Cefoselis (BioDeep_00000008542)

 

Secondary id: BioDeep_00001870018


代谢物信息卡片


Cefoselisum

化学式: C19H22N8O6S2 (522.1103672)
中文名称: 头孢噻利
谱图信息: 最多检出来源 Mentha canadensis(plant) 96.88%

分子结构信息

SMILES: CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(Cn3ccc(=N)n3CCO)CSC12)c1csc(=N)[nH]1
InChI: InChI=1S/C19H22N8O6S2/c1-33-24-12(10-8-35-19(21)22-10)15(29)23-13-16(30)27-14(18(31)32)9(7-34-17(13)27)6-25-3-2-11(20)26(25)4-5-28/h2-3,8,13,17,20,28H,4-7H2,1H3,(H4,21,22,23,29,31,32)/b24-12-/t13-,17-/m1/s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

2 个代谢物同义名

Cefoselis; Cefoselisum



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yifeng Zheng, Neng Wang, Shengqi Wang, Bo Pan, Bowen Yang, Juping Zhang, Xuan Wang, Zhiyu Wang. Cefoselis enhances breast cancer chemosensitivity by directly targeting GRP78/LRP5 signalling of cancer stem cells. Clinical and translational medicine. 2023 Feb; 13(2):e1119. doi: 10.1002/ctm2.1119. [PMID: 36808887]
  • M Nagata, M Yasuhara. Effect of experimental renal failure on the pharmacodynamics of cefoselis-induced seizures in rats. Biological & pharmaceutical bulletin. 2001 Sep; 24(9):1049-52. doi: 10.1248/bpb.24.1049. [PMID: 11558567]
  • M E Ganapathy, W Huang, D P Rajan, A L Carter, M Sugawara, K Iseki, F H Leibach, V Ganapathy. beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. The Journal of biological chemistry. 2000 Jan; 275(3):1699-707. doi: 10.1074/jbc.275.3.1699. [PMID: 10636865]
  • K Suzuki, M Horiba, K Ishikawa, S Katoh. [Clinical study of a new injectable cephem, FK037, for acute bacterial prostatitis]. Hinyokika kiyo. Acta urologica Japonica. 1994 Dec; 40(12):1131-7. doi: NULL. [PMID: 7863869]
  • R Wise, J M Andrews, P O'Neill, A Jolley, C Fowler, M C Rogge. Pharmacokinetics and distribution in tissue of FK-037, a new parenteral cephalosporin. Antimicrobial agents and chemotherapy. 1994 Oct; 38(10):2369-72. doi: 10.1128/aac.38.10.2369. [PMID: 7840572]
  • A K Houston, R N Jones. Post-antibiotic effect of FK-037 and biapenem tested against five bacterial species. Journal of chemotherapy (Florence, Italy). 1994 Feb; 6(1):12-4. doi: 10.1080/1120009x.1994.11741121. [PMID: 8071670]
  • K Hatano, Y Wakai, Y Watanabe, Y Mine. Simulation of human plasma levels of beta-lactams in mice by multiple dosing and the relationship between the therapeutic efficacy and pharmacodynamic parameters. Chemotherapy. 1994 Jan; 40(1):1-7. doi: 10.1159/000239162. [PMID: 8306809]
  • Y Mine, Y Watanabe, H Sakamoto, K Hatano, K Kuno, T Kamimura, S Tawara, Y Matsumoto, F Matsumoto, S Kuwahara. Excellent activity of FK037, a novel parenteral broad-spectrum cephalosporin, against methicillin-resistant staphylococci. The Journal of antibiotics. 1993 Jan; 46(1):99-119. doi: 10.7164/antibiotics.46.99. [PMID: 8436564]
  • H Sakamoto, K Hatano, Y Higashi, Y Mine, S Nakamoto, S Tawara, T Kamimura, F Matsumoto, S Kuwahara. Animal pharmacokinetics of FK037, a novel parenteral broad-spectrum cephalosporin. The Journal of antibiotics. 1993 Jan; 46(1):120-30. doi: 10.7164/antibiotics.46.120. [PMID: 8436544]
  • Y Mine, Y Watanabe, H Sakamoto, K Hatano, K Kuno, Y Higashi, T Kamimura, Y Matsumoto, S Tawara, F Matsumoto. In vitro antibacterial activity of FK037, a novel parenteral broad-spectrum cephalosporin. The Journal of antibiotics. 1993 Jan; 46(1):71-87. doi: 10.7164/antibiotics.46.71. [PMID: 8436562]
  • Y Mine, Y Watanabe, H Sakamoto, K Hatano, Y Wakai, T Kamimura, S Tawara, S Matsumoto, F Matsumoto, S Kuwahara. In vivo antibacterial activity of FK037, a novel parenteral broad-spectrum cephalosporin. The Journal of antibiotics. 1993 Jan; 46(1):88-98. doi: 10.7164/antibiotics.46.88. [PMID: 8436563]