7-Methylguanosine 5'-phosphate (BioDeep_00000005372)

 

Secondary id: BioDeep_00001869695

human metabolite


代谢物信息卡片


9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-6-hydroxy-2-imino-7-methyl-3,9-dihydro-2H-purin-7-ium

化学式: C11H17N5O8P+ (378.0815)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(feces) 12.09%

分子结构信息

SMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)(O)O)O)O
InChI: InChI=1S/C11H16N5O8P/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(24-10)2-23-25(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H4-,12,13,14,19,20,21,22)/p+1/t4-,6-,7-,10-/m1/s1

描述信息

7-methylguanosine 5-phosphate is part of the RNA degradation pathway. It is a substrate for: m7GpppX diphosphatase, and m7GpppX diphosphatase.

同义名列表

10 个代谢物同义名

9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-6-hydroxy-2-imino-7-methyl-3,9-dihydro-2H-purin-7-ium; 7-Methylguanosine 5-(dihydrogen phosphoric acid); 7-Methylguanosine 5-(dihydrogen phosphate); 7-Methylguanosine 5-phosphoric acid(1+); 7-Methylguanosine 5-phosphoric acid; 7-Methylguanosine-5-monophosphate; 7-Methylguanosine 5-phosphate; 7-methyl-5-guanylic acid; N7-Methyl-GMP; 7-Methyl GMP



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(6)

BioCyc(0)

PlantCyc(0)

代谢反应

98 个相关的代谢反应过程信息。

Reactome(98)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 CMPK2, DCP2, DCPS, EIF4E, FHIT, NT5C2, NUDT12, NUDT16, NUDT3, PPP5C, RIGI
Nucleus 8 DCP2, DCPS, EIF4E, FHIT, NUDT12, NUDT16, NUDT3, PPP5C
cytosol 12 DCP2, DCPS, EIF4E, FHIT, GOLPH3, HBB, NT5C2, NUDT15, NUDT19, NUDT3, PPP5C, RIGI
nuclear body 1 EIF4E
trans-Golgi network 1 GOLPH3
nucleoplasm 5 CMPK2, DCP2, DCPS, NUDT16, PPP5C
Cell membrane 3 DENND2B, GOLPH3, PPP5C
ruffle membrane 1 RIGI
Cytoplasmic granule 1 NUDT12
cell cortex 1 DENND2B
cell junction 1 DCP2
glutamatergic synapse 2 EIF4E, NUDT3
Golgi apparatus 1 GOLPH3
Golgi membrane 1 GOLPH3
postsynapse 1 EIF4E
Cytoplasm, cytosol 1 NT5C2
endosome 1 GOLPH3
plasma membrane 5 DENND2B, FHIT, GOLPH3, IFNLR1, PPP5C
Membrane 3 GOLPH3, HBB, IFNLR1
extracellular exosome 2 EIF4E, HBB
extracellular space 1 HBB
perinuclear region of cytoplasm 1 EIF4E
bicellular tight junction 1 RIGI
mitochondrion 5 CMPK2, DCPS, FHIT, GOLPH3, NUDT19
protein-containing complex 1 PPP5C
intracellular membrane-bounded organelle 2 GOLPH3, PPP5C
Single-pass type I membrane protein 1 IFNLR1
Secreted 1 PRB2
extracellular region 2 HBB, PRB2
mitochondrial matrix 1 NUDT2
actin cytoskeleton 1 RIGI
nucleolus 1 NUDT16
Cytoplasm, P-body 2 DCP2, EIF4E
P-body 3 DCP2, DCPS, EIF4E
recycling endosome 1 DENND2B
Peroxisome 3 NUDT12, NUDT17, NUDT19
peroxisomal matrix 2 NUDT12, NUDT19
mitochondrial intermembrane space 1 GOLPH3
nuclear speck 1 EIF4E
cytoplasmic ribonucleoprotein granule 2 DCP2, EIF4E
Nucleus, nucleolus 1 NUDT16
blood microparticle 1 HBB
fibrillar center 1 FHIT
Nucleus, nucleoplasm 1 NUDT16
Golgi cisterna membrane 1 GOLPH3
Cytoplasm, Stress granule 1 EIF4E
cytoplasmic stress granule 1 EIF4E
Nucleus speckle 1 EIF4E
ficolin-1-rich granule lumen 1 HBB
chromatoid body 1 EIF4E
tertiary granule lumen 1 HBB
Golgi cisterna 1 GOLPH3
ribonucleoprotein complex 1 RIGI
protein folding chaperone complex 1 PPP5C
eukaryotic translation initiation factor 4F complex 1 EIF4E
RISC complex 2 DCP2, EIF4E
hemoglobin complex 1 HBB
endocytic vesicle lumen 1 HBB
haptoglobin-hemoglobin complex 1 HBB
Nucleus, nuclear body 1 EIF4E
[Isoform 1]: Cytoplasm, cell cortex 1 DENND2B
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • T W Munns, M K Liszewski, S K Freeman, J L Kaine. Detection of human autoantibodies specific for 5'-m7GMP and m7G(5')ppp(5')N. Biochemical and biophysical research communications. 1985 Apr; 128(2):1014-9. doi: 10.1016/0006-291x(85)90148-2. [PMID: 3873239]
  • B A Larkins, A C Mason, W J Hurkman. Molecular mechanisms regulating the synthesis of storage proteins in maize endosperm. Critical reviews in food science and nutrition. 1982; 16(2):199-215. doi: 10.1080/10408398209527334. [PMID: 7039978]
  • E D Hickey, L A Weber, C Baglioni. Inhibition of initiation of protein synthesis by 7-methylguanosine-5'-monophosphate. Proceedings of the National Academy of Sciences of the United States of America. 1976 Jan; 73(1):19-23. doi: 10.1073/pnas.73.1.19. [PMID: 1061116]