Gamma-delta-Dioxovaleric acid (BioDeep_00000005002)

 

Secondary id: BioDeep_00001869849

human metabolite Endogenous


代谢物信息卡片


4-Oxoglutaric acid semialdehyde

化学式: C5H6O4 (130.0266)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 8.45%

分子结构信息

SMILES: C(CC(=O)O)C(=O)C=O
InChI: InChI=1S/C5H6O4/c6-3-4(7)1-2-5(8)9/h3H,1-2H2,(H,8,9)

描述信息

gamma-delta-Dioxovaleric acid (DOVA) is the final oxidation product of 5-aminolevulinic acid, a precursor of porphyrin in the biosynthesis of heme. It can accumulate in liver, brain, and other organs under pathological conditions such as acute intermittent porphyria. [HMDB]
Gamma-delta-Dioxovaleric acid (DOVA) is the final oxidation product of 5-aminolevulinic acid, a precursor of porphyrin in the biosynthesis of heme. It can accumulate in liver, brain, and other organs under pathological conditions such as acute intermittent porphyria.

同义名列表

14 个代谢物同义名

4-Oxoglutaric acid semialdehyde; Gamma-delta-Dioxovaleric acid; 4-Oxoglutarate semialdehyde; g-delta-Dioxovaleric acid; gamma,delta-Dioxovalerate; gamma-delta-Dioxovalerate; 4,5-Dioxopentanoic acid; 4,5-Dioxovaleric acid; g-δ-dioxovaleric acid; g-delta-Dioxovalerate; Γ-δ-dioxovaleric acid; 4,5-Dioxopentanoate; Γ-δ-dioxovalerate; g-δ-dioxovalerate



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Janice Onuki, Priscila C Teixeira, Marisa H G Medeiros, Dieter Dörnemann, Thierry Douki, Jean Cadet, Paolo Di Mascio. Is 5-aminolevulinic acid involved in the hepatocellular carcinogenesis of acute intermittent porphyria?. Cellular and molecular biology (Noisy-le-Grand, France). 2002 Feb; 48(1):17-26. doi: . [PMID: 11930945]
  • J Cadet, V M Carvalho, J Onuki, T Douki, M H Medeiros, P D Di Mascio. Purine DNA adducts of 4,5-dioxovaleric acid and 2,4-decadienal. IARC scientific publications. 1999; ?(150):103-13. doi: . [PMID: 10626212]
  • R Sagar, P Salotra, R Bhatnagar, K Datta. L-alanine: 4,5-dioxovalerate transaminase in Leishmania donovani that differs from mammalian enzyme. Microbiological research. 1995 Nov; 150(4):419-23. doi: 10.1016/s0944-5013(11)80024-8. [PMID: 8564368]
  • M H Medeiros, P Di Mascio, S Gründel, S Soboll, H Sies, E J Bechara. Catabolism of 5-aminolevulinic acid to CO2 by rat liver mitochondria. Archives of biochemistry and biophysics. 1994 Apr; 310(1):205-9. doi: 10.1006/abbi.1994.1158. [PMID: 8161206]
  • R van Brummelen, S Bissbort. Chicken eggshell porphyrins and the glyoxalase pathway: its possible physiological role. Comparative biochemistry and physiology. B, Comparative biochemistry. 1993 Apr; 104(4):657-62. doi: 10.1016/0305-0491(93)90193-9. [PMID: 8472535]
  • K A Morton, J P Kushner, J G Straka, B F Burnham. Biosynthesis of 5-aminolevulinic acid and heme from 4,5-dioxovalerate in the rat. The Journal of clinical investigation. 1983 Jun; 71(6):1744-9. doi: 10.1172/jci110929. [PMID: 6863542]
  • E Okuno, Y Minatogawa, R Kido. A new biosynthetic route of porphyrin precursors in common between animals and plants. Biochemical and biophysical research communications. 1983 May; 112(3):986-90. doi: 10.1016/0006-291x(83)91715-1. [PMID: 6342621]
  • R J Porra, O Klein. The determination of 4,5-dioxovaleric acid in plant preparations and a procedure for the assay of L-alanine:4,5-dioxovaleric acid aminotransferase (EC 2.6.1.43) activity. Analytical biochemistry. 1981 Sep; 116(2):511-8. doi: 10.1016/0003-2697(81)90395-x. [PMID: 6976135]