Mephentermine (BioDeep_00000002732)
Secondary id: BioDeep_00001867935
human metabolite blood metabolite
代谢物信息卡片
化学式: C11H17N (163.1361)
中文名称: 美芬丁胺
谱图信息:
最多检出来源 Homo sapiens(blood) 1.37%
分子结构信息
SMILES: CC(C)(CC1=CC=CC=C1)NC
InChI: InChI=1S/C11H17N/c1-11(2,12-3)9-10-7-5-4-6-8-10/h4-8,12H,9H2,1-3H3
描述信息
A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CA - Adrenergic and dopaminergic agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:6755
- KEGG: C07889
- KEGGdrug: D08180
- PubChem: 3677
- HMDB: HMDB0015452
- Metlin: METLIN43865
- DrugBank: DB01365
- ChEMBL: CHEMBL1201234
- Wikipedia: Mephentermine
- MeSH: Mephentermine
- chemspider: 3549
- CAS: 1212-72-2
- CAS: 100-92-5
- PMhub: MS000004634
- PubChem: 10091
- NIKKAJI: J4.989A
- RefMet: Mephentermine
- KNApSAcK: 6755
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yun Jeong Choi, Arum Sim, Min Kyung Kim, Sunglll Suh, Moon Kyo In, Jin Young Kim. Determination of phentermine, N-hydroxyphentermine and mephentermine in urine using dilute and shoot liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Sep; 1029-1030(?):22-27. doi:
10.1016/j.jchromb.2016.06.045. [PMID: 27398632] - Shreepathi Krishna Achar, Cherish Paul, Elsa Varghese. Unilateral pulmonary edema after laparoscopic nephrectomy.
Journal of anaesthesiology, clinical pharmacology.
2011 Oct; 27(4):556-8. doi:
10.4103/0970-9185.86609. [PMID: 22096298] - R J B Peters, J E Oosterink, A A M Stolker, C Georgakopoulos, M W F Nielen. Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories.
Analytical and bioanalytical chemistry.
2010 Apr; 396(7):2583-98. doi:
10.1007/s00216-010-3484-3. [PMID: 20155493] - B Pradhan. Spinal anesthesia for cesarean section: comparison of 5.0\% lignocaine and 0.5\% bupivacaine.
Nepal Medical College journal : NMCJ.
2010 Mar; 12(1):30-3. doi:
. [PMID: 20677606] - Wei-Hsun Huang, Chin-Hung Liu, Ray H Liu, Ying Lung Tseng. Confirming urinary excretion of mephentermine and phentermine following the ingestion of oxethazaine by gas chromatography-mass spectrometry analysis.
Journal of analytical toxicology.
2010 Mar; 34(2):73-7. doi:
10.1093/jat/34.2.73. [PMID: 20223098] - Michael Moawad, Cheang S Khoo, Samiuela Lee, James R Hennell. Simultaneous determination of eight sympathomimetic amines in urine by gas chromatography/mass spectrometry.
Journal of AOAC International.
2010 Jan; 93(1):116-22. doi:
. [PMID: 20334173] - Mei-Chich Hsu, Su-Fan Lin, Cheng-Ping Kuan, Wei-Lan Chu, Kuei-Hui Chan, Guo-Ping Chang-Chien. Oxethazaine as the source of mephentermine and phentermine in athlete's urine.
Forensic science international.
2009 Mar; 185(1-3):e1-5. doi:
10.1016/j.forsciint.2008.12.009. [PMID: 19157735] - Seung-Woon Myung, Sung-Ho Yoon, Myungsoo Kim. Analysis of benzene ethylamine derivatives in urine using the programmable dynamic liquid-phase microextraction (LPME) device.
The Analyst.
2003 Dec; 128(12):1443-6. doi:
10.1039/b312227c. [PMID: 14737229] - M Mori, M Kobayashi, H Uemura, T Miyahara, H Kozuka. Intestinal metabolism of mephentermine and its biliary metabolites in male Wistar rats.
Xenobiotica; the fate of foreign compounds in biological systems.
1992 Jun; 22(6):701-8. doi:
10.3109/00498259209053132. [PMID: 1441593] - M A Mori, M Kobayashi, Y Yumoto, K Nakafuku, T Miyahara, H Kozuka. Metabolism of mephentermine in male guinea pigs and male mice.
Xenobiotica; the fate of foreign compounds in biological systems.
1991 Oct; 21(10):1301-9. doi:
10.3109/00498259109043205. [PMID: 1796607] - M A Mori, N Uy-Yu, K Sakai, M Inoue, T Miyahara, H Kozuka. Isolation of urinary p-hydroxylated metabolites of mephentermine and phentermine in male Wistar rats.
Xenobiotica; the fate of foreign compounds in biological systems.
1990 Jul; 20(7):653-6. doi:
10.3109/00498259009046881. [PMID: 2238700] - M Mori, N Uy, K Sakai, M Inoue, T Miyahara, H Kozuka. Urinary and biliary metabolites of mephentermine in male Wistar rats.
Xenobiotica; the fate of foreign compounds in biological systems.
1989 Mar; 19(3):287-99. doi:
10.3109/00498258909042274. [PMID: 2665325] - H D Dell, M Donike, H Jacobi, R Kamp. [In vitro stability and biotransformation of 3'-hydroxy-2-[N-methyl-N-(1,1-dimethyl-2-phenethyl)amino] acetophenone (TVX 960) (author's transl)].
Arzneimittel-Forschung.
1980; 30(7):1138-44. doi:
NULL. [PMID: 7191296] - R P Ahlquist. Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor.
American heart journal.
1976 Nov; 92(5):661-4. doi:
10.1016/s0002-8703(76)80086-5. [PMID: 10722] - A H Beckett, P M Bélanger. The identification and analysis of the metabolic products of mephentermine.
The Journal of pharmacy and pharmacology.
1975 Dec; 27(12):928-36. doi:
10.1111/j.2042-7158.1975.tb10250.x. [PMID: 2665] - C H Cashin. Effect of sympathomimetic drugs in eliciting hypertensive responses to reserpine in the rat, after pretreatment with monoamineoxidase inhibitors.
British journal of pharmacology.
1972 Feb; 44(2):203-9. doi:
10.1111/j.1476-5381.1972.tb07256.x. [PMID: 4668590] - H J Lieschke. [Influencing of the kidney function by new sympathomimetics].
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete.
1971 Jul; 26(13):Suppl:175-6 c. doi:
NULL. [PMID: 5125157] - L C Mills, J H Moyer. Indications for adrenergic stimulators in shock.
Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology.
1971 Jun; 4(4):385-95. doi:
NULL. [PMID: 5566718] - A H Beckett, L G Brookes. The metabolism and urinary excretion in man of phentermine, and the influence of N-methyl and p-chloro-substitution.
The Journal of pharmacy and pharmacology.
1971 Apr; 23(4):288-94. doi:
10.1111/j.2042-7158.1971.tb08659.x. [PMID: 4396907] - J W Schweitzer, A J Friedhoff. Amphetamines in human urine: rapid estimation by gas-liquid chromatography.
Clinical chemistry.
1970 Sep; 16(9):786-8. doi:
10.1093/clinchem/16.9.786. [PMID: 5493173] - B M Angrist, J W Schweitzer, S Gershon, A J Friedhoff. Mephentermine psychosis: misuse of the Wyamine inhaler.
The American journal of psychiatry.
1970 Mar; 126(9):1315-7. doi:
10.1176/ajp.126.9.1315. [PMID: 5413209] - L Lareng. [Action of various analeptics on the kidney].
Anesthesie, analgesie, reanimation.
1969 Sep; 26(5):707-10. doi:
NULL. [PMID: 4391673] - NULL. Treatment of shock associated with myocardial infarction.
The Medical letter on drugs and therapeutics.
1969 Apr; 11(7):29-31. doi:
NULL. [PMID: 5781647] - A H Beckett, E J Triggs. Buccal absorption of basic drugs and its application as an in vivo model of passive drug transfer through lipid membranes.
The Journal of pharmacy and pharmacology.
1967 Dec; 19(?):Suppl:31S-41S. doi:
". [PMID: 4383854] - A H Beckett, G T Tucker, A C Moffat. Routine detection and identification in urine of stimulants and other drugs, some of which may be used to modify performance in sport.
The Journal of pharmacy and pharmacology.
1967 May; 19(5):273-94. doi:
10.1111/j.2042-7158.1967.tb08089.x. [PMID: 4382400] - C B Smith. The role of monoamine oxidase in the intraneuronal metabolism of norepinephrine released by indirectly-acting sympathomimetic amines or by adrenergic nerve stimulation.
The Journal of pharmacology and experimental therapeutics.
1966 Feb; 151(2):207-20. doi:
NULL. [PMID: 5932599] - A B Dobkin, P H Byles. Comparison of anaesthesia with innovar, halothane and methoxyflurane-nitrous oxide.
Acta anaesthesiologica Scandinavica. Supplementum.
1966; 18(?):1-43. doi:
10.1111/j.1399-6576.1966.tb00326.x. [PMID: 4287535] - D A FISHER, M D MORRIS. IDIOPATHIC EDEMA ND HYPERALDOSTERONURIA: POSTURAL VENOUS PLASMA POOLING.
Pediatrics.
1965 Mar; 35(?):413-24. doi:
NULL. [PMID: 14258654] - B BLACKWELL. THE MANAGEMENT OF BARBITURATE OVERDOSE IN NON-SPECIALIZED UNITS.
The British journal of clinical practice.
1964 Mar; 18(?):135-44. doi:
NULL. [PMID: 14130456] - G P NOVELLI, B TORCHIANA. [THE CHANGES IN RENAL CIRCULATORY OUTPUT CAUSED BY SOME DRUGS USED IN ANESTHESIA AND RESUSCITATION].
Minerva nefrologica.
1963 Oct; 10(?):224-5. doi:
NULL. [PMID: 14096863] - G P NOVELLI, B TORCHIANA, M RISTORI. [The response of the renal circulation to some vasopressor drugs].
Acta anaesthesiologica.
1963 Jan; 14(?):55-68. doi:
NULL. [PMID: 13939114]
