17,30H2,1H3,(H,35,36)
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:79978
- KEGG: C15552
- PubChem: 114899
- ChEMBL: CHEMBL1188080
- ChEMBL: CHEMBL535139
- CAS: 114785-12-5
- PubChem: 17396544
- NIKKAJI: J386.726I
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hui-Lin Guo, Xiao-Hui Liao, Qi Liu, Ling Zhang. Angiotensin II Type 2 Receptor Decreases Transforming Growth Factor-β Type II Receptor Expression and Function in Human Renal Proximal Tubule Cells.
PloS one.
2016; 11(2):e0148696. doi:
10.1371/journal.pone.0148696. [PMID: 26867007] - Walther Bild, Lucian Hritcu, Cristinel Stefanescu, Alin Ciobica. Inhibition of central angiotensin II enhances memory function and reduces oxidative stress status in rat hippocampus.
Progress in neuro-psychopharmacology & biological psychiatry.
2013 Jun; 43(?):79-88. doi:
10.1016/j.pnpbp.2012.12.009. [PMID: 23266710] - Barbara Cresci, Stefano Giannini, Laura Pala, Carmelo Mavilia, Cinzia Manuelli, Pietro Cappugi, Enrico Maggi, Carlo M Rotella, Enrico Magg. AT1 and AT2 receptors in human glomerular endothelial cells at different passages.
Microvascular research.
2003 Jul; 66(1):22-9. doi:
10.1016/s0026-2862(03)00009-8. [PMID: 12826071] - R Ardaillou. Angiotensin II receptors.
Journal of the American Society of Nephrology : JASN.
1999 Jan; 10 Suppl 11(?):S30-9. doi:
NULL. [PMID: 9892138] - C G Brilla, C Scheer, H Rupp. Angiotensin II and intracellular calcium of adult cardiac fibroblasts.
Journal of molecular and cellular cardiology.
1998 Jun; 30(6):1237-46. doi:
10.1006/jmcc.1998.0689. [PMID: 9689597] - M Ruiz-Ortega, J Egido. Angiotensin II modulates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts.
Kidney international.
1997 Dec; 52(6):1497-510. doi:
10.1038/ki.1997.480. [PMID: 9407495] - M Kakiki, K Morohashi, M Nomura, T Omura, T Horie. Expression of aldosterone synthase cytochrome P450 (P450aldo) mRNA in rat adrenal glomerulosa cells by angiotensin II type 1 receptor.
Endocrine research.
1997 Nov; 23(4):277-95. doi:
10.1080/07435809709031858. [PMID: 9430819] - T Yotsumoto, T Naitoh, K Shikada, S Tanaka. Effects of specific antagonists of angiotensin II receptors and captopril on diabetic nephropathy in mice.
Japanese journal of pharmacology.
1997 Sep; 75(1):59-64. doi:
10.1254/jjp.75.59. [PMID: 9334886] - M Kakiki, K Morohashi, M Nomura, T Omura, T Horie. Regulation of aldosterone synthase cytochrome P450 (CYP11B2) and 11 beta-hydroxylase cytochrome P450 (CYP11B1) expression in rat adrenal zona glomerulosa cells by low sodium diet and angiotensin II receptor antagonists.
Biological & pharmaceutical bulletin.
1997 Sep; 20(9):962-8. doi:
10.1248/bpb.20.962. [PMID: 9331977] - J A Olivares-Reyes, M Macías-Silva, J A García-Sáinz. Atypical angiotensin II receptors coupled to phosphoinositide turnover/calcium signalling in catfish hepatocytes.
Biochimica et biophysica acta.
1997 Jun; 1357(2):201-8. doi:
10.1016/s0167-4889(97)00022-0. [PMID: 9223623] - S Czekalski, D Chansel, S Vandermeersch, P Ronco, R Ardaillou. Evidence for angiotensin IV receptors in human collecting duct cells.
Kidney international.
1996 Oct; 50(4):1125-31. doi:
10.1038/ki.1996.419. [PMID: 8887269] - S Meffert, M Stoll, U M Steckelings, S P Bottari, T Unger. The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells.
Molecular and cellular endocrinology.
1996 Aug; 122(1):59-67. doi:
10.1016/0303-7207(96)03873-7. [PMID: 8898348] - S Höhle, J Culman, M Boser, F Qadri, T Unger. Effect of angiotensin AT2 and muscarinic receptor blockade on osmotically induced vasopressin release.
European journal of pharmacology.
1996 Apr; 300(1-2):119-23. doi:
10.1016/0014-2999(95)00855-1. [PMID: 8741176] - J V Sitzmann, Y Wu, G Aguilera, P A Cahill, R C Burns. Loss of angiotensin-II receptors in portal hypertensive rabbits.
Hepatology (Baltimore, Md.).
1995 Aug; 22(2):559-64. doi:
NULL. [PMID: 7635425] - R M Catalioto, R Porchia, A R Renzetti, M Criscuoli, A Subissi, A Giachetti. Angiotensin II-induced responses in vascular smooth muscle cells: inhibition by non-peptide receptor antagonists.
European journal of pharmacology.
1995 Jul; 280(3):285-92. doi:
10.1016/0014-2999(95)00206-z. [PMID: 8566096] - S Höhle, H Spitznagel, W Rascher, J Culman, T Unger. Angiotensin AT1 receptor-mediated vasopressin release and drinking are potentiated by an AT2 receptor antagonist.
European journal of pharmacology.
1995 Mar; 275(3):277-82. doi:
10.1016/0014-2999(95)00005-6. [PMID: 7768295] - M de Gasparo, N R Levens. Pharmacology of angiotensin II receptors in the kidney.
Kidney international.
1994 Dec; 46(6):1486-91. doi:
10.1038/ki.1994.426. [PMID: 7699986] - C Darimont, G Vassaux, G Ailhaud, R Negrel. Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II.
Endocrinology.
1994 Nov; 135(5):2030-6. doi:
10.1210/endo.135.5.7956925. [PMID: 7956925] - L A Sechi, C A Griffin, M Schambelan. The cardiac renin-angiotensin system in STZ-induced diabetes.
Diabetes.
1994 Oct; 43(10):1180-4. doi:
10.2337/diab.43.10.1180. [PMID: 7926285] - T Wada, Y Inada, T Sanada, M Ojima, Y Shibouta, M Noda, K Nishikawa. Effect of an angiotensin II receptor antagonist, CV-11974, and its prodrug, TCV-116, on production of aldosterone.
European journal of pharmacology.
1994 Feb; 253(1-2):27-34. doi:
10.1016/0014-2999(94)90753-6. [PMID: 8013547] - K M Michels, F M Heemskerk, J M Saavedra. Selective changes in angiotensin II AT1 and AT2 receptor subtypes in the rat superior colliculus following eye enucleation.
Neuroscience.
1994 Feb; 58(4):835-44. doi:
10.1016/0306-4522(94)90460-x. [PMID: 8190260] - C S Cobb, J A Brown. Characterization of putative glomerular receptors for angiotensin II in the rainbow trout Oncorhynchus mykiss using the antagonists Losartan, PD 123177, and saralasin.
General and comparative endocrinology.
1993 Oct; 92(1):123-31. doi:
10.1006/gcen.1993.1149. [PMID: 8262354] - P B Timmermans, P C Wong, A T Chiu, W F Herblin, P Benfield, D J Carini, R J Lee, R R Wexler, J A Saye, R D Smith. Angiotensin II receptors and angiotensin II receptor antagonists.
Pharmacological reviews.
1993 Jun; 45(2):205-51. doi:
NULL. [PMID: 8372104] - K L Clark, M J Robertson, G M Drew. Role of angiotensin AT1 and AT2 receptors in mediating the renal effects of angiotensin II in the anaesthetized dog.
British journal of pharmacology.
1993 May; 109(1):148-56. doi:
10.1111/j.1476-5381.1993.tb13545.x. [PMID: 8495237] - P Dagenais, E Escher. Anti-angiotensin antibodies cross-reactive with nonpeptide angiotensin antagonists as angiotensin receptor model.
Regulatory peptides.
1993 Mar; 44(2):239-47. doi:
10.1016/0167-0115(93)90248-7. [PMID: 8385792] - D T Dudley, R M Summerfelt. Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells.
Regulatory peptides.
1993 Mar; 44(2):199-206. doi:
10.1016/0167-0115(93)90243-2. [PMID: 8469774] - D T Pals, S J Couch. Renin release induced by losartan (DuP 753), an angiotensin II receptor antagonist.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1993 Jan; 15(1):1-13. doi:
10.3109/10641969309041609. [PMID: 8385523] - J Poggioli, G Lazar, P Houillier, J P Gardin, J M Achard, M Paillard. Effects of angiotensin II and nonpeptide receptor antagonists on transduction pathways in rat proximal tubule.
The American journal of physiology.
1992 Oct; 263(4 Pt 1):C750-8. doi:
10.1152/ajpcell.1992.263.4.c750. [PMID: 1329542] - P C Wong, D D Christ, P B Timmermans. Enhancement of losartan (DuP 753)-induced angiotensin II receptor antagonism by PD123177 in rats.
European journal of pharmacology.
1992 Sep; 220(2-3):267-70. doi:
10.1016/0014-2999(92)90758-v. [PMID: 1425998] - L A Sechi, E F Grady, C A Griffin, J E Kalinyak, M Schambelan. Distribution of angiotensin II receptor subtypes in rat and human kidney.
The American journal of physiology.
1992 Feb; 262(2 Pt 2):F236-40. doi:
10.1152/ajprenal.1992.262.2.f236. [PMID: 1539685] - L A Sechi, E F Grady, C A Griffin, J E Kalinyak, M Schambelan. Characterization of angiotensin II receptor subtypes in the rat kidney and heart using the non-peptide antagonists DuP 753 and PD 123 177.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension.
1991 Dec; 9(6):S224-5. doi:
NULL. [PMID: 1818953] - M G Cogan, F Y Liu, P C Wong, P B Timmermans. Comparison of inhibitory potency by nonpeptide angiotensin II receptor antagonists PD123177 and DuP 753 on proximal nephron and renal transport.
The Journal of pharmacology and experimental therapeutics.
1991 Nov; 259(2):687-91. doi:
. [PMID: 1941617] - P C Wong, S D Hart, J V Duncia, P B Timmermans. Nonpeptide angiotensin II receptor antagonists. Studies with DuP 753 and EXP3174 in dogs.
European journal of pharmacology.
1991 Sep; 202(3):323-30. doi:
10.1016/0014-2999(91)90274-t. [PMID: 1748155] - R E Gibson, H H Thorpe, M E Cartwright, J D Frank, T W Schorn, P B Bunting, P K Siegl. Angiotensin II receptor subtypes in renal cortex of rats and rhesus monkeys.
The American journal of physiology.
1991 Sep; 261(3 Pt 2):F512-8. doi:
10.1152/ajprenal.1991.261.3.f512. [PMID: 1653532] - P C Wong, S D Hart, P B Timmermans. Effect of angiotensin II antagonism on canine renal sympathetic nerve function.
Hypertension (Dallas, Tex. : 1979).
1991 Jun; 17(6 Pt 2):1127-34. doi:
10.1161/01.hyp.17.6.1127. [PMID: 2045159] - W F Herblin, S M Diamond, P B Timmermans. Localization of angiotensin II receptor subtypes in the rabbit adrenal and kidney.
Peptides.
1991 May; 12(3):581-4. doi:
10.1016/0196-9781(91)90105-x. [PMID: 1923936]