Glaucarubin (BioDeep_00000006959)

 

Secondary id: BioDeep_00001869667

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


4,5,16,17-Tetrahydroxy-6,14,18-trimethyl-9-oxo-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-8-yl 2-hydroxy-2-methylbutanoic acid

化学式: C25H36O10 (496.2308356)
中文名称: 格劳卡昔
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.01%

分子结构信息

SMILES: CCC(C)(C(=O)OC1C2C(C(C3(C4C2(CO3)C(CC5C4(C(C(C=C5C)O)O)C)OC1=O)O)O)C)O
InChI: InChI=1S/C25H36O10/c1-6-22(4,31)21(30)35-16-15-11(3)17(27)25(32)20-23(5)12(10(2)7-13(26)18(23)28)8-14(34-19(16)29)24(15,20)9-33-25/h7,11-18,20,26-28,31-32H,6,8-9H2,1-5H3/t11-,12+,13+,14-,15-,16-,17-,18-,20-,22+,23-,24+,25+/m1/s1

描述信息

Glaucarubin is found in fats and oils. Glaucarubin is isolated from Simarouba glauca (aceituno
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
Isolated from Simarouba glauca (aceituno). Glaucarubin is found in fats and oils.
D000970 - Antineoplastic Agents

同义名列表

9 个代谢物同义名

4,5,16,17-Tetrahydroxy-6,14,18-trimethyl-9-oxo-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-8-yl 2-hydroxy-2-methylbutanoic acid; 4,5,16,17-tetrahydroxy-6,14,18-trimethyl-9-oxo-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-8-yl 2-hydroxy-2-methylbutanoate; Picras-3-en-16-one,11,20-epoxy-1,2,11,12-tetrahydroxy-15-[(2S)-2-hydroxy-2-methyl-1-oxobutoxy]-,(1b,2a,11b,12a,15b)-; alpha-Kirondrin; Glaucarubina; Simarubaceae; Glaucarubin; b-Kirondrin; Kirondrin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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  • Mariana Laundry de Mesquita, José Elias de Paula, Cláudia Pessoa, Manoel Odorico de Moraes, Letícia Veras Costa-Lotufo, Raphael Grougnet, Sylvie Michel, François Tillequin, Laila Salmen Espindola. Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines. Journal of ethnopharmacology. 2009 Jun; 123(3):439-45. doi: 10.1016/j.jep.2009.03.018. [PMID: 19501276]
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  • Sandra Apers, Kanyanga Cimanga, Dirk Vanden Berghe, Els Van Meenen, Albert Otshudi Longanga, André Foriers, Arnold Vlietinck, Luc Pieters. Antiviral activity of simalikalactone D, a quassinoid from Quassia africana. Planta medica. 2002 Jan; 68(1):20-4. doi: 10.1055/s-2002-19870. [PMID: 11842321]
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  • H H Ang, K L Chan, J W Mak. Effect of 7-day daily replacement of culture medium containing Eurycoma longifolia Jack constituents on the Malaysian Plasmodium falciparum isolates. Journal of ethnopharmacology. 1995 Dec; 49(3):171-5. doi: 10.1016/0378-8741(95)01321-0. [PMID: 8824743]
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  • T Sakaki, S Yoshimura, T Tsuyuki, T Takahashi, T Honda. Yadanzioside P, a new antileukemic quassinoid glycoside from Brucea javanica (L.) Merr with the 3-O-(beta-D-glucopyranosyl)bruceantin structure. Chemical & pharmaceutical bulletin. 1986 Oct; 34(10):4447-50. doi: 10.1248/cpb.34.4447. [PMID: 3829175]
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  • R J Robins, M R Morgan, M J Rhodes, J M Furze. An enzyme-linked immunosorbent assay for quassin and closely related metabolites. Analytical biochemistry. 1984 Jan; 136(1):145-56. doi: 10.1016/0003-2697(84)90316-6. [PMID: 6711803]
  • F D Gillin, D S Reiner, M Suffness. Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica. Antimicrobial agents and chemotherapy. 1982 Aug; 22(2):342-5. doi: 10.1128/aac.22.2.342. [PMID: 6100431]
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  • J Polonsky, Z Varon, C Moretti, G R Pettit, C L Herald, J A Rideout, S B Saha, H N Khastgir. The antineoplastic quassinoids of Simaba cuspidata spruce and Ailanthus grandis Prain. Journal of natural products. 1980 Jul; 43(4):503-9. doi: 10.1021/np50010a012. [PMID: 7431025]
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