prontosil (BioDeep_00000007795)

   

Chemicals and Drugs Antibiotics


代谢物信息卡片


p-[(2,4-diaminophenyl)azo]benzenesulphonamide

化学式: C12H13N5O2S (291.07899180000004)
中文名称: 磺胺米柯定
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1N=NC2=C(C=C(C=C2)N)N)S(=O)(=O)N
InChI: InChI=1S/C12H13N5O2S/c13-8-1-6-12(11(14)7-8)17-16-9-2-4-10(5-3-9)20(15,18)19/h1-7H,13-14H2,(H2,15,18,19)

描述信息

A diphenyldiazene compound having two amino substituents at the 2- and 4-positions and an aminosulphonyl substituent at the 4-position. It was the first antibacterial drug, (introduced 1935) and the first of the sulfonamide antibiotics.
C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent

同义名列表

4 个代谢物同义名

p-[(2,4-diaminophenyl)azo]benzenesulphonamide; prontosil; Sulfamidochrysoidine; Prontosil rubrum



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Pere Domingo, Virginia Pomar, Albert Mauri, Nicolau Barquet. Standing on the shoulders of giants: two centuries of struggle against meningococcal disease. The Lancet. Infectious diseases. 2019 08; 19(8):e284-e294. doi: 10.1016/s1473-3099(19)30040-4. [PMID: 31053493]
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  • Teresa A Figueiredo, Rita G Sobral, Ana Madalena Ludovice, João Manuel Feio de Almeida, Nhat K Bui, Waldemar Vollmer, Hermínia de Lencastre, Alexander Tomasz. Identification of genetic determinants and enzymes involved with the amidation of glutamic acid residues in the peptidoglycan of Staphylococcus aureus. PLoS pathogens. 2012 Jan; 8(1):e1002508. doi: 10.1371/journal.ppat.1002508. [PMID: 22303291]
  • Mario Lorenz, Mandy Fechner, Janine Kalkowski, Kati Fröhlich, Anne Trautmann, Volker Böhm, Gerhard Liebisch, Stefan Lehneis, Gerd Schmitz, Antje Ludwig, Gert Baumann, Karl Stangl, Verena Stangl. Effects of lycopene on the initial state of atherosclerosis in New Zealand White (NZW) rabbits. PloS one. 2012; 7(1):e30808. doi: 10.1371/journal.pone.0030808. [PMID: 22295112]
  • Jean-Philippe Lavigne, Xavier Vitrac, Louis Bernard, Franck Bruyère, Albert Sotto. Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections. BMC research notes. 2011 Nov; 4(?):522. doi: 10.1186/1756-0500-4-522. [PMID: 22126300]
  • Andreas Wittgens, Till Tiso, Torsten T Arndt, Pamela Wenk, Johannes Hemmerich, Carsten Müller, Rolf Wichmann, Benjamin Küpper, Michaela Zwick, Susanne Wilhelm, Rudolf Hausmann, Christoph Syldatk, Frank Rosenau, Lars M Blank. Growth independent rhamnolipid production from glucose using the non-pathogenic Pseudomonas putida KT2440. Microbial cell factories. 2011 Oct; 10(?):80. doi: 10.1186/1475-2859-10-80. [PMID: 21999513]
  • Kasper Hettinga, Hein van Valenberg, Sacco de Vries, Sjef Boeren, Toon van Hooijdonk, Johan van Arendonk, Jacques Vervoort. The host defense proteome of human and bovine milk. PloS one. 2011 Apr; 6(4):e19433. doi: 10.1371/journal.pone.0019433. [PMID: 21556375]
  • Ben de Wet, Tobias Zech, Mogjiborahman Salek, Oreste Acuto, Thomas Harder. Proteomic characterization of plasma membrane-proximal T cell activation responses. The Journal of biological chemistry. 2011 Feb; 286(6):4072-80. doi: 10.1074/jbc.m110.165415. [PMID: 21127068]
  • Anne T Nies, Ute Hofmann, Claudia Resch, Elke Schaeffeler, Maria Rius, Matthias Schwab. Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs). PloS one. 2011; 6(7):e22163. doi: 10.1371/journal.pone.0022163. [PMID: 21779389]
  • Samir Anssour, Ian T Baldwin. Variation in antiherbivore defense responses in synthetic Nicotiana allopolyploids correlates with changes in uniparental patterns of gene expression. Plant physiology. 2010 Aug; 153(4):1907-18. doi: 10.1104/pp.110.156786. [PMID: 20525855]
  • Christian Lindermayr, Simone Sell, Bernd Müller, Dario Leister, Jörg Durner. Redox regulation of the NPR1-TGA1 system of Arabidopsis thaliana by nitric oxide. The Plant cell. 2010 Aug; 22(8):2894-907. doi: 10.1105/tpc.109.066464. [PMID: 20716698]
  • Cornelia Kiank, Jan-Philip Zeden, Solveig Drude, Grazyna Domanska, Gerhard Fusch, Winfried Otten, Christine Schuett. Psychological stress-induced, IDO1-dependent tryptophan catabolism: implications on immunosuppression in mice and humans. PloS one. 2010 Jul; 5(7):e11825. doi: 10.1371/journal.pone.0011825. [PMID: 20689575]
  • Alfredo J Ibáñez, Judith Scharte, Philipp Bones, Alexander Pirkl, Stefan Meldau, Ian T Baldwin, Franz Hillenkamp, Engelbert Weis, Klaus Dreisewerd. Rapid metabolic profiling of Nicotiana tabacum defence responses against Phytophthora nicotianae using direct infrared laser desorption ionization mass spectrometry and principal component analysis. Plant methods. 2010 Jun; 6(?):14. doi: 10.1186/1746-4811-6-14. [PMID: 20534155]
  • M Cristina Palmieri, Christian Lindermayr, Hermann Bauwe, Clara Steinhauser, Joerg Durner. Regulation of plant glycine decarboxylase by s-nitrosylation and glutathionylation. Plant physiology. 2010 Mar; 152(3):1514-28. doi: 10.1104/pp.109.152579. [PMID: 20089767]
  • Qing-Ming Che, Ying Chen, Li-Yi Pan, Hong He. [Study on bile excretion of scutellarein]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Oct; 31(20):1710-2. doi: . [PMID: 17225543]
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