2-Maleylacetate (BioDeep_00000004874)

 

Secondary id: BioDeep_00001870270

human metabolite natural product


代谢物信息卡片


(2Z)-4-oxohex-2-enedioic acid

化学式: C6H6O5 (158.0215)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(plant) 8.85%

分子结构信息

SMILES: C(=C\C(=O)CC(=O)O)\C(=O)O
InChI: InChI=1S/C6H6O5/c7-4(3-6(10)11)1-2-5(8)9/h1-2H,3H2,(H,8,9)(H,10,11)/b2-1-

描述信息

This compound belongs to the family of Medium-chain Keto Acids and Derivatives. These are keto acids with a 6 to 12 carbon atoms long side chain

同义名列表

15 个代谢物同义名

(2Z)-4-oxohex-2-enedioic acid; (Z)-4-oxo-2-Hexenedioic acid; 4-keto hex-2-enedioic acid; 4-oxohex-2E-enedioic acid; 4-Oxohex-2-enedioic acid; (Z)-4-oxo-2-Hexenedioate; 4-Oxohex-2-enedioate; 2-Maleylacetic acid; fumarylacetic acid; Maleoylacetic acid; 2-Hexenedioic acid; Maleylacetic acid; 2-Maleylacetate; Maleylacetate; 2-Maleylacetate



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CNP, PMP2, SYK, TNIP3
Nucleus 3 PMP2, PROP1, SYK
cytosol 5 CLC, PMP2, SERPINE2, SYK, TNIP3
Cell membrane 1 SYK
Lipid-anchor 1 CNP
Cytoplasmic granule 1 CLC
Synapse 2 CNP, NPS
cell surface 1 SDC1
mitochondrial inner membrane 1 CNP
neuromuscular junction 1 SERPINE2
Cytoplasm, cytosol 2 CLC, SYK
plasma membrane 2 SDC1, SYK
Membrane 3 CNP, SDC1, TMEM131
extracellular exosome 6 BTD, CNP, PCOLCE, PMP2, SDC1, SPINK1
extracellular space 5 BTD, CLC, CNP, PCOLCE, SERPINE2
lysosomal lumen 1 SDC1
perinuclear region of cytoplasm 2 CNP, INF2
protein-containing complex 2 SDC1, SYK
Single-pass type I membrane protein 2 SDC1, TMEM131
Secreted 4 CLC, PCOLCE, SDC1, SPINK1
extracellular region 5 BTD, CLC, NPS, PCOLCE, SERPINE2
mitochondrial outer membrane 1 CNP
mitochondrial matrix 1 BTD
transcription regulator complex 1 PROP1
external side of plasma membrane 1 SDC1
Extracellular vesicle 1 SERPINE2
Cytoplasm, perinuclear region 1 INF2
microtubule 1 CNP
collagen trimer 1 PCOLCE
collagen-containing extracellular matrix 2 CLC, SERPINE2
chromatin 1 PROP1
Secreted, extracellular space 1 BTD
actin filament 1 INF2
microvillus 1 CNP
Melanosome 1 CNP
myelin sheath 1 PMP2
pseudopodium 1 CNP
platelet alpha granule 1 SERPINE2
Golgi lumen 1 SDC1
Secreted, extracellular exosome 1 SDC1
early phagosome 1 SYK
CRLF-CLCF1 complex 1 CLC
hemoglobin complex 1 HBQ1
haptoglobin-hemoglobin complex 1 HBQ1
T cell receptor complex 1 SYK
myelin sheath abaxonal region 1 CNP
myelin sheath adaxonal region 1 CNP
B cell receptor complex 1 SYK
CNTFR-CLCF1 complex 1 CLC


文献列表

  • Yong Nie, Yue-Qin Tang, Yan Li, Chang-Qiao Chi, Man Cai, Xiao-Lei Wu. The genome sequence of Polymorphum gilvum SL003B-26A1(T) reveals its genetic basis for crude oil degradation and adaptation to the saline soil. PloS one. 2012; 7(2):e31261. doi: 10.1371/journal.pone.0031261. [PMID: 22359583]
  • Michael F Seidl, Guido Van den Ackerveken, Francine Govers, Berend Snel. A domain-centric analysis of oomycete plant pathogen genomes reveals unique protein organization. Plant physiology. 2011 Feb; 155(2):628-44. doi: 10.1104/pp.110.167841. [PMID: 21119047]
  • Hamid Sobhanian, Roya Razavizadeh, Yohei Nanjo, Ali Akbar Ehsanpour, Ferdous Rastgar Jazii, Nasrin Motamed, Setsuko Komatsu. Proteome analysis of soybean leaves, hypocotyls and roots under salt stress. Proteome science. 2010 Mar; 8(?):19. doi: 10.1186/1477-5956-8-19. [PMID: 20350314]
  • Beatriz Cámara, Macarena Marín, Michael Schlömann, Hans-Jürgen Hecht, Howard Junca, Dietmar H Pieper. trans-Dienelactone hydrolase from Pseudomonas reinekei MT1, a novel zinc-dependent hydrolase. Biochemical and biophysical research communications. 2008 Nov; 376(2):423-8. doi: 10.1016/j.bbrc.2008.09.006. [PMID: 18789896]
  • Chandramohan V Ammini, Jose Fernandez-Canon, Albert L Shroads, Rachel Cornett, Jang Cheung, Margaret O James, George N Henderson, Markus Grompe, Peter W Stacpoole. Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents. Biochemical pharmacology. 2003 Nov; 66(10):2029-38. doi: 10.1016/j.bcp.2003.07.002. [PMID: 14599561]
  • Hoffman B M Lantum, Judith Cornejo, Robert H Pierce, M W Anders. Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency. Toxicological sciences : an official journal of the Society of Toxicology. 2003 Jul; 74(1):192-202. doi: 10.1093/toxsci/kfg104. [PMID: 12730618]
  • A Brock. Binding of digitoxin to human serum albumin: influence of ionic strength and ionic medium on the digitoxin-albumin complex formation. Acta pharmacologica et toxicologica. 1975 Nov; 37(5):361-8. doi: 10.1111/j.1600-0773.1975.tb00854.x. [PMID: 887]