11a-Hydroxyprogesterone (BioDeep_00000005301)

 

Secondary id: BioDeep_00000405401

human metabolite Endogenous


代谢物信息卡片


(1S,2R,10S,11S,15S,17R)-14-acetyl-17-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

化学式: C21H30O3 (330.2195)
中文名称: 11α-羟孕酮
谱图信息: 最多检出来源 Homo sapiens(blood) 17.52%

分子结构信息

SMILES: CC(=O)C1CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C
InChI: InChI=1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16?,17-,18+,19+,20-,21+/m0/s1

描述信息

Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestagens, and is the major naturally occurring human progestagen. -- Wikipedia; Progesterones reproductive function serves to convert the endometrium to its secretory stage to prepare the uterus for implantation. If pregnancy does not occur, progesterone levels will decrease leading to menstruation in the human. Normal menstrual bleeding is a progesterone withdrawal bleeding. -- Wikipedia; During implantation and gestation, progesterone appears to decrease the maternal immune response to allow for the acceptance of the pregnancy. Progesterone decreases contractility of the uterine musculature. The fetus metabolizes placental progesterone in the production of adrenal mineralo- and glucosteroids. A drop in progesterone levels is possibly one step that facilitates the onset of labor. In addition progesterone inhibits lactation during pregnancy. The fall in progesterone levels following delivery is one of the triggers for milk production. Progesterone has an effect upon vaginal epithelium and cervical mucus. -- Wikipedia [HMDB]
Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestagens, and is the major naturally occurring human progestagen. Progesterones reproductive function serves to convert the endometrium to its secretory stage to prepare the uterus for implantation. If pregnancy does not occur, progesterone levels will decrease leading to menstruation in the human. Normal menstrual bleeding is a progesterone withdrawal bleeding. During implantation and gestation, progesterone appears to decrease the maternal immune response to allow for the acceptance of the pregnancy. Progesterone decreases contractility of the uterine musculature. The fetus metabolizes placental progesterone in the production of adrenal mineralo- and glucosteroids. A drop in progesterone levels is possibly one step that facilitates the onset of labor. In addition, progesterone inhibits lactation during pregnancy. The fall in progesterone levels following delivery is one of the triggers for milk production. Progesterone has an effect upon vaginal epithelium and cervical mucus.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D011372 - Progestins

同义名列表

13 个代谢物同义名

(1S,2R,10S,11S,15S,17R)-14-acetyl-17-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one; Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-; 11a-Hydroxy-pregn-4-ene-3,20-dione; 11a-Hydroxypregn-4-ene-3,20-dione; 11α-Hydroxyprogesterone; Pregn-4-en-11a-ol-3,20-dione; 4-Pregnene-11a-ol-3,20-dione; 11alpha-hydroxyprogesterone; 11a-Hydroxy-progesterone; 11Α-hydroxyprogesterone; 11a-Hydroxyprogesterone; 11-Hydroxyprogesterone; 11alpha-Hydroxyprogesterone



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Vojtech Kapras, Alena Slavickova, Eva Stastna, Ladislav Vyklicky, Karel Vales, Hana Chodounska. Synthesis of deuterium labeled NMDA receptor inhibitor - 20-Oxo-5β-[9,12,12-(2)H(3)]pregnan-3α-yl-L-glutamyl 1-ester. Steroids. 2012 Feb; 77(3):282-7. doi: 10.1016/j.steroids.2011.12.019. [PMID: 22209708]
  • Gaspar A Fernández Nievas, Francisco J Barrantes, Silvia S Antollini. Conformation-sensitive steroid and fatty acid sites in the transmembrane domain of the nicotinic acetylcholine receptor. Biochemistry. 2007 Mar; 46(11):3503-12. doi: 10.1021/bi061388z. [PMID: 17319650]
  • A A Zohri. Progesterone transformation as a biochemical aid in classification of the genus Emericella. Folia microbiologica. 2000; 45(5):391-6. doi: 10.1007/bf02817611. [PMID: 11347266]
  • H Morita, M Zhou, M F Foecking, E P Gomez-Sanchez, E N Cozza, C E Gomez-Sanchez. 11 beta-Hydroxysteroid dehydrogenase type 2 complementary deoxyribonucleic acid stably transfected into Chinese hamster ovary cells: specific inhibition by 11 alpha-hydroxyprogesterone. Endocrinology. 1996 Jun; 137(6):2308-14. doi: 10.1210/endo.137.6.8641180. [PMID: 8641180]
  • D J Holmes-Walker, G S Conway, J W Honour, G Rumsby, H S Jacobs. Menstrual disturbance and hypersecretion of progesterone in women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Clinical endocrinology. 1995 Sep; 43(3):291-6. doi: 10.1111/j.1365-2265.1995.tb02034.x. [PMID: 7586597]
  • G W Souness, S A Latif, J L Laurenzo, D J Morris. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on corticosterone in the ADX rat. Endocrinology. 1995 Apr; 136(4):1809-12. doi: 10.1210/endo.136.4.7895695. [PMID: 7895695]
  • V M Braga, S J Gendler. Modulation of Muc-1 mucin expression in the mouse uterus during the estrus cycle, early pregnancy and placentation. Journal of cell science. 1993 Jun; 105 ( Pt 2)(?):397-405. doi: 10.1242/jcs.105.2.397. [PMID: 7691839]
  • S J Park, Y J Kim, H S Pyo, J Park. Analysis of corticosteroids in urine by HPLC and thermospray LC/MS. Journal of analytical toxicology. 1990 Mar; 14(2):102-8. doi: 10.1093/jat/14.2.102. [PMID: 1691351]
  • C M Rondinone, A Roldán. Effect of 11 beta OH pregna-1,4-diene-3,20-dione (delta HOP) on thymocyte plasma membranes. Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia. 1990; 40(3):357-64. doi: . [PMID: 2094168]
  • C M Rondinone, R Schillaci, C P Lantos, A Roldán. Appearance and persistence of 11 beta-hydroxypregna-1,4-diene-3,20-dione (delta HOP) effect 'in vivo'. Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia. 1989; 39(2):181-8. doi: NULL. [PMID: 2618755]
  • B Gueux, J Fiet, H Galons, R Boneté, J M Villette, P Vexiau, M T Pham-Huu-Trung, M C Raux-Eurin, M Gourmelen, J L Brérault. The measurement of 11 beta-hydroxy-4-pregnene-3,20-dione (21-deoxycorticosterone) by radioimmunoassay in human plasma. Journal of steroid biochemistry. 1987 Jan; 26(1):145-50. doi: 10.1016/0022-4731(87)90043-4. [PMID: 3546944]
  • J EICHHORN, O HECHTER. Role of 11 beta hydroxyprogesterone as intermediary in biosynthesis of cortisol and corticosterone. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1958 Mar; 97(3):614-9. doi: 10.3181/00379727-97-23823. [PMID: 13518352]