Mangiferin (BioDeep_00000018968)

Main id: BioDeep_00000230176

 

human metabolite PANOMIX_OTCML-2023 Antitumor activity natural product


代谢物信息卡片


1,3,6,7-tetrahydroxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9H-xanthen-9-one

化学式: C19H18O11 (422.0849)
中文名称: 芒果苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc1c(c2=O)cc(c(c1)O)O)O)[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O
InChI: InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2

描述信息

Mangiferin is found in fruits. Mangiferin is a constituent of Mangifera indica (mango)
Constituent of Mangifera indica (mango). Mangiferin is found in mango and fruits.
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities[1][2][3].
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities[1][2][3].

同义名列表

19 个代谢物同义名

1,3,6,7-tetrahydroxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9H-xanthen-9-one; 2-b-D-Glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one, 9ci; 2-beta-D-Glucopyranosyl-1,3,6,7-tetrahydroxy xanthone; 1,3,6,7-Tetrahydroxyxanthone C2-beta-D-glucoside; Mangiferin from mangifera indica bark; MLS000563058; Mannipherin; Chedisaride; Euxanthogen; Hedysaride; Alpizarine; Mangiferin; Chinoinin; Hedysarid; Chinomine; alpizarin; Chinomin; Aphloiol; Mangiferin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

481 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Dominika Zajac, Agnieszka Stasinska, Rene Delgado, Mieczyslaw Pokorski. Mangiferin and its traversal into the brain. Advances in experimental medicine and biology. 2013; 756(?):105-11. doi: 10.1007/978-94-007-4549-0_14. [PMID: 22836625]
  • Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang, Chenggang Huang. Metabolism and pharmacokinetics of mangiferin in conventional rats, pseudo-germ-free rats, and streptozotocin-induced diabetic rats. Drug metabolism and disposition: the biological fate of chemicals. 2012 Nov; 40(11):2109-18. doi: 10.1124/dmd.112.045849. [PMID: 22859782]
  • Alexandra Hudecová, Barbara Kusznierewicz, Elise Rundén-Pran, Zuzana Magdolenová, Katarína Hasplová, Alessandra Rinna, Lise Marie Fjellsbø, Marcin Kruszewski, Anna Lankoff, Wiggo Johan Sandberg, Magne Refsnes, Tonje Skuland, Per Schwarze, Gunnar Brunborg, Magnar Bjøras, Andrew Collins, Eva Miadoková, Eliska Gálová, Mária Dusinská. Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea. Mutagenesis. 2012 Nov; 27(6):759-69. doi: 10.1093/mutage/ges046. [PMID: 22940646]
  • Bosai He, Qing Li, Ying Jia, Longshan Zhao, Feng Xiao, Chunxiao Lv, Huarong Xu, Xiaohui Chen, Kaishun Bi. A UFLC-MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: application to a comparative pharmacokinetic study in normal and insomnic rats. Journal of mass spectrometry : JMS. 2012 Oct; 47(10):1333-40. doi: 10.1002/jms.3072. [PMID: 23019165]
  • Rui Liu, Zhidong Liu, Chengui Zhang, Boli Zhang. Nanostructured lipid carriers as novel ophthalmic delivery system for mangiferin: improving in vivo ocular bioavailability. Journal of pharmaceutical sciences. 2012 Oct; 101(10):3833-44. doi: 10.1002/jps.23251. [PMID: 22767401]
  • Yanfen Niu, Wei Lu, Lihui Gao, Hua Lin, Xu Liu, Ling Li. Reducing effect of mangiferin on serum uric acid levels in mice. Pharmaceutical biology. 2012 Sep; 50(9):1177-82. doi: 10.3109/13880209.2012.663763. [PMID: 22881143]
  • Lucía Márquez, Borja García-Bueno, José L M Madrigal, Juan C Leza. Mangiferin decreases inflammation and oxidative damage in rat brain after stress. European journal of nutrition. 2012 Sep; 51(6):729-39. doi: 10.1007/s00394-011-0252-x. [PMID: 21986672]
  • Alexandra Hudecová, Barbara Kusznierewicz, Katarína Hašplová, Anna Huk, Zuzana Magdolenová, Eva Miadoková, Eliška Gálová, Mária Dušinská. Gentiana asclepiadea exerts antioxidant activity and enhances DNA repair of hydrogen peroxide- and silver nanoparticles-induced DNA damage. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Sep; 50(9):3352-9. doi: 10.1016/j.fct.2012.06.017. [PMID: 22721983]
  • I Rodeiro, S Hernandez, J Morffi, J A Herrera, M J Gómez-Lechón, R Delgado, J J Espinosa-Aguirre. Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Sep; 50(9):3360-6. doi: 10.1016/j.fct.2012.06.032. [PMID: 22749943]
  • Hui-Seong Kim, Jae Hyoung Song, Ui Joung Youn, Jin Won Hyun, Woo Seok Jeong, Mi Young Lee, Hwa Jung Choi, Hyeong-Kyu Lee, Sungwook Chae. Inhibition of UVB-induced wrinkle formation and MMP-9 expression by mangiferin isolated from Anemarrhena asphodeloides. European journal of pharmacology. 2012 Aug; 689(1-3):38-44. doi: 10.1016/j.ejphar.2012.05.050. [PMID: 22683868]
  • Claudine Campa, Laurence Mondolot, Arsene Rakotondravao, Luc P R Bidel, Annick Gargadennec, Emmanuel Couturon, Philippe La Fisca, Jean-Jacques Rakotomalala, Christian Jay-Allemand, Aaron P Davis. A survey of mangiferin and hydroxycinnamic acid ester accumulation in coffee (Coffea) leaves: biological implications and uses. Annals of botany. 2012 Aug; 110(3):595-613. doi: 10.1093/aob/mcs119. [PMID: 22700941]
  • Talita Cavalcante Morais, Synara Cavalcante Lopes, Karine Maria Martins Bezerra Carvalho, Bruno Rodrigues Arruda, Francisco Thiago Correia de Souza, Maria Teresa Salles Trevisan, Vietla Satyanarayana Rao, Flávia Almeida Santos. Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice involving cholinergic mechanism. World journal of gastroenterology. 2012 Jul; 18(25):3207-14. doi: 10.3748/wjg.v18.i25.3207. [PMID: 22783044]
  • Siddaruda M Biradar, Hanumanthachar Joshi, Tarak K Chheda. Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer's disease. European journal of pharmacology. 2012 May; 683(1-3):140-7. doi: 10.1016/j.ejphar.2012.02.042. [PMID: 22426032]
  • Rabyah B Ali, Item J Atangwho, Navneet Kaur, Omar Saad Abraika, Mariam Ahmad, Roziahanim Mahmud, Mohd Z Asmawi. Bioassay-guided antidiabetic study of Phaleria macrocarpa fruit extract. Molecules (Basel, Switzerland). 2012 Apr; 17(5):4986-5002. doi: 10.3390/molecules17054986. [PMID: 22547320]
  • Joydeep Das, Jyotirmoy Ghosh, Anandita Roy, Parames C Sil. Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2-NFκB pathways. Toxicology and applied pharmacology. 2012 Apr; 260(1):35-47. doi: 10.1016/j.taap.2012.01.015. [PMID: 22310181]
  • Bhaskarmurthy Deepak Hiraganahalli, Velusami Chandrasekaran Chinampudur, Shekhar Dethe, Deepak Mundkinajeddu, Manoj Kumar Pandre, Jaya Balachandran, Amit Agarwal. Hepatoprotective and antioxidant activity of standardized herbal extracts. Pharmacognosy magazine. 2012 Apr; 8(30):116-23. doi: 10.4103/0973-1296.96553. [PMID: 22701284]
  • Gorawit Yusakul, Wongsathorn Kitirattrakarn, Narunat Tanwanichkul, Hiroyuki Tanaka, Waraporn Putalun. Development and application of an enzyme-linked immunosorbent assay for specific detection of mangiferin content in various cultivars of Mangifera indica leaves using anti-mangiferin polyclonal antibody. Journal of food science. 2012 Apr; 77(4):C414-9. doi: 10.1111/j.1750-3841.2011.02610.x. [PMID: 22394207]
  • Manoranjan Ghosh, Joydeep Das, Parames C Sil. D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-κB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin. Free radical research. 2012 Feb; 46(2):116-32. doi: 10.3109/10715762.2011.644240. [PMID: 22118634]
  • Jixia Li, Margarita Malakhova, Madhusoodanan Mottamal, Kanamata Reddy, Igor Kurinov, Andria Carper, Alyssa Langfald, Naomi Oi, Myoung Ok Kim, Feng Zhu, Carlos P Sosa, Keyuan Zhou, Ann M Bode, Zigang Dong. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer research. 2012 Jan; 72(1):260-70. doi: 10.1158/0008-5472.can-11-2596. [PMID: 22084399]
  • Yi Hong Tang, Zhao Lin Sun, Ming Song Fan, Zhi Xiong Li, Cheng Gang Huang. Anti-diabetic effects of TongGuanWan, a Chinese traditional herbal formula, in C57BL/KsJ-db/db mice. Planta medica. 2012 Jan; 78(1):18-23. doi: 10.1055/s-0031-1280268. [PMID: 22002851]
  • Yucun Niu, Songtao Li, Lixin Na, Rennan Feng, Liyan Liu, Ying Li, Changhao Sun. Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK. PloS one. 2012; 7(1):e30782. doi: 10.1371/journal.pone.0030782. [PMID: 22292039]
  • Adam Kokotkiewicz, Maria Luczkiewicz, Anna Hering, Renata Ochocka, Krzysztof Gorynski, Adam Bucinski, Pawel Sowinski. Micropropagation of Cyclopia genistoides, an endemic South African plant of economic importance. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2012 Jan; 67(1-2):65-76. doi: 10.1515/znc-2012-1-209. [PMID: 22486043]
  • Pradeep Pratap Singh, Ambika, Shive Murat Singh Chauhan. Activity-guided isolation of antioxidant xanthones from Swertia chirayita (Roxb.) H. Karsten (Gentianaceae). Natural product research. 2012; 26(18):1682-6. doi: 10.1080/14786419.2011.592836. [PMID: 21985644]
  • Jun Hou, Dezhi Zheng, Kaihua Fan, Botao Yu, Wenjing Xiao, Jie Ma, Weihua Jin, Yonghong Tan, Juan Wu. Combination of mangiferin and dipeptidyl peptidase-4 inhibitor sitagliptin improves impaired glucose tolerance in streptozotocin-diabetic rats. Pharmacology. 2012; 90(3-4):177-82. doi: 10.1159/000342128. [PMID: 22948814]
  • Fenglei Luo, Qiang Lv, Yuqin Zhao, Guibing Hu, Guodi Huang, Jiukai Zhang, Chongde Sun, Xian Li, Kunsong Chen. Quantification and purification of mangiferin from Chinese Mango (Mangifera indica L.) cultivars and its protective effect on human umbilical vein endothelial cells under H(2)O(2)-induced stress. International journal of molecular sciences. 2012; 13(9):11260-74. doi: 10.3390/ijms130911260. [PMID: 23109851]
  • Dezhi Zheng, Jun Hou, Yingbin Xiao, Zhe Zhao, Lin Chen. Cardioprotective effect of mangiferin on left ventricular remodeling in rats. Pharmacology. 2012; 90(1-2):78-87. doi: 10.1159/000339450. [PMID: 22759807]
  • Kishalay Jana, Kausik Chatterjee, Kazi Monjur Ali, Debasis De, Tushar Kanti Bera, Debidas Ghosh. Antihyperglycemic and antioxidative effects of the hydro-methanolic extract of the seeds of Caesalpinia bonduc on streptozotocin-induced diabetes in male albino rats. Pharmacognosy research. 2012 Jan; 4(1):57-62. doi: 10.4103/0974-8490.91044. [PMID: 22224063]
  • Mukesh S Sikarwar, M B Patil. Antihyperlipidemic activity of Salacia chinensis root extracts in triton-induced and atherogenic diet-induced hyperlipidemic rats. Indian journal of pharmacology. 2012 Jan; 44(1):88-92. doi: 10.4103/0253-7613.91875. [PMID: 22345877]
  • Vietla S Rao, Ana C Carvalho, Maria Teresa S Trevisan, Geanne M Andrade, Helio V Nobre-Júnior, Manoel O Moraes, Hemerson I Magalhães, Talita C Morais, Flavia A Santos. Mangiferin ameliorates 6-hydroxydopamine-induced cytotoxicity and oxidative stress in ketamine model of schizophrenia. Pharmacological reports : PR. 2012; 64(4):848-56. doi: 10.1016/s1734-1140(12)70879-4. [PMID: 23087136]
  • Najla Gooda Sahib, Nazamid Saari, Amin Ismail, Alfi Khatib, Fawzi Mahomoodally, Azizah Abdul Hamid. Plants' metabolites as potential antiobesity agents. TheScientificWorldJournal. 2012; 2012(?):436039. doi: 10.1100/2012/436039. [PMID: 22666121]
  • Angela I Calderón, Johayra Simithy-Williams, Mahabir P Gupta. Antimalarial natural products drug discovery in Panama. Pharmaceutical biology. 2012 Jan; 50(1):61-71. doi: 10.3109/13880209.2011.602417. [PMID: 22196582]
  • Chung-Hung Chan, Gek-Cheng Ngoh, Rozita Yusoff. A brief review on anti diabetic plants: Global distribution, active ingredients, extraction techniques and acting mechanisms. Pharmacognosy reviews. 2012 Jan; 6(11):22-8. doi: 10.4103/0973-7847.95854. [PMID: 22654401]
  • Fuchuan Guo, Conghui Huang, Xilu Liao, Yemei Wang, Ying He, Rennan Feng, Ying Li, Changhao Sun. Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters. Molecular nutrition & food research. 2011 Dec; 55(12):1809-18. doi: 10.1002/mnfr.201100392. [PMID: 22038976]
  • Pascale Talamond, Geneviève Conejero, Jean-Luc Verdeil, Jean-Luc Poëssel. Isolation of C-glycosyl xanthones from Coffea pseudozanguebariae and their location. Natural product communications. 2011 Dec; 6(12):1885-8. doi: ". [PMID: 22312730]
  • Stephen Cw Sze, Ho-Pan Cheung, Tzi-Bun Ng, Zhang-Jing Zhang, Kam-Lok Wong, Hei-Kiu Wong, Yong-Mei Hu, Christine Mn Yow, Yao Tong. Effects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause. Chinese medicine. 2011 Nov; 6(?):40. doi: 10.1186/1749-8546-6-40. [PMID: 22047073]
  • Shashi Kant Singh, Saurabh K Sinha, S K Prasad, R Kumar, Bhawani S Bithu, S Sadish Kumar, P Singh. Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic. Asian Pacific journal of tropical medicine. 2011 Nov; 4(11):866-9. doi: 10.1016/s1995-7645(11)60210-1. [PMID: 22078948]
  • Min Xu, Ming Zhang, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang. Phenolic compounds from the whole plants of Gentiana rhodantha (Gentianaceae). Chemistry & biodiversity. 2011 Oct; 8(10):1891-900. doi: 10.1002/cbdv.201000220. [PMID: 22006717]
  • Dagmar García Rivera, Ivones Hernández, Nelson Merino, Yilian Luque, Alina Álvarez, Yanet Martín, Aylin Amador, Lauro Nuevas, René Delgado. Mangifera indica L. extract (Vimang) and mangiferin reduce the airway inflammation and Th2 cytokines in murine model of allergic asthma. The Journal of pharmacy and pharmacology. 2011 Oct; 63(10):1336-45. doi: 10.1111/j.2042-7158.2011.01328.x. [PMID: 21899550]
  • A Upaganlawar, R Balaraman. Cardioprotective Effects of Lagenaria siceraria Fruit Juice on Isoproterenol-induced Myocardial Infarction in Wistar Rats: A Biochemical and Histoarchitecture Study. Journal of young pharmacists : JYP. 2011 Oct; 3(4):297-303. doi: 10.4103/0975-1483.90241. [PMID: 22224036]
  • Fouad Abdulrahman Hassan, Amin Ismail, Azizah Abdulhamid, Azrina Azlan. Identification and quantification of phenolic compounds in bambangan (Mangifera pajang Kort.) peels and their free radical scavenging activity. Journal of agricultural and food chemistry. 2011 Sep; 59(17):9102-11. doi: 10.1021/jf201270n. [PMID: 21800901]
  • Yuan-Yuan Zhang, Qi Wang, Lian-Wen Qi, Xiao-Ying Qin, Min-Jian Qin. Characterization and determination of the major constituents in Belamcandae Rhizoma by HPLC-DAD-ESI-MS(n). Journal of pharmaceutical and biomedical analysis. 2011 Sep; 56(2):304-14. doi: 10.1016/j.jpba.2011.05.040. [PMID: 21715119]
  • Shubhankar Das, B Nageshwar Rao, B S Satish Rao. Mangiferin attenuates methylmercury induced cytotoxicity against IMR-32, human neuroblastoma cells by the inhibition of oxidative stress and free radical scavenging potential. Chemico-biological interactions. 2011 Sep; 193(2):129-40. doi: 10.1016/j.cbi.2011.06.002. [PMID: 21703249]
  • Qianliang Chen, Zhangyan Shi, Xiaoming Sun, Wenquan Wang, Changhua Ma, Jianyong Liu. [Comparison research on quality of cultivated and wild Anemarrhena Rhizome from Yi County]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Sep; 36(17):2316-20. doi: . [PMID: 22121793]
  • Rui Liu, Zhidong Liu, Chengui Zhang, Boli Zhang. Gelucire44/14 as a novel absorption enhancer for drugs with different hydrophilicities: in vitro and in vivo improvement on transcorneal permeation. Journal of pharmaceutical sciences. 2011 Aug; 100(8):3186-3195. doi: 10.1002/jps.22540. [PMID: 21416467]
  • Huihui Liu, Ke Wang, Yihong Tang, Zhaolin Sun, Longhai Jian, Zhixiong Li, Bin Wu, Chenggang Huang. Structure elucidation of in vivo and in vitro metabolites of mangiferin. Journal of pharmaceutical and biomedical analysis. 2011 Jul; 55(5):1075-82. doi: 10.1016/j.jpba.2011.03.012. [PMID: 21466941]
  • Zhiquan Wei, Li Yan, Jiagang Deng, Jing Deng. [Effects of mangiferin on MAPK signaling pathway in chronic inflammation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Jul; 36(13):1798-802. doi: . [PMID: 22032148]
  • Kunming Qin, Hao Cai, Xiao Liu, Tulin Lu, Qianbo Fang, Zhongqing Yao, Zisheng Xu, Baochang Cai. Screening and analysis of the multiple absorbed bioactive components and metabolites of Baihe Zhimu Tang by the metabolic fingerprinting technique and liquid chromatography/diode array detection-electrospray ionization-mass spectrometry. Pharmacognosy magazine. 2011 Jul; 7(27):177-85. doi: 10.4103/0973-1296.84219. [PMID: 21969787]
  • Tsutomu Shimada, Eiichi Nagai, Yukiko Harasawa, Michiru Watanabe, Kenichi Negishi, Tomoko Akase, Yoshimichi Sai, Ken-Ichi Miyamoto, Masaki Aburada. Salacia reticulata inhibits differentiation of 3T3-L1 adipocytes. Journal of ethnopharmacology. 2011 Jun; 136(1):67-74. doi: 10.1016/j.jep.2011.04.012. [PMID: 21511020]
  • Dagmar García-Rivera, René Delgado, Nadia Bougarne, Guy Haegeman, Wim Vanden Berghe. Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells. Cancer letters. 2011 Jun; 305(1):21-31. doi: 10.1016/j.canlet.2011.02.011. [PMID: 21420233]
  • Antoinette Petrova, Lester M Davids, Fanie Rautenbach, Jeanine L Marnewick. Photoprotection by honeybush extracts, hesperidin and mangiferin against UVB-induced skin damage in SKH-1 mice. Journal of photochemistry and photobiology. B, Biology. 2011 May; 103(2):126-39. doi: 10.1016/j.jphotobiol.2011.02.020. [PMID: 21435898]
  • Qin Wang, Jiagang Deng, Ke Yang, Lancheng Xu. [Effects of mangiferin on cytokines in rats with chronic bronchitis and expression of macrophage COX-2 in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 May; 36(10):1348-52. doi: . [PMID: 21837981]
  • S S Jalalpure, N B Gadge. Diuretic effects of young fruit extracts of bombax ceiba L. In rats. Indian journal of pharmaceutical sciences. 2011 May; 73(3):306-11. doi: 10.4103/0250-474x.93525. [PMID: 22457557]
  • Xiuping Chen, Fangyun Sun, Lifeng Ma, Jinhua Wang, Hailin Qin, Guanhua Du. In vitro evaluation on the antioxidant capacity of triethylchebulate, an aglycone from Terminalia chebula Retz fruit. Indian journal of pharmacology. 2011 May; 43(3):320-3. doi: 10.4103/0253-7613.81508. [PMID: 21713099]
  • Junfeng Wang, Cuizhu Zhao, Chang Liu, Guangmin Xia, Fengning Xiang. Introgression of Swertia mussotii gene into Bupleurum scorzonerifolium via somatic hybridization. BMC plant biology. 2011 Apr; 11(?):71. doi: 10.1186/1471-2229-11-71. [PMID: 21513581]
  • Shengjun Fan, Yuanqin Gu, Guoyu Li, Mingyu Zhang, Baoxin Li, Hong Zhang, Yunlong Hou. [Determination of mangiferin in rat plasma and aqueous humor by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Mar; 36(5):598-602. doi: 10.4268/cjcmm20110518. [PMID: 21657080]
  • Lizhen Huang, Jiang He, Ruihua Lu, Xia Ge, Jingjing Guo. Investigation on a host-guest inclusion system by β-cyclodextrin derivative and its analytical application. Bioorganic & medicinal chemistry letters. 2011 Feb; 21(4):1113-7. doi: 10.1016/j.bmcl.2010.12.125. [PMID: 21273073]
  • Jie Feng, Xiu-Wei Yang, Ru-Feng Wang. Bio-assay guided isolation and identification of α-glucosidase inhibitors from the leaves of Aquilaria sinensis. Phytochemistry. 2011 Feb; 72(2-3):242-7. doi: 10.1016/j.phytochem.2010.11.025. [PMID: 21215978]
  • Lan He, Yanfei Qi, Xianglu Rong, Jianmin Jiang, Qinglin Yang, Johji Yamahara, Michael Murray, Yuhao Li. The Ayurvedic Medicine Salacia oblonga Attenuates Diabetic Renal Fibrosis in Rats: Suppression of Angiotensin II/AT1 Signaling. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):807451. doi: 10.1093/ecam/nep095. [PMID: 19706694]
  • Sunil Kumar, Smita Narwal, Vipin Kumar, Om Prakash. α-glucosidase inhibitors from plants: A natural approach to treat diabetes. Pharmacognosy reviews. 2011 Jan; 5(9):19-29. doi: 10.4103/0973-7847.79096. [PMID: 22096315]
  • Tomoko Akase, Tsutomu Shimada, Yukiko Harasawa, Tomohide Akase, Yukinobu Ikeya, Eiichi Nagai, Seiichi Iizuka, Gojiro Nakagami, Shinji Iizaka, Hiromi Sanada, Masaki Aburada. Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):484590. doi: 10.1093/ecam/nep052. [PMID: 19505975]
  • Linda Sissing, Jeanine Marnewick, Maryna de Kock, Sonja Swanevelder, Elizabeth Joubert, Wentzel Gelderblom. Modulating effects of rooibos and honeybush herbal teas on the development of esophageal papillomas in rats. Nutrition and cancer. 2011; 63(4):600-10. doi: 10.1080/01635581.2011.539313. [PMID: 21541901]
  • Rudi Hendra, Syahida Ahmad, Aspollah Sukari, M Yunus Shukor, Ehsan Oskoueian. Flavonoid analyses and antimicrobial activity of various parts of Phaleria macrocarpa (Scheff.) Boerl fruit. International journal of molecular sciences. 2011; 12(6):3422-31. doi: 10.3390/ijms12063422. [PMID: 21747685]
  • Kiran S Panickar, Richard A Anderson. Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia. International journal of molecular sciences. 2011; 12(11):8181-207. doi: 10.3390/ijms12118181. [PMID: 22174658]
  • Yiming Liu, Fuping Xu, Xing Zeng, Liu Yang, Yuanhui Deng, Zhifeng Wu, Yi Feng, Xiong Li. Application of a liquid chromatography/tandem mass spectrometry method to pharmacokinetic study of mangiferin in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Dec; 878(32):3345-50. doi: 10.1016/j.jchromb.2010.10.014. [PMID: 21081292]
  • Bárbara B Garrido-Suárez, Gabino Garrido, Rene Delgado, Fe Bosch, María del C Rabí. A Mangifera indica L. extract could be used to treat neuropathic pain and implication of mangiferin. Molecules (Basel, Switzerland). 2010 Dec; 15(12):9035-45. doi: 10.3390/molecules15129035. [PMID: 21150823]
  • C M Ajila, L Jaganmohan Rao, U J S Prasada Rao. Characterization of bioactive compounds from raw and ripe Mangifera indica L. peel extracts. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010 Dec; 48(12):3406-11. doi: 10.1016/j.fct.2010.09.012. [PMID: 20851730]
  • Rui Liu, Zhidong Liu, Lexin Shu, Chengui Zhang, Boli Zhang. [Effect of three penetration enhancers on corneal permeability of mangiferin in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Dec; 35(23):3131-5. doi: 10.4268/cjcmm20102308. [PMID: 21355232]
  • Nebojsa Menkovic, Zorica Juranic, Tatjana Stanojkovic, Tatjana Raonic-Stevanovic, Katarina Savikin, Gordana Zdunić, Nenad Borojevic. Radioprotective activity of Gentiana lutea extract and mangiferin. Phytotherapy research : PTR. 2010 Nov; 24(11):1693-6. doi: 10.1002/ptr.3225. [PMID: 21031630]
  • Qing-hua Hu, Xian Zhang, Yu Wang, Ling-dong Kong. [Mangiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuricemic mice]. Yao xue xue bao = Acta pharmaceutica Sinica. 2010 Oct; 45(10):1239-46. doi: . [PMID: 21348301]
  • Allana K L Santos, José G M Costa, Irwin R A Menezes, Isaac F Cansanção, Karla K A Santos, Edinardo F F Matias, Henrique D M Coutinho. Antioxidant activity of five Brazilian plants used as traditional medicines and food in Brazil. Pharmacognosy magazine. 2010 Oct; 6(24):335-8. doi: 10.4103/0973-1296.71789. [PMID: 21120039]
  • Neeraj K Sethiya, Ashish Trivedi, Mayur B Patel, S H Mishra. Comparative pharmacognostical investigation on four ethanobotanicals traditionally used as Shankhpushpi in India. Journal of advanced pharmaceutical technology & research. 2010 Oct; 1(4):388-95. doi: 10.4103/0110-5558.76437. [PMID: 22247878]
  • Xingsheng Wang, Jianmin Liao, Dengke Yin, Fan Zhan, Sufei Dai, Guangyan Xie, Xiaobing Sang. Establishment of a novel model for studying the effects of extracts of Chinese herb medicine on human type II 5alpha-reductase in vitro. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2010 Sep; 130(9):1207-14. doi: 10.1248/yakushi.130.1207. [PMID: 20823678]
  • Yunlong Hou, Shengjun Fan, Hong Zhang, Yuanqin Gu, Xuhui Yu, Baoxin Li. Pharmacokinetic study of mangiferin in rat plasma and retina using high-performance liquid chromatography. Molecular vision. 2010 Aug; 16(?):1659-68. doi: NULL. [PMID: 20806037]
  • Ming Zhang, Zuping He, Lixin Wen, Jing Wu, Liyun Yuan, Yin Lu, Chengzhi Guo, Li Zhu, Sijun Deng, Hui Yuan. Cadmium suppresses the proliferation of piglet Sertoli cells and causes their DNA damage, cell apoptosis and aberrant ultrastructure. Reproductive biology and endocrinology : RB&E. 2010 Aug; 8(?):97. doi: 10.1186/1477-7827-8-97. [PMID: 20712887]
  • Elisabetta Chieli, Nadia Romiti, Idania Rodeiro, Gabino Garrido. In vitro modulation of ABCB1/P-glycoprotein expression by polyphenols from Mangifera indica. Chemico-biological interactions. 2010 Aug; 186(3):287-94. doi: 10.1016/j.cbi.2010.05.012. [PMID: 20513373]
  • Lihong Wu, Haifeng Guan, Li Yu, Guixing Chou, Zhengtao Wang. [Quality standard of Gentiana rhodantha]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Aug; 35(16):2099-102. doi: ". [PMID: 21046738]
  • Hong Zhang, Yunlong Hou, Yan Liu, Xuhui Yu, Baoxin Li, Hao Cui. Determination of mangiferin in rat eyes and pharmacokinetic study in plasma after oral administration of mangiferin-hydroxypropyl-beta-cyclodextrin inclusion. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2010 Aug; 26(4):319-24. doi: 10.1089/jop.2010.0024. [PMID: 20653476]
  • Kaitong Li, Yixuan Zhang, Yang Cao, Yue Shi. [Determination of chlorogenic acid and mangiferin in Folium Pyrrosiae from different habitats and species by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Aug; 35(16):2075-8. doi: 10.4268/cjcmm20101607. [PMID: 21046732]
  • Fei Cai, Wen Xu, Hua Wei, Lianna Sun, Shouhong Gao, Qi Yang, Jin Feng, Feng Zhang, Wansheng Chen. Simultaneous determination of active xanthone glycosides, timosaponins and alkaloids in rat plasma after oral administration of Zi-Shen Pill extract for the pharmacokinetic study by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Jul; 878(21):1845-54. doi: 10.1016/j.jchromb.2010.05.024. [PMID: 20541984]
  • Xuan Li, Xiaobing Cui, Xiaoyu Sun, Xiaodong Li, Quan Zhu, Wei Li. Mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats. Phytotherapy research : PTR. 2010 Jun; 24(6):893-9. doi: 10.1002/ptr.3045. [PMID: 19960420]
  • Constance Bock, Waldemar Ternes. The phenolic acids from bacterial degradation of the mangiferin aglycone are quantified in the feces of pigs after oral ingestion of an extract of Cyclopia genistoides (honeybush tea). Nutrition research (New York, N.Y.). 2010 May; 30(5):348-57. doi: 10.1016/j.nutres.2010.05.005. [PMID: 20579527]
  • E Kasi Viswanadh, B Nageshwar Rao, B S Satish Rao. Antigenotoxic effect of mangiferin and changes in antioxidant enzyme levels of Swiss albino mice treated with cadmium chloride. Human & experimental toxicology. 2010 May; 29(5):409-18. doi: 10.1177/0960327110361752. [PMID: 20150354]
  • Noor Huda Daud, Cho Sanda Aung, Amitha K Hewavitharana, Ashley S Wilkinson, Jean-Thomas Pierson, Sarah J Roberts-Thomson, P Nicholas Shaw, Gregory R Monteith, Michael J Gidley, Marie-Odile Parat. Mango extracts and the mango component mangiferin promote endothelial cell migration. Journal of agricultural and food chemistry. 2010 Apr; 58(8):5181-6. doi: 10.1021/jf100249s. [PMID: 20349963]
  • Nagaraj Gowda, Pradeep Kumar, Surender Panghal, Mashru Rajshree. ICH guidance in practice: validated reversed-phase HPLC method for the determination of active mangiferin from extracts of Mangifera indica Linn. Journal of chromatographic science. 2010 Feb; 48(2):156-60. doi: 10.1093/chromsci/48.2.156. [PMID: 20109296]
  • Elizabeth Joubert, Marena Manley, Christina Maicu, Dalene de Beer. Effect of pre-drying treatments and storage on color and phenolic composition of green honeybush (Cyclopia subternata) herbal tea. Journal of agricultural and food chemistry. 2010 Jan; 58(1):338-44. doi: 10.1021/jf902754b. [PMID: 19916502]
  • Dandan Han, Chengjun Chen, Cong Zhang, Yu Zhang, Xing Tang. Determination of mangiferin in rat plasma by liquid-liquid extraction with UPLC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2010 Jan; 51(1):260-3. doi: 10.1016/j.jpba.2009.07.021. [PMID: 19699046]
  • Neeraj K Sethiya, M B Patel, S H Mishra. Phytopharmacologic aspects of Canscora decussata Roem and Schult. Pharmacognosy reviews. 2010 Jan; 4(7):49-57. doi: 10.4103/0973-7847.65326. [PMID: 22228941]
  • Pascal Danthu, Christian Lubrano, Laurence Flavet, Voninavoko Rahajanirina, Olivier Behra, Claude Fromageot, Raymond Rabevohitra, Edmond Roger. Biological factors influencing production of xanthones in Aphloia theiformis. Chemistry & biodiversity. 2010 Jan; 7(1):140-50. doi: 10.1002/cbdv.200900199. [PMID: 20087987]
  • Harsahay Meena, H K Pandey, M C Arya, Zakwan Ahmed. Shilajit: A panacea for high-altitude problems. International journal of Ayurveda research. 2010 Jan; 1(1):37-40. doi: 10.4103/0974-7788.59942. [PMID: 20532096]
  • K Nagendra Prasad, Lye Yee Chew, Hock Eng Khoo, Kin Weng Kong, Azrina Azlan, Amin Ismail. Antioxidant capacities of peel, pulp, and seed fractions of Canarium odontophyllum Miq. fruit. Journal of biomedicine & biotechnology. 2010; 2010(?):. doi: 10.1155/2010/871379. [PMID: 20936182]
  • K A Shah, M B Patel, R J Patel, P K Parmar. Mangifera indica (mango). Pharmacognosy reviews. 2010 Jan; 4(7):42-8. doi: 10.4103/0973-7847.65325. [PMID: 22228940]
  • Elisabetta Chieli, Nadia Romiti, Idania Rodeiro, Gabino Garrido. In vitro effects of Mangifera indica and polyphenols derived on ABCB1/P-glycoprotein activity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2009 Nov; 47(11):2703-10. doi: 10.1016/j.fct.2009.07.017. [PMID: 19632288]
  • Yeny Lemus-Molina, Maria Victoria Sánchez-Gómez, René Delgado-Hernández, Carlos Matute. Mangifera indica L. extract attenuates glutamate-induced neurotoxicity on rat cortical neurons. Neurotoxicology. 2009 Nov; 30(6):1053-8. doi: 10.1016/j.neuro.2009.06.012. [PMID: 19591864]
  • María Dolores Girón, Natalia Sevillano, Rafael Salto, Ali Haidour, Manuel Manzano, M L Jiménez, Ricardo Rueda, José M López-Pedrosa. Salacia oblonga extract increases glucose transporter 4-mediated glucose uptake in L6 rat myotubes: role of mangiferin. Clinical nutrition (Edinburgh, Scotland). 2009 Oct; 28(5):565-74. doi: 10.1016/j.clnu.2009.04.018. [PMID: 19477051]
  • Bomi Lee, Hien Trung Trinh, Eun-Ah Bae, Kangshik Jung, Dong-Hyun Kim. Mangiferin inhibits passive cutaneous anaphylaxis reaction and pruritus in mice. Planta medica. 2009 Oct; 75(13):1415-7. doi: 10.1055/s-0029-1185773. [PMID: 19533581]
  • Zheng-Hong Guo, Rong-Gang Xi, Xiao-Bo Wang, Li-Jun Wu, Hui-Yuan Gao. [A new trincallane derivative from Salacia hainanensis Chun et How]. Yao xue xue bao = Acta pharmaceutica Sinica. 2009 Oct; 44(10):1123-6. doi: ". [PMID: 20055135]
  • Hui Lin, Jingfeng Lan, Min Guan, Fenling Sheng, Haixia Zhang. Spectroscopic investigation of interaction between mangiferin and bovine serum albumin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2009 Sep; 73(5):936-41. doi: 10.1016/j.saa.2009.04.025. [PMID: 19501542]
  • Bomi Lee, Kangsik Jung, Dong-Hyun Kim. Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice. Pharmacology, biochemistry, and behavior. 2009 Aug; 93(2):121-7. doi: 10.1016/j.pbb.2009.04.021. [PMID: 19426756]
  • Adam Kokotkiewicz, Malgorzata Wnuk, Adam Bucinski, Maria Luczkiewicz. In vitro cultures of Cyclopia plants (honeybush) as a source of bioactive xanthones and flavanones. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2009 Jul; 64(7-8):533-40. doi: 10.1515/znc-2009-7-812. [PMID: 19791506]